SG11202105424PA - Irak degraders and uses thereof - Google Patents

Irak degraders and uses thereof

Info

Publication number
SG11202105424PA
SG11202105424PA SG11202105424PA SG11202105424PA SG11202105424PA SG 11202105424P A SG11202105424P A SG 11202105424PA SG 11202105424P A SG11202105424P A SG 11202105424PA SG 11202105424P A SG11202105424P A SG 11202105424PA SG 11202105424P A SG11202105424P A SG 11202105424PA
Authority
SG
Singapore
Prior art keywords
degraders
irak
irak degraders
Prior art date
Application number
SG11202105424PA
Inventor
Nello Mainolfi
Nan Ji
Arthur F Kluge
Matthew M Weiss
Yi Zhang
Xiaozhang Zheng
Original Assignee
Kymera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymera Therapeutics Inc filed Critical Kymera Therapeutics Inc
Publication of SG11202105424PA publication Critical patent/SG11202105424PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
SG11202105424PA 2018-11-30 2019-12-02 Irak degraders and uses thereof SG11202105424PA (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201862774051P 2018-11-30 2018-11-30
US201962788460P 2019-01-04 2019-01-04
US201962793992P 2019-01-18 2019-01-18
US201962826743P 2019-03-29 2019-03-29
US201962831007P 2019-04-08 2019-04-08
US201962851427P 2019-05-22 2019-05-22
US201962868574P 2019-06-28 2019-06-28
US201962875347P 2019-07-17 2019-07-17
US201962879117P 2019-07-26 2019-07-26
PCT/US2019/064070 WO2020113233A1 (en) 2018-11-30 2019-12-02 Irak degraders and uses thereof

Publications (1)

Publication Number Publication Date
SG11202105424PA true SG11202105424PA (en) 2021-06-29

Family

ID=70853519

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105424PA SG11202105424PA (en) 2018-11-30 2019-12-02 Irak degraders and uses thereof

Country Status (13)

