SU6668A1
(ru)
|
1921-07-19 |
1924-09-15 |
А.Д. Несмеянов |
Центробежный распылитель дл жидкости
|
SU5416A1
(ru)
|
1926-06-03 |
1928-05-31 |
Тормейер Г. |
Двигатель компаунд внутреннего горени
|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
US3935230A
(en)
|
1972-10-24 |
1976-01-27 |
E. R. Squibb & Sons, Inc. |
α, α, α, α', α', α'-Hexafluorodi-m-tolylamine derivatives
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
DE4134467A1
(de)
|
1991-10-18 |
1993-04-22 |
Thomae Gmbh Dr K |
Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
US5587458A
(en)
|
1991-10-07 |
1996-12-24 |
Aronex Pharmaceuticals, Inc. |
Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
|
EP0625200B1
(en)
|
1992-02-06 |
2005-05-11 |
Chiron Corporation |
Biosynthetic binding protein for cancer marker
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
US5441952A
(en)
|
1993-04-05 |
1995-08-15 |
Merck & Co., Inc. |
Fibrinogen receptor antagonists
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
CA2216809A1
(en)
|
1995-04-04 |
1996-10-10 |
Alan Naylor |
Imidazo[1,2-a]pyridine derivatives
|
CA2218503C
(en)
|
1995-04-20 |
2001-07-24 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
DK0780386T3
(da)
|
1995-12-20 |
2003-02-03 |
Hoffmann La Roche |
Matrixmetalloproteaseinhibitorer
|
DE69637855D1
(de)
|
1995-12-22 |
2009-04-16 |
Novo Nordisk As |
Verbindungen mit wachstumshormon-freisetzenden eigenschaften
|
PT885198E
(pt)
|
1996-03-05 |
2002-06-28 |
Astrazeneca Ab |
Derivados de 4-anilinoquinazolina
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
ID19430A
(id)
|
1996-07-13 |
1998-07-09 |
Glaxo Group Ltd |
Senyawa senyawa heterosiklik
|
AR007857A1
(es)
|
1996-07-13 |
1999-11-24 |
Glaxo Group Ltd |
Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen.
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
TR199900066T2
(xx)
|
1996-07-18 |
1999-04-21 |
Pfizer Inc. |
Matriks metalloproteazlar�n fosfinat bazl� inhibit�rleri
|
IL128189A0
(en)
|
1996-08-23 |
1999-11-30 |
Pfizer |
Arylsulfonylamino hydroxamic acid derivatives
|
KR100622323B1
(ko)
|
1996-10-01 |
2006-11-30 |
교와 핫꼬 고교 가부시끼가이샤 |
질소-함유헤테로고리화합물
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
US6077864A
(en)
|
1997-01-06 |
2000-06-20 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
PL335027A1
(en)
|
1997-02-03 |
2000-03-27 |
Pfizer Prod Inc |
Derivatives of arylsulphonylamino hydroxamic acid
|
CA2279863A1
(en)
|
1997-02-07 |
1998-08-13 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
BR9807678A
(pt)
|
1997-02-11 |
2000-02-15 |
Pfizer |
Derivados de ácidos arilsulfonil-hidroxâmicos
|
EP0984930B1
(en)
|
1997-05-07 |
2005-04-06 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
WO1998054093A1
(en)
|
1997-05-30 |
1998-12-03 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
KR100372138B1
(ko)
|
1997-08-08 |
2003-02-14 |
화이자 프로덕츠 인코포레이티드 |
아릴옥시아릴설포닐아미노 하이드록삼산 유도체
|
AU8816298A
(en)
|
1997-08-22 |
1999-03-16 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
WO1999016755A1
(en)
|
1997-09-26 |
1999-04-08 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
SK6652000A3
(en)
|
1997-11-11 |
2002-05-09 |
Pfizer Prod Inc |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
GB9800569D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
ES2220004T3
(es)
|
1998-04-10 |
2004-12-01 |
Pfizer Products Inc. |
Derivados del acido ciclobutil-ariloxiarilsulfonilaminohidroxamico.
