PT863916E - Tripeptidos de polifluoroalquil triptofano inibidores de trombina - Google Patents

Tripeptidos de polifluoroalquil triptofano inibidores de trombina

Info

Publication number: PT863916E
Authority: PT; Portugal
Prior art keywords: triphyde; polyphloroalquil; triptofan; trombin; inhibitors
Prior art date: 1995-10-02

Application number

PT96931485T

Other languages

English (en)

Inventor

Joy Antony Malikayl

Joseph Paul Burkhart

Robert James Broersma

Norton Paul Peet

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-02

Filing date

1996-09-06

Publication date

2002-07-31

1996-09-06 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2002-07-31 Publication of PT863916E publication Critical patent/PT863916E/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

PT96931485T 1995-10-02 1996-09-06 Tripeptidos de polifluoroalquil triptofano inibidores de trombina PT863916E (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US475595P	1995-10-02	1995-10-02
US56661595A	1995-12-04	1995-12-04
US08/698,931 US6069232A (en)	1995-10-02	1996-08-26	Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors

Publications (1)

Publication Number	Publication Date
PT863916E true PT863916E (pt)	2002-07-31

Family

ID=27357700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96931485T PT863916E (pt)	1995-10-02	1996-09-06	Tripeptidos de polifluoroalquil triptofano inibidores de trombina

Country Status (19)

Country	Link
US (1)	US6069232A (pt)
EP (1)	EP0863916B1 (pt)
KR (1)	KR19990063942A (pt)
CN (1)	CN1137134C (pt)
AR (1)	AR003756A1 (pt)
AT (1)	ATE215963T1 (pt)
AU (1)	AU700312B2 (pt)
CA (1)	CA2233698C (pt)
DE (1)	DE69620627T2 (pt)
DK (1)	DK0863916T3 (pt)
ES (1)	ES2171717T3 (pt)
HK (1)	HK1015797A1 (pt)
HU (1)	HUP9901290A3 (pt)
IL (1)	IL123597A (pt)
NO (1)	NO981468L (pt)
NZ (1)	NZ318627A (pt)
PT (1)	PT863916E (pt)
TW (1)	TW339335B (pt)
WO (1)	WO1997012904A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6214841B1 (en)	1997-05-15	2001-04-10	Eli Lilly And Company	Antithrombotic compound
EP1051431A1 (de)	1998-01-26	2000-11-15	Basf Aktiengesellschaft	Thrombininhibitoren
YU42401A (sh) *	1998-12-14	2003-12-31	Ortho-Mcneil Pharmaceuticals Inc.	Supstituisani heterociklični acil-tripeptidi korisni kao modulatori receptora trombina
GB0716992D0 (en)	2007-08-31	2007-10-10	Immune Targeting Systems Its L	Influenza antigen delivery vectors and constructs
GB0408164D0 (en)	2004-04-13	2004-05-19	Immune Targeting Systems Ltd	Antigen delivery vectors and constructs
DK2785700T3 (en) *	2011-11-29	2016-06-13	Perosphere Inc	Agent for preventing the action of anti-coagulants.
CN103450067B (zh) *	2012-05-29	2015-01-07	首都医科大学	乙基连接的双吲哚-3-基-乙酰氨基酸、其制备、抗血栓作用和应用
EP3684785A1 (en)	2017-09-19	2020-07-29	Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.	N-methylated cyclic peptides and their prodrugs
EP3684417A1 (en) *	2017-09-19	2020-07-29	Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.	Lipophilic peptide prodrugs
EP3684794A1 (en)	2017-09-19	2020-07-29	Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.	Somatostatin prodrugs