Country Link
US (3) US11352350B2 (en)
EP (1) EP3886904A4 (en)
JP (1) JP2022516401A (en)
KR (1) KR20210111252A (en)
CN (1) CN113423427A (en)
AU (1) AU2019389174A1 (en)
BR (1) BR112021010484A2 (en)
CA (1) CA3119773A1 (en)
CO (1) CO2021007068A2 (en)
IL (1) IL283471A (en)
MX (1) MX2021006154A (en)
SG (1) SG11202105424PA (en)
WO (1) WO2020113233A1 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111362966B (en) 2014-01-13 2022-03-11 奥列基因发现技术有限公司 Bicyclic heterocyclic derivatives as IRAK4 inhibitors
IL275649B2 (en) 2017-12-26 2023-12-01 Kymera Therapeutics Inc Irak degraders and uses thereof
CN112969505B (en) 2018-10-31 2023-11-14 吉利德科学公司 Substituted 6-azabenzimidazole compounds having HPK1 inhibitory activity
PE20211655A1 (en) 2018-10-31 2021-08-24 Gilead Sciences Inc 6-AZABENZIMIDAZOLE COMPOUNDS SUBSTITUTED AS HPK1 INHIBITORS
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
EP3946360A4 (en) 2019-04-05 2023-05-10 Kymera Therapeutics, Inc. Stat degraders and uses thereof
TWI826690B (en) 2019-05-23 2023-12-21 美商基利科學股份有限公司 Substituted eneoxindoles and uses thereof
WO2020264499A1 (en) * 2019-06-28 2020-12-30 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
JP2023509366A (en) 2019-12-17 2023-03-08 カイメラ セラピューティクス， インコーポレイテッド IRAK dissolving agents and their uses
US20230122219A1 (en) * 2020-02-03 2023-04-20 Kymera Therapeutics, Inc. Irak degraders and uses thereof
EP4161521A1 (en) * 2020-06-03 2023-04-12 Kymera Therapeutics, Inc. Deuterated irak degraders and uses thereof
TW202210483A (en) * 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Crystalline forms of irak degraders
WO2022012623A1 (en) * 2020-07-16 2022-01-20 Beigene, Ltd. Degradation of (egfr) by conjugation of egfr inhibitors with e3 ligase ligand and methods of use
US20230265116A1 (en) * 2020-07-16 2023-08-24 Beigene, Ltd. Degradation of (egfr) by conjugation of egfr inhibitors with e3 ligase ligand and methods of use
CA3187255A1 (en) 2020-07-30 2022-02-03 Duncan Walker Methods of treating mutant lymphomas
CN113512025B (en) * 2020-07-31 2023-01-06 四川大学 Indazole ester compound and pharmaceutical application thereof
EP4194457A1 (en) 2020-08-05 2023-06-14 Shanghai Leadingtac Pharmaceutical Co., Ltd. Compound for targeting and degrading protein, and preparation method therefor and use thereof
EP4238968A1 (en) * 2020-10-26 2023-09-06 Shanghai Leadingtac Pharmaceutical Co., Ltd. Indazole derivative, and preparation method therefor and use thereof
US20230101353A1 (en) * 2020-12-30 2023-03-30 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2022161414A1 (en) * 2021-01-26 2022-08-04 成都茵创园医药科技有限公司 Aromatic compound, pharmaceutical composition containing same, and application thereof
IL304905A (en) * 2021-02-15 2023-10-01 Kymera Therapeutics Inc Irak4 degraders and uses thereof
TW202245788A (en) * 2021-02-15 2022-12-01 美商凱麥拉醫療公司 Irak4 degraders and uses thereof
US20220331330A1 (en) * 2021-04-08 2022-10-20 Curis, Inc. Combination therapies for the treatment of cancer
WO2022251224A1 (en) * 2021-05-28 2022-12-01 Recurium Ip Holdings, Llc Wee1 inhibitors and methods for treating cancer
CN115504963A (en) * 2021-06-22 2022-12-23 苏州开拓药业股份有限公司 C-Myc protein degradation agent
WO2023016518A1 (en) 2021-08-11 2023-02-16 四川海思科制药有限公司 Heterocyclic derivative, and composition and pharmaceutical use thereof
TW202315606A (en) 2021-08-23 2023-04-16 大陸商上海領泰生物醫藥科技有限公司 Irak4 degradation agent and preparation method and application thereof
WO2023036175A1 (en) * 2021-09-08 2023-03-16 南京明德新药研发有限公司 Glutarimide compound and use thereof
WO2023045978A1 (en) * 2021-09-26 2023-03-30 南京明德新药研发有限公司 2,6-piperidinedione compound and application thereof
WO2023076556A1 (en) * 2021-10-29 2023-05-04 Kymera Therapeutics, Inc. Irak4 degraders and synthesis thereof
WO2023107145A1 (en) * 2021-12-06 2023-06-15 Emmaus Life Sciences, Inc. Compositions and methods for treating cancer
TW202333670A (en) * 2022-01-04 2023-09-01 大陸商海思科醫藥集團股份有限公司 Compound for inhibiting and degrading irak4, and pharmaceutical composition and pharmaceutical application thereof
WO2023147594A2 (en) * 2022-01-31 2023-08-03 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2023192586A1 (en) * 2022-03-31 2023-10-05 Kymera Therapeutics, Inc. Irak degraders and uses thereof
TW202400250A (en) 2022-04-12 2024-01-01 美商健臻公司 Use of irak4 modulators for gene therapy
WO2023201274A1 (en) 2022-04-12 2023-10-19 Genzyme Corporation Use of an irak4 modulator for gene therapy
WO2023237049A1 (en) * 2022-06-09 2023-12-14 Beigene, Ltd. Degradation of irak4 by conjugation of irak4 inhibitors with e3 ligase ligand and methods of use
WO2023241644A1 (en) * 2022-06-15 2023-12-21 杭州多域生物技术有限公司 Five-membered ring-fused six-membered compound, preparation method therefor, and pharmaceutical composition and use thereof
WO2024073507A1 (en) 2022-09-28 2024-04-04 Theseus Pharmaceuticals, Inc. Macrocyclic compounds and uses thereof
CN115557916B (en) * 2022-10-20 2023-11-14 恒光新材料(江苏)股份有限公司 Preparation method of morpholinylethyl dimethylaminopropyl ether