|
IL139934A
(en)
|
1998-05-29 |
2007-10-31 |
Sugen Inc |
History 2 - Indulinone converted to pyrrole and pharmaceutical preparations containing them
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
PT1004578E
(pt)
|
1998-11-05 |
2004-06-30 |
Pfizer Prod Inc |
Derivados hidroxamida do acido 5-oxo-pirrolidino-2-carboxilico
|
HUP0104693A3
(en)
|
1998-12-16 |
2003-12-29 |
Warner Lambert Co |
Treatment of arthritis with mek inhibitors
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
WO2000047574A1
(en)
|
1999-02-11 |
2000-08-17 |
Pfizer Products Inc. |
Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
|
IL129299A0
(en)
|
1999-03-31 |
2000-02-17 |
Mor Research Applic Ltd |
Monoclonal antibodies antigens and diagnosis of malignant diseases
|
AU784634B2
(en)
|
1999-11-30 |
2006-05-18 |
Mayo Foundation For Medical Education And Research |
B7-H1, a novel immunoregulatory molecule
|
MY130363A
(en)
|
2000-02-15 |
2007-06-29 |
Sugen Inc |
"pyrrole substituted 2-indolinone protein kinase inhibitors"
|
AU3704101A
(en)
|
2000-02-17 |
2001-08-27 |
Amgen Inc |
Kinase inhibitors
|
EE05450B1
(et)
|
2000-07-19 |
2011-08-15 |
Warner-Lambert Company |
4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine
|
KR100831116B1
(ko)
|
2000-08-18 |
2008-05-20 |
밀레니엄 파머슈티컬스 인코퍼레이티드 |
키나아제 억제제로서의 퀴나졸린 유도체
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
PL221491B1
(pl)
|
2002-03-08 |
2016-04-29 |
Eisai R&D Man Co |
Związki makrocykliczne, środek farmaceutyczny zawierający te związki oraz zastosowanie tych związków
|
PL401637A1
(pl)
|
2002-03-13 |
2013-05-27 |
Array Biopharma Inc. |
N3 alkilowane pochodne benzimidazolu jako inhibitory MEK
|
AU2003231231A1
(en)
|
2002-05-06 |
2003-11-11 |
Bayer Pharmaceuticals Corporation |
Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
SI2206517T1
(sl)
|
2002-07-03 |
2023-12-29 |
Ono Pharmaceutical Co., Ltd. |
Imunopotencirni sestavki,ki obsegajo protitelesa proti PD-L1
|
AU2003272548A1
(en)
|
2002-09-16 |
2004-04-30 |
Plexxikon, Inc. |
Crystal structure of pim-1 kinase
|
CN100567296C
(zh)
|
2002-12-18 |
2009-12-09 |
沃泰克斯药物股份有限公司 |
可用作蛋白激酶抑制剂的***并哒嗪
|
JP4511943B2
(ja)
|
2002-12-23 |
2010-07-28 |
ワイス エルエルシー |
Pd−1に対する抗体およびその使用
|
JP2006151810A
(ja)
|
2002-12-26 |
2006-06-15 |
Daiichi Asubio Pharma Co Ltd |
ジヒドロチエノキノリン誘導体及びそれを含む細胞接着阻害剤
|
EP1601672B1
(en)
*
|
2003-02-14 |
2006-07-26 |
Pfizer Products Inc. |
Triazolo-pyridines as anti-inflammatory compounds
|
WO2004074244A2
(en)
|
2003-02-20 |
2004-09-02 |
Smithkline Beecham Corporation |
Pyrimidine compounds
|
US20070105839A1
(en)
|
2003-09-18 |
2007-05-10 |
Patricia Imbach |
2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders
|
PL1678166T3
(pl)
|
2003-10-14 |
2009-12-31 |
Univ Arizona |
Inhibitory kinaz białkowych
