PE20200296A1 - Moduladores de nlrp3 - Google Patents
Moduladores de nlrp3Info
- Publication number
- PE20200296A1 PE20200296A1 PE2020000051A PE2020000051A PE20200296A1 PE 20200296 A1 PE20200296 A1 PE 20200296A1 PE 2020000051 A PE2020000051 A PE 2020000051A PE 2020000051 A PE2020000051 A PE 2020000051A PE 20200296 A1 PE20200296 A1 PE 20200296A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- alkynylene
- alkenylene
- alkylene
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La presente invencion se refiere a un compuesto de Formula (l), o una sal aceptable de este, donde: W' es R2 o Q'-R2; Q' es NH,O o S; W es H, R2 o Q-R2; Q es NR1, CHR1, O o S; R1 es independientemente H o X-R5; en donde: X se selecciona de alquileno C1-10,alquenileno C2-10 y alquinileno C2-10 en donde cada uno esta opcionalmente interrumpido por un O o S; R5 se selecciona de : hidrogeno, -OH, alcoxi C1-4, entre otros; R2 se selecciona independientemente de : H, R6 y -Q2-Y-R6; Q2 se selecciona de un enlace , C(O) entre otros; Y se selecciona de alquileno C1-10, alquenileno C2-10 y alquinileno C2-10 en donde cada uno esta opcionalmente interrumpido por un O, S, entre otros; R6 se selecciona independientemente de hidrogeno, OH, alcoxi C1-4 , ente otros. Son compuestos preferidos los compuestos de formula (i), (ii), (iii), entre otros. Tambien se refiere a una composicion farmaceutica que comprende el compuesto de formula (I). Dicho compuesto modula (agoniza o parcialmente agoniza) a la subfamilia NLRP3 de los receptores tipo dominio de oligomerizacion de fijacion a nucleotidos (NLR), siendo utiles en el tratamiento del cancer.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762532932P | 2017-07-14 | 2017-07-14 | |
US201862662405P | 2018-04-25 | 2018-04-25 | |
US201862689412P | 2018-06-25 | 2018-06-25 | |
PCT/US2018/041723 WO2019014402A1 (en) | 2017-07-14 | 2018-07-12 | MODULATORS OF NLRP3 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20200296A1 true PE20200296A1 (es) | 2020-02-06 |
Family
ID=63036509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020000051A PE20200296A1 (es) | 2017-07-14 | 2018-07-12 | Moduladores de nlrp3 |
Country Status (16)
Country | Link |
---|---|
US (2) | US11344543B2 (es) |
EP (1) | EP3652166A1 (es) |
JP (1) | JP7159282B2 (es) |
KR (1) | KR20200028434A (es) |
CN (2) | CN111793060B (es) |
AU (1) | AU2018301681B2 (es) |
BR (1) | BR112020000523A2 (es) |
CA (1) | CA3069524A1 (es) |
CL (1) | CL2020000085A1 (es) |
CO (1) | CO2020000227A2 (es) |
IL (1) | IL271935A (es) |
NZ (1) | NZ761519A (es) |
PE (1) | PE20200296A1 (es) |
SG (1) | SG11202000248UA (es) |
TW (1) | TWI791556B (es) |
WO (1) | WO2019014402A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20210114983A (ko) * | 2019-01-14 | 2021-09-24 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Nlrp3 조정제 |
EP3911641A1 (en) * | 2019-01-14 | 2021-11-24 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
CN113195469A (zh) * | 2019-02-19 | 2021-07-30 | 四川科伦博泰生物医药股份有限公司 | 含氮并环化合物、其制备方法及用途 |
WO2021114691A1 (zh) * | 2019-12-13 | 2021-06-17 | 四川科伦博泰生物医药股份有限公司 | 含氮并环化合物、其制备方法及用途 |
AU2020446002A1 (en) | 2020-04-29 | 2022-12-22 | Shanghai Ringene Biopharma Co., Ltd. | Benzothiazolyl biaryl compound, and preparation method and use |
CN115362155A (zh) * | 2020-07-22 | 2022-11-18 | 中国医药研究开发中心有限公司 | 芳胺类衍生物及其制备方法和医药用途 |
KR102409345B1 (ko) * | 2020-09-22 | 2022-06-16 | 가톨릭대학교 산학협력단 | Nlrp3 인플라마좀 억제제 및 이의 용도 |
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US10533007B2 (en) | 2016-04-19 | 2020-01-14 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
ES2955132T3 (es) | 2016-12-19 | 2023-11-28 | Epizyme Inc | Compuestos heterocíclicos sustituidos con amina como inhibidores de EHMT2 y métodos de uso de los mismos |
TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
-
2018
- 2018-07-12 BR BR112020000523-1A patent/BR112020000523A2/pt active Search and Examination
- 2018-07-12 PE PE2020000051A patent/PE20200296A1/es unknown
- 2018-07-12 EP EP18746537.2A patent/EP3652166A1/en active Pending
- 2018-07-12 CN CN202010596091.5A patent/CN111793060B/zh active Active
- 2018-07-12 SG SG11202000248UA patent/SG11202000248UA/en unknown
- 2018-07-12 US US16/629,980 patent/US11344543B2/en active Active
- 2018-07-12 AU AU2018301681A patent/AU2018301681B2/en active Active
- 2018-07-12 NZ NZ761519A patent/NZ761519A/en unknown
- 2018-07-12 KR KR1020207003984A patent/KR20200028434A/ko not_active Application Discontinuation
- 2018-07-12 CN CN201880046886.XA patent/CN110914258A/zh active Pending
- 2018-07-12 WO PCT/US2018/041723 patent/WO2019014402A1/en unknown
- 2018-07-12 CA CA3069524A patent/CA3069524A1/en active Pending
- 2018-07-12 JP JP2020501154A patent/JP7159282B2/ja active Active
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2020
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- 2020-01-10 CO CONC2020/0000227A patent/CO2020000227A2/es unknown
- 2020-01-10 CL CL2020000085A patent/CL2020000085A1/es unknown
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2022
- 2022-04-28 US US17/731,279 patent/US20220257587A1/en active Pending
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TWI791556B (zh) | 2023-02-11 |
US20200129500A1 (en) | 2020-04-30 |
CN110914258A (zh) | 2020-03-24 |
CL2020000085A1 (es) | 2020-07-10 |
AU2018301681B2 (en) | 2022-07-14 |
CA3069524A1 (en) | 2019-01-17 |
TW201908304A (zh) | 2019-03-01 |
US20220257587A1 (en) | 2022-08-18 |
CN111793060B (zh) | 2023-06-06 |
IL271935A (en) | 2020-02-27 |
JP2020527139A (ja) | 2020-09-03 |
BR112020000523A2 (pt) | 2020-07-14 |
KR20200028434A (ko) | 2020-03-16 |
CN111793060A (zh) | 2020-10-20 |
NZ761519A (en) | 2023-07-28 |
JP7159282B2 (ja) | 2022-10-24 |
SG11202000248UA (en) | 2020-02-27 |
CO2020000227A2 (es) | 2020-01-17 |
EP3652166A1 (en) | 2020-05-20 |
WO2019014402A1 (en) | 2019-01-17 |
US11344543B2 (en) | 2022-05-31 |
AU2018301681A1 (en) | 2020-02-27 |
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