Family Cites Families (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650750A (en) 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US5516931A (en) 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4709016A (en) 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US5360811A (en) 1990-03-13 1994-11-01 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
JP3545461B2 (en) 1993-09-10 2004-07-21 エーザイ株式会社 Bicyclic heterocycle-containing sulfonamide derivatives
AU4596096A (en) 1994-09-06 1996-03-27 Banyu Pharmaceutical Co., Ltd. Novel carbapenem derivative
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US6306663B1 (en) 1999-02-12 2001-10-23 Proteinex, Inc. Controlling protein levels in eucaryotic organisms
PT1382339E (en) 1999-12-10 2008-02-06 Pfizer Prod Inc Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives
DE10002509A1 (en) 2000-01-21 2001-07-26 Gruenenthal Gmbh New substituted glutarimide derivatives are IL-12 antagonists, are useful as immunomodulators and for the treatment of angiopathy, hematological or oncological disorders
ES2243461T3 (en) 2000-02-28 2005-12-01 Sugen, Inc. COMPOUNDS OF 3- (PIROLILLACTONE) -2-INDOLINONE AS QUINASE INHIBITORS.
PE20020354A1 (en) 2000-09-01 2002-06-12 Novartis Ag HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS
US7208157B2 (en) 2000-09-08 2007-04-24 California Institute Of Technology Proteolysis targeting chimeric pharmaceutical
US7041298B2 (en) 2000-09-08 2006-05-09 California Institute Of Technology Proteolysis targeting chimeric pharmaceutical
PT1389617E (en) 2001-04-27 2007-04-30 Zenyaku Kogyo Kk Heterocyclic compound and antitumor agent containing the same as active ingredient
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
IL166718A0 (en) 2002-08-14 2006-01-15 Atugen Ag Further use of protein kinase n beta
JP2006523237A (en) 2003-04-03 2006-10-12 セマフォア ファーマシューティカルズ， インコーポレイテッド PI-3 kinase inhibitor prodrug
JP4980715B2 (en) 2003-05-30 2012-07-18 ジェミン エックス ファーマシューティカルズ カナダ インコーポレイテッド Tricyclic heterocyclic compounds, compositions and methods for treating cancer or viral diseases
CA2531069A1 (en) 2003-07-03 2005-01-27 The Trustees Of The University Of Pennsylvania Inhibition of syk kinase expression
JP4398263B2 (en) 2004-01-13 2010-01-13 富士通株式会社 Route design method
EP3943494A1 (en) 2004-05-13 2022-01-26 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
AU2006206458B2 (en) 2005-01-19 2012-10-25 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
DK1866339T3 (en) 2005-03-25 2013-09-02 Gitr Inc GTR-binding molecules and their applications
US7390799B2 (en) 2005-05-12 2008-06-24 Abbott Laboratories Apoptosis promoters
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
DK1907424T3 (en) 2005-07-01 2015-11-09 Squibb & Sons Llc HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED death ligand 1 (PD-L1)
US7402325B2 (en) 2005-07-28 2008-07-22 Phoenix Biotechnology, Inc. Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
ES2513165T3 (en) 2005-10-07 2014-10-24 Exelixis, Inc. N- (3-amino-quinoxalin-2-yl) -sulfonamide derivatives and their use as phosphatidylinositol-3-kinase inhibitors
MY167260A (en) 2005-11-01 2018-08-14 Targegen Inc Bi-aryl meta-pyrimidine inhibitors of kinases
ES2700433T3 (en) 2005-12-13 2019-02-15 Incyte Holdings Corp Derivatives of pyrrolo [2,3-d] pyrimidine as inhibitors of Janus kinases
NZ569293A (en) 2005-12-23 2011-10-28 Zealand Pharma As Modified lysine-mimetic compounds
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي PI-3 Kinase inhibitors and methods of their use
WO2007129161A2 (en) 2006-04-26 2007-11-15 F. Hoffmann-La Roche Ag Thieno [3, 2-d] pyrimidine derivative useful as pi3k inhibitor
ES2585902T3 (en) 2006-09-22 2016-10-10 Pharmacyclics Llc Bruton tyrosine kinase inhibitors
US20100279316A1 (en) 2007-01-19 2010-11-04 Leonid Gorelik Antibodies to Phosphorylated IRAK4
PL2152701T3 (en) 2007-03-12 2016-10-31 Phenyl amino pyrimidine compounds and uses thereof
WO2008118802A1 (en) 2007-03-23 2008-10-02 Regents Of The University Of Minnesota Therapeutic compounds
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
PE20090717A1 (en) 2007-05-18 2009-07-18 Smithkline Beecham Corp QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS
US8370032B2 (en) 2007-07-12 2013-02-05 Toyota Motor Engineering & Manufacturing North America, Inc. Systems and methods for shift control for vehicular transmission
ES2591281T3 (en) 2007-07-12 2016-11-25 Gitr, Inc. Combination therapies that employ GITR binding molecules
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
EP2217716A4 (en) 2007-11-09 2011-02-09 Salk Inst For Biological Studi Use of tam receptor inhibitors as antimicrobials
