SG11202005912PA - Irak degraders and uses thereof - Google Patents
Irak degraders and uses thereofInfo
- Publication number
- SG11202005912PA SG11202005912PA SG11202005912PA SG11202005912PA SG11202005912PA SG 11202005912P A SG11202005912P A SG 11202005912PA SG 11202005912P A SG11202005912P A SG 11202005912PA SG 11202005912P A SG11202005912P A SG 11202005912PA SG 11202005912P A SG11202005912P A SG 11202005912PA
- Authority
- SG
- Singapore
- Prior art keywords
- degraders
- irak
- irak degraders
- Prior art date
Links
- 239000001064 degrader Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762610397P | 2017-12-26 | 2017-12-26 | |
US201862653178P | 2018-04-05 | 2018-04-05 | |
US201862694955P | 2018-07-06 | 2018-07-06 | |
US201862712377P | 2018-07-31 | 2018-07-31 | |
PCT/US2018/067304 WO2019133531A1 (en) | 2017-12-26 | 2018-12-21 | Irak degraders and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202005912PA true SG11202005912PA (en) | 2020-07-29 |
Family
ID=66949188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202005912PA SG11202005912PA (en) | 2017-12-26 | 2018-12-21 | Irak degraders and uses thereof |
Country Status (11)
Country | Link |
---|---|
US (4) | US10874743B2 (en) |
EP (1) | EP3731869A4 (en) |
JP (2) | JP2021508703A (en) |
CN (1) | CN112105385A (en) |
AU (1) | AU2018396142A1 (en) |
BR (1) | BR112020012997A2 (en) |
CA (1) | CA3086763A1 (en) |
IL (2) | IL304055A (en) |
MX (1) | MX2020006812A (en) |
SG (1) | SG11202005912PA (en) |
WO (1) | WO2019133531A1 (en) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7366031B2 (en) * | 2017-09-22 | 2023-10-20 | カイメラ セラピューティクス, インコーポレイテッド | Proteolytic agents and their use |
WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
BR112020012997A2 (en) | 2017-12-26 | 2020-12-01 | Kymera Therapeutics, Inc. | irak degraders and uses thereof |
US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
WO2019196812A1 (en) * | 2018-04-09 | 2019-10-17 | 上海科技大学 | Protein degradation targeting compound, anti-tumor application, intermediate thereof and use of intermediate |
US20220348556A1 (en) * | 2018-07-06 | 2022-11-03 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
WO2020010177A1 (en) * | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
WO2020010451A1 (en) * | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists |
CN112533898A (en) | 2018-07-31 | 2021-03-19 | 日商泛美克斯股份有限公司 | Heterocyclic compounds |
CA3121667A1 (en) * | 2018-09-30 | 2020-04-02 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Isoindoline compound, preparation method, pharmaceutical composition and use thereof |
US20220009916A1 (en) * | 2018-11-02 | 2022-01-13 | Dana-Farber Cancer Institute, Inc. | Acetylation writer inhibitor development and uses thereof |
WO2020113233A1 (en) * | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
JP2022523916A (en) | 2019-01-30 | 2022-04-27 | モンテリノ・セラピューティクス・インコーポレイテッド | Bifunctional compounds and methods for ubiquitination targeting androgen receptors |
SG11202110829YA (en) | 2019-04-05 | 2021-10-28 | Kymera Therapeutics Inc | Stat degraders and uses thereof |
WO2021011868A1 (en) * | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
JP2021024787A (en) | 2019-07-31 | 2021-02-22 | ファイメクス株式会社 | Heterocyclic compound |
JPWO2021020585A1 (en) * | 2019-07-31 | 2021-02-04 | ||
JP7353474B2 (en) * | 2019-09-24 | 2023-09-29 | 上海美悦生物科技発展有限公司 | IRAK inhibitor, its manufacturing method and use |
WO2021092239A1 (en) * | 2019-11-05 | 2021-05-14 | Dermira, Inc. | Topical compositions comprising irak4 inhibitors for use in treating dermatological conditions characterised by inflammation |
US20230190940A1 (en) * | 2019-12-10 | 2023-06-22 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
WO2021127283A2 (en) * | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
JP2023509366A (en) * | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス, インコーポレイテッド | IRAK dissolving agents and their uses |
PE20230159A1 (en) | 2019-12-18 | 2023-02-01 | Novartis Ag | 3-(5-METHOXY-1-OXOISOINDOLIN-2-IL)PIPERIDIN-2,6-DIONE DERIVATIVES AND USES |
JP2023509394A (en) | 2019-12-23 | 2023-03-08 | カイメラ セラピューティクス, インコーポレイテッド | SMARCA decomposing agents and their use |
WO2021158634A1 (en) * | 2020-02-03 | 2021-08-12 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
WO2021162493A1 (en) * | 2020-02-14 | 2021-08-19 | 보로노이 주식회사 | Protein kinase degradation inducing compound, and use thereof |
TW202140489A (en) | 2020-02-19 | 2021-11-01 | 美商紐力克斯醫療股份有限公司 | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
