DE69627179T2 - Substituierte 2-anilino-pyrimidines verwendbar als protein kinase inhibitoren - Google Patents

Substituierte 2-anilino-pyrimidines verwendbar als protein kinase inhibitoren Download PDF

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Publication number
DE69627179T2
DE69627179T2 DE69627179T DE69627179T DE69627179T2 DE 69627179 T2 DE69627179 T2 DE 69627179T2 DE 69627179 T DE69627179 T DE 69627179T DE 69627179 T DE69627179 T DE 69627179T DE 69627179 T2 DE69627179 T2 DE 69627179T2
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Prior art keywords
anilino
substituted
protein kinase
kinase inhibitors
pyrimidines used
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Expired - Fee Related
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DE69627179T
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English (en)
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DE69627179D1 (de
Inventor
Peter David Davis
David Festus Charles Moffat
Jeremy Martin Davis
Martin Clive Hutchings
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UCB Celltech Ltd
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Celltech R&D Ltd
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Publication of DE69627179T2 publication Critical patent/DE69627179T2/de
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE69627179T 1995-11-20 1996-11-20 Substituierte 2-anilino-pyrimidines verwendbar als protein kinase inhibitoren Expired - Fee Related DE69627179T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9523675.8A GB9523675D0 (en) 1995-11-20 1995-11-20 Chemical compounds
PCT/GB1996/002854 WO1997019065A1 (en) 1995-11-20 1996-11-20 Substituted 2-anilinopyrimidines useful as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
DE69627179D1 DE69627179D1 (de) 2003-05-08
DE69627179T2 true DE69627179T2 (de) 2004-01-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69627179T Expired - Fee Related DE69627179T2 (de) 1995-11-20 1996-11-20 Substituierte 2-anilino-pyrimidines verwendbar als protein kinase inhibitoren

Country Status (7)

Country Link
US (2) US5958935A (de)
EP (1) EP0862560B1 (de)
AU (1) AU7631496A (de)
DE (1) DE69627179T2 (de)
ES (1) ES2195020T3 (de)
GB (1) GB9523675D0 (de)
WO (1) WO1997019065A1 (de)

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US6235746B1 (en) 2001-05-22
AU7631496A (en) 1997-06-11
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US5958935A (en) 1999-09-28
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