JP5583592B2 (en) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション IDO inhibitor
DK2288610T3 (en) 2008-03-11 2016-11-28 Incyte Holdings Corp Azetidinesulfonic AND CYCLOBUTANDERIVATER AS JAK INHIBITORS
CA2722159C (en) 2008-04-24 2016-04-05 Newlink Genetics Corporation Substituted phenylimidazole compounds and their use as ido inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
BRPI0917592B1 (en) 2008-12-09 2021-08-17 Genentech, Inc ANTI-PD-L1 ANTIBODY, COMPOSITION, MANUFACTURED ARTICLES AND USES OF A COMPOSITION
US8921037B2 (en) 2008-12-16 2014-12-30 Bo Han PF4-depleted platelet rich plasma preparations and methods for hard and soft tissue repair
KR20170119746A (en) 2009-09-03 2017-10-27 머크 샤프 앤드 돔 코포레이션 Anti-gitr antibodies
JP2012254939A (en) 2009-10-07 2012-12-27 Astellas Pharma Inc Oxazole compound
US8722720B2 (en) 2009-10-28 2014-05-13 Newlink Genetics Corporation Imidazole derivatives as IDO inhibitors
HUE026201T2 (en) 2009-12-10 2016-05-30 Hoffmann La Roche Antibodies binding to human CSF1R extracellular domain 4 and their use
SG183847A1 (en) 2010-03-04 2012-10-30 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
US9169323B2 (en) 2010-03-05 2015-10-27 Hoffmann-La Roche Inc. Antibodies against human CSF-1R
BR112012022046A2 (en) 2010-03-05 2017-02-14 F Hoffamann-La Roche Ag "antibody, pharmaceutical composition, nucleic acid, expression vectors, host cell and method for producing a recombinant antibody".
US8114621B2 (en) 2010-03-12 2012-02-14 Saladax Biomedical Inc. Lenalidomide and thalidomide immunoassays
ES2820517T3 (en) 2010-05-04 2021-04-21 Five Prime Therapeutics Inc Antibodies that bind to CSF1R
US9765019B2 (en) 2010-06-30 2017-09-19 Brandeis University Small-molecule-targeted protein degradation
CN105367577B (en) 2010-07-13 2019-04-23 弗·哈夫曼-拉罗切有限公司 Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator
NZ607710A (en) 2010-09-09 2014-11-28 Pfizer 4-1bb binding molecules
RU2632900C2 (en) 2010-11-19 2017-10-11 Лиганд Фармасьютикалс Инкорпорейтед Heterocyclic amines and their application
AU2011338615B2 (en) 2010-12-07 2017-07-27 Yale University Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
BR122021026173B1 (en) 2010-12-09 2023-12-05 The Trustees Of The University Of Pennsylvania PHARMACEUTICAL COMPOSITION
EP2655357B1 (en) 2010-12-20 2016-06-22 Merck Serono S.A. Indazolyl triazole derivatives as irak inhibitors
US8703941B2 (en) 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
WO2012129258A1 (en) 2011-03-22 2012-09-27 Merck Sharp & Dohme Corp. Amidopyrazole inhibitors of interleukin receptor-associated kinases
NO2694640T3 (en) 2011-04-15 2018-03-17
KR101970025B1 (en) 2011-04-20 2019-04-17 메디뮨 엘엘씨 Antibodies and other molecules that bind b7-h1 and pd-1
AU2012301383B2 (en) 2011-08-31 2015-11-26 Huntsman Advanced Materials Licensing (Switzerland) Gmbh Process for the impregnation of air core reactors, impregnated air core reactor and use of an impregnation system
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
WO2013066729A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
DK2785375T3 (en) 2011-11-28 2020-10-12 Merck Patent Gmbh ANTI-PD-L1 ANTIBODIES AND USES THEREOF
JP6242804B2 (en) 2011-12-15 2017-12-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Antibody to human CSF-1R and use thereof
WO2013106535A1 (en) 2012-01-10 2013-07-18 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EP2802608A4 (en) 2012-01-12 2015-08-05 Univ Yale Compounds&methods for the enhanced degradation of targeted proteins&other polypeptides by an e3 ubiquitin ligase
WO2013106646A2 (en) 2012-01-12 2013-07-18 Yale University Compounds and methods for the inhibition of vcb e3 ubiquitin ligase
JP6096807B2 (en) 2012-01-13 2017-03-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Triazolyl-substituted pyridyl compounds useful as kinase inhibitors
EP2802579B1 (en) 2012-01-13 2016-04-13 Bristol-Myers Squibb Company Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
US9242975B2 (en) 2012-01-13 2016-01-26 Bristol-Myers Squibb Company Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors
EP2812355A4 (en) 2012-02-06 2016-03-02 Hoffmann La Roche Compositions and methods for using csf1r inhibitors
AR090263A1 (en) 2012-03-08 2014-10-29 Hoffmann La Roche COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME
KR20200011616A (en) 2012-05-11 2020-02-03 파이브 프라임 테라퓨틱스, 인크. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csfir)
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
WO2014008992A1 (en) 2012-07-10 2014-01-16 Ares Trading S.A. Pyrimidine pyrazolyl derivatives
US20140018361A1 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
BR112015000561A2 (en) 2012-07-11 2017-06-27 Nimbus Iris Inc irak inhibitors and uses thereof