US20230158152A1 (en) * | 2020-03-17 | 2023-05-25 | Medshine Discovery Inc. | Proteolysis regulator and method for using same |
IL296451A (en) * | 2020-03-19 | 2022-11-01 | Kymera Therapeutics Inc | Mdm2 degraders and uses thereof |
IL296731A (en) * | 2020-03-31 | 2022-11-01 | Orum Therapeutics Inc | Conjugates |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
US20230167081A1 (en) * | 2020-04-30 | 2023-06-01 | President And Fellows Of Harvard College | 5-amino-2-piperidinon-3-yl-1-oxoisoindoline derivatives for degradation of ikzf2 degraders |
TW202208381A (en) | 2020-05-06 | 2022-03-01 | 美商紐力克斯醫療股份有限公司 | Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof |
WO2021236695A1 (en) * | 2020-05-18 | 2021-11-25 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
TW202210483A (en) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Crystalline forms of irak degraders |
US20230250110A1 (en) * | 2020-06-03 | 2023-08-10 | Kymera Therapeutics, Inc. | Deuterated irak degraders and uses thereof |
EP4168410A1 (en) | 2020-06-22 | 2023-04-26 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Methotrexate analogs and methods of use |
US11857551B1 (en) | 2020-07-10 | 2024-01-02 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
KR20230044480A (en) | 2020-07-30 | 2023-04-04 | 카이메라 쎄라퓨틱스 인코포레이티드 | Methods of treating mutant lymphoma |
EP4232059A1 (en) * | 2020-10-21 | 2023-08-30 | Kymera Therapeutics, Inc. | Double degraders and uses thereof |
TW202237601A (en) * | 2020-12-09 | 2022-10-01 | 美商凱麥拉醫療公司 | Irak degraders and uses thereof |
WO2022152821A1 (en) | 2021-01-13 | 2022-07-21 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
WO2022161414A1 (en) * | 2021-01-26 | 2022-08-04 | 成都茵创园医药科技有限公司 | Aromatic compound, pharmaceutical composition containing same, and application thereof |
WO2022171123A1 (en) * | 2021-02-10 | 2022-08-18 | Beigene, Ltd. | Egfr degraders and methods of use |
TW202245789A (en) * | 2021-02-15 | 2022-12-01 | 美商凱麥拉醫療公司 | Irak4 degraders and uses thereof |
WO2022229466A2 (en) | 2021-04-30 | 2022-11-03 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Non-covalent halotag ligands |
WO2022236339A1 (en) * | 2021-05-07 | 2022-11-10 | Kymera Therapeutics, Inc. | Deuterated irak degraders and uses thereof |
CN113549060A (en) * | 2021-07-28 | 2021-10-26 | 派普医药(江苏)有限公司 | Synthetic method of 3-amino-1- (tetrahydrofuran-2-yloxy) -1H-pyrazole-4-carbonitrile |
TW202315632A (en) | 2021-08-18 | 2023-04-16 | 美商新銳思生物製藥股份有限公司 | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
TW202317097A (en) * | 2021-09-08 | 2023-05-01 | 大陸商南京明德新藥研發有限公司 | Glutarimide compounds and applications thereof |
WO2023045978A1 (en) * | 2021-09-26 | 2023-03-30 | 南京明德新药研发有限公司 | 2,6-piperidinedione compound and application thereof |
WO2023076161A1 (en) * | 2021-10-25 | 2023-05-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
WO2023104155A1 (en) * | 2021-12-08 | 2023-06-15 | 标新生物医药科技(上海)有限公司 | Ligand compounds for e3 ubiquitin ligase, protein degraders developed on basis of ligand compounds, and uses thereof |
CN114213283B (en) * | 2022-01-04 | 2023-06-02 | 攀枝花学院 | Method for preparing [2- [1- (Fmoc-amino) ethoxy ] acetic acid by one-pot method |
TW202333670A (en) * | 2022-01-04 | 2023-09-01 | 大陸商海思科醫藥集團股份有限公司 | Compound for inhibiting and degrading irak4, and pharmaceutical composition and pharmaceutical application thereof |
WO2023137439A1 (en) * | 2022-01-14 | 2023-07-20 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
WO2023180388A1 (en) | 2022-03-24 | 2023-09-28 | Glaxosmithkline Intellectual Property Development Limited | 2,4-dioxotetrahydropyrimidinyl derivatives as degrons in protacs |
WO2023192586A1 (en) * | 2022-03-31 | 2023-10-05 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
CN117157298A (en) * | 2022-03-31 | 2023-12-01 | 石药集团中奇制药技术(石家庄)有限公司 | Dual-function chimeric heterocyclic compound of interleukin-1 receptor related kinase 4, preparation method, medicinal composition and application thereof |
WO2023201274A1 (en) | 2022-04-12 | 2023-10-19 | Genzyme Corporation | Use of an irak4 modulator for gene therapy |
WO2023201272A1 (en) | 2022-04-12 | 2023-10-19 | Genzyme Corporation | Use of irak4 modulators for gene therapy |
WO2023237049A1 (en) * | 2022-06-09 | 2023-12-14 | Beigene, Ltd. | Degradation of irak4 by conjugation of irak4 inhibitors with e3 ligase ligand and methods of use |
CN114843114B (en) * | 2022-06-30 | 2022-10-25 | 深圳市今朝时代股份有限公司 | Nitrogen-doping-based electrode material and application thereof to supercapacitor |
WO2024073507A1 (en) | 2022-09-28 | 2024-04-04 | Theseus Pharmaceuticals, Inc. | Macrocyclic compounds and uses thereof |
