US3126375A
(en)
|
|
1964-03-24 |
|
Chioacyl |
US2789118A
(en)
|
1956-03-30 |
1957-04-16 |
American Cyanamid Co |
16-alpha oxy-belta1, 4-pregnadienes
|
US2990401A
(en)
|
1958-06-18 |
1961-06-27 |
American Cyanamid Co |
11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
|
US3048581A
(en)
|
1960-04-25 |
1962-08-07 |
Olin Mathieson |
Acetals and ketals of 16, 17-dihydroxy steroids
|
US3749712A
(en)
|
1970-09-25 |
1973-07-31 |
Sigma Tau Ind Farmaceuti |
Triamcinolone acetonide esters and process for their preparation
|
SE378110B
(lt)
|
1972-05-19 |
1975-08-18 |
Bofors Ab |
|
US3996359A
(en)
|
1972-05-19 |
1976-12-07 |
Ab Bofors |
Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
|
SE378109B
(lt)
|
1972-05-19 |
1975-08-18 |
Bofors Ab |
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
US4294926A
(en)
|
1979-06-15 |
1981-10-13 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
US4319039A
(en)
|
1979-06-15 |
1982-03-09 |
Merck & Co., Inc. |
Preparation of ammonium salt of hypocholesteremic fermentation product
|
US4444784A
(en)
|
1980-08-05 |
1984-04-24 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
DK149080C
(da)
|
1980-06-06 |
1986-07-28 |
Sankyo Co |
Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
|
JPS5889191A
(ja)
|
1981-11-20 |
1983-05-27 |
Sankyo Co Ltd |
3−ヒドロキシ−ml−236b誘導体の製造法
|
US5354772A
(en)
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
US4911165A
(en)
|
1983-01-12 |
1990-03-27 |
Ethicon, Inc. |
Pliabilized polypropylene surgical filaments
|
US4681893A
(en)
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
US4782084A
(en)
|
1987-06-29 |
1988-11-01 |
Merck & Co., Inc. |
HMG-COA reductase inhibitors
|
US4885314A
(en)
|
1987-06-29 |
1989-12-05 |
Merck & Co., Inc. |
Novel HMG-CoA reductase inhibitors
|
US4820850A
(en)
|
1987-07-10 |
1989-04-11 |
Merck & Co., Inc. |
Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
|
US5030447A
(en)
|
1988-03-31 |
1991-07-09 |
E. R. Squibb & Sons, Inc. |
Pharmaceutical compositions having good stability
|
US5180589A
(en)
|
1988-03-31 |
1993-01-19 |
E. R. Squibb & Sons, Inc. |
Pravastatin pharmaceuatical compositions having good stability
|
US4916239A
(en)
|
1988-07-19 |
1990-04-10 |
Merck & Co., Inc. |
Process for the lactonization of mevinic acids and analogs thereof
|
EP0360390A1
(en)
|
1988-07-25 |
1990-03-28 |
Glaxo Group Limited |
Spirolactam derivatives
|
US5118853A
(en)
|
1988-10-13 |
1992-06-02 |
Sandoz Ltd. |
Processes for the synthesis of 3-disubstituted aminoacroleins
|
US5290946A
(en)
|
1988-10-13 |
1994-03-01 |
Sandoz Ltd. |
Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
|
WO1990005525A1
(en)
|
1988-11-23 |
1990-05-31 |
Pfizer Inc. |
Quinuclidine derivatives as substance p antagonists
|
US4929437A
(en)
|
1989-02-02 |
1990-05-29 |
Merck & Co., Inc. |
Coenzyme Q10 with HMG-CoA reductase inhibitors
|
US5164372A
(en)
|
1989-04-28 |
1992-11-17 |
Fujisawa Pharmaceutical Company, Ltd. |
Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
|
US5189164A
(en)
|
1989-05-22 |
1993-02-23 |
Sandoz Ltd. |
Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
PH27357A
(en)
|
1989-09-22 |
1993-06-21 |
Fujisawa Pharmaceutical Co |
Pyrazole derivatives and pharmaceutical compositions comprising the same
|
US5286634A
(en)
|
1989-09-28 |
1994-02-15 |
Stadler Joan K |
Synergistic method for host cell transformation
|
IE903957A1
(en)
|
1989-11-06 |
1991-05-08 |
Sanofi Sa |
Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
|
FR2654726B1
(fr)
|
1989-11-23 |
1992-02-14 |
Rhone Poulenc Sante |
Nouveaux derives de l'isoindolone et leur preparation.
|
FR2654725B1
(fr)
|
1989-11-23 |
1992-02-14 |
Rhone Poulenc Sante |
Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
GB8929070D0
(en)
|
1989-12-22 |
1990-02-28 |
Fujisawa Pharmaceutical Co |
Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
|
UA41251C2
(uk)
|
1990-01-04 |
2001-09-17 |
Пфайзер, Інк. |
Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
|
US5232929A
(en)
|
1990-11-28 |
1993-08-03 |
Pfizer Inc. |
3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
EP0515681A4
(en)
|
1990-02-15 |
1993-12-29 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptide compound
|
US5214136A
(en)
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
US5420245A
(en)
|
1990-04-18 |
1995-05-30 |
Board Of Regents, The University Of Texas |
Tetrapeptide-based inhibitors of farnesyl transferase
|
US5451586A
(en)
|
1990-06-01 |
1995-09-19 |
Pfizer Inc. |
3-amino-2-aryl quinuclidines
|
ATE116317T1
(de)
|
1990-07-23 |
1995-01-15 |
Pfizer |
Chinuclidinderivate.