US9085586B2 (en) 2012-07-11 2015-07-21 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
KR102414005B1 (en) 2012-08-09 2022-06-27 셀진 코포레이션 Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CN104684582A (en) 2012-08-31 2015-06-03 戊瑞治疗有限公司 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
MX2015003188A (en) 2012-09-19 2015-07-17 Hoffmann La Roche 2-oxo-2,3,4,5-tetrahydro-1 h-benzo[b]diazepines and their use in the treatment of cancer.
EP2903617B1 (en) 2012-10-08 2019-01-30 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
EP2903613B1 (en) 2012-10-08 2017-11-22 Merck Sharp & Dohme Corp. Pyrazole derivatives useful as inhibitors of irak4 activity
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
AR093403A1 (en) 2012-11-08 2015-06-03 Bristol Myers Squibb Co PIRIDIL COMPOUNDS REPLACED WITH USEFUL RENTALS AS MODULATORS OF THE ANSWERS OF IL-12, IL23 AND / OR INFa
PE20150953A1 (en) 2012-11-08 2015-06-20 Bristol Myers Squibb Co HETEROARYL SUBSTITUTE PYRIDYL COMPOUNDS USEFUL AS KINASE MODULATORS
GB201311910D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel Compounds
US9567320B2 (en) 2013-02-07 2017-02-14 Merck Patent Gmbh Pyridazinone-amides derivatives
JP6267729B2 (en) 2013-02-07 2018-01-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Macrocyclic pyridazinone derivatives
US9617282B2 (en) 2013-03-15 2017-04-11 Biogen Ma Inc. Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases
EP3049086A4 (en) 2013-09-27 2017-02-22 Nimbus Iris, Inc. Irak inhibitors and uses thereof
NZ718430A (en) 2013-10-04 2021-12-24 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
TW201605847A (en) 2013-11-08 2016-02-16 武田藥品工業股份有限公司 Heterocyclic compound
CN106029650B (en) 2013-11-18 2019-10-25 豪夫迈·罗氏有限公司 Tetrahydro-benzodiazepine * ketone
JP6496731B2 (en) 2013-11-27 2019-04-03 シグナルケム・ライフサイエンシーズ・コーポレイションＳｉｇｎａｌｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ Aminopyridine derivatives as TAM family kinase inhibitors
TWI667233B (en) 2013-12-19 2019-08-01 德商拜耳製藥公司 Novel indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments
TW201609693A (en) 2014-01-03 2016-03-16 必治妥美雅史谷比公司 Heteroaryl substituted incotinamide compounds
EP3092226B1 (en) 2014-01-10 2019-03-13 Aurigene Discovery Technologies Limited Indazole compounds as irak4 inhibitors
CN111362966B (en) 2014-01-13 2022-03-11 奥列基因发现技术有限公司 Bicyclic heterocyclic derivatives as IRAK4 inhibitors
WO2015140133A1 (en) 2014-03-17 2015-09-24 F. Hoffmann-La Roche Ag Piperidine-dione derivatives
DK3119772T3 (en) 2014-03-19 2019-08-26 Boehringer Ingelheim Int HETEROARYL SICK INHIBITORS
EP3126330B1 (en) 2014-04-04 2019-02-27 Pfizer Inc Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors
JP6778114B2 (en) 2014-04-14 2020-10-28 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． Imid-based proteolysis modulators and related uses
US20160058872A1 (en) 2014-04-14 2016-03-03 Arvinas, Inc. Imide-based modulators of proteolysis and associated methods of use
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
MX2016013668A (en) 2014-04-22 2017-01-20 Nimbus Iris Inc Irak inhibitors and uses thereof.
MX2016017147A (en) 2014-06-20 2017-06-07 Aurigene Discovery Tech Ltd Substituted indazole compounds as irak4 inhibitors.
EP3827836A1 (en) 2014-06-27 2021-06-02 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
WO2016011390A1 (en) 2014-07-18 2016-01-21 Biogen Ma Inc. Irak4 inhibiting agents
US20160022642A1 (en) 2014-07-25 2016-01-28 Yale University Compounds Useful for Promoting Protein Degradation and Methods Using Same
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
WO2016053772A1 (en) 2014-09-30 2016-04-07 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
EP3200790B1 (en) 2014-09-30 2020-08-26 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
US9926330B2 (en) 2014-09-30 2018-03-27 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
WO2016053771A1 (en) 2014-09-30 2016-04-07 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
PT3221306T (en) 2014-11-20 2020-02-19 Merck Patent Gmbh Heteroaryl compounds as irak inhibitors and uses thereof
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US20170327469A1 (en) 2015-01-20 2017-11-16 Arvinas, Inc. Compounds and methods for the targeted degradation of androgen receptor
KR20230119040A (en) 2015-01-20 2023-08-14 아비나스 오퍼레이션스, 인코포레이티드 Compounds and Methods for the Targeted Degradation of the Androgen Receptor
EP3268367B8 (en) * 2015-03-12 2022-11-16 Merck Sharp & Dohme LLC Carboxamide inhibitors of irak4 activity
WO2016144846A1 (en) * 2015-03-12 2016-09-15 Merck Sharp & Dohme Corp. Pyrazolopyrimidine inhibitors of irak4 activity
US10040798B2 (en) 2015-03-12 2018-08-07 Merck Sharp & Dohme Corp. Pyrrolopyridazine inhibitors of IRAK4 activity