CN115626916B (en) * | 2022-10-24 | 2024-01-30 | 河南科技大学第一附属医院 | Pomalidomide derivative as well as preparation method and application thereof |
CN115872877A (en) * | 2022-12-21 | 2023-03-31 | 南京安伦化工科技有限公司 | Synthesis method of aminotetraethyleneglycol |
Family Cites Families (219)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4709016A (en) | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
US5516931A (en) | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
US4650750A (en) | 1982-02-01 | 1987-03-17 | Giese Roger W | Method of chemical analysis employing molecular release tag compounds |
US5650270A (en) | 1982-02-01 | 1997-07-22 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
US5360811A (en) | 1990-03-13 | 1994-11-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents |
JP3545461B2 (en) | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | Bicyclic heterocycle-containing sulfonamide derivatives |
US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
PL218519B1 (en) | 1999-12-10 | 2014-12-31 | Pfizer Prod Inc | PYRROLO[2,3−d]PYRIMIDINE COMPOUNDS |
DE10002509A1 (en) | 2000-01-21 | 2001-07-26 | Gruenenthal Gmbh | New substituted glutarimide derivatives are IL-12 antagonists, are useful as immunomodulators and for the treatment of angiopathy, hematological or oncological disorders |
CA2400649A1 (en) | 2000-02-28 | 2001-09-07 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
PE20020354A1 (en) | 2000-09-01 | 2002-06-12 | Novartis Ag | HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS |
US7041298B2 (en) | 2000-09-08 | 2006-05-09 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
US7208157B2 (en) | 2000-09-08 | 2007-04-24 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
EP1389617B1 (en) | 2001-04-27 | 2007-01-03 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compound and antitumor agent containing the same as active ingredient |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
ES2319894T3 (en) | 2002-08-14 | 2009-05-14 | Silence Therapeutics Aktiengesellschaft | USE OF PROTEIN QUINASA-N-BETA. |
SG160211A1 (en) | 2003-04-03 | 2010-04-29 | Semafore Pharmaceuticals Inc | Pi-3 kinase inhibitor prodrugs |
SI1644363T1 (en) | 2003-05-30 | 2012-07-31 | Gemin X Pharmaceuticals Canada Inc | Triheterocyclic compounds, compositions, and methods for treating cancer |
CA2531069A1 (en) | 2003-07-03 | 2005-01-27 | The Trustees Of The University Of Pennsylvania | Inhibition of syk kinase expression |
JP4398263B2 (en) | 2004-01-13 | 2010-01-13 | 富士通株式会社 | Route design method |
CN102229609A (en) | 2004-05-13 | 2011-11-02 | 艾科斯有限公司 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
TWI380996B (en) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | Anti-ox40l antibodies |
RU2416616C2 (en) | 2005-01-19 | 2011-04-20 | Райджел Фармасьютикалз, Инк. | Prodrugs of 2,4-pyrimidine diamine compounds and use thereof |
PT2343320T (en) | 2005-03-25 | 2018-01-23 | Gitr Inc | Anti-gitr antibodies and uses thereof |
NZ583758A (en) | 2005-05-12 | 2011-02-25 | Abbott Lab | Apoptosis promoters |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
KR101607288B1 (en) | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | Human monoclonal antibodies to programmed death ligand 1(pd-l1) |
US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
EA024305B1 (en) | 2005-10-07 | 2016-09-30 | Экселиксис, Инк. | Phosphatidylinositol 3-kinase inhibitors and use thereof |
RU2597364C2 (en) | 2005-11-01 | 2016-09-10 | Таргеджен, Инк. | Bi-aryl-meta-pyrimidine kinase inhibitors |
WO2007070514A1 (en) | 2005-12-13 | 2007-06-21 | Incyte Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
AU2006332945C1 (en) | 2005-12-23 | 2013-02-28 | Wyeth | Modified lysine-mimetic compounds |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | PI-3 Kinase inhibitors and methods of their use |
CL2007001165A1 (en) | 2006-04-26 | 2008-01-25 | Hoffmann La Roche | 2- (1h-indazol-4-yl) -6- (4-methanesulfonyl-piperazin-1-ylmethyl) -4-morpholin-4-yl-thieno [3,2-d] pyrimidine; preparation procedure; pharmaceutical composition; process of preparing said composition; pharmaceutical kit; and use to treat diseases such as cancer, immune disorders and cardiovascular diseases. |
SI2530083T1 (en) | 2006-09-22 | 2016-09-30 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
US20100279316A1 (en) * | 2007-01-19 | 2010-11-04 | Leonid Gorelik | Antibodies to Phosphorylated IRAK4 |
RS54533B1 (en) | 2007-03-12 | 2016-06-30 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine compounds and uses thereof |
