DK2699264T3 - Antistoffer og andre molekyler, der binder b7-h1 og pd-1 - Google Patents
Antistoffer og andre molekyler, der binder b7-h1 og pd-1 Download PDFInfo
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- DK2699264T3 DK2699264T3 DK12774724.4T DK12774724T DK2699264T3 DK 2699264 T3 DK2699264 T3 DK 2699264T3 DK 12774724 T DK12774724 T DK 12774724T DK 2699264 T3 DK2699264 T3 DK 2699264T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (11)
1. Antistof eller et antigenbindende fragment deraf, der binder til human PD-1, der omfatter en variabel region af let kæde, der omfatter aminosyresekvensen ifølge SEQ ID NO: 98, og en variabel region af tung kæde, der omfatter aminosyresekvensen ifølge SEQ ID NO: 106.
2. Antistof eller antigenbindende fragment deraf ifølge krav 1, hvor antistoffet eller det antigenbindende fragment deraf (A) svækker evnen hos en ligand til PD-1 til at binde til PD-1; (B) svækker eller fuldstændigt neutraliserer evnen hos PD-1 til at mediere signaltransduktion; (C) medierer T-celleproliferation; eller (D) øger produktionen af IFN-γ.
3. Antistof eller antigenbindende fragment deraf ifølge krav 1 eller krav 2, der omfatter mindst en del af en konstant region af immunoglobulin (Fc) .
4. Antistof eller antigenbindende fragment deraf ifølge krav 3, hvor den konstante region af immunoglobulin (Fc) er en konstant region af human immunoglobulin (Fc).
5. Antistof eller antigenbindende fragment deraf ifølge krav 4, hvor de humane konstante domæner er IgA-, IgD-, IgE-, IgG-eller IgM-domæner.
6. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 3 til 5, hvor humane IgG-konstante domæner er IgGl-, IgG2-, IgG3- eller IgG4-domæner.
7. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 6, hvor antistoffet eller det antigenbindende fragment deraf er påviseligt mærket eller omfatter et konjugeret toksin, lægemiddel eller enzym eller en konjugeret receptor eller receptorligand.
8. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 7, hvor antistoffet er et monoklonalt antistof, et humant antistof, et kimært antistof, et humaniseret antistof eller et enkeltkædet antistof.
9. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 8, hvor antistoffet er et bispecifikt, trispecifikt eller multispecifikt antistof.
10. Farmaceutisk sammensætning, der omfatter antistoffet eller det antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 9 og et fysiologisk acceptabelt bæremiddel eller excipiens.
11. Farmaceutisk sammensætning ifølge krav 10 til anvendelse til behandling af cancer eller en infektionssygdom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477414P | 2011-04-20 | 2011-04-20 | |
| PCT/US2012/034223 WO2012145493A1 (en) | 2011-04-20 | 2012-04-19 | Antibodies and other molecules that bind b7-h1 and pd-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2699264T3 true DK2699264T3 (da) | 2018-06-25 |
Family
ID=47041916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12774724.4T DK2699264T3 (da) | 2011-04-20 | 2012-04-19 | Antistoffer og andre molekyler, der binder b7-h1 og pd-1 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9205148B2 (da) |
| EP (2) | EP3403672A1 (da) |
| JP (2) | JP6072771B2 (da) |
| KR (1) | KR101970025B1 (da) |
| CN (1) | CN103608040B (da) |
| AU (1) | AU2012245477C1 (da) |
| CA (1) | CA2833636A1 (da) |
| CY (1) | CY1120626T1 (da) |
| DK (1) | DK2699264T3 (da) |
| ES (1) | ES2669310T3 (da) |
| HR (1) | HRP20180893T1 (da) |
| HU (1) | HUE037651T2 (da) |
| LT (1) | LT2699264T (da) |
| MX (1) | MX338353B (da) |
| PL (1) | PL2699264T3 (da) |
| PT (1) | PT2699264T (da) |
| RS (1) | RS57324B1 (da) |
| RU (1) | RU2625034C2 (da) |
| SI (1) | SI2699264T1 (da) |
| WO (1) | WO2012145493A1 (da) |
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| NZ631405A (en) | 2012-10-02 | 2017-01-27 | Bristol Myers Squibb Co | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
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-
2012
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- 2012-04-19 PL PL12774724T patent/PL2699264T3/pl unknown
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- 2012-04-19 CN CN201280030691.9A patent/CN103608040B/zh not_active Expired - Fee Related
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- 2012-04-19 PT PT127747244T patent/PT2699264T/pt unknown
- 2012-04-19 WO PCT/US2012/034223 patent/WO2012145493A1/en active Application Filing
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| EP3403672A1 (en) | 2018-11-21 |
| AU2012245477A1 (en) | 2013-10-31 |
| MX2013012088A (es) | 2014-04-30 |
| EP2699264A1 (en) | 2014-02-26 |
| PL2699264T3 (pl) | 2018-08-31 |
| CA2833636A1 (en) | 2012-10-26 |
| LT2699264T (lt) | 2018-07-10 |
| ES2669310T3 (es) | 2018-05-24 |
| EP2699264A4 (en) | 2014-10-08 |
| AU2012245477B2 (en) | 2017-03-23 |
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| HRP20180893T1 (hr) | 2018-07-27 |
| PT2699264T (pt) | 2018-05-23 |
| US20140044738A1 (en) | 2014-02-13 |
| WO2012145493A1 (en) | 2012-10-26 |
| MX338353B (es) | 2016-04-13 |
| EP2699264B1 (en) | 2018-03-14 |
| CN103608040A (zh) | 2014-02-26 |
| SI2699264T1 (en) | 2018-08-31 |
| RU2013151455A (ru) | 2015-05-27 |
| JP2014523401A (ja) | 2014-09-11 |
| KR101970025B1 (ko) | 2019-04-17 |
| RU2625034C2 (ru) | 2017-07-11 |
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| CY1120626T1 (el) | 2019-12-11 |
| JP2017101042A (ja) | 2017-06-08 |
| KR20140048121A (ko) | 2014-04-23 |
| JP6072771B2 (ja) | 2017-02-01 |
| US9205148B2 (en) | 2015-12-08 |
| US20160130348A1 (en) | 2016-05-12 |
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