WO2016144848A1 (en) 2015-03-12 2016-09-15 Merck Sharp & Dohme Corp. Pyrrolotriazine inhibitors of irak4 activity
EP3268003B1 (en) 2015-03-12 2020-07-29 Merck Sharp & Dohme Corp. Thienopyrazine inhibitors of irak4 activity
BR112017019751A2 (en) 2015-03-18 2018-05-29 Arvinas Inc bifunctional compound, pharmaceutical composition, and methods for treating or preventing a disease or disorder, and for degrading a target protein in a cell
KR20170138457A (en) 2015-04-22 2017-12-15 리겔 파마슈티칼스, 인크. Pyrazole compounds and methods of making and using such compounds
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
WO2016174183A1 (en) 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Combinations of inhibitors of irak4 with inhibitors of btk
BR112017025975B1 (en) 2015-06-04 2023-12-12 Arvinas Operations, Inc COMPOUND, COMPOSITION, IN VITRO METHOD FOR INDUCING DEGRADATION OF A TARGET PROTEIN IN A CELL, AND, USE OF A COMPOSITION
EP3302482A4 (en) 2015-06-05 2018-12-19 Arvinas, Inc. Tank-binding kinase-1 protacs and associated methods of use
US10702527B2 (en) 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
EP3313840B1 (en) 2015-06-24 2019-07-24 Bristol-Myers Squibb Company Heteroaryl substituted aminopyridine compounds
CN105085620B (en) 2015-06-25 2018-05-08 中山大学附属第一医院 A kind of compound for targeting ubiquitination degraded Smad3
WO2017004133A1 (en) 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2017004134A1 (en) 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US9848583B2 (en) 2015-07-02 2017-12-26 Ellis Junior Smith Retractable leash
WO2017007612A1 (en) 2015-07-07 2017-01-12 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
MX2018000360A (en) 2015-07-10 2018-06-11 Arvinas Inc Mdm2-based modulators of proteolysis and associated methods of use.
BR112017028269A2 (en) 2015-07-13 2018-09-04 Arvinas Inc compound, pharmaceutical composition, use of an effective amount of a compound, disease state or condition, and method for identifying a compound.
ES2773046T3 (en) 2015-07-14 2020-07-09 Mission Therapeutics Ltd Cyanopyrrolidines as DUB inhibitors for cancer treatment
MX2018000396A (en) 2015-07-15 2018-05-02 Aurigene Discovery Tech Ltd Substituted aza compounds as irak-4 inhibitors.
CU20180006A7 (en) 2015-07-15 2018-06-05 Aurigene Discovery Tech Ltd INDAZAOL AND AZAINDAZOL COMPOUNDS AS IRAK-4 INHIBITORS
WO2017030814A1 (en) 2015-08-19 2017-02-23 Arvinas, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
EP3858825A1 (en) 2015-08-27 2021-08-04 Pfizer Inc. Bicyclic-fused heteroaryl compounds as irak4 modulators
GB201516243D0 (en) * 2015-09-14 2015-10-28 Glaxosmithkline Ip Dev Ltd Novel compounds
MX2018002986A (en) 2015-09-18 2018-05-02 Merck Patent Gmbh Heteroaryl compounds as irak inhibitors and uses thereof.
KR20180064382A (en) 2015-09-18 2018-06-14 메르크 파텐트 게엠베하 Heteroaryl compounds as IRAK inhibitors and uses thereof
MA43037A (en) 2015-10-02 2018-08-08 Dana Farber Cancer Inst Inc BROMODOMAIN INHIBITOR POLYTHERAPY AND CHECKPOINT BLOCKING
US10526309B2 (en) 2015-10-02 2020-01-07 The University Of North Carolina At Chapel Hill Pan-TAM inhibitors and Mer/Axl dual inhibitors
MX2018005340A (en) 2015-11-02 2018-05-17 Univ Yale Proteolysis targeting chimera compounds and methods of preparing and using same.
EP3394066A2 (en) 2015-12-22 2018-10-31 H. Hoffnabb-La Roche Ag PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
WO2017117473A1 (en) 2015-12-30 2017-07-06 Dana-Farber Cancer Institute, Inc. Bifunctional molescules for her3 degradation and methods of use
US20190016703A1 (en) 2015-12-30 2019-01-17 Dana-Farber Cancer Institute, Inc. Bifunctional compounds for her3 degradation and methods of use
ES2904557T3 (en) 2016-01-20 2022-04-05 Biogen Ma Inc Iraq4 inhibitory agents
CN109153644B (en) 2016-03-16 2022-10-21 H·李·莫菲特癌症中心研究有限公司 Small molecules against CEREBLON to enhance effector T cell function
US20170281784A1 (en) 2016-04-05 2017-10-05 Arvinas, Inc. Protein-protein interaction inducing technology
RU2021102253A (en) 2016-04-06 2021-03-03 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган DESTRUCTORS OF MDM2 PROTEIN
JP7001614B2 (en) 2016-04-06 2022-02-03 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Monofunctional intermediate for ligand-gated target proteolysis
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
CN109562113A (en) 2016-05-10 2019-04-02 C4医药公司 Loop coil degron body for target protein degradation
EP3454856A4 (en) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CN109790143A (en) 2016-05-10 2019-05-21 C4医药公司 The C of amine connection for target protein degradation3Glutarimide degron body
WO2017201069A1 (en) 2016-05-18 2017-11-23 Biotheryx, Inc. Oxoindoline derivatives as protein function modulators
