DK1945631T3 - 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer - Google Patents

4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer

Info

Publication number
DK1945631T3
DK1945631T3 DK06794902.4T DK06794902T DK1945631T3 DK 1945631 T3 DK1945631 T3 DK 1945631T3 DK 06794902 T DK06794902 T DK 06794902T DK 1945631 T3 DK1945631 T3 DK 1945631T3
Authority
DK
Denmark
Prior art keywords
aminopyrazole
cancer treatment
pyrimidine derivatives
derivatives used
tyrosinkinase
Prior art date
Application number
DK06794902.4T
Other languages
English (en)
Inventor
Xiaomei Feng
Huiping Guan
Ying Kan
Stephanos Ioannidis
Bo Peng
Mei Su
Bin Wang
Tao Wang
Hai-Jun Zhang
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1945631T3 publication Critical patent/DK1945631T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK06794902.4T 2005-10-28 2006-10-26 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer DK1945631T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73129905P 2005-10-28 2005-10-28
US80306106P 2006-05-24 2006-05-24
PCT/GB2006/003978 WO2007049041A1 (en) 2005-10-28 2006-10-26 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer

Publications (1)

Publication Number Publication Date
DK1945631T3 true DK1945631T3 (da) 2012-10-22

Family

ID=37575154

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06794902.4T DK1945631T3 (da) 2005-10-28 2006-10-26 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer

Country Status (22)

Country Link
US (3) US20080287475A1 (da)
EP (2) EP2388259A1 (da)
JP (1) JP2009513615A (da)
KR (1) KR20080063846A (da)
AR (1) AR056210A1 (da)
AU (1) AU2006307657B2 (da)
BR (1) BRPI0618011A2 (da)
CA (1) CA2626375A1 (da)
DK (1) DK1945631T3 (da)
EC (1) ECSP088450A (da)
ES (1) ES2391783T3 (da)
HR (1) HRP20120824T1 (da)
IL (1) IL190935A0 (da)
MX (1) MX2008005398A (da)
NO (1) NO20081893L (da)
NZ (1) NZ567584A (da)
PL (1) PL1945631T3 (da)
PT (1) PT1945631E (da)
RU (1) RU2463302C2 (da)
TW (1) TW200800963A (da)
UY (1) UY29886A1 (da)
WO (1) WO2007049041A1 (da)

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BRPI0618011A2 (pt) * 2005-10-28 2011-08-16 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, métodos para produzir um efeito anti-proliferativo e um efeito pró-apoptósico em um animal de sangue quente, para tratar doença e para produzir um efeito inibidor de jak em um animal de sangue quente
SG166827A1 (en) 2005-11-03 2010-12-29 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
UY30444A1 (es) 2006-06-30 2008-01-31 Astrazeneca Ab Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos.
TW200826937A (en) 2006-11-01 2008-07-01 Astrazeneca Ab New use
TW200823196A (en) 2006-11-01 2008-06-01 Astrazeneca Ab New use

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ES2391783T3 (es) 2012-11-29
IL190935A0 (en) 2009-09-22
NO20081893L (no) 2008-05-20
BRPI0618011A2 (pt) 2011-08-16
KR20080063846A (ko) 2008-07-07
US8088784B2 (en) 2012-01-03
AU2006307657A1 (en) 2007-05-03
NZ567584A (en) 2011-08-26
US20100160325A1 (en) 2010-06-24
RU2463302C2 (ru) 2012-10-10
EP1945631B8 (en) 2013-01-02
EP2388259A1 (en) 2011-11-23
CA2626375A1 (en) 2007-05-03
TW200800963A (en) 2008-01-01
PT1945631E (pt) 2012-10-15
WO2007049041A8 (en) 2012-11-01
ECSP088450A (es) 2008-06-30
WO2007049041A1 (en) 2007-05-03
AR056210A1 (es) 2007-09-26
PL1945631T3 (pl) 2012-12-31
EP1945631A1 (en) 2008-07-23
EP1945631B1 (en) 2012-08-08
UY29886A1 (es) 2007-05-31
HRP20120824T1 (hr) 2012-11-30
RU2008120848A (ru) 2009-12-10
AU2006307657B2 (en) 2010-10-28
US20080287475A1 (en) 2008-11-20
MX2008005398A (es) 2008-09-24
US20120071480A1 (en) 2012-03-22
JP2009513615A (ja) 2009-04-02

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