WO2008118802A1 (en) | 2007-03-23 | 2008-10-02 | Regents Of The University Of Minnesota | Therapeutic compounds |
EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
PE20090717A1 (en) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS |
WO2009009116A2 (en) | 2007-07-12 | 2009-01-15 | Tolerx, Inc. | Combination therapies employing gitr binding molecules |
EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
CA2960659C (en) | 2007-11-09 | 2021-07-13 | The Salk Institute For Biological Studies | Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors |
CA2707308C (en) | 2007-11-30 | 2016-08-02 | Newlink Genetics Corporation | Ido inhibitors |
TWI444382B (en) | 2008-03-11 | 2014-07-11 | Incyte Corp | Azetidine and cyclobutane derivatives as jak inhibitors |
JP2011518841A (en) | 2008-04-24 | 2011-06-30 | ニューリンク ジェネティクス, インコーポレイテッド | IDO inhibitor |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
SG196798A1 (en) | 2008-12-09 | 2014-02-13 | Genentech Inc | Anti-pd-l1 antibodies and their use to enhance t-cell function |
US8921037B2 (en) | 2008-12-16 | 2014-12-30 | Bo Han | PF4-depleted platelet rich plasma preparations and methods for hard and soft tissue repair |
RU2646139C1 (en) | 2009-09-03 | 2018-03-01 | Мерк Шарп И Доум Корп. | Anti-gitr antibodies |
JP2012254939A (en) | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | Oxazole compound |
ES2601226T3 (en) | 2009-10-28 | 2017-02-14 | Newlink Genetics Corporation | Imidazole derivatives as IDO inhibitors |
CN102791738B (en) | 2009-12-10 | 2015-10-07 | 霍夫曼-拉罗奇有限公司 | Preferentially in conjunction with the antibody and uses thereof of people CSF1R extracellular domain 4 |
PL2542256T3 (en) | 2010-03-04 | 2020-01-31 | Macrogenics, Inc. | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
EP2542587A1 (en) | 2010-03-05 | 2013-01-09 | F. Hoffmann-La Roche AG | Antibodies against human csf-1r and uses thereof |
EP2542588A1 (en) | 2010-03-05 | 2013-01-09 | F. Hoffmann-La Roche AG | Antibodies against human csf-1r and uses thereof |
US8114621B2 (en) | 2010-03-12 | 2012-02-14 | Saladax Biomedical Inc. | Lenalidomide and thalidomide immunoassays |
EP3943154A1 (en) | 2010-05-04 | 2022-01-26 | Five Prime Therapeutics, Inc. | Antibodies that bind csf1r |
US9765019B2 (en) | 2010-06-30 | 2017-09-19 | Brandeis University | Small-molecule-targeted protein degradation |
CN105367577B (en) | 2010-07-13 | 2019-04-23 | 弗·哈夫曼-拉罗切有限公司 | Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator |
SG10201506906VA (en) | 2010-09-09 | 2015-10-29 | Pfizer | 4-1bb binding molecules |
EP2640708A1 (en) | 2010-11-19 | 2013-09-25 | Ligand Pharmaceuticals Inc. | Heterocycle amines and uses thereof |
EP2649099A4 (en) | 2010-12-07 | 2016-10-19 | Univ Yale | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same |
NZ612512A (en) | 2010-12-09 | 2015-03-27 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
KR101842098B1 (en) | 2010-12-20 | 2018-03-26 | 메르크 세로노 에스. 에이. | Indazolyl triazole derivatives as irak inhibitors |
EP2663312B1 (en) | 2011-01-10 | 2017-10-11 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
EP2688872A4 (en) | 2011-03-22 | 2014-08-27 | Merck Sharp & Dohme | Amidopyrazole inhibitors of interleukin receptor-associated kinases |
NO2694640T3 (en) | 2011-04-15 | 2018-03-17 | ||
ES2669310T3 (en) | 2011-04-20 | 2018-05-24 | Medimmune, Llc | Antibodies and other molecules that bind with B7-H1 and PD-1 |
WO2013042137A1 (en) | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
WO2013066729A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Aminopyrimidinones as interleukin receptor-associated kinase inhibitors |
PT2785375T (en) | 2011-11-28 | 2020-10-29 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
JP6242804B2 (en) | 2011-12-15 | 2017-12-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Antibody to human CSF-1R and use thereof |
TW201728592A (en) | 2012-01-10 | 2017-08-16 | 林伯士艾瑞斯公司 | IRAK inhibitors and uses thereof |
WO2013106646A2 (en) | 2012-01-12 | 2013-07-18 | Yale University | Compounds and methods for the inhibition of vcb e3 ubiquitin ligase |
WO2013106643A2 (en) | 2012-01-12 | 2013-07-18 | Yale University | Compounds & methods for the enhanced degradation of targeted proteins & other polypeptides by an e3 ubiquitin ligase |
WO2013106614A1 (en) | 2012-01-13 | 2013-07-18 | Bristol-Myers Squibb Company | Triazolyl-substituted pyridyl compounds useful as kinase inhibitors |
WO2013106641A1 (en) | 2012-01-13 | 2013-07-18 | Bristol-Myers Squibb Company | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors |
JP6109195B2 (en) | 2012-01-13 | 2017-04-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Heterocycle-substituted pyridyl compounds useful as kinase inhibitors |
MX2014008961A (en) | 2012-02-06 | 2014-10-14 | Genentech Inc | Compositions and methods for using csf1r inhibitors. |
AR090263A1 (en) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME |
KR20220162819A (en) | 2012-05-11 | 2022-12-08 | 파이브 프라임 테라퓨틱스, 인크. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csfir) |
AR091649A1 (en) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES |
MX2015000129A (en) | 2012-07-10 | 2015-04-14 | Ares Trading Sa | Pyrimidine pyrazolyl derivatives. |
US20140018361A1 (en) | 2012-07-11 | 2014-01-16 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
BR112015000561A2 (en) | 2012-07-11 | 2017-06-27 | Nimbus Iris Inc | irak inhibitors and uses thereof |
WO2014011902A1 (en) | 2012-07-11 | 2014-01-16 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
CN104684582A (en) | 2012-08-31 | 2015-06-03 | 戊瑞治疗有限公司 | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
ES2613858T3 (en) | 2012-09-19 | 2017-05-26 | F. Hoffmann-La Roche Ag | 2-Oxo-2,3,4,5-tetrahydro-1H-benzo [b] diazepines and their use in the treatment of cancer |
EP2903613B1 (en) | 2012-10-08 | 2017-11-22 | Merck Sharp & Dohme Corp. | Pyrazole derivatives useful as inhibitors of irak4 activity |
EP2903617B1 (en) | 2012-10-08 | 2019-01-30 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
US9758522B2 (en) | 2012-10-19 | 2017-09-12 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
CN104781254B (en) * | 2012-11-08 | 2016-12-14 | 百时美施贵宝公司 | Can as kinase modulator through the substituted pyridinyl compounds of heteroaryl |
AR093403A1 (en) * | 2012-11-08 | 2015-06-03 | Bristol Myers Squibb Co | PIRIDIL COMPOUNDS REPLACED WITH USEFUL RENTALS AS MODULATORS OF THE ANSWERS OF IL-12, IL23 AND / OR INFa |
US9546153B2 (en) * | 2012-11-08 | 2017-01-17 | Bristol-Myers Squibb Company | Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators |
GB201311910D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel Compounds |
LT2953952T (en) | 2013-02-07 | 2017-08-25 | Merck Patent Gmbh | Macrocyclic pyridazinone derivatives |
CA2900431C (en) | 2013-02-07 | 2021-05-04 | Merck Patent Gmbh | Pyridazinone-amides derivatives |
WO2014143672A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Macrocyclic compounds as irak4 inhibitors for the treatment of inflammatory diseases |
WO2015048281A1 (en) | 2013-09-27 | 2015-04-02 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
MY175778A (en) | 2013-10-04 | 2020-07-08 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
EA201690952A1 (en) | 2013-11-08 | 2016-08-31 | Такеда Фармасьютикал Компани Лимитед | PYRAZOL FOR THE TREATMENT OF AUTOIMMUNE DISORDERS |
CN106029650B (en) | 2013-11-18 | 2019-10-25 | 豪夫迈·罗氏有限公司 | Tetrahydro-benzodiazepine * ketone |
JP6496731B2 (en) | 2013-11-27 | 2019-04-03 | シグナルケム・ライフサイエンシーズ・コーポレイションSignalchem Lifesciences Corporation | Aminopyridine derivatives as TAM family kinase inhibitors |
TWI667233B (en) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | Novel indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments |
AR098991A1 (en) | 2014-01-03 | 2016-06-22 | Bristol Myers Squibb Co | NICOTINAMIDE COMPOUNDS REPLACED WITH HETEROARILE |
KR20160115933A (en) | 2014-01-10 | 2016-10-06 | 오리진 디스커버리 테크놀로지스 리미티드 | Indazole compounds as irak4 inhibitors |
CU24389B1 (en) | 2014-01-13 | 2019-04-04 | Aurigene Discovery Tech Ltd | BICYCLIC HETEROCICLYL COMPOUNDS AS IRAK4 INHIBITORS |
CN106573906A (en) | 2014-03-17 | 2017-04-19 | 豪夫迈·罗氏有限公司 | Piperidine-dione derivatives |
CN110183440B (en) | 2014-03-19 | 2022-04-22 | 勃林格殷格翰国际有限公司 | Heteroaryl SYK inhibitors |
HUE044180T2 (en) | 2014-04-04 | 2019-10-28 | Pfizer | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors |
JP6778114B2 (en) | 2014-04-14 | 2020-10-28 | アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. | Imid-based proteolysis modulators and related uses |
US20160058872A1 (en) | 2014-04-14 | 2016-03-03 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
BR112016024414A2 (en) | 2014-04-22 | 2017-08-15 | Nimbus Iris Inc | irak inhibitors and uses thereof |
MX2016017147A (en) | 2014-06-20 | 2017-06-07 | Aurigene Discovery Tech Ltd | Substituted indazole compounds as irak4 inhibitors. |
WO2015200795A1 (en) | 2014-06-27 | 2015-12-30 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases |
TW201613872A (en) | 2014-07-18 | 2016-04-16 | Biogen Ma Inc | IRAK4 inhibiting agents |