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
HUT68667A
(en)
|
1990-09-28 |
1995-07-28 |
Pfizer |
Fused ring analogs of nitrogen containing nonaromatic heterocycles
|
GB9023116D0
(en)
|
1990-10-24 |
1990-12-05 |
Fujisawa Pharmaceutical Co |
Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
|
DK0498069T3
(da)
|
1990-12-21 |
1995-12-04 |
Fujisawa Pharmaceutical Co |
Ny anvendelse af peptidderivat
|
CA2100163A1
(en)
|
1991-01-10 |
1992-07-11 |
John A. Lowe, Iii |
N-alkyl quinuclidinium salts
|
EP0499313B1
(en)
|
1991-02-11 |
1997-06-11 |
MERCK SHARP & DOHME LTD. |
Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
|
US5373003A
(en)
|
1991-03-01 |
1994-12-13 |
Pfizer Inc. |
1-azabicyclo[3.2.2]nonan-3-amine derivatives
|
US5747469A
(en)
|
1991-03-06 |
1998-05-05 |
Board Of Regents, The University Of Texas System |
Methods and compositions comprising DNA damaging agents and p53
|
KR0145432B1
(ko)
|
1991-03-26 |
1998-07-15 |
알렌 제이. 스피겔 |
치환된 피페리딘의 입체선택적 제조 방법
|
FR2677361A1
(fr)
|
1991-06-04 |
1992-12-11 |
Adir |
Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
|
FR2676053B1
(fr)
|
1991-05-03 |
1993-08-27 |
Sanofi Elf |
Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
|
FR2676055B1
(fr)
|
1991-05-03 |
1993-09-03 |
Sanofi Elf |
Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
|
FR2676446B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
FR2676443B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux derives de perhydroisoindole et leur preparation.
|
FR2676442B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
FR2676447B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux derives du thiopyranopyrrole et leur preparation.
|
WO1992020661A1
(en)
|
1991-05-22 |
1992-11-26 |
Merck & Co., Inc. |
N, n-diacylpiperazines
|
WO1992020676A1
(en)
|
1991-05-22 |
1992-11-26 |
Pfizer Inc. |
Substituted 3-aminoquinuclidines
|
CA2102179C
(en)
|
1991-05-31 |
1998-10-27 |
Fumitaka Ito |
Quinuclidine derivatives
|
GB9113219D0
(en)
|
1991-06-19 |
1991-08-07 |
Fujisawa Pharmaceutical Co |
Peptide compound,processes for preparation thereof and pharmaceutical composition comprising the same
|
HU224443B1
(hu)
|
1991-06-20 |
2005-09-28 |
Pfizer Inc. |
Fluor-alkoxi-benzaldehid-származékok
|
TW202432B
(lt)
|
1991-06-21 |
1993-03-21 |
Pfizer |
|
US5288730A
(en)
|
1991-06-24 |
1994-02-22 |
Merck Sharp & Dohme Limited |
Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
|
EP0536817A1
(en)
|
1991-07-05 |
1993-04-14 |
MERCK SHARP & DOHME LTD. |
Azabicyclic compounds as tachykinin antagonists
|
EP0593557B1
(en)
|
1991-07-05 |
1996-01-31 |
MERCK SHARP & DOHME LTD. |
Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
|
JPH06509087A
(ja)
|
1991-07-05 |
1994-10-13 |
メルク シヤープ エンド ドーム リミテツド |
芳香族化合物、それらを含む医薬組成物、及び治療におけるそれらの使用
|
US5495047A
(en)
|
1991-07-10 |
1996-02-27 |
Merck, Sharp & Dohme (Ltd.) |
Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy
|
DE69208089T2
(de)
|
1991-07-10 |
1996-08-22 |
Merck Sharp & Dohme |
Aromatische verbindungen diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische verwendung
|
MY110227A
(en)
|
1991-08-12 |
1998-03-31 |
Ciba Geigy Ag |
1-acylpiperindine compounds.