|
ATE412652T1
(de)
*
|
2004-08-12 |
2008-11-15 |
Pfizer |
Triazolopyridinylsulfanylderivate als inhibitoren der p38-map-kinase
|
TW200633990A
(en)
|
2004-11-18 |
2006-10-01 |
Takeda Pharmaceuticals Co |
Amide compound
|
US7723340B2
(en)
|
2005-01-13 |
2010-05-25 |
Signal Pharmaceuticals, Llc |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
|
CN101189239A
(zh)
|
2005-04-28 |
2008-05-28 |
休普基因公司 |
蛋白激酶抑制剂
|
KR101339628B1
(ko)
|
2005-05-09 |
2013-12-09 |
메다렉스, 인코포레이티드 |
예정 사멸 인자 1(pd-1)에 대한 인간 모노클로날 항체, 및 항-pd-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법
|
NZ564592A
(en)
|
2005-07-01 |
2011-11-25 |
Medarex Inc |
Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
|
CA2618218C
(en)
|
2005-07-21 |
2015-06-30 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of mek
|
EP1910369A1
(en)
|
2005-07-29 |
2008-04-16 |
Astellas Pharma Inc. |
Fused heterocycles as lck inhibitors
|
EP1923388A4
(en)
|
2005-08-12 |
2011-03-09 |
Takeda Pharmaceutical |
BRAIN / NERVE CELL PROTECTION AND THERAPEUTIC FOR SLEEP DISORDERS
|
WO2007025090A2
(en)
|
2005-08-25 |
2007-03-01 |
Kalypsys, Inc. |
Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
|
DE102005042742A1
(de)
|
2005-09-02 |
2007-03-08 |
Schering Ag |
Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
|
US7750000B2
(en)
|
2005-09-02 |
2010-07-06 |
Bayer Schering Pharma Ag |
Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
|
TW200745123A
(en)
|
2005-10-06 |
2007-12-16 |
Schering Corp |
Pyrazolopyrimidines as protein kinase inhibitors
|
JP2009523724A
(ja)
|
2006-01-13 |
2009-06-25 |
ファーマサイクリクス,インコーポレイテッド |
チロシンキナーゼ阻害剤およびその使用方法
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
US20090012079A1
(en)
*
|
2006-02-09 |
2009-01-08 |
Russell Andrew Lewthwaite |
Triazolopyridine Compounds
|
MX2008015638A
(es)
|
2006-06-09 |
2009-01-09 |
Icos Corp |
Acidos fenil aceticos sustituidos como antagonistas de dp-2.
|
DE102006029447A1
(de)
|
2006-06-21 |
2007-12-27 |
Bayer Schering Pharma Ag |
Oxo-substituierte Imidazo[1,2b]pyridazine, deren Herstellung und Verwendung als Arzneimittel
|
EP1873157A1
(en)
|
2006-06-21 |
2008-01-02 |
Bayer Schering Pharma Aktiengesellschaft |
Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
|
EP1900739A1
(en)
|
2006-08-30 |
2008-03-19 |
Cellzome Ag |
Diazolodiazine derivatives as kinase inhibitors
|
US20110021513A1
(en)
|
2006-09-07 |
2011-01-27 |
Biogen Idec Ma Inc. |
Modulators of interleukin-1 receptor-associated kinase
|
HUE031334T2
(hu)
|
2006-09-22 |
2017-07-28 |
Pharmacyclics Llc |
Bruton-tirozinkináz inhibitorok
|
CN101516885A
(zh)
|
2006-09-29 |
2009-08-26 |
诺瓦提斯公司 |
作为pi3k脂质激酶抑制剂的吡唑并嘧啶类化合物
|
BRPI0718266A2
(pt)
|
2006-10-30 |
2014-01-07 |
Novartis Ag |
Compostos heterocíclicos como agentes anti-inflamatórios.
