SG11201810023QA - Anti-tim-3 antibodies and methods of use thereof - Google Patents

Anti-tim-3 antibodies and methods of use thereof

Info

Publication number
SG11201810023QA
SG11201810023QA SG11201810023QA SG11201810023QA SG11201810023QA SG 11201810023Q A SG11201810023Q A SG 11201810023QA SG 11201810023Q A SG11201810023Q A SG 11201810023QA SG 11201810023Q A SG11201810023Q A SG 11201810023QA SG 11201810023Q A SG11201810023Q A SG 11201810023QA
Authority
SG
Singapore
Prior art keywords
antibodies
international
igg1 variant
rule
tim
Prior art date
Application number
SG11201810023QA
Inventor
Dijk Marc Van
Ekaterina Vladimirovna Breous-Nystrom
Nicholas Stuart Wilson
Jeremy Dale Waight
Dennis John Underwood
Original Assignee
Agenus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenus Inc filed Critical Agenus Inc
Publication of SG11201810023QA publication Critical patent/SG11201810023QA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H1110111111111111111111111111110110101111110011111011101111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\") WO 2017/205721 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: achusetts 02149 (US). UNDERWOOD, Dennis John; 28 C07K 16/28 (2006.01) A61K 39/00 (2006.01) John A Andrew Street, Boston, Massachusetts 02130 (US). (21) International Application Number: (74) Agent: WILKINS, Andrew T. et al.; Lathrop & Gage LLP, PCT/US2017/034645 28 State Street, Suite 700, Boston, Massachusetts 02109 (22) International Filing Date: (US). 26 May 2017 (26.05.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/342,610 27 May 2016 (27.05.2016) US HR, KW, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 62/420,276 10 November 2016 (10.11.2016) US MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (71) Applicant: AGENUS INC. [US/US]; 3 Forbes Road, Lex- PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, ington, MA 02421 (US). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (72) Inventors: VAN DIJK, Marc; Gaailaan 16, 3722ZH TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Bilthoven (NL). BREOUS-NYSTROM, Ekaterina (84) Designated States (unless otherwise indicated, for every Vladimirovna; Waldenburgerstrasse 15, 4052 Basel (CH). kind of regional protection available): ARIPO (BW, GH, — WILSON, Nicholas Stuart; 68 Electric Avenue, Apart- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ment 1, Somerville, Massachusetts 02144 (US). WAIGHT, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Jeremy Dale; 25 Charlton Street, Apt. 403, Everett, Mass- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = _ _ (54) Title: ANTI-TIM-3 ANTIBODIES AND METHODS OF USE THEREOF = Figure 4 = _ Binding to human CD8+ T cells = = = = 2000 -®- lsotype control = = .,, -40- pab2085 (IgG1) = 1500 — V.. -.-- pab2184 (IgG1 variant) 40,... -6-- pab2186 (IgG1 variant) = = LE- - 8 - pab2187 (IgG1 variant) 2 1000 -v--- pab2188 (IgG1 variant) = - pab2189 (IgG1 variant) --ar. pab2190 (IgG1 variant) — = 500 -Y- pab2191 (IgG1 variant) -kr pab2192 (IgG1 variant) 4-- -- '5 4 0—, 0. 11, x0 0 — 1-1 -4 1 1-1 ei Antibody concentration ( lginil [log]) IN kr) 0 ei ----- (57) : The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 IN , I function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expres- 0 sion vectors and host cells for making these antibodies, and methods of treating ei a subject using these antibodies. O [Continued on next page] WO 2017/205721 Al MUM 31010101IMMEMODIMIIMINEilin#011 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the identity of the inventor (Rule 4.170) — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(U)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))
SG11201810023QA 2016-05-27 2017-05-26 Anti-tim-3 antibodies and methods of use thereof SG11201810023QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662342610P 2016-05-27 2016-05-27
US201662420276P 2016-11-10 2016-11-10
PCT/US2017/034645 WO2017205721A1 (en) 2016-05-27 2017-05-26 Anti-tim-3 antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201810023QA true SG11201810023QA (en) 2018-12-28

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SG10201912563XA SG10201912563XA (en) 2016-05-27 2017-05-26 Anti-tim-3 antibodies and methods of use thereof

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Country Status (16)

Country Link
US (4) US10639368B2 (en)
EP (1) EP3464360A1 (en)
JP (2) JP7267012B2 (en)
KR (3) KR102366813B1 (en)
CN (1) CN109476751B (en)
AU (2) AU2017271588B2 (en)
BR (1) BR112018074463A2 (en)
CA (1) CA3024508A1 (en)
MA (1) MA45123A (en)
MX (2) MX2018014387A (en)
MY (1) MY195089A (en)
NZ (1) NZ749355A (en)
PH (1) PH12018502400A1 (en)
SG (2) SG11201810023QA (en)
TW (2) TW202244062A (en)
WO (1) WO2017205721A1 (en)

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