|
ATE136885T1
(de)
|
1991-08-20 |
1996-05-15 |
Merck Sharp & Dohme |
Azacyclische verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
|
DK0533280T4
(da)
|
1991-09-20 |
2005-02-28 |
Glaxo Group Ltd |
Ny medicinsk anvendelse af tachykininantagonister
|
CA2118704C
(en)
|
1991-09-26 |
1997-01-21 |
John A. Lowe, Iii |
Fused tricyclic nitrogen containing heterocycles as substance p receptor antagonists
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
WO1993009116A1
(en)
|
1991-11-07 |
1993-05-13 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Quinuclidine compound and medicinal use thereof
|
HUT70741A
(en)
|
1991-11-12 |
1995-10-30 |
Pfizer |
Acyclic ethylenediamine derivatives as substance p receptor antagonists
|
EP0545478A1
(en)
|
1991-12-03 |
1993-06-09 |
MERCK SHARP & DOHME LTD. |
Heterocyclic compounds as tachykinin antagonists
|
HU9203780D0
(en)
|
1991-12-12 |
1993-03-29 |
Sandoz Ag |
Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
|
GB9200535D0
(en)
|
1992-01-10 |
1992-02-26 |
Fujisawa Pharmaceutical Co |
New compound
|
GB9201179D0
(en)
|
1992-01-21 |
1992-03-11 |
Glaxo Group Ltd |
Chemical compounds
|
US5328927A
(en)
|
1992-03-03 |
1994-07-12 |
Merck Sharpe & Dohme, Ltd. |
Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
|
JP2656702B2
(ja)
|
1992-03-23 |
1997-09-24 |
ファイザー製薬株式会社 |
ペプチド性キヌクリジン
|
FR2689888B1
(fr)
|
1992-04-10 |
1994-06-10 |
Rhone Poulenc Rorer Sa |
Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
EP0636130A1
(en)
|
1992-04-15 |
1995-02-01 |
Merck Sharp & Dohme Ltd. |
Azacyclic compounds
|
GB2266529A
(en)
|
1992-05-01 |
1993-11-03 |
Merck Sharp & Dohme |
Tetrahydroisoquinoline derivatives
|
JPH08500481A
(ja)
|
1992-05-11 |
1996-01-23 |
リボザイム・ファーマシューティカルズ・インコーポレーテッド |
ウイルスの複製を阻害するための方法および薬剤
|
US5977343A
(en)
|
1992-05-14 |
1999-11-02 |
Ribozyme Pharmaceuticals, Inc. |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
|
US20030206887A1
(en)
*
|
1992-05-14 |
2003-11-06 |
David Morrissey |
RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
|
US5498614A
(en)
|
1992-05-18 |
1996-03-12 |
Pfizer Inc. |
Bridged aza-bicyclic derivatives as substance P antagonist
|
GB9211193D0
(en)
|
1992-05-27 |
1992-07-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
IL106142A
(en)
|
1992-06-29 |
1997-03-18 |
Merck & Co Inc |
Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
|
US5719147A
(en)
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
US5637699A
(en)
|
1992-06-29 |
1997-06-10 |
Merck & Co., Inc. |
Process for preparing morpholine tachykinin receptor antagonists
|
AU4713293A
(en)
|
1992-07-13 |
1994-01-31 |
Merck Sharp & Dohme Limited |
Heterocyclic amide derivatives as tachykinin derivatives
|
EP0786522A2
(en)
|
1992-07-17 |
1997-07-30 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecules for treatment of stenotic conditions
|
GB2268931A
(en)
|
1992-07-22 |
1994-01-26 |
Merck Sharp & Dohme |
Azabicyclic tachykinin-receptor antagonists
|
US5561130A
(en)
|
1992-07-28 |
1996-10-01 |
Merck Sharp & Dohme Limited |
Azacyclic compounds
|
GB2269170A
(en)
|
1992-07-29 |
1994-02-02 |
Merck Sharp & Dohme |
Azatricyclic tachykinin antagonists
|
AU4718093A
(en)
|
1992-07-31 |
1994-03-03 |
Merck Sharp & Dohme Limited |
Substituted amines as tachykinin receptor antagonists
|
US5688804A
(en)
|
1992-08-04 |
1997-11-18 |
Pfizer Inc. |
3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor antagonists
|
GB9216911D0
(en)
|
1992-08-10 |
1992-09-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
PT655055E
(pt)
|
1992-08-13 |
2001-03-30 |
Warner Lambert Co |
Antagonistas de taquiquinina
|
ATE208376T1
(de)
|
1992-08-19 |
2001-11-15 |
Pfizer |
Substituierte benzylamin-stickstoff enthaltende nichtaromatische heterocyclen
|
US5387595A
(en)
|
1992-08-26 |
1995-02-07 |
Merck & Co., Inc. |
Alicyclic compounds as tachykinin receptor antagonists
|
DE69315920T2
(de)
|
1992-09-04 |
1998-06-10 |
Takeda Chemical Industries Ltd |
Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung
|
US5563161A
(en)
|
1992-09-10 |
1996-10-08 |
Merck Sharp & Dohme Ltd. |
Alcohols and ethers with aromatic substituents as tachykinin-antagonists
|
US6235886B1
(en)
|
1993-09-03 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Methods of synthesis and use
|
GB9220286D0
(en)
|
1992-09-25 |
1992-11-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
JP2656699B2
(ja)
|
1992-10-21 |
1997-09-24 |
ファイザー製薬株式会社 |
置換ベンジルアミノキヌクリジン
|
GB9222262D0
(en)
|
1992-10-23 |
1992-12-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9222486D0
(en)
|
1992-10-26 |
1992-12-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
JP2656700B2
(ja)
|
1992-10-28 |
1997-09-24 |
ファイザー製薬株式会社 |
置換キヌクリジン誘導体
|