|
WO2008055233A1
(en)
|
2006-10-31 |
2008-05-08 |
Supergen, Inc. |
Protein kinase inhibitors
|
US8987233B2
(en)
|
2006-11-03 |
2015-03-24 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
US20120058997A1
(en)
*
|
2006-11-06 |
2012-03-08 |
Supergen, Inc. |
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
|
BRPI0718029A2
(pt)
*
|
2006-11-06 |
2013-11-26 |
Supergen Inc |
Derivados de imidazo(1,2-b)piridazina e pirazolo(1,5-a)pirimidina e seu uso como inibidores da proteína cinase
|
WO2008082839A2
(en)
|
2006-12-29 |
2008-07-10 |
Abbott Laboratories |
Pim kinase inhibitors as cancer chemotherapeutics
|
ES2702362T3
(es)
|
2007-01-31 |
2019-02-28 |
Ym Biosciences Australia Pty |
Compuestos a base de tiopirimidina y usos de los mismos
|
MX2009009304A
(es)
|
2007-03-01 |
2009-11-18 |
Novartis Ag |
Inhibidores de cinasa pim y metodos para su uso.
|
JP2010520222A
(ja)
|
2007-03-01 |
2010-06-10 |
スーパージェン, インコーポレイテッド |
ピリミジン−2,4−ジアミン誘導体およびjak2キナーゼ阻害剤としてのピリミジン−2,4−ジアミン誘導体の使用
|
US7834024B2
(en)
|
2007-03-26 |
2010-11-16 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
SG10202107066WA
(en)
|
2007-03-28 |
2021-07-29 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
US20120101114A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
EP2139869A2
(en)
|
2007-04-13 |
2010-01-06 |
SuperGen, Inc. |
Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
US9244059B2
(en)
|
2007-04-30 |
2016-01-26 |
Immutep Parc Club Orsay |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
CA2691357C
(en)
|
2007-06-18 |
2014-09-23 |
N.V. Organon |
Antibodies to human programmed death receptor pd-1
|
WO2009017954A1
(en)
|
2007-08-01 |
2009-02-05 |
Phenomix Corporation |
Inhibitors of jak2 kinase
|
KR101584823B1
(ko)
|
2007-09-12 |
2016-01-22 |
제넨테크, 인크. |
포스포이노시타이드 3-키나제 저해제 화합물과 화학치료제의 배합물 및 이의 사용방법
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
US8354528B2
(en)
|
2007-10-25 |
2013-01-15 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
WO2009060197A1
(en)
*
|
2007-11-08 |
2009-05-14 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazopyridazines for use as protein kinase inhibitors
|
EP2217235A4
(en)
|
2007-11-15 |
2011-01-12 |
Musc Found For Res Dev |
PROTEIN INHIBITORS PIM KINASES, COMPOSITIONS AND METHODS FOR TREATING CANCER
|
JP5587206B2
(ja)
|
2007-12-19 |
2014-09-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
JAK2阻害剤として有用なピラゾロ[1,5−a]ピリミジン
|
US20110028405A1
(en)
|
2007-12-20 |
2011-02-03 |
Richard John Harrison |
Sulfamides as zap-70 inhibitors
|
UY31679A1
(es)
|
2008-03-03 |
2009-09-30 |
|
Inhibidores de cinasa pim y metodos para su uso
|
US8168794B2
(en)
|
2008-03-03 |
2012-05-01 |
Novartis Ag |
Pim kinase inhibitors and methods of their use
|
WO2009114335A2
(en)
|
2008-03-12 |
2009-09-17 |
Merck & Co., Inc. |
Pd-1 binding proteins
|
ES2645689T3
(es)
|
2008-05-21 |
2017-12-07 |
Ariad Pharmaceuticals, Inc. |
