AR060358A1 - Quinazolinas para la inhibicion de pdk 1 - Google Patents

Quinazolinas para la inhibicion de pdk 1

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Publication number
AR060358A1
AR060358A1 ARP070101448A ARP070101448A AR060358A1 AR 060358 A1 AR060358 A1 AR 060358A1 AR P070101448 A ARP070101448 A AR P070101448A AR P070101448 A ARP070101448 A AR P070101448A AR 060358 A1 AR060358 A1 AR 060358A1
Authority
AR
Argentina
Prior art keywords
substituted
heteroaryl
aryl
heterocyclyl
alkyl
Prior art date
Application number
ARP070101448A
Other languages
English (en)
Inventor
P Amiri
R Warne
S Bashman
W Wang
J Dove
A Rico
Rolf Jansen
J Murray
X Lin
R Jain
A Wagnan
S Subramanian
X Wang
S Ramurthy
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of AR060358A1 publication Critical patent/AR060358A1/es

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • A61P13/00—Drugs for disorders of the urinary system
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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Abstract

Composiciones farmacéuticas que incluyen dichos compuestos y métodos para tratar enfermedades proliferativas tales como cánceres, con los compuestos o composiciones. Reivindicacion 1: Un compuesto de formula 1, en donde: uno de W1 o W2 es R1 y el otro es -L-A1; L es un enlace covalente, carbonilo, carbonilamino, aminocarbonilo, -O-, -S-, -SO-, -SO2-, -NH-, alquilo C1-3, alquilo C1-3 sustituido, o un alquilo interrumpido con -O-, -S-,-SO-, -SO2-, -NH-, carbonilo, carbonilamino, o aminocarbonilo; A1 es arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclilo, o heterociclilo sustituido; Y es H, alquilo C1-3, halo, ciano, nitro, o amino; R1 se selecciona entre el grupo que consiste de H, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, alcoxi, alcoxi sustituido, acilo, acilamino, aciloxi, amino, amino sustituido, aminocarbonilo, aminotiocarbonilo, aminocarbonilamino, aminotiocarbonilamino, aminocarboniloxi, aminosulfonilo, aminosulfoniloxi, aminosulfonilamino, amidino, carboxilo, carboxiléster, (carboxiléster)amino, (carboxiléster)oxi, ciano, halo, hidroxi, nitro, SO3H, sulfonilo, sulfonilo sustituido, sulfoniloxi, tioacilo, tiol, alquiltio, alquiltio sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, cicloalquilo, cicloalquilo sustituido, heterociclilo, heterociclilo sustituido, ariloxi, ariloxi sustituido, heteroariloxi, heteroariloxi sustituido, cicloalquiloxi, cicloalquiloxi sustituido, heterocicliloxi, y heterocicliloxi sustituido; R2 y R3 se seleccionan en forma independiente entre el grupo que consiste de H, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, alcoxi, alcoxi sustituido, acilo, acilamino, aciloxi, amino, amino sustituido, aminocarbonilo, aminotiocarbonilo, aminocarbonilamino, aminotiocarbonilamino, aminocarboniloxi, aminosulfonilo, aminosulfoniloxi, aminosulfonilamino, amidino, carboxilo, carboxiléster, (carboxiléster)amino, (carboxiléster)oxi, ciano, halo, hidroxi, nitro, SO3H sulfonilo, sulfonilo sustituido, sulfoniloxi, tioacilo, tiol, alquiltio, alquiltio sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, cicloalquilo, cicloalquilo sustituido, heterociclilo, y heterociclilo sustituido; y R4 es arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, cicloalquilo, cicloalquilo sustituido, heterociclilo, o heterociclilo sustituido, con la salvedad de que cuando R4 es heteroarilo o heteroarilo sustituido, W2 no es arilo o heteroarilo; o un estereoisomero, tautomero o sal aceptable para uso farmacéutico del mismo.
ARP070101448A 2006-04-06 2007-04-04 Quinazolinas para la inhibicion de pdk 1 AR060358A1 (es)

Applications Claiming Priority (1)

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US79030406P 2006-04-06 2006-04-06

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US (1) US7932262B2 (es)
EP (1) EP2004615A2 (es)
JP (1) JP2009532486A (es)
KR (1) KR20080111114A (es)
CN (1) CN101454294A (es)
AR (1) AR060358A1 (es)
AU (1) AU2007235339A1 (es)
BR (1) BRPI0710521A2 (es)
CA (1) CA2648529A1 (es)
CR (1) CR10427A (es)
EA (1) EA200870415A1 (es)
EC (1) ECSP088823A (es)
GT (1) GT200800202A (es)
MA (1) MA30358B1 (es)
MX (1) MX2008012852A (es)
NO (1) NO20084665L (es)
PE (1) PE20080059A1 (es)
SM (1) SMP200800059B (es)
TN (1) TNSN08375A1 (es)
TW (1) TW200808739A (es)
WO (1) WO2007117607A2 (es)
ZA (1) ZA200808307B (es)

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