EP0666856B1
(en)
|
1992-10-28 |
2000-01-05 |
MERCK SHARP & DOHME LTD. |
4-arylmethyloxymethyl piperidines as tachykinin antagonists
|
AU5342894A
(en)
|
1992-10-30 |
1994-05-24 |
Merck Sharp & Dohme Limited |
Tachykinin antagonists
|
JP2668164B2
(ja)
|
1992-11-12 |
1997-10-27 |
ファイザー・インク. |
P物質拮抗薬としてのキヌクリジン誘導体
|
US5261188A
(en)
|
1992-11-23 |
1993-11-16 |
The Standard Products Company |
Belt weatherstrip with bulb
|
WO1994013663A1
(en)
|
1992-12-10 |
1994-06-23 |
Pfizer Inc. |
Aminomethylene substituted non-aromatic heterocycles and use as substance p antagonists
|
US5604260A
(en)
|
1992-12-11 |
1997-02-18 |
Merck Frosst Canada Inc. |
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
|
EP0673367A1
(en)
|
1992-12-14 |
1995-09-27 |
MERCK SHARP & DOHME LTD. |
4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperidines as tachykinin receptor antagonists
|
CA2111902A1
(en)
|
1992-12-21 |
1994-06-22 |
Jack Beuford Campbell |
Antitumor compositions and methods of treatment
|
GB9226581D0
(en)
|
1992-12-21 |
1993-02-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9300051D0
(en)
|
1993-01-04 |
1993-03-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
ATE160345T1
(de)
|
1993-01-15 |
1997-12-15 |
Searle & Co |
3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel
|
EP0610793A1
(en)
|
1993-02-08 |
1994-08-17 |
Takeda Chemical Industries, Ltd. |
Tetracyclic morpholine derivatives and their use or analgesics
|
US5633266A
(en)
|
1993-02-18 |
1997-05-27 |
Merck Sharp & Dohme Ltd. |
Azacyclic compounds compositions containing them and their use as tachykinin antagonists
|
WO1994019320A1
(en)
|
1993-02-22 |
1994-09-01 |
Merck Sharp & Dohme Limited |
Aromatic compounds, compositions containing them and their use in therapy
|
WO1994019357A1
(en)
|
1993-02-23 |
1994-09-01 |
Merrell Dow Pharmaceuticals Inc. |
Farnesyl:protein transferase inhibitors as anticancer agents
|
US5298627A
(en)
|
1993-03-03 |
1994-03-29 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
DK0687268T3
(da)
|
1993-03-04 |
1998-10-12 |
Pfizer |
Spiroazacykliske derivater som substans P-antagonister
|
US5409944A
(en)
|
1993-03-12 |
1995-04-25 |
Merck Frosst Canada, Inc. |
Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
|
JP3987963B2
(ja)
|
1993-03-17 |
2007-10-10 |
スリーエム カンパニー |
エステルー,アミド−又はメルカプトエステル−誘導分散促進剤を含むエーロゾル配合物
|
CA2118985A1
(en)
|
1993-04-02 |
1994-10-03 |
Dinesh V. Patel |
Heterocyclic inhibitors of farnesyl protein transferase
|
US5496833A
(en)
|
1993-04-13 |
1996-03-05 |
Merck Sharp & Dohme Limited |
Piperidine tachykinin receptor antagonists
|
CA2160462C
(en)
|
1993-05-06 |
1998-12-15 |
Timothy P. Burkholder |
Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
|
WO1994026723A2
(en)
|
1993-05-14 |
1994-11-24 |
Genentech, Inc. |
ras FARNESYL TRANSFERASE INHIBITORS
|
US5602098A
(en)
|
1993-05-18 |
1997-02-11 |
University Of Pittsburgh |
Inhibition of farnesyltransferase
|
IL109646A0
(en)
|
1993-05-19 |
1994-08-26 |
Pfizer |
Heteroatom substituted alkyl benzylamino-quinuclidines
|
US5380738A
(en)
|
1993-05-21 |
1995-01-10 |
Monsanto Company |
2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
|
CA2163995A1
(en)
|
1993-06-07 |
1994-12-22 |
Malcolm Maccoss |
Spiro-substituted azacycles as neurokinin antagonists
|
US5474995A
(en)
|
1993-06-24 |
1995-12-12 |
Merck Frosst Canada, Inc. |
Phenyl heterocycles as cox-2 inhibitors
|
GB9602877D0
(en)
|
1996-02-13 |
1996-04-10 |
Merck Frosst Canada Inc |
3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
|
US5436265A
(en)
|
1993-11-12 |
1995-07-25 |
Merck Frosst Canada, Inc. |
1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
|
EP0634402A1
(en)
|
1993-07-14 |
1995-01-18 |
Takeda Chemical Industries, Ltd. |
Isochinolinone derivatives, their production and use
|
WO1995002595A1
(en)
|
1993-07-15 |
1995-01-26 |
Pfizer Inc. |
Benzyloxyquinuclidines as substance p antagonists
|
TW365603B
(en)
|
1993-07-30 |
1999-08-01 |
Rhone Poulenc Rorer Sa |
Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
|
GB9315808D0
(en)
|
1993-07-30 |
1993-09-15 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9317987D0
(en)
|
1993-08-26 |
1993-10-13 |
Glaxo Group Ltd |
Chemical compounds
|
EP0728139B1
(en)
|
1993-09-03 |
2003-08-13 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
EP1209157A1
(en)
|
1993-09-17 |
2002-05-29 |
Pfizer Inc. |
Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds
|
DK0719253T3
(da)
|
1993-09-17 |
2004-07-26 |
Pfizer |
3-amino-5-carboxy-substituerede piperidiner og 3-amino-4-carboxy-substituerede pyrrolidiner som tachykininantagonister
|
EP0670314A4
(en)
|
1993-09-22 |
1996-04-10 |
Kyowa Hakko Kogyo Kk |
FARNESYL-TRANSFERASE INHIBITOR.