Derivados de fósforo como inhibidores de quinasas
|
CA2726844C
(en)
|
2008-06-20 |
2016-08-30 |
Genentech, Inc. |
Triazolopyridine jak inhibitor compounds and methods
|
RU2536584C2
(ru)
|
2008-06-27 |
2014-12-27 |
Авила Терапьютикс, Инк. |
Гетероарильные соединения и их применение
|
FR2933409B1
(fr)
|
2008-07-03 |
2010-08-27 |
Centre Nat Rech Scient |
NOUVEAUX PYRROLO °2,3-a! CARBAZOLES ET LEUR UTILISATION COMME INHIBITEURS DES KINASES PIM
|
EP3311818A3
(en)
|
2008-07-16 |
2018-07-18 |
Pharmacyclics, LLC |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
RU2011108563A
(ru)
|
2008-08-05 |
2012-09-10 |
Таргеджен, Инк. (US) |
Способы лечения талассемии
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
TWI496779B
(zh)
|
2008-08-19 |
2015-08-21 |
Array Biopharma Inc |
作為pim激酶抑制劑之***吡啶化合物
|
US8557809B2
(en)
|
2008-08-19 |
2013-10-15 |
Array Biopharma Inc. |
Triazolopyridine compounds as PIM kinase inhibitors
|
EP2328920A2
(en)
|
2008-08-25 |
2011-06-08 |
Amplimmune, Inc. |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
CA2735782A1
(en)
|
2008-09-02 |
2010-03-11 |
Novartis Ag |
Heterocyclic pim-kinase inhibitors
|
EA020136B1
(ru)
|
2008-09-02 |
2014-08-29 |
Новартис Аг |
Производные пиколинамида в качестве ингибиторов киназы
|
AU2009289316A1
(en)
|
2008-09-02 |
2010-03-11 |
Novartis Ag |
Bicyclic kinase inhibitors
|
JP2012501670A
(ja)
|
2008-09-12 |
2012-01-26 |
アイシス・イノベーション・リミテッド |
Pd−1特異抗体およびその使用
|
PL2350075T3
(pl)
|
2008-09-22 |
2014-07-31 |
Array Biopharma Inc |
Podstawione związki imidazo[1,2b]pirydazynowe jako inhibitory kinaz Trk
|
MX2011003195A
(es)
|
2008-09-26 |
2011-08-12 |
Dana Farber Cancer Inst Inc |
Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos.
|
CN104479018B
(zh)
|
2008-12-09 |
2018-09-21 |
霍夫曼-拉罗奇有限公司 |
抗-pd-l1抗体及它们用于增强t细胞功能的用途
|
TW201035100A
(en)
|
2008-12-19 |
2010-10-01 |
Cephalon Inc |
Pyrrolotriazines as ALK and JAK2 inhibitors
|
CA2758916A1
(en)
|
2009-04-15 |
2010-10-21 |
Pui-Kai Li |
Curcumin analogs as dual jak2/stat3 inhibitors and methods of making and using the same
|
US8367681B2
(en)
|
2009-05-20 |
2013-02-05 |
Cylene Pharmaceuticals, Inc. |
Pyrazolopyrimidines and related heterocycles as kinase inhibitors
|
WO2010148351A1
(en)
|
2009-06-18 |
2010-12-23 |
Cylene Pharmaceuticals, Inc. |
Rhodanines and related heterocycles as kinase inhibitors
|
TW201107329A
(en)
|
2009-07-30 |
2011-03-01 |
Oncotherapy Science Inc |
Fused imidazole derivative having ttk inhibitory action
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
EP2332917B1
(en)
|
2009-11-11 |
2012-08-01 |
Sygnis Bioscience GmbH & Co. KG |
Compounds for PIM kinase inhibition and for treating malignancy
|
KR101573109B1
(ko)
|
2009-11-24 |
2015-12-01 |
메디뮨 리미티드 |
B7―h1에 대한 표적화된 결합 물질
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
WO2011076519A1
(en)
|
2009-12-22 |
2011-06-30 |
Unilever Nv |
A process for preparing a tea product
|