JP2019522633A (en) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド PROTAC antibody conjugates and methods of use
WO2017205766A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205762A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017207385A1 (en) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted 3-methylindazoles, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
GB201610147D0 (en) 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
ES2940911T3 (en) 2016-06-27 2023-05-12 Rigel Pharmaceuticals Inc 2,4-diamino-pyrimidine compounds and their use as IRAK4 inhibitors
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
JP2019196309A (en) 2016-09-15 2019-11-14 武田薬品工業株式会社 Heterocyclic compound
US10925868B2 (en) * 2016-11-10 2021-02-23 Dana-Farber Cancer Institute, Inc. Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use
JP7308146B2 (en) 2016-11-22 2023-07-13 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE AND USES THEREOF
US10994015B2 (en) * 2016-12-23 2021-05-04 Arvinas Operations, Inc. EGFR proteolysis targeting chimeric molecules and associated methods of use
WO2018140809A1 (en) * 2017-01-26 2018-08-02 Arvinas, Inc. Modulators of estrogen receptor proteolysis and associated methods of use
CN110612294B (en) 2017-01-31 2024-01-16 阿尔维纳斯运营股份有限公司 Human cerebulin ligands and bifunctional compounds comprising same
JOP20180011A1 (en) 2017-02-16 2019-01-30 Gilead Sciences Inc PYRROLO[1,2-b] PYRIDAZINE DERIVATIVES
EA039189B1 (en) 2017-05-11 2021-12-15 Бристол-Маерс Сквибб Компани Thienopyridines and benzothiophenes as irak4 inhibitors
EP3641762A4 (en) 2017-06-20 2021-03-10 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
WO2019043214A1 (en) 2017-09-04 2019-03-07 F. Hoffmann-La Roche Ag Glutarimide
AU2018338314A1 (en) * 2017-09-22 2020-04-09 Kymera Therapeutics, Inc Protein degraders and uses thereof
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
WO2019084026A1 (en) 2017-10-24 2019-05-02 Genentech, Inc. (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
WO2019084030A1 (en) 2017-10-24 2019-05-02 Genentech, Inc. (4-hydroxypyrrolidin-2-yl)-hydroxamate compounds and methods of use thereof
CN111372585A (en) 2017-11-16 2020-07-03 C4医药公司 Degradants and degreddeterminants for target protein degradation
WO2019099926A1 (en) 2017-11-17 2019-05-23 Arvinas, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
IL275649B2 (en) 2017-12-26 2023-12-01 Kymera Therapeutics Inc Irak degraders and uses thereof
EP3737675A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3752504A4 (en) * 2018-02-14 2021-06-09 Dana Farber Cancer Institute, Inc. Irak degraders and uses thereof
US11802132B2 (en) 2018-02-23 2023-10-31 Dana-Farber Cancer Institute, Inc. Small molecules for inducing selective protein degradation and uses thereof
EP3578561A1 (en) 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiro compounds
WO2020010210A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Mertk degraders and uses thereof
EP3817748A4 (en) 2018-07-06 2022-08-24 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
US20220348556A1 (en) 2018-07-06 2022-11-03 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020018788A1 (en) 2018-07-20 2020-01-23 Dana-Farber Cancer Institute, Inc. Degraders that target proteins via keap1
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
US20220324880A1 (en) 2019-06-10 2022-10-13 Kymara Therapeutics, Inc. Smarca inhibitors and uses thereof
US20230087825A1 (en) 2019-06-10 2023-03-23 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
WO2020251972A1 (en) 2019-06-10 2020-12-17 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
US20230072658A1 (en) 2019-06-10 2023-03-09 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
US20230089916A1 (en) 2019-06-28 2023-03-23 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2020264499A1 (en) 2019-06-28 2020-12-30 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021011634A1 (en) 2019-07-15 2021-01-21 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US20220281831A1 (en) 2019-07-15 2022-09-08 Kymera Therapeutics, Inc. Fused-glutarimide crbn ligands and uses thereof
US20230132715A1 (en) 2019-07-17 2023-05-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021011871A1 (en) 2019-07-17 2021-01-21 Kymera Therapeutics, Inc. Mertk degraders and uses thereof
EP4031243A1 (en) 2019-09-16 2022-07-27 Novartis AG Glue degraders and methods of use thereof
EP4076536A1 (en) 2019-12-17 2022-10-26 Kymera Therapeutics, Inc. Irak degraders and uses thereof
JP2023509366A (en) 2019-12-17 2023-03-08 カイメラ セラピューティクス， インコーポレイテッド IRAK dissolving agents and their uses
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof

Also Published As

Publication number Publication date
BR112021010484A2 (en) 2021-08-24
KR20210111252A (en) 2021-09-10
WO2020113233A1 (en) 2020-06-04
US20220324854A1 (en) 2022-10-13
US11807636B2 (en) 2023-11-07
MX2021006154A (en) 2021-08-24
CO2021007068A2 (en) 2021-09-30
EP3886904A4 (en) 2022-07-13
US11352350B2 (en) 2022-06-07
US20210323952A1 (en) 2021-10-21
IL283471A (en) 2021-07-29
US11117889B1 (en) 2021-09-14
JP2022516401A (en) 2022-02-28
CA3119773A1 (en) 2020-06-04
CN113423427A (en) 2021-09-21
AU2019389174A1 (en) 2021-07-01
EP3886904A1 (en) 2021-10-06

Similar Documents

Publication Publication Date Title
IL283471A (en) Irak degraders and uses thereof
IL289267A (en) Irak degraders and uses thereof
IL275649A (en) Irak degraders and uses thereof
EP4076520A4 (en) Irak degraders and uses thereof
IL273432A (en) Protein degraders and uses thereof
EP3752504A4 (en) Irak degraders and uses thereof
IL273236A (en) Pyrazolopyrimidinone compounds and uses thereof
IL293377A (en) Hsd17b13 variants and uses thereof
EP4076524A4 (en) Irak degraders and uses thereof
IL286969A (en) Stat degraders and uses thereof
EP4076448A4 (en) Fluoroalkyl-oxadiazoles and uses thereof
EP4081308A4 (en) Smarca degraders and uses thereof
IL278881A (en) Cannabinoids and uses thereof
IL278832A (en) Optimized gp41-binding molecules and uses thereof
IL279483A (en) Cyanotriazole compounds and uses thereof
IL277502A (en) Compounds and uses thereof
SG11201912432VA (en) Emm-23 materials and processes and uses thereof
IL273671A (en) Cornulin (crnn) variants and uses thereof
IL269836B (en) Substituted n-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
SG11202007112SA (en) Emm-37 materials and processes and uses thereof
GB201801102D0 (en) New compounds and uses
IL280369A (en) New myokines and uses thereof
IL269843B (en) Substituted n-arylethyl-2-arylquinoline-4-carboxamides and use thereof
SG11202005282VA (en) Emm-31 materials and processes and uses thereof
GB201806349D0 (en) New compounds and uses