|
IS4208A
(is)
|
1993-09-22 |
1995-03-23 |
Glaxo Group Limited |
3-(tetrazólýl-benzyl)amínó-piperadidín afleiður
|
US5624803A
(en)
|
1993-10-14 |
1997-04-29 |
The Regents Of The University Of California |
In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
|
CA2173963C
(en)
|
1993-10-15 |
2002-03-19 |
W. Robert Bishop |
Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
US5661152A
(en)
|
1993-10-15 |
1997-08-26 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
IL111235A
(en)
|
1993-10-15 |
2001-03-19 |
Schering Plough Corp |
Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
|
US5721236A
(en)
|
1993-10-15 |
1998-02-24 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US5719148A
(en)
|
1993-10-15 |
1998-02-17 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
JP2875393B2
(ja)
|
1993-10-15 |
1999-03-31 |
シェーリング コーポレイション |
G−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物
|
PT725790E
(pt)
|
1993-10-25 |
2001-08-30 |
Parke Davis & Co |
Inibidores tetra e penta-peptidicos substituidos da proteina farnesil transferase
|
AU7947594A
(en)
|
1993-10-27 |
1995-05-22 |
Merck Sharp & Dohme Limited |
Substituted amides as tachykinin antagonists
|
US5344991A
(en)
|
1993-10-29 |
1994-09-06 |
G.D. Searle & Co. |
1,2 diarylcyclopentenyl compounds for the treatment of inflammation
|
US5783593A
(en)
|
1993-11-04 |
1998-07-21 |
Abbott Laboratories |
Inhibitors of squalene synthetase and protein farnesyltransferase
|
ES2130452T3
(es)
|
1993-11-04 |
1999-07-01 |
Abbott Lab |
Derivados de ciclobutano utilizados como inhibidores de la escualeno-sintetasa y de la farnesiltransferasa proteica.
|
WO1995012612A1
(en)
|
1993-11-05 |
1995-05-11 |
Warner-Lambert Company |
Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
|
US6403577B1
(en)
|
1993-11-17 |
2002-06-11 |
Eli Lilly And Company |
Hexamethyleneiminyl tachykinin receptor antagonists
|
US5466823A
(en)
|
1993-11-30 |
1995-11-14 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides
|
IT1271462B
(it)
|
1993-12-03 |
1997-05-28 |
Menarini Farma Ind |
Antagonisti delle tachichinine,procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche.
|
US5484799A
(en)
|
1993-12-09 |
1996-01-16 |
Abbott Laboratories |
Antifungal dorrigocin derivatives
|
IL111960A
(en)
|
1993-12-17 |
1999-12-22 |
Merck & Co Inc |
Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
|
EP0736007A4
(en)
|
1993-12-21 |
1997-03-19 |
Lilly Co Eli |
NON-PEPTIDE ANTAGONISTS OF TACHYKININ RECEPTORS
|
CN1046515C
(zh)
|
1993-12-29 |
1999-11-17 |
辉瑞大药厂 |
二氮杂双环神经激肽拮抗剂
|
NZ277839A
(en)
|
1993-12-29 |
1998-01-26 |
Merck Sharp & Dohme |
Substituted morpholine derivatives, preparation and pharmaceutical compositions thereof
|
JPH09507500A
(ja)
|
1994-01-13 |
1997-07-29 |
メルク シヤープ エンド ドーム リミテツド |
gem二置換アザシクロ系のタキキニン拮抗薬
|
WO1995020575A1
(en)
|
1994-01-28 |
1995-08-03 |
Merck Sharp & Dohme Limited |
Aralkylamino substituted azacyclic therapeutic agents
|
US5393790A
(en)
|
1994-02-10 |
1995-02-28 |
G.D. Searle & Co. |
Substituted spiro compounds for the treatment of inflammation
|
GB9402688D0
(en)
|
1994-02-11 |
1994-04-06 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5610165A
(en)
|
1994-02-17 |
1997-03-11 |
Merck & Co., Inc. |
N-acylpiperidine tachykinin antagonists
|
US5902880A
(en)
|
1994-08-19 |
1999-05-11 |
Ribozyme Pharmaceuticals, Inc. |
RNA polymerase III-based expression of therapeutic RNAs
|
IL112778A0
(en)
|
1994-03-04 |
1995-05-26 |
Merck & Co Inc |
Substituted heterocycles, their preparation and pharmaceutical compositions containing them
|
WO1995024612A1
(de)
|
1994-03-07 |
1995-09-14 |
International Business Machines Corporation |
Verfahren und vorrichtung zur schnellen interpolation von zwischenwerten aus periodischen phasenverschobenen signalen und zur erkennung von defekten in einem drehkörper
|
EP0750609A4
(en)
|
1994-03-15 |
1997-09-24 |
Eisai Co Ltd |
ISOPRENYLE TRANSFERASE INHIBITORS
|
FR2718136B1
(fr)
|
1994-03-29 |
1996-06-21 |
Sanofi Sa |
Composés aromatiques aminés, procédé pour leur obtention et compositions pharmaceutiques les contenant.