PL2516425T3
(pl)
|
2009-12-23 |
2016-03-31 |
Jasco Pharmaceuticals Llc |
Inhibitory kinaz aminopirydynowych
|
UY33213A
(es)
|
2010-02-18 |
2011-09-30 |
Almirall Sa |
Derivados de pirazol como inhibidores de jak
|
WO2011110604A1
(en)
|
2010-03-11 |
2011-09-15 |
Ucb Pharma, S.A. |
Pd-1 antibody
|
CN107898791A
(zh)
|
2010-06-03 |
2018-04-13 |
药品循环有限责任公司 |
布鲁顿酪氨酸激酶(btk)抑制剂的应用
|
HUE040213T2
(hu)
|
2010-06-11 |
2019-02-28 |
Kyowa Hakko Kirin Co Ltd |
Anti-TIM antitest
|
CA2802344C
(en)
|
2010-06-18 |
2023-06-13 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
WO2012004217A1
(en)
|
2010-07-06 |
2012-01-12 |
Novartis Ag |
Cyclic ether compounds useful as kinase inhibitors
|
TWI541243B
(zh)
*
|
2010-09-10 |
2016-07-11 |
拜耳知識產權公司 |
經取代咪唑并嗒
|
RU2652638C2
(ru)
|
2010-12-17 |
2018-04-28 |
НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. |
Замещенные пиразолхиназолиновые производные в качестве ингибиторов киназы
|
WO2012154274A1
(en)
|
2011-02-25 |
2012-11-15 |
Array Biopharma Inc. |
Triazolopyridine compounds as pim kinase inhibitors
|
EP2681197A1
(en)
|
2011-03-04 |
2014-01-08 |
Novartis AG |
Tetrasubstituted cyclohexyl compounds as kinase inhibitors
|
EP2688886A1
(en)
|
2011-03-22 |
2014-01-29 |
Amgen Inc. |
Azole compounds as pim inhibitors
|
RU2625034C2
(ru)
|
2011-04-20 |
2017-07-11 |
МЕДИММЬЮН, ЭлЭлСи |
Антитела и другие молекулы, которые связывают в7-н1 и pd-1
|
JP6200884B2
(ja)
|
2011-06-14 |
2017-09-20 |
ノバルティス アーゲー |
骨髄増殖性腫瘍などの癌の治療におけるパノビノスタットおよびルキソリチニブの組合せ
|
ES2560611T3
(es)
|
2011-06-20 |
2016-02-22 |
Incyte Holdings Corporation |
Derivados de fenil de azetidinilo, carboxamida de piridilo o pirazinilo como inhibidores de JAK
|
WO2013006490A2
(en)
|
2011-07-01 |
2013-01-10 |
Cellerant Therapeutics, Inc. |
Antibodies that specifically bind to tim3
|
KR20140048968A
(ko)
|
2011-07-13 |
2014-04-24 |
파마시클릭스, 인코포레이티드 |
브루톤형 티로신 키나제의 억제제
|
EP3812387A1
(en)
|
2011-07-21 |
2021-04-28 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Heterocyclic protein kinase inhibitors
|
AU2012288413B2
(en)
|
2011-07-24 |
2016-10-13 |
Curetech Ltd. |
Variants of humanized immunomodulatory monoclonal antibodies
|
CN102924446B
(zh)
|
2011-08-11 |
2015-08-26 |
上海吉铠医药科技有限公司 |
Pim激酶抑制剂及其制备方法与在制药中的应用
|
BR112014009276A8
(pt)
|
2011-10-19 |
2017-06-20 |
Pharmacyclics Inc |
uso de inibidores de tirosina quinase de bruton (btk)
|
HUE051954T2
(hu)
|
2011-11-28 |
2021-03-29 |
Merck Patent Gmbh |
ANTI-PD-L1 ellenanyagok és alkalmazásaik
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
WO2013134219A1
(en)
|
2012-03-09 |
2013-09-12 |
Lexicon Pharmaceuticals, Inc. |
Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
|
US9133134B2
(en)
|
2012-05-16 |
2015-09-15 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
MX2014014253A
(es)
|
2012-05-21 |
2015-02-17 |
Novartis Ag |
Novedosas n-piridinil-amidas sustituidas en el anillo como inhibidoras de cinasa.
