SE2050559A1 - PD-1 as a predictive marker for therapy in cancer - Google Patents
PD-1 as a predictive marker for therapy in cancerInfo
- Publication number
- SE2050559A1 SE2050559A1 SE2050559A SE2050559A SE2050559A1 SE 2050559 A1 SE2050559 A1 SE 2050559A1 SE 2050559 A SE2050559 A SE 2050559A SE 2050559 A SE2050559 A SE 2050559A SE 2050559 A1 SE2050559 A1 SE 2050559A1
- Authority
- SE
- Sweden
- Prior art keywords
- therapy
- cancer
- predictive marker
- determining
- breast cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/54—Determining the risk of relapse
Abstract
There is provided a method for treating breast cancer comprising the steps:a) obtaining a tissue sample of a tumour from a breast cancer patient, b) determining the expression level of PD-1 in the sample,c) determining that the expression level is below a threshold level,d) providing intensified treatment as radiotherapy treatment, systemic therapy or mastectomy to the patient.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE2050559A SE2050559A1 (en) | 2020-05-13 | 2020-05-13 | PD-1 as a predictive marker for therapy in cancer |
AU2021272986A AU2021272986A1 (en) | 2020-05-13 | 2021-05-12 | PD-1 as a predictive marker for therapy in cancer |
CA3183417A CA3183417A1 (en) | 2020-05-13 | 2021-05-12 | Pd-1 as a predictive marker for therapy in cancer |
PCT/US2021/032080 WO2021231641A1 (en) | 2020-05-13 | 2021-05-12 | Pd-1 as a predictive marker for therapy in cancer |
EP21803206.8A EP4149616A1 (en) | 2020-05-13 | 2021-05-12 | Pd-1 as a predictive marker for therapy in cancer |
US17/998,334 US20230375549A1 (en) | 2020-05-13 | 2021-05-12 | Pd-1 as a predictive marker for therapy in cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE2050559A SE2050559A1 (en) | 2020-05-13 | 2020-05-13 | PD-1 as a predictive marker for therapy in cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
SE2050559A1 true SE2050559A1 (en) | 2021-11-14 |
Family
ID=78816986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE2050559A SE2050559A1 (en) | 2020-05-13 | 2020-05-13 | PD-1 as a predictive marker for therapy in cancer |
Country Status (1)
Country | Link |
---|---|
SE (1) | SE2050559A1 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012145493A1 (en) * | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
WO2015116868A2 (en) * | 2014-01-29 | 2015-08-06 | Caris Mpi, Inc. | Molecular profiling of immune modulators |
WO2017140826A1 (en) * | 2016-02-18 | 2017-08-24 | Institut Gustave Roussy | Methods and kits for predicting the sensitivity of a subject to immunotherapy |
WO2018160841A1 (en) * | 2017-03-01 | 2018-09-07 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
WO2018191660A1 (en) * | 2017-04-14 | 2018-10-18 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
-
2020
- 2020-05-13 SE SE2050559A patent/SE2050559A1/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012145493A1 (en) * | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
WO2015116868A2 (en) * | 2014-01-29 | 2015-08-06 | Caris Mpi, Inc. | Molecular profiling of immune modulators |
WO2017140826A1 (en) * | 2016-02-18 | 2017-08-24 | Institut Gustave Roussy | Methods and kits for predicting the sensitivity of a subject to immunotherapy |
WO2018160841A1 (en) * | 2017-03-01 | 2018-09-07 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
WO2018191660A1 (en) * | 2017-04-14 | 2018-10-18 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
Non-Patent Citations (2)
Title |
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Lu L et al., "Elevated T cell activation score is associated with improved survival of breast cancer", Breast Cancer Res Treat, 2017, 164(3):689-696 * |
Yeong J et al., "Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer", J Immunother Cancer, 2019, 7:34 * |
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Legal Events
Date | Code | Title | Description |
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NAV | Patent application has lapsed |