|
RU95104898A
(ru)
|
1994-03-31 |
1996-12-27 |
Бристоль-Мейерз Сквибб Компани (US) |
Имидазолсодержащие ингибиторы фарнезид-протеинтрансферазы, способ лечения связанных с ней заболеваний
|
US5523430A
(en)
|
1994-04-14 |
1996-06-04 |
Bristol-Myers Squibb Company |
Protein farnesyl transferase inhibitors
|
US5610145A
(en)
|
1994-04-15 |
1997-03-11 |
Warner-Lambert Company |
Tachykinin antagonists
|
IL113472A0
(en)
|
1994-04-29 |
1995-07-31 |
Lilly Co Eli |
Non-peptidyl tachykinin receptor antogonists
|
EP0758329A1
(en)
|
1994-05-05 |
1997-02-19 |
MERCK SHARP & DOHME LTD. |
Morpholine derivatives and their use as antagonists of tachikinins
|
CZ325496A3
(en)
|
1994-05-07 |
1997-09-17 |
Boehringer Ingelheim Kg |
Amino acid derivatives, process for preparing and pharmaceutical compositions containing thereof
|
US5510510A
(en)
|
1994-05-10 |
1996-04-23 |
Bristol-Meyers Squibb Company |
Inhibitors of farnesyl protein transferase
|
US6447796B1
(en)
|
1994-05-16 |
2002-09-10 |
The United States Of America As Represented By The Secretary Of The Army |
Sustained release hydrophobic bioactive PLGA microspheres
|
US5563255A
(en)
|
1994-05-31 |
1996-10-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
CA2187531A1
(en)
|
1994-06-06 |
1995-12-14 |
David Christopher Horwell |
Tachykinin (nk1) receptor antagonists
|
DE69507476D1
(de)
|
1994-06-10 |
1999-03-04 |
Rhone Poulenc Rorer Sa |
Farnesyl-transferase-inhibitoren, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen
|
EP0686629A3
(en)
|
1994-06-10 |
1999-02-10 |
Eli Lilly And Company |
Cyclohexyl tachykinine receptor antagonists
|
US5571792A
(en)
|
1994-06-30 |
1996-11-05 |
Warner-Lambert Company |
Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
|
CN1067067C
(zh)
|
1994-07-12 |
2001-06-13 |
伊莱利利公司 |
杂环速激肽受体拮抗物
|
CA2154116A1
(en)
|
1994-07-22 |
1996-01-23 |
Philip Arthur Hipskind |
1-aryl-2-acetamidopentanone derivatives for use as tachykinin receptor antagonists
|
GB9415997D0
(en)
|
1994-08-08 |
1994-09-28 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9415996D0
(en)
|
1994-08-08 |
1994-09-28 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO1996005529A1
(en)
|
1994-08-09 |
1996-02-22 |
Micron Optics, Inc. |
Temperature compensated fiber fabry-perot filters
|
TW432061B
(en)
|
1994-08-09 |
2001-05-01 |
Pfizer Res & Dev |
Lactams
|
CA2155448A1
(en)
|
1994-08-11 |
1996-02-12 |
Katerina Leftheris |
Inhibitors of farnesyl protein transferase
|
WO1996005168A1
(fr)
|
1994-08-11 |
1996-02-22 |
Banyu Pharmaceutical Co., Ltd. |
Derive d'amide substitue
|
EP0805154A1
(en)
|
1994-08-12 |
1997-11-05 |
Banyu Pharmaceutical Co., Ltd. |
N,n-disubstituted amic acid derivative
|
DE69521208T2
(de)
|
1994-08-15 |
2001-11-08 |
Merck Sharp & Dohme |
Morpholinderivate und ihre verwendung als therapeutische mittel
|
DE4429506B4
(de)
|
1994-08-19 |
2007-09-13 |
Degussa Gmbh |
Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
|
US6146886A
(en)
|
1994-08-19 |
2000-11-14 |
Ribozyme Pharmaceuticals, Inc. |
RNA polymerase III-based expression of therapeutic RNAs
|
DE4429653C2
(de)
|
1994-08-20 |
1997-04-03 |
Anton Dr More |
Konverter und Verfahren zum Frischen von Metallschmelzen insbesondere von Roheisen zu Stahl
|
CA2198084C
(en)
|
1994-08-25 |
2000-03-28 |
Timothy P. Burkholder |
Novel substituted piperidines useful for the treatment of allergic diseases
|
DE69405864T2
(de)
|
1994-08-29 |
1998-03-26 |
Akzo Nobel Nv |
Verfahren zur Herstellung von quaternären Diestern
|
GB9417956D0
(en)
|
1994-09-02 |
1994-10-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9418545D0
(en)
|
1994-09-15 |
1994-11-02 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5457107A
(en)
|
1994-09-16 |
1995-10-10 |
Merck & Co., Inc. |
Polymorphic form of a tachykinin receptor antagonist
|
US5820873A
(en)
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
ATE212981T1
(de)
|
1994-09-30 |
2002-02-15 |
Novartis Erfind Verwalt Gmbh |
1-acyl-4-aliphatische aminopiperidin verbindungen
|
US5753613A
(en)
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
TW397825B
(en)
|
1994-10-14 |
2000-07-11 |
Novartis Ag |
Aroyl-piperidine derivatives
|
FR2725986B1
(fr)
|
1994-10-21 |
1996-11-29 |
Adir |
Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
EP0709375B1
(en)
|
1994-10-25 |
2005-05-18 |
AstraZeneca AB |
Therapeutic heterocycles
|
GB9421709D0
(en)
|
1994-10-27 |
1994-12-14 |
Zeneca Ltd |