|
EP2854843A4
(en)
|
2012-05-31 |
2016-06-01 |
Sorrento Therapeutics Inc |
ANTIGEN BINDING PROTEINS THAT BIND PD-L1
|
MY194911A
(en)
|
2012-06-04 |
2022-12-22 |
Pharmacyclics Llc |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
UY34887A
(es)
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
MX2015001081A
(es)
|
2012-07-24 |
2015-10-14 |
Pharmacyclics Inc |
Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).
|
US9845356B2
(en)
|
2012-08-03 |
2017-12-19 |
Dana-Farber Cancer Institute, Inc. |
Single agent anti-PD-L1 and PD-L2 dual binding antibodies and methods of use
|
US8703981B2
(en)
|
2012-08-03 |
2014-04-22 |
Xerox Corporation |
Lignosulfonate compounds for solid ink applications
|
RU2645672C2
(ru)
|
2012-08-06 |
2018-02-27 |
Ацея Байосайенсиз Инк. |
Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ
|
KR101446742B1
(ko)
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
N2,n4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
CN102880459A
(zh)
|
2012-08-14 |
2013-01-16 |
张涛 |
基于VisualLisp编程语言下的编译实现方法及***
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
WO2014033631A1
(en)
|
2012-08-31 |
2014-03-06 |
Novartis Ag |
N-(3-pyridyl) biarylamides as kinase inhibitors
|
US9493454B2
(en)
|
2012-09-26 |
2016-11-15 |
Tolero Pharmaceuticals, Inc. |
Multiple kinase pathway inhibitors
|
CN107892719B
(zh)
|
2012-10-04 |
2022-01-14 |
达纳-法伯癌症研究所公司 |
人单克隆抗-pd-l1抗体和使用方法
|
CN104854107A
(zh)
|
2012-11-15 |
2015-08-19 |
药品循环公司 |
作为激酶抑制剂的吡咯并嘧啶化合物
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
RS60244B1
(sr)
|
2013-01-15 |
2020-06-30 |
Incyte Holdings Corp |
Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze
|
EA201591051A1
(ru)
|
2013-02-08 |
2016-06-30 |
Селджен Авиломикс Рисерч, Инк. |
Ингибиторы erk и варианты их применения
|
US10322125B2
(en)
|
2013-02-22 |
2019-06-18 |
Emory University |
TGF-beta enhancing compositions for cartilage repair and methods related thereto
|
US9708326B2
(en)
|
2013-02-25 |
2017-07-18 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
JP2016512549A
(ja)
|
2013-03-14 |
2016-04-28 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼ阻害剤及びcyp3a4阻害剤の組み合わせ
|
EP2970205B1
(en)
|
2013-03-14 |
2019-05-08 |
Tolero Pharmaceuticals, Inc. |
Jak2 and alk2 inhibitors and methods for their use
|
ME03796B
(me)
|
2013-03-15 |
2021-04-20 |
Glaxosmithkline Ip Dev Ltd |
Anti-lag-3 vezujući proteini
|
AU2014251028A1
(en)
|
2013-04-08 |
2015-11-05 |
Janssen Pharmaceutica Nv |
Ibrutinib combination therapy
|
US9815897B2
(en)
|
2013-05-02 |
2017-11-14 |
Anaptysbio, Inc. |
Antibodies directed against programmed death-1 (PD-1)
|
CN111423511B
(zh)
|
2013-05-31 |
2024-02-23 |
索伦托药业有限公司 |
与pd-1结合的抗原结合蛋白
|
KR102094011B1
(ko)
|
2013-06-13 |
2020-03-26 |
삼성전자주식회사 |
전자 장치에서 노이즈를 제거하기 위한 장치 및 방법
|
WO2014209804A1
(en)
|
2013-06-24 |
2014-12-31 |
Biomed Valley Discoveries, Inc. |
Bispecific antibodies
|
CA2917167A1
(en)
|
2013-07-02 |
2015-01-08 |
Pharmacyclics Llc |
Purinone compounds as kinase inhibitors
|
MX2016001683A
(es)
|
2013-08-08 |
2016-05-02 |
Novartis Ag |
Combinaciones de inhibidores de quinasa pim.
