AR115052A1 - Anticuerpos multiespecíficos y utilización de los mismos - Google Patents
Anticuerpos multiespecíficos y utilización de los mismosInfo
- Publication number
- AR115052A1 AR115052A1 ARP190101003A ARP190101003A AR115052A1 AR 115052 A1 AR115052 A1 AR 115052A1 AR P190101003 A ARP190101003 A AR P190101003A AR P190101003 A ARP190101003 A AR P190101003A AR 115052 A1 AR115052 A1 AR 115052A1
- Authority
- AR
- Argentina
- Prior art keywords
- specific antibodies
- hla
- bind
- formulations
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La presente se refiere a anticuerpos multiespecíficos que se unen a HLA-G y a un antígeno activador de células T, a su preparación, y a formulaciones y métodos de utilización de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18168053 | 2018-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115052A1 true AR115052A1 (es) | 2020-11-25 |
Family
ID=62025743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190101003A AR115052A1 (es) | 2018-04-18 | 2019-04-16 | Anticuerpos multiespecíficos y utilización de los mismos |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210147554A1 (es) |
EP (1) | EP3781594A1 (es) |
JP (2) | JP2021521785A (es) |
KR (1) | KR20210005639A (es) |
CN (1) | CN111989343B (es) |
AR (1) | AR115052A1 (es) |
AU (1) | AU2019256744A1 (es) |
BR (1) | BR112020021111A2 (es) |
CA (1) | CA3095547A1 (es) |
CL (1) | CL2020002539A1 (es) |
CO (1) | CO2020012360A2 (es) |
IL (1) | IL277559A (es) |
MA (1) | MA52285A (es) |
MX (1) | MX2020010946A (es) |
PE (1) | PE20210517A1 (es) |
PH (1) | PH12020500667A1 (es) |
SG (1) | SG11202009692SA (es) |
TW (1) | TW201945394A (es) |
WO (1) | WO2019202041A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7411627B2 (ja) | 2018-07-09 | 2024-01-11 | ファイヴ プライム セラピューティクス インク | Ilt4と結合する抗体 |
CN113528448B (zh) * | 2020-04-14 | 2023-01-24 | 同济大学 | 一种人胚胎干细胞的构建方法 |
JP2023530083A (ja) * | 2020-06-11 | 2023-07-13 | ティゾナ セラピューティクス | Hla-g及び別の抗原に対して結合特異性を有する二重特異性免疫細胞エンゲージャー |
MX2023001256A (es) * | 2020-07-29 | 2023-05-16 | Janssen Biotech Inc | Proteínas que comprenden dominios de unión al antígeno hla-g y sus usos. |
JP7326584B2 (ja) * | 2020-12-17 | 2023-08-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗hla-g抗体及びその使用 |
US20220306747A1 (en) * | 2021-03-24 | 2022-09-29 | China Medical University Hospital | Anti-tumor antigen nanobody and nucleic acid encoding sequence thereof, and uses of the same |
US11795227B2 (en) * | 2021-03-24 | 2023-10-24 | Shine-On Biomedical Co., Ltd. | Immunomodulation and anti-tumor-related nanobody and nucleic acid encoding sequence thereof, and uses of the same |
CN113398253B (zh) * | 2021-05-14 | 2023-01-24 | 北京化工大学 | β2微球蛋白聚集抑制剂 |
EP4347635A2 (en) * | 2021-05-26 | 2024-04-10 | Board of Regents, The University of Texas System | Chimeric antigen receptor to target hla-g-positive cancers |
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KR102317315B1 (ko) | 2014-08-04 | 2021-10-27 | 에프. 호프만-라 로슈 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
EP3209684B1 (en) | 2014-10-24 | 2020-12-23 | F.Hoffmann-La Roche Ag | Vh-vl-interdomain angle based antibody humanization |
US20190119385A1 (en) * | 2015-03-27 | 2019-04-25 | University Of Southern California | Hla-g as a novel target for car t-cell immunotherapy |
CN107787332B (zh) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 多特异性抗原结合蛋白 |
-
2019
- 2019-04-16 AR ARP190101003A patent/AR115052A1/es unknown
- 2019-04-17 BR BR112020021111-7A patent/BR112020021111A2/pt not_active Application Discontinuation
- 2019-04-17 JP JP2020557212A patent/JP2021521785A/ja active Pending
- 2019-04-17 MA MA052285A patent/MA52285A/fr unknown
- 2019-04-17 KR KR1020207033026A patent/KR20210005639A/ko not_active Application Discontinuation
- 2019-04-17 SG SG11202009692SA patent/SG11202009692SA/en unknown
- 2019-04-17 CN CN201980026851.4A patent/CN111989343B/zh active Active
- 2019-04-17 PE PE2020001543A patent/PE20210517A1/es unknown
- 2019-04-17 AU AU2019256744A patent/AU2019256744A1/en not_active Abandoned
- 2019-04-17 EP EP19718695.0A patent/EP3781594A1/en active Pending
- 2019-04-17 TW TW108113353A patent/TW201945394A/zh unknown
- 2019-04-17 MX MX2020010946A patent/MX2020010946A/es unknown
- 2019-04-17 CA CA3095547A patent/CA3095547A1/en not_active Abandoned
- 2019-04-17 WO PCT/EP2019/060008 patent/WO2019202041A1/en unknown
-
2020
- 2020-09-23 IL IL277559A patent/IL277559A/en unknown
- 2020-09-30 CO CONC2020/0012360A patent/CO2020012360A2/es unknown
- 2020-10-01 CL CL2020002539A patent/CL2020002539A1/es unknown
- 2020-10-15 PH PH12020500667A patent/PH12020500667A1/en unknown
- 2020-10-16 US US17/072,549 patent/US20210147554A1/en active Pending
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2023
- 2023-02-27 JP JP2023028123A patent/JP2023081898A/ja active Pending
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TW201945394A (zh) | 2019-12-01 |
MA52285A (fr) | 2021-02-24 |
CL2020002539A1 (es) | 2021-01-22 |
CO2020012360A2 (es) | 2020-10-30 |
MX2020010946A (es) | 2020-11-09 |
CA3095547A1 (en) | 2019-10-24 |
BR112020021111A2 (pt) | 2021-02-17 |
PE20210517A1 (es) | 2021-03-17 |
IL277559A (en) | 2020-11-30 |
US20210147554A1 (en) | 2021-05-20 |
AU2019256744A1 (en) | 2020-11-19 |
JP2021521785A (ja) | 2021-08-30 |
EP3781594A1 (en) | 2021-02-24 |
SG11202009692SA (en) | 2020-11-27 |
KR20210005639A (ko) | 2021-01-14 |
PH12020500667A1 (en) | 2021-07-26 |
CN111989343B (zh) | 2023-12-26 |
JP2023081898A (ja) | 2023-06-13 |
WO2019202041A1 (en) | 2019-10-24 |
CN111989343A (zh) | 2020-11-24 |
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