Therapeutic compounds
|
DE69507284T2
(de)
|
1994-11-22 |
1999-07-01 |
Philips Electronics Nv |
Halbleiter mit einem träger auf dem ein substrat mit einem halbleiter-element mittels einer klebeschicht und ein leiterbahn-muster befestigt sind
|
EP0714891A1
(en)
|
1994-11-22 |
1996-06-05 |
Eli Lilly And Company |
Heterocyclic tachykinin receptor antagonists
|
FR2727411B1
(fr)
|
1994-11-30 |
1997-01-03 |
Rhone Poulenc Rorer Sa |
Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
|
WO1996017861A1
(en)
|
1994-12-09 |
1996-06-13 |
Warner-Lambert Company |
Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
|
PE38997A1
(es)
|
1994-12-13 |
1997-10-02 |
Novartis Ag |
Antagonista de taquicinina
|
WO1996018736A2
(en)
|
1994-12-13 |
1996-06-20 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
|
GB9426103D0
(en)
|
1994-12-23 |
1995-02-22 |
Merck Sharp & Dohme |
Therapeutic agents
|
AU703440B2
(en)
|
1995-01-09 |
1999-03-25 |
Magla International Ltd. |
Wear resistant image printing on latex surfaces
|
JP3929069B2
(ja)
|
1995-01-12 |
2007-06-13 |
ユニバーシティ オブ ピッツバーグ |
プレニルトランスフェラーゼの阻害剤
|
DE69633607T2
(de)
|
1995-01-12 |
2006-02-23 |
Glaxo Group Ltd., Greenford |
Piperidinderivate mit tachykinin-antagonistischer wirkung
|
FR2729390A1
(fr)
|
1995-01-18 |
1996-07-19 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
FR2729951B1
(fr)
|
1995-01-30 |
1997-04-18 |
Sanofi Sa |
Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
|
FR2730491B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
FR2730492B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
US5633272A
(en)
|
1995-02-13 |
1997-05-27 |
Talley; John J. |
Substituted isoxazoles for the treatment of inflammation
|
GB9505492D0
(en)
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9505491D0
(en)
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5554641A
(en)
|
1995-03-20 |
1996-09-10 |
Horwell; David C. |
Nonpeptides as tachykinin antagonists
|
GB9505692D0
(en)
|
1995-03-21 |
1995-05-10 |
Glaxo Group Ltd |
Chemical compounds
|
US5700806A
(en)
|
1995-03-24 |
1997-12-23 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
ATE242243T1
(de)
|
1995-03-24 |
2003-06-15 |
Takeda Chemical Industries Ltd |
Zyklische verbindungen, ihre herstellung und ihre verwendung als tachykininrezeptorantagonisten
|
US5684013A
(en)
|
1995-03-24 |
1997-11-04 |
Schering Corporation |
Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
IL117580A0
(en)
|
1995-03-29 |
1996-07-23 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
|
US5565568A
(en)
|
1995-04-06 |
1996-10-15 |
Eli Lilly And Company |
2-acylaminopropanamides as tachykinin receptor antagonists
|
US5891872A
(en)
|
1995-04-07 |
1999-04-06 |
Schering Corporation |
Tricyclic compounds
|
IL117798A
(en)
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
US5712280A
(en)
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
JP3038016B2
(ja)
|
1995-04-07 |
2000-05-08 |
シェーリング コーポレイション |
ファルネシルタンパク質トランスフェラーゼを阻害する、カルボニルピペラジニルおよびカルボニルピペリジニル化合物
|
ES2224164T3
(es)
|
1995-04-13 |
2005-03-01 |
Aventis Pharmaceuticals Inc. |
Nuevos derivados de piperazina sustituida que tienen actividad como antagonistas de los receptores de taququinina.
|
WO1996032099A1
(en)
|
1995-04-14 |
1996-10-17 |
Glaxo Wellcome Inc. |
Metered dose inhaler for albuterol
|
US5831115A
(en)
|
1995-04-21 |
1998-11-03 |
Abbott Laboratories |
Inhibitors of squalene synthase and protein farnesyltransferase
|
IL118101A0
(en)
|
1995-05-03 |
1996-09-12 |
Abbott Lab |
Inhibitors of farnesyltransferase
|
CA2222041A1
(en)
|
1995-05-25 |
1996-11-28 |
Fujisawa Pharmaceutical Co., Ltd. |
1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists
|
US5705385A
(en)
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
EP0832271B8
(en)
|
1995-06-07 |
2005-03-02 |
INEX Pharmaceuticals Corp. |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
AU6034296A
(en)
|
1995-06-16 |
1997-01-15 |
Warner-Lambert Company |
Tricyclic inhibitors of protein farnesyltransferase
|
GB9513118D0
(en)
|
1995-06-28 |
1995-08-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9513117D0
(en)
|
1995-06-28 |
1995-08-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9513121D0
(en)
|
1995-06-28 |
1995-08-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
MX9800187A
(es)
|
1995-07-07 |
1998-05-31 |
Pfizer |
Compuestos de benzolactama substituidos como antagonistas de la substancia p.