|
JP2016528298A
(ja)
|
2013-08-23 |
2016-09-15 |
インサイト・コーポレイションIncyte Corporation |
Pimキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物
|
KR102100419B1
(ko)
|
2013-09-13 |
2020-04-14 |
베이진 스위찰랜드 게엠베하 |
항-pd1 항체 및 이의 치료 및 진단 용도
|
TN2016000094A1
(en)
|
2013-09-30 |
2017-07-05 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase.
|
WO2015061668A1
(en)
|
2013-10-25 |
2015-04-30 |
Dana-Farber Cancer Institute, Inc. |
Anti-pd-l1 monoclonal antibodies and fragments thereof
|
WO2015081158A1
(en)
|
2013-11-26 |
2015-06-04 |
Bristol-Myers Squibb Company |
Method of treating hiv by disrupting pd-1/pd-l1 signaling
|
MY184154A
(en)
|
2013-12-12 |
2021-03-23 |
Shanghai hengrui pharmaceutical co ltd |
Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
|
JP2017509319A
(ja)
|
2014-01-15 |
2017-04-06 |
カドモン コーポレイション,リミティド ライアビリティ カンパニー |
免疫調節剤
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗pd-l1之人類抗體
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
EP3988572A1
(en)
|
2014-01-28 |
2022-04-27 |
Bristol-Myers Squibb Company |
Anti-lag-3 antibodies to treat hematological malignancies
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
TWI697500B
(zh)
|
2014-03-14 |
2020-07-01 |
瑞士商諾華公司 |
針對lag-3之抗體分子及其用途
|
US10064866B2
(en)
|
2014-04-08 |
2018-09-04 |
Incyte Corporation |
Treatment of B-cell malignancies by a combination JAK and PI3K inhibitors
|
US20150306112A1
(en)
|
2014-04-25 |
2015-10-29 |
National Cheng Kung University |
Zhankuic acid A, a JAK2/3 tyrosine kinase inhibitor, and a potential therapeutic agent for hepatitis
|
AU2015265870B2
(en)
|
2014-05-29 |
2020-07-09 |
Ventana Medical Systems, Inc. |
PD-L1 antibodies and uses thereof
|
WO2015195163A1
(en)
|
2014-06-20 |
2015-12-23 |
R-Pharm Overseas, Inc. |
Pd-l1 antagonist fully human antibody
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
CN106604742B
(zh)
|
2014-07-03 |
2019-01-11 |
百济神州有限公司 |
抗pd-l1抗体及其作为治疗剂及诊断剂的用途
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
CN114920840A
(zh)
|
2014-10-14 |
2022-08-19 |
诺华股份有限公司 |
针对pd-l1的抗体分子及其用途
|
HUE047784T2
(hu)
|
2014-11-06 |
2020-05-28 |
Hoffmann La Roche |
Anti-TIM3 antitestek és alkalmazási eljárások
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
WO2016111947A2
(en)
|
2015-01-05 |
2016-07-14 |
Jounce Therapeutics, Inc. |
Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
|
CA2978892A1
(en)
|
2015-03-06 |
2016-09-15 |
Sorrento Therapeutics, Inc. |
Antibody therapeutics that bind tim3
|
MA41867A
(fr)
|
2015-04-01 |
2018-02-06 |
Anaptysbio Inc |
Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3)
|
WO2016161248A1
(en)
|
2015-04-02 |
2016-10-06 |
Tolero Pharmaceuticals, Inc. |
Targeting pim kinases in combination with btk inhibition
|
CN105919955A
(zh)
|
2016-06-13 |
2016-09-07 |
佛山市腾瑞医药科技有限公司 |
一种鲁索利替尼制剂及其应用
|
CA3095580A1
(en)
|
2018-04-13 |
2019-10-17 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer
|