DK1625121T3 - Pyrimidinderivater til behandling af abnorm cellevækst - Google Patents
Pyrimidinderivater til behandling af abnorm cellevækstInfo
- Publication number
- DK1625121T3 DK1625121T3 DK03778613.4T DK03778613T DK1625121T3 DK 1625121 T3 DK1625121 T3 DK 1625121T3 DK 03778613 T DK03778613 T DK 03778613T DK 1625121 T3 DK1625121 T3 DK 1625121T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- cell growth
- abnormal cell
- pyrimidine derivatives
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43567002P | 2002-12-20 | 2002-12-20 | |
| US50074203P | 2003-09-05 | 2003-09-05 | |
| PCT/IB2003/005883 WO2004056807A1 (en) | 2002-12-20 | 2003-12-08 | Pyrimidine derivatives for the treatment of abnormal cell growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1625121T3 true DK1625121T3 (da) | 2010-05-10 |
Family
ID=32685406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03778613.4T DK1625121T3 (da) | 2002-12-20 | 2003-12-08 | Pyrimidinderivater til behandling af abnorm cellevækst |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US7109335B2 (da) |
| EP (1) | EP1625121B1 (da) |
| AP (1) | AP2385A (da) |
| AR (1) | AR043682A1 (da) |
| AT (1) | ATE458731T1 (da) |
| AU (2) | AU2003285614B2 (da) |
| CA (1) | CA2529611C (da) |
| CR (2) | CR8266A (da) |
| CY (1) | CY1110069T1 (da) |
| DE (1) | DE60331479D1 (da) |
| DK (1) | DK1625121T3 (da) |
| DO (1) | DOP2003000793A (da) |
| EA (1) | EA013248B1 (da) |
| EC (1) | ECSP066406A (da) |
| ES (1) | ES2338545T3 (da) |
| GE (1) | GEP20084357B (da) |
| IL (1) | IL172047A (da) |
| MX (1) | MXPA06002608A (da) |
| MY (1) | MY142109A (da) |
| NL (1) | NL1025067C2 (da) |
| NZ (1) | NZ543719A (da) |
| OA (1) | OA13309A (da) |
| PA (1) | PA8593001A1 (da) |
| PE (1) | PE20041016A1 (da) |
| PL (1) | PL379330A1 (da) |
| PT (1) | PT1625121E (da) |
| RS (1) | RS20060097A (da) |
| SI (1) | SI1625121T1 (da) |
| TN (1) | TNSN06074A1 (da) |
| TW (1) | TWI283673B (da) |
| WO (1) | WO2004056807A1 (da) |
Families Citing this family (46)
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|---|---|---|---|---|
| SI1625121T1 (sl) | 2002-12-20 | 2010-04-30 | Pfizer Prod Inc | Derivati pirimidina za zdravljenje abnormalne rasti celic |
| US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| DE10349423A1 (de) * | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| EA200601796A1 (ru) * | 2004-05-14 | 2007-04-27 | Пфайзер Продактс, Инк. | Пиримидиновые производные для лечения аномального клеточного роста |
| JP2007537238A (ja) | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の治療のためのピリミジン誘導体 |
| US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| MXPA06013164A (es) * | 2004-05-14 | 2007-02-13 | Pfizer Prod Inc | Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal. |
| WO2005111024A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2005118544A2 (en) * | 2004-05-18 | 2005-12-15 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
| WO2005123191A1 (en) * | 2004-06-21 | 2005-12-29 | Pharmacia & Upjohn Company Llc | Pyk2 inhibitors for stimulation of osteoblast function |
| EP1741709A1 (en) | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals |
| WO2007049041A1 (en) * | 2005-10-28 | 2007-05-03 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| WO2007063384A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| CA2673125C (en) | 2006-10-19 | 2015-04-21 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| DE102007010801A1 (de) | 2007-03-02 | 2008-09-04 | Bayer Cropscience Ag | Diaminopyrimidine als Fungizide |
| JP2010522697A (ja) * | 2007-03-16 | 2010-07-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション | キナーゼタンパク質結合阻害剤 |
| CA2684447C (en) * | 2007-04-18 | 2012-01-24 | Pfizer Products Inc. | Sulfonyl amide derivatives for the treatment of abnormal cell growth |
| KR101294731B1 (ko) * | 2007-06-04 | 2013-08-16 | 삼성디스플레이 주식회사 | 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법 |
| CA2693594A1 (en) | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| CL2009000600A1 (es) * | 2008-03-20 | 2010-05-07 | Bayer Cropscience Ag | Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas. |
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| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| EP2464633A1 (en) | 2009-08-14 | 2012-06-20 | Boehringer Ingelheim International GmbH | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| EP2395001A1 (en) | 2010-05-21 | 2011-12-14 | Chemilia AB | Novel pyrimidine derivatives |
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| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
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| DE102010034699A1 (de) | 2010-08-18 | 2012-02-23 | Merck Patent Gmbh | Pyrimidinderivate |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 大環状キナーゼ阻害剤 |
| EP2675794B1 (en) | 2011-02-17 | 2019-02-13 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
