RU2009126723A - Антитела к ox40l - Google Patents
Антитела к ox40l Download PDFInfo
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- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract
1. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, а также включает комбинацию вариабельных областей, независимо друг от друга выбранных из группы, включающий следующие комбинации: ! а) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 1, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 2; ! б) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 3, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 4; ! в) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 5, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 6; ! г) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 7, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 8; ! д) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 9, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 10; ! е) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 11 или 16, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 12. ! 2. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, и включает в качестве ! а) тяжелой γ-цепи SEQ ID NO: 58 и легкой каппа-цепи SEQ ID NO: 61, ! б) тяжелой γ-цепи SEQ ID NO: 62 и легкой �
Claims (22)
1. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, а также включает комбинацию вариабельных областей, независимо друг от друга выбранных из группы, включающий следующие комбинации:
а) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 1, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 2;
б) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 3, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 4;
в) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 5, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 6;
г) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 7, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 8;
д) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 9, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 10;
е) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 11 или 16, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 12.
2. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, и включает в качестве
а) тяжелой γ-цепи SEQ ID NO: 58 и легкой каппа-цепи SEQ ID NO: 61,
б) тяжелой γ-цепи SEQ ID NO: 62 и легкой каппа-цепи SEQ ID NO: 65 или
в) тяжелой γ-цепи SEQ ID NO: 66 и легкой каппа-цепи SEQ ID NO: 69.
3. Антитело по п.1, отличающееся тем, что антитело представляет собой Fab-, F(ab')2- или одноцепочечный фрагмент.
4. Антитело по п.2, отличающееся тем, что антитело представляет собой Fab-, F(ab')2- или одноцепочечный фрагмент.
5. Молекула нуклеиновой кислоты, кодирующая молекулу антитела, отличающаяся тем, что указанное антитело связывается с OX40L человека и содержит комбинацию вариабельных областей, независимо друг от друга выбранных из группы, включающий следующие комбинации:
а) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 1, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 2;
б) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 3, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 4;
в) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 5, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 6;
г) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 7, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 8;
д) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 9, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 10;
е) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 11 или 16, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 12.
6. Молекула нуклеиновой кислоты, кодирующая антитело, которое связывается с OX40L человека, отличающаяся тем, что она кодирует антитело, включающее
а) тяжелой γ-цепи SEQ ID NO: 58 и легкой каппа-цепи SEQ ID NO: 61,
б) тяжелой γ-цепи SEQ ID NO: 62 и легкой каппа-цепи SEQ ID NO: 65 или
в) тяжелой γ-цепи SEQ ID NO: 66 и легкой каппа-цепи SEQ ID NO: 69.
7. Вектор, содержащий молекулу нуклеиновой кислоты по п.5.
8. Вектор, содержащий молекулу нуклеиновой кислоты по п.6.
9. Клетка-хозяин, включающая вектор, который содержит молекулу нуклеиновой кислоты по п.5.
10. Клетка-хозяин, включающая вектор, который содержит молекулу нуклеиновой кислоты по п.6.
11. Способ получения антитела, которое связывается с OX40L человека и содержит Fc-фрагмент, полученный из организма человека, отличающийся тем, что культивируют клетку-хозяина, включающую вектор, содержащий молекулу нуклеиновой кислоты по п.5, в условиях, которые обеспечивают синтез молекулы антитела, и выделяют молекулу антитела из культуры.
12. Способ получения антитела, которое связывается с OX40L человека и содержит Fc-фрагмент, полученный из организма человека, отличающийся тем, что культивируют клетку-хозяина, включающую вектор, содержащий молекулу нуклеиновой кислоты по п.6, в условиях, которые обеспечивают синтез молекулы антитела, и выделяют молекулу антитела из культуры.
13. Способ получения антитела, которое связывается с OX40L человека, отличающийся тем, что последовательность нуклеиновой кислоты по п.5 модифицируют таким образом, чтобы это модифицированное антитело не связывалось с фактором комплемента Clq и/или человеческим Fcγ-рецептором на NK-клетках, встраивают указанную модифицированную первую нуклеиновую кислоту и вторую нуклеиновую кислоту, кодирующую легкую цепь антитела, в экспрессионный вектор, встраивают вектор в прокариотическую или эукариотическую клетку-хозяина, культивируют клетку-хозяина в условиях, которые обеспечивают синтез антитела, и выделяют антитело из культуры.