US20160022642A1 (en) | 2014-07-25 | 2016-01-28 | Yale University | Compounds Useful for Promoting Protein Degradation and Methods Using Same |
US10071164B2 (en) | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
EP3200790B1 (en) | 2014-09-30 | 2020-08-26 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
EP3200788B1 (en) | 2014-09-30 | 2019-09-18 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
WO2016053772A1 (en) | 2014-09-30 | 2016-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
US9969749B2 (en) | 2014-09-30 | 2018-05-15 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
PT3221306T (en) | 2014-11-20 | 2020-02-19 | Merck Patent Gmbh | Heteroaryl compounds as irak inhibitors and uses thereof |
US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
EP3256470B1 (en) | 2014-12-23 | 2023-07-26 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
WO2016105581A1 (en) * | 2014-12-23 | 2016-06-30 | South Dakota Board Of Regents | Electrospun three-dimensional nanofibrous scaffolds with interconnected and hierarchically structured pores |
MX2017009454A (en) | 2015-01-20 | 2017-10-20 | Arvinas Inc | Compounds and methods for the targeted degradation of the androgen receptor. |
US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
WO2016144849A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Thienopyrazine inhibitors of irak4 activity |
WO2016144848A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrrolotriazine inhibitors of irak4 activity |
EP3268367B8 (en) | 2015-03-12 | 2022-11-16 | Merck Sharp & Dohme LLC | Carboxamide inhibitors of irak4 activity |
WO2016144847A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrrolopyridazine inhibitors of irak4 activity |
EP3267996B1 (en) | 2015-03-12 | 2020-11-11 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of irak4 activity |
WO2016149668A1 (en) | 2015-03-18 | 2016-09-22 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
MY189941A (en) | 2015-04-22 | 2022-03-22 | Rigel Pharmaceuticals Inc | Pyrazole compounds and method for making and using the compounds |
US20180289685A1 (en) | 2015-04-30 | 2018-10-11 | Bayer Pharma Aktiengesellschaft | Combinations of inhibitors of irak4 with inhibitors of btk |
BR112017025975B1 (en) | 2015-06-04 | 2023-12-12 | Arvinas Operations, Inc | COMPOUND, COMPOSITION, IN VITRO METHOD FOR INDUCING DEGRADATION OF A TARGET PROTEIN IN A CELL, AND, USE OF A COMPOSITION |
US20180147202A1 (en) | 2015-06-05 | 2018-05-31 | Arvinas, Inc. | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE |
TW201718571A (en) | 2015-06-24 | 2017-06-01 | 必治妥美雅史谷比公司 | Heteroaryl substituted aminopyridine compounds |
JP6720355B2 (en) * | 2015-06-24 | 2020-07-08 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Heteroaryl-substituted aminopyridine compounds |
CN105085620B (en) | 2015-06-25 | 2018-05-08 | 中山大学附属第一医院 | A kind of compound for targeting ubiquitination degraded Smad3 |
WO2017004134A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
WO2017004133A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
CA2988430A1 (en) | 2015-07-10 | 2017-01-19 | Arvinas, Inc. | Mdm2-based modulators of proteolysis and associated methods of use |
BR112017028269A2 (en) | 2015-07-13 | 2018-09-04 | Arvinas Inc | compound, pharmaceutical composition, use of an effective amount of a compound, disease state or condition, and method for identifying a compound. |
AU2016293441A1 (en) | 2015-07-15 | 2018-02-01 | Aurigene Discovery Technologies Limited | Indazole and azaindazole compounds as IRAK-4 inhibitors |
CN108024971A (en) | 2015-07-15 | 2018-05-11 | 奥列基因发现技术有限公司 | Substituted nitric heterocyclic compound as IRAK-4 inhibitor |
WO2017030814A1 (en) | 2015-08-19 | 2017-02-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
CN107949559B (en) | 2015-08-27 | 2020-12-11 | 辉瑞公司 | Bicyclic fused heteroaryl or aryl compounds as IRAK4 modulators |
KR20180064382A (en) | 2015-09-18 | 2018-06-14 | 메르크 파텐트 게엠베하 | Heteroaryl compounds as IRAK inhibitors and uses thereof |
MX2018002986A (en) | 2015-09-18 | 2018-05-02 | Merck Patent Gmbh | Heteroaryl compounds as irak inhibitors and uses thereof. |
US10526309B2 (en) | 2015-10-02 | 2020-01-07 | The University Of North Carolina At Chapel Hill | Pan-TAM inhibitors and Mer/Axl dual inhibitors |
EP3370715A4 (en) | 2015-11-02 | 2019-05-15 | Yale University | Proteolysis targeting chimera compounds and methods of preparing and using same |
JP6895439B2 (en) | 2015-12-22 | 2021-06-30 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Pyrazolo [1,5a] pyrimidine derivative as an IRAK4 regulator |