| CA2827171C (en) | 2011-02-17 | 2019-04-09 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
| EP2502924A1 (en) | 2011-03-24 | 2012-09-26 | Chemilia AB | Novel pyrimidine derivatives |
| US9006241B2 (en) | 2011-03-24 | 2015-04-14 | Noviga Research Ab | Pyrimidine derivatives |
| DE102011111400A1 (de) | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| MX348606B (es) * | 2011-11-29 | 2017-06-21 | Genentech Inc | Derivados de aminopirimidina como moduladores de proteina cinasa 2 de repeticion rica en leucina (lrrk2). |
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| EP2711365A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
| EP2711364A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
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| WO2019117813A1 (en) * | 2017-12-15 | 2019-06-20 | National University Of Singapore | Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis |
| CN116888100A (zh) * | 2021-04-08 | 2023-10-13 | 杭州阿诺生物医药科技有限公司 | 一种高活性的hpk1激酶抑制剂 |
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| SI1625121T1 (sl) * | 2002-12-20 | 2010-04-30 | Pfizer Prod Inc | Derivati pirimidina za zdravljenje abnormalne rasti celic |
| EP1950206A1 (en) | 2002-12-20 | 2008-07-30 | Sosei R&D Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
| US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| MXPA06002552A (es) | 2003-09-05 | 2006-06-20 | Pfizer Prod Inc | Sintesis selectivas de pirimidinas sustituidas con cf3. |
| WO2005111024A1 (en) | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| MXPA06013164A (es) | 2004-05-14 | 2007-02-13 | Pfizer Prod Inc | Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal. |
| JP2007537238A (ja) | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の治療のためのピリミジン誘導体 |
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2003
- 2003-12-08 SI SI200331771T patent/SI1625121T1/sl unknown
- 2003-12-08 AU AU2003285614A patent/AU2003285614B2/en not_active Expired
- 2003-12-08 CA CA002529611A patent/CA2529611C/en not_active Expired - Lifetime
- 2003-12-08 RS YUP-2006/0097A patent/RS20060097A/sr unknown
- 2003-12-08 MX MXPA06002608A patent/MXPA06002608A/es active IP Right Grant
- 2003-12-08 AT AT03778613T patent/ATE458731T1/de active
- 2003-12-08 PL PL379330A patent/PL379330A1/pl not_active Application Discontinuation
- 2003-12-08 DE DE60331479T patent/DE60331479D1/de not_active Expired - Lifetime
- 2003-12-08 ES ES03778613T patent/ES2338545T3/es not_active Expired - Lifetime
- 2003-12-08 GE GEAP20039074A patent/GEP20084357B/en unknown
- 2003-12-08 DK DK03778613.4T patent/DK1625121T3/da active
- 2003-12-08 WO PCT/IB2003/005883 patent/WO2004056807A1/en active Application Filing
- 2003-12-08 EP EP03778613A patent/EP1625121B1/en not_active Expired - Lifetime
- 2003-12-08 AP AP2005003438A patent/AP2385A/xx active
- 2003-12-08 OA OA1200600067A patent/OA13309A/en unknown
- 2003-12-08 PT PT03778613T patent/PT1625121E/pt unknown
- 2003-12-08 EA EA200600122A patent/EA013248B1/ru not_active IP Right Cessation
- 2003-12-11 US US10/733,215 patent/US7109335B2/en not_active Expired - Lifetime
- 2003-12-16 TW TW092135619A patent/TWI283673B/zh not_active IP Right Cessation
- 2003-12-17 MY MYPI20034835A patent/MY142109A/en unknown
- 2003-12-17 DO DO2003000793A patent/DOP2003000793A/es unknown
- 2003-12-18 PA PA20038593001A patent/PA8593001A1/es unknown
- 2003-12-18 AR ARP030104715A patent/AR043682A1/es unknown
- 2003-12-18 NL NL1025067A patent/NL1025067C2/nl not_active IP Right Cessation
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2004
- 2004-01-05 PE PE2004000041A patent/PE20041016A1/es not_active Application Discontinuation
- 2004-12-08 NZ NZ543719A patent/NZ543719A/en not_active IP Right Cessation
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2005
- 2005-11-20 IL IL172047A patent/IL172047A/en active IP Right Grant
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2006
- 2006-03-02 CR CR8266A patent/CR8266A/es unknown
- 2006-03-03 EC EC2006006406A patent/ECSP066406A/es unknown
- 2006-03-03 TN TNP2006000074A patent/TNSN06074A1/en unknown
- 2006-08-17 US US11/506,689 patent/US7351712B2/en not_active Expired - Lifetime
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2008
- 2008-03-31 US US12/059,889 patent/US7674796B2/en not_active Expired - Lifetime
- 2008-07-29 US US12/181,991 patent/US7741336B2/en not_active Expired - Lifetime
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2009
- 2009-08-14 AU AU2009208172A patent/AU2009208172B2/en not_active Expired
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2010
- 2010-04-20 CY CY20101100360T patent/CY1110069T1/el unknown
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2011
- 2011-07-06 CR CR20110380A patent/CR20110380A/es not_active Application Discontinuation
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