14. Способ получения антитела, которое связывается с OX40L человека, отличающийся тем, что последовательность нуклеиновой кислоты по п.6 модифицируют таким образом, чтобы это модифицированное антитело не связывалось с фактором комплемента Clq и/или человеческим Fcγ-рецептором на NK-клетках, встраивают указанную модифицированную первую нуклеиновую кислоту и вторую нуклеиновую кислоту, кодирующую легкую цепь антитела, в экспрессионный вектор, встраивают вектор в прокариотическую или эукариотическую клетку-хозяина, культивируют клетку-хозяина в условиях, которые обеспечивают синтез антитела, и выделяют антитело из культуры.
15. Композиция, содержащая молекулу антитела по п.1 в дозовом количестве 0,1 мг/кг.
16. Композиция, содержащая молекулу антитела по п.2 в дозовом количестве 0,1 мг/кг.
17. Композиция, содержащая молекулу антитела по п.1 в дозовом количестве 0,1 мг/кг и представляющая собой фармацевтическую или диагностическую композицию.
18. Композиция, содержащая молекулу антитела по п.2 в дозовом количестве 0,1 мг/кг и представляющая собой фармацевтическую или диагностическую композицию.
19. Фармацевтическая композиция, содержащая антитело по п.1 в дозовом количестве 0,1 мг/кг, и по меньшей мере один фармацевтически приемлемый эксципиент.
20. Фармацевтическая композиция, содержащая антитело по п.2 в дозовом количестве 0,1 мг/кг, и по меньшей мере один фармацевтически приемлемый эксципиент.
21. Применение антитела по п.1 для приготовления лекарственного средства, предназначенного для профилактики и лечения воспалительных заболеваний.
22. Применение антитела по п.2 для приготовления лекарственного средства, предназначенного для профилактики и лечения воспалительных заболеваний.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04022158.2 | 2004-09-17 | ||
EP04022158 | 2004-09-17 | ||
EP04030546.8 | 2004-12-23 | ||
EP04030546 | 2004-12-23 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2007114328/13A Division RU2395523C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ох40l |
Publications (2)
Publication Number | Publication Date |
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RU2009126723A true RU2009126723A (ru) | 2011-01-20 |
RU2423383C2 RU2423383C2 (ru) | 2011-07-10 |
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Application Number | Title | Priority Date | Filing Date |
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RU2007114328/13A RU2395523C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ох40l |
RU2009126723/10A RU2423383C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ox40l |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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RU2007114328/13A RU2395523C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ох40l |
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US (3) | US7501496B1 (ru) |
EP (2) | EP1791869B1 (ru) |
JP (2) | JP4594986B2 (ru) |
KR (2) | KR100895597B1 (ru) |
CN (1) | CN101684157A (ru) |
AR (1) | AR051925A1 (ru) |
AU (1) | AU2005284310B2 (ru) |
BR (1) | BRPI0515554A (ru) |
CA (1) | CA2580140C (ru) |
CL (1) | CL2010000426A1 (ru) |
ES (1) | ES2433916T3 (ru) |
HK (1) | HK1108000A1 (ru) |
IL (1) | IL181575A (ru) |
MX (1) | MX2007002905A (ru) |
MY (1) | MY149442A (ru) |
NO (1) | NO20071430L (ru) |
NZ (2) | NZ553333A (ru) |
RU (2) | RU2395523C2 (ru) |
SG (1) | SG147444A1 (ru) |
TW (2) | TWI309240B (ru) |
WO (1) | WO2006029879A2 (ru) |
Families Citing this family (871)
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PL1907424T3 (pl) * | 2005-07-01 | 2015-12-31 | Squibb & Sons Llc | Ludzkie monoklonalne przeciwciała wobec liganda zaprogramowanej śmierci 1 (PD-L1) |
AR057253A1 (es) | 2005-12-16 | 2007-11-21 | Genentech Inc | Anticuerpos anti-ox40l y metodos que los utilizan |
DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
DK2009101T3 (en) | 2006-03-31 | 2018-01-15 | Chugai Pharmaceutical Co Ltd | Antibody modification method for purification of a bispecific antibody |
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US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
SG10201605394SA (en) | 2007-09-26 | 2016-08-30 | Chugai Pharmaceutical Co Ltd | Modified Antibody Constant Region |
EP2586795B1 (en) | 2007-10-05 | 2018-05-16 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
WO2009141239A1 (en) * | 2008-05-20 | 2009-11-26 | F. Hoffmann-La Roche Ag | A pharmaceutical formulation comprising an antibody against ox40l, uses thereof |
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