WO2017117474A1 (en) | 2015-12-30 | 2017-07-06 | Dana-Farber Cancer Institute, Inc. | Bifunctional compounds for her3 degradation and methods of use |
WO2017117473A1 (en) | 2015-12-30 | 2017-07-06 | Dana-Farber Cancer Institute, Inc. | Bifunctional molescules for her3 degradation and methods of use |
ES2904557T3 (en) | 2016-01-20 | 2022-04-05 | Biogen Ma Inc | Iraq4 inhibitory agents |
CA3017740A1 (en) | 2016-03-16 | 2017-09-21 | Pearlie BURNETTE | Small molecules against cereblon to enhance effector t cell function |
US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
EP3440082A1 (en) | 2016-04-06 | 2019-02-13 | The Regents of The University of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
RU2021102253A (en) | 2016-04-06 | 2021-03-03 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | DESTRUCTORS OF MDM2 PROTEIN |
CN109562113A (en) | 2016-05-10 | 2019-04-02 | C4医药公司 | Loop coil degron body for target protein degradation |
CN109562107A (en) | 2016-05-10 | 2019-04-02 | C4医药公司 | Heterocycle degron body for target protein degradation |
WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
WO2017197056A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
WO2017201069A1 (en) | 2016-05-18 | 2017-11-23 | Biotheryx, Inc. | Oxoindoline derivatives as protein function modulators |
PL3458101T3 (en) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Protac antibody conjugates and methods of use |
WO2017205762A1 (en) | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
WO2017205766A1 (en) | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
WO2017207385A1 (en) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted 3-methylindazoles, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments |
GB201610147D0 (en) * | 2016-06-10 | 2016-07-27 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
US10710983B2 (en) | 2016-06-27 | 2020-07-14 | Rigel Pharmaceuticals, Inc. | 2,4-diamino-pyrimidine compounds and method for making and using the compounds |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
JP2019196309A (en) | 2016-09-15 | 2019-11-14 | 武田薬品工業株式会社 | Heterocyclic compound |
US10925868B2 (en) | 2016-11-10 | 2021-02-23 | Dana-Farber Cancer Institute, Inc. | Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use |
EP3544970B1 (en) | 2016-11-22 | 2021-11-17 | Dana-Farber Cancer Institute, Inc. | Inhibitors of interleukin-1 receptor-associated kinases and uses thereof |
CN108322937B (en) | 2017-01-18 | 2020-08-11 | 上海诺基亚贝尔股份有限公司 | Resource allocation method and orchestrator for network slices in a radio access network |
KR20190116315A (en) | 2017-01-31 | 2019-10-14 | 아비나스 오퍼레이션스, 인코포레이티드 | Cereblon Ligand and Bifunctional Compounds Comprising the Same |
JOP20180011A1 (en) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | PYRROLO[1,2-b] PYRIDAZINE DERIVATIVES |
HUE056493T2 (en) | 2017-05-11 | 2022-02-28 | Bristol Myers Squibb Co | Thienopyridines and benzothiophenes useful as irak4 inhibitors |
EP3641762A4 (en) | 2017-06-20 | 2021-03-10 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
WO2019043214A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | Glutarimide |
JP7366031B2 (en) | 2017-09-22 | 2023-10-20 | カイメラ セラピューティクス, インコーポレイテッド | Proteolytic agents and their use |
WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-hydroxypyrrolidin-2-yl)-hydroxamate compounds and methods of use thereof |
EP3700901A1 (en) | 2017-10-24 | 2020-09-02 | Genentech, Inc. | (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof |
EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | Degraders and degrons for targeted protein degradation |
EP3710443A1 (en) * | 2017-11-17 | 2020-09-23 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides |
BR112020012997A2 (en) | 2017-12-26 | 2020-12-01 | Kymera Therapeutics, Inc. | irak degraders and uses thereof |
US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
AU2019220632B2 (en) | 2018-02-14 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | IRAK degraders and uses thereof |
WO2019165229A1 (en) | 2018-02-23 | 2019-08-29 | Dana-Farber Cancer Institute, Inc. | Small molecules for inducing selective protein degradation and uses thereof |
EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
WO2020010210A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Mertk degraders and uses thereof |
WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
US20220348556A1 (en) | 2018-07-06 | 2022-11-03 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
WO2020018788A1 (en) | 2018-07-20 | 2020-01-23 | Dana-Farber Cancer Institute, Inc. | Degraders that target proteins via keap1 |