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4061625A (en) *	1975-07-11	1977-12-06	Ab Kabi	Novel chromogenic thrombin substrates
US4247454A (en) *	1975-07-11	1981-01-27	Ab Kabi	Novel chromogenic thrombin substrates
US4275153A (en) *	1978-08-03	1981-06-23	American Hospital Supply Corporation	Analytical fluorogenic substrates for proteolytic enzymes
US4216142A (en) *	1978-12-18	1980-08-05	Abbott Laboratories	Chromogenic substrates for the proteolytic enzymes
US4217269A (en) *	1979-03-23	1980-08-12	Abbott Laboratories	Dipeptide chromogenic substrates
US4221706A (en) *	1979-06-14	1980-09-09	Abbott Laboratories	Chromogenic substrates
US4318904A (en) *	1980-04-25	1982-03-09	Research Corporation	Peptide affinity labels for thrombin and other trypsin-like proteases
HU184368B (en) *	1981-01-13	1984-08-28	Gyogyszerkutato Intezet	Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
JPS5856695A (ja) *	1981-09-28	1983-04-04	Nitto Boseki Co Ltd	新規なトロンビン測定用基質
FR2550447B1 (fr) *	1983-08-10	1986-01-17	Ile De France	Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
US4643991A (en) *	1984-12-18	1987-02-17	The University Of Kentucky Research Foundation	Peptide elastase inhibitors and methods
HU192646B (en) *	1984-12-21	1987-06-29	Gyogyszerkutato Intezet	Process for preparing new n-alkyl-peptide aldehydes
FR2575753B1 (fr) *	1985-01-07	1987-02-20	Adir	Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ZA86746B (en) *	1985-02-04	1986-09-24	Merrell Dow Pharma	Novel peptidase inhibitors
DE3505555A1 (de) *	1985-02-18	1986-09-11	Behringwerke Ag, 3550 Marburg	Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US4762821A (en) *	1985-03-22	1988-08-09	Syntex (U.S.A.) Inc.	N',N"-dialkylguanidino dipeptides
DE3683541D1 (de) *	1985-06-07	1992-03-05	Ici America Inc	Selektionierte difluorverbindungen.
JPS62126197A (ja) *	1985-11-26	1987-06-08	Nitto Boseki Co Ltd	新規な血漿キニノゲナーゼ測定用化合物
FR2598412B1 (fr) *	1986-03-12	1988-10-21	Sanofi Sa	Nouveaux derives de diarylcetones et leurs procedes de preparation et les compositions pharmaceutiques les contenant
AU595309B2 (en) *	1986-05-09	1990-03-29	Dainippon Pharmaceutical Co. Ltd.	Tripeptide derivatives
DE3783280T2 (de) *	1986-07-16	1993-05-06	Eniricerche Spa	Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
US4929602A (en) *	1987-11-25	1990-05-29	Scripps Clinic And Research Foundation	Method of inhibiting platelet dependent arterial thrombosis
ZA905737B (en) *	1989-07-26	1991-05-29	Merrell Dow Pharma	Novel peptidase inhibitors
US5053392A (en) *	1989-12-01	1991-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
EP0570428B1 (en) *	1991-02-04	1998-12-16	Akzo Nobel N.V.	FACTOR IIa INHIBITORS
EP0503203A1 (en) *	1991-03-15	1992-09-16	Merrell Dow Pharmaceuticals Inc.	Novel thrombin inhibitors
US5391705A (en) *	1991-03-15	1995-02-21	Merrell Dow Pharmaceuticals Inc.	Polyfluorinated tripeptide thrombin inhibitors
CA2159834A1 (en) *	1993-04-30	1994-11-10	Daniel F. Veber	Thrombin inhibitors
GB2287027A (en) *	1994-03-04	1995-09-06	Lilly Co Eli	Tripeptide antithrombotic agents

