AR119382A1 - Anticuerpos de pre-direccionamiento y métodos de uso - Google Patents
Anticuerpos de pre-direccionamiento y métodos de usoInfo
- Publication number
- AR119382A1 AR119382A1 ARP200101934A ARP200101934A AR119382A1 AR 119382 A1 AR119382 A1 AR 119382A1 AR P200101934 A ARP200101934 A AR P200101934A AR P200101934 A ARP200101934 A AR P200101934A AR 119382 A1 AR119382 A1 AR 119382A1
- Authority
- AR
- Argentina
- Prior art keywords
- domain
- binding site
- antigen
- antibody
- radiolabeled compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0495—Pretargeting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La presente se refiere a anticuerpos que se unen a antígenos en células objetivo y que dirigen radionucleidos a dichas células, y a métodos para utilizar los mismos. Reivindicación 1: Un conjunto de anticuerpos que comprende: i) un primer anticuerpo que se une a un antígeno expresado en la superficie de una célula objetivo, y que además comprende un dominio VH de un sitio de unión a antígeno para un compuesto radiomarcado, pero que no comprende un dominio VL de un sitio de unión a antígeno para el compuesto radiomarcado; y ii) un segundo anticuerpo que se une a dicho antígeno expresado en la superficie de la célula objetivo, y que además comprende un dominio VL de un sitio de unión a antígeno para el compuesto radiomarcado, pero que no comprende un dominio VH del sitio de unión a antígeno para el compuesto radiomarcado, en donde dicho dominio VH del primer anticuerpo y dicho dominio VL del segundo anticuerpo son juntos capaces de formar un sitio de unión a antígeno funcional para el compuesto radiomarcado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19186135 | 2019-07-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR119382A1 true AR119382A1 (es) | 2021-12-15 |
Family
ID=67262219
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200101934A AR119382A1 (es) | 2019-07-12 | 2020-07-08 | Anticuerpos de pre-direccionamiento y métodos de uso |
ARP210101933A AR122930A1 (es) | 2019-07-12 | 2021-07-08 | Anticuerpos de pre-direccionamiento y métodos de uso |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210101933A AR122930A1 (es) | 2019-07-12 | 2021-07-08 | Anticuerpos de pre-direccionamiento y métodos de uso |
Country Status (17)
Country | Link |
---|---|
US (1) | US20220267463A1 (es) |
EP (1) | EP3997130A1 (es) |
JP (1) | JP2022540610A (es) |
KR (1) | KR20220034208A (es) |
CN (1) | CN114341188A (es) |
AR (2) | AR119382A1 (es) |
AU (1) | AU2020313285A1 (es) |
BR (1) | BR112022000481A2 (es) |
CA (1) | CA3143464A1 (es) |
CL (1) | CL2022000052A1 (es) |
CO (1) | CO2022001021A2 (es) |
CR (1) | CR20220061A (es) |
IL (1) | IL289040A (es) |
MX (1) | MX2022000379A (es) |
PE (1) | PE20220596A1 (es) |
TW (1) | TW202115117A (es) |
WO (1) | WO2021009047A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021303508A1 (en) * | 2020-07-10 | 2023-02-02 | F. Hoffmann-La Roche Ag | Antibodies which bind to cancer cells and target radionuclides to said cells |
EP4277705A1 (en) * | 2021-01-12 | 2023-11-22 | F. Hoffmann-La Roche AG | Split antibodies which bind to cancer cells and target radionuclides to said cells |
Family Cites Families (74)
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2020
- 2020-07-08 AR ARP200101934A patent/AR119382A1/es unknown
- 2020-07-10 AU AU2020313285A patent/AU2020313285A1/en active Pending
- 2020-07-10 US US17/625,719 patent/US20220267463A1/en active Pending
- 2020-07-10 KR KR1020227004727A patent/KR20220034208A/ko unknown
- 2020-07-10 EP EP20737035.4A patent/EP3997130A1/en active Pending
- 2020-07-10 CA CA3143464A patent/CA3143464A1/en active Pending
- 2020-07-10 CN CN202080062757.7A patent/CN114341188A/zh active Pending
- 2020-07-10 PE PE2021002320A patent/PE20220596A1/es unknown
- 2020-07-10 WO PCT/EP2020/069561 patent/WO2021009047A1/en unknown
- 2020-07-10 MX MX2022000379A patent/MX2022000379A/es unknown
- 2020-07-10 TW TW109123333A patent/TW202115117A/zh unknown
- 2020-07-10 BR BR112022000481A patent/BR112022000481A2/pt unknown
- 2020-07-10 JP JP2022501132A patent/JP2022540610A/ja active Pending
- 2020-07-10 CR CR20220061A patent/CR20220061A/es unknown
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2021
- 2021-07-08 AR ARP210101933A patent/AR122930A1/es unknown
- 2021-12-15 IL IL289040A patent/IL289040A/en unknown
-
2022
- 2022-01-10 CL CL2022000052A patent/CL2022000052A1/es unknown
- 2022-01-31 CO CONC2022/0001021A patent/CO2022001021A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20220034208A (ko) | 2022-03-17 |
WO2021009047A1 (en) | 2021-01-21 |
CR20220061A (es) | 2022-04-20 |
CA3143464A1 (en) | 2021-01-21 |
CL2022000052A1 (es) | 2022-10-21 |
JP2022540610A (ja) | 2022-09-16 |
AR122930A1 (es) | 2022-10-19 |
EP3997130A1 (en) | 2022-05-18 |
BR112022000481A2 (pt) | 2022-03-08 |
CO2022001021A2 (es) | 2022-04-29 |
AU2020313285A1 (en) | 2022-02-17 |
IL289040A (en) | 2022-02-01 |
TW202115117A (zh) | 2021-04-16 |
US20220267463A1 (en) | 2022-08-25 |
PE20220596A1 (es) | 2022-04-22 |
MX2022000379A (es) | 2022-02-10 |
CN114341188A (zh) | 2022-04-12 |
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