WO2020113233A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
WO2020251974A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca inhibitors and uses thereof |
WO2020251971A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
WO2020251972A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
US20230087825A1 (en) | 2019-06-10 | 2023-03-23 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
WO2020264490A1 (en) | 2019-06-28 | 2020-12-30 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
KR20220032063A (en) | 2019-06-28 | 2022-03-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | IRAK disintegrants and uses thereof |
WO2021011634A1 (en) | 2019-07-15 | 2021-01-21 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
WO2021011631A1 (en) | 2019-07-15 | 2021-01-21 | Kymera Therapeutics, Inc. | Fused-glutarimide crbn ligands and uses thereof |
WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
WO2021011871A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Mertk degraders and uses thereof |
WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
JP2023509366A (en) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス, インコーポレイテッド | IRAK dissolving agents and their uses |
WO2021127278A1 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
-
2018
- 2018-12-21 BR BR112020012997-6A patent/BR112020012997A2/en unknown
- 2018-12-21 IL IL304055A patent/IL304055A/en unknown
- 2018-12-21 WO PCT/US2018/067304 patent/WO2019133531A1/en unknown
- 2018-12-21 CN CN201880089841.0A patent/CN112105385A/en active Pending
- 2018-12-21 JP JP2020535655A patent/JP2021508703A/en active Pending
- 2018-12-21 IL IL275649A patent/IL275649B2/en unknown
- 2018-12-21 CA CA3086763A patent/CA3086763A1/en active Pending
- 2018-12-21 SG SG11202005912PA patent/SG11202005912PA/en unknown
- 2018-12-21 US US16/230,792 patent/US10874743B2/en active Active
- 2018-12-21 EP EP18894876.4A patent/EP3731869A4/en active Pending
- 2018-12-21 AU AU2018396142A patent/AU2018396142A1/en active Pending
- 2018-12-21 MX MX2020006812A patent/MX2020006812A/en unknown
-
2020
- 2020-10-16 US US17/073,019 patent/US11318205B1/en active Active
-
2022
- 2022-02-10 US US17/650,545 patent/US11723980B2/en active Active
-
2023
- 2023-04-24 US US18/305,911 patent/US20230398223A1/en active Pending
-
2024
- 2024-01-11 JP JP2024002339A patent/JP2024038329A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2020006812A (en) | 2020-11-06 |
CN112105385A (en) | 2020-12-18 |
AU2018396142A1 (en) | 2020-07-16 |
EP3731869A1 (en) | 2020-11-04 |
US20230106066A1 (en) | 2023-04-06 |
US20230398223A1 (en) | 2023-12-14 |
IL275649B1 (en) | 2023-08-01 |
JP2024038329A (en) | 2024-03-19 |
EP3731869A4 (en) | 2021-09-22 |
US11723980B2 (en) | 2023-08-15 |
IL275649A (en) | 2020-08-31 |
US20190192668A1 (en) | 2019-06-27 |
US10874743B2 (en) | 2020-12-29 |
BR112020012997A2 (en) | 2020-12-01 |
IL304055A (en) | 2023-08-01 |
JP2021508703A (en) | 2021-03-11 |
IL275649B2 (en) | 2023-12-01 |
WO2019133531A1 (en) | 2019-07-04 |
US11318205B1 (en) | 2022-05-03 |
CA3086763A1 (en) | 2019-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL275649A (en) | Irak degraders and uses thereof | |
IL283471A (en) | Irak degraders and uses thereof | |
IL289267A (en) | Irak degraders and uses thereof | |
IL273432A (en) | Protein degraders and uses thereof | |
IL273236A (en) | Pyrazolopyrimidinone compounds and uses thereof | |
EP4076520A4 (en) | Irak degraders and uses thereof | |
IL293377A (en) | Hsd17b13 variants and uses thereof | |
EP3752504A4 (en) | Irak degraders and uses thereof | |
GB201714745D0 (en) | New compounds and uses | |
GB201714740D0 (en) | New compounds and uses | |
EP4081308A4 (en) | Smarca degraders and uses thereof | |
GB201714734D0 (en) | New compounds and uses | |
HUE060805T2 (en) | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds | |
GB201714736D0 (en) | New compounds and uses | |
IL265531A (en) | N 3 -cyclically substituted thienouraciles and use thereof | |
IL264473A (en) | Gpr156 variants and uses thereof | |
SG11201912432VA (en) | Emm-23 materials and processes and uses thereof | |
IL273671A (en) | Cornulin (crnn) variants and uses thereof | |
IL275211A (en) | Fast and partition-resilient blockchains | |
IL269836B (en) | Substituted n-arylethyl-2-aminoquinoline-4-carboxamides and use thereof | |
ZA201905513B (en) | Rorgamma modulators and uses thereof | |
ZA201905511B (en) | Rorgamma modulators and uses thereof | |
GB201712110D0 (en) | New compounds and uses | |
GB201700404D0 (en) | Compounds and composistions | |
IL272792B (en) | Azaindolylpyridone and diazaindolylpyridone compounds |