1996
- 1996-08-26 US US08/698,931 patent/US6069232A/en not_active Expired - Lifetime
- 1996-09-06 KR KR1019980702415A patent/KR19990063942A/ko active IP Right Grant
- 1996-09-06 AT AT96931485T patent/ATE215963T1/de not_active IP Right Cessation
- 1996-09-06 WO PCT/US1996/014363 patent/WO1997012904A1/en active IP Right Grant
- 1996-09-06 EP EP96931485A patent/EP0863916B1/en not_active Expired - Lifetime
- 1996-09-06 AU AU70154/96A patent/AU700312B2/en not_active Ceased
- 1996-09-06 HU HU9901290A patent/HUP9901290A3/hu unknown
- 1996-09-06 NZ NZ318627A patent/NZ318627A/xx unknown
- 1996-09-06 CN CNB961973862A patent/CN1137134C/zh not_active Expired - Fee Related
- 1996-09-06 PT PT96931485T patent/PT863916E/pt unknown
- 1996-09-06 IL IL12359796A patent/IL123597A/xx not_active IP Right Cessation
- 1996-09-06 DK DK96931485T patent/DK0863916T3/da active
- 1996-09-06 CA CA002233698A patent/CA2233698C/en not_active Expired - Fee Related
- 1996-09-06 DE DE69620627T patent/DE69620627T2/de not_active Expired - Fee Related
- 1996-09-06 ES ES96931485T patent/ES2171717T3/es not_active Expired - Lifetime
- 1996-09-30 TW TW085111905A patent/TW339335B/zh active
- 1996-10-01 AR ARP960104555A patent/AR003756A1/es not_active Application Discontinuation
1998
- 1998-04-01 NO NO981468A patent/NO981468L/no not_active Application Discontinuation
1999
- 1999-03-09 HK HK99100976A patent/HK1015797A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE215963T1 (de)	2002-04-15
AU7015496A (en)	1997-04-28
CA2233698A1 (en)	1997-04-10
CN1198748A (zh)	1998-11-11
NO981468D0 (no)	1998-04-01
WO1997012904A1 (en)	1997-04-10
TW339335B (en)	1998-09-01
NO981468L (no)	1998-04-01
ES2171717T3 (es)	2002-09-16
CN1137134C (zh)	2004-02-04
AU700312B2 (en)	1998-12-24
DE69620627D1 (en)	2002-05-16
NZ318627A (en)	1999-11-29
AR003756A1 (es)	1998-09-09
IL123597A (en)	2003-01-12
IL123597A0 (en)	1998-10-30
CA2233698C (en)	2002-04-09
HK1015797A1 (en)	1999-10-22
US6069232A (en)	2000-05-30
EP0863916B1 (en)	2002-04-10
DE69620627T2 (de)	2002-10-17
HUP9901290A3 (en)	1999-11-29
HUP9901290A2 (hu)	1999-08-30
DK0863916T3 (da)	2002-07-29
EP0863916A1 (en)	1998-09-16
KR19990063942A (ko)	1999-07-26

Publication	Publication Date	Title
PT858464E (pt)	2003-08-29	Inibidores de trombina
BR9609682A (pt)	1999-07-06	Foto-desinfetantes de baixa nuança
PT958287E (pt)	2002-12-31	Inibidores de sulfamida-metaloprotease
NO952840D0 (no)	1995-07-17	Stötfangersystem
ATA135896A (de)	2001-02-15	Skibob
PT863916E (pt)	2002-07-31	Tripeptidos de polifluoroalquil triptofano inibidores de trombina
ATE198470T1 (de)	2001-01-15	Alkenyl-benzoylguanidine
PT839024E (pt)	2004-08-31	Formulacoes de monensina
BR9610514A (pt)	1999-03-30	Inibidores cicloantihelmínticos
ATE240972T1 (de)	2003-06-15	Cyclopeptolide
ATA119896A (de)	2002-04-15	Scheibenmähwerk
PT869966E (pt)	2005-07-29	Pro-farmacos de inibidores de trombina
BR9501643A (pt)	1997-09-16	Helistato
KR970703937A (ko)	1997-08-09	금속단백질 분해효소 억제제(Metallproteinase inhibitors)
KR960028533U (ko)	1996-09-17	＂t＂ 자
BR7500505U (pt)	1995-12-12	Amolador de facas
BR7500991U (pt)	1996-06-18	Caríndio
BR7501485U (pt)	1997-11-18	Fibropiso
BR7500809U (pt)	1997-05-13	Tele-negocios
BR7500838U (pt)	1997-05-13	Vassourágua
BR7500192U (pt)	1995-06-06	Parasitofiltro
BR7500703U (pt)	1997-05-13	Rodopratic
BR7501298U (pt)	1997-09-16	Torre-audio-visual
BR7501299U (pt)	1997-09-16	Geladeira-prática
BR7501301U (pt)	1997-09-16	Guarda-chuva-mochila