|
FR2736641B1
(fr)
|
1995-07-10 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
AT402617B
(de)
|
1995-07-11 |
1997-07-25 |
Datacon Schweitzer & Zeindl Gm |
Anlage zum automatisierten, hermetischen anlage zum automatisierten, hermetischen verschliessen von gehäusen verschliessen von gehäusen
|
FR2736638B1
(fr)
|
1995-07-12 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
CH690163A5
(fr)
|
1995-07-28 |
2000-05-31 |
Symphar Sa |
Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
|
TW340842B
(en)
|
1995-08-24 |
1998-09-21 |
Pfizer |
Substituted benzylaminopiperidine compounds
|
US6020343A
(en)
|
1995-10-13 |
2000-02-01 |
Merck Frosst Canada, Inc. |
(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
|
AU722883B2
(en)
|
1995-10-18 |
2000-08-10 |
Merck & Co., Inc. |
Cyclopentyl tachykinin receptor antagonists
|
DE19541283A1
(de)
|
1995-11-06 |
1997-05-07 |
Boehringer Ingelheim Kg |
Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
|
DE69627377T2
(de)
|
1995-11-06 |
2004-02-05 |
University Of Pittsburgh |
Inhibitoren der protein-isoprenyl-transferase
|
GB9523244D0
(en)
|
1995-11-14 |
1996-01-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
DE59610943D1
(de)
|
1995-11-17 |
2004-04-22 |
Biotechnolog Forschung Gmbh |
Epothilon-Derivate, ihre Herstellung und Verwendung
|
JP2000500502A
(ja)
|
1995-11-22 |
2000-01-18 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル―タンパク質トランスフェラーゼ阻害剤
|
US6060469A
(en)
|
1995-11-23 |
2000-05-09 |
Merck Sharp & Dohme Ltd. |
Spiro-piperidine derivatives and their use as tachykinin antagonists
|
GB9524157D0
(en)
|
1995-11-25 |
1996-01-24 |
Pfizer Ltd |
Therapeutic agents
|
RU2135494C1
(ru)
|
1995-12-01 |
1999-08-27 |
Санкио Компани Лимитед |
Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
|
CA2231105C
(en)
|
1995-12-08 |
2005-09-13 |
Janssen Pharmaceutica N.V. |
Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives
|
GB9525296D0
(en)
|
1995-12-11 |
1996-02-07 |
Merck Sharp & Dohme |
Therapeutic agents
|
AU730194B2
(en)
|
1995-12-22 |
2001-03-01 |
Merck Sharp & Dohme Corp. |
Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
WO1997026246A1
(en)
|
1996-01-16 |
1997-07-24 |
Warner-Lambert Company |
Substituted histidine inhibitors of protein farnesyltransferase
|
US6673927B2
(en)
|
1996-02-16 |
2004-01-06 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Farnesyl transferase inhibitors
|
WO1997038665A2
(en)
|
1996-04-03 |
1997-10-23 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
CN1098256C
(zh)
|
1996-04-12 |
2003-01-08 |
G·D·瑟尔公司 |
作为cox-2抑制剂前药的取代的苯磺酰胺衍生物
|
CN1219174A
(zh)
|
1996-05-22 |
1999-06-09 |
沃尼尔·朗伯公司 |
蛋白质法呢基转移酶的抑制剂
|
CA2260216A1
(en)
|
1996-07-15 |
1998-01-22 |
Bristol-Myers Squibb Company |
Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
|
US5861419A
(en)
|
1996-07-18 |
1999-01-19 |
Merck Frosst Canad, Inc. |
Substituted pyridines as selective cyclooxygenase-2 inhibitors
|
CA2273083C
(en)
|
1996-12-03 |
2012-09-18 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto, analogues and uses thereof
|
AUPO434196A0
(en)
*
|
1996-12-24 |
1997-01-23 |
Crown In The Right Of The Queensland Department Of Health, The |
An improved therapeutic
|
CA2276150A1
(en)
|
1996-12-30 |
1998-07-09 |
Steven D. Young |
Inhibitors of farnesyl-protein transferase
|
CA2276081A1
(en)
|
1996-12-30 |
1998-07-09 |
Lekhanh O. Tran |
Inhibitors of farnesyl-protein transferase
|
US6001311A
(en)
|
1997-02-05 |
1999-12-14 |
Protogene Laboratories, Inc. |
Apparatus for diverse chemical synthesis using two-dimensional array
|
US6126919A
(en)
|
1997-02-07 |
2000-10-03 |
3M Innovative Properties Company |
Biocompatible compounds for pharmaceutical drug delivery systems
|
US6235310B1
(en)
|
1997-04-04 |
2001-05-22 |
Valentis, Inc. |
Methods of delivery using cationic lipids and helper lipids
|
US6835395B1
(en)
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
JP4656675B2
(ja)
|
1997-05-14 |
2011-03-23 |
ユニバーシティー オブ ブリティッシュ コロンビア |
脂質小胞への荷電した治療剤の高率封入
|
AU7983798A
(en)
|
1997-06-23 |
1999-01-04 |
Sequus Pharmaceuticals, Inc. |
Liposome-entrapped polynucleotide composition and method
|
US6395713B1
(en)
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
AR013269A1
(es)
|
1997-08-04 |
2000-12-13 |
Scras |
Producto que contiene por lo menos un rna de doble filamento combinado con por lo menos un agente anti-viral, para la utilizacion terapeutica en eltratamiento de una enfermedad viral, en especial de la hepatitis viral
|
US6054576A
(en)
|
1997-10-02 |
2000-04-25 |
Ribozyme Pharmaceuticals, Inc. |
Deprotection of RNA
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
CA2317549C
(en)
|
1998-01-05 |
2006-04-11 |
University Of Washington |
Composition for enhancing transport through lipid-containing membranes, and uses thereof
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
WO1999054459A2
(en)
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
GB9827152D0
(en)
|
1998-07-03 |
1999-02-03 |
Devgen Nv |
Characterisation of gene function using double stranded rna inhibition
|
CA2335393C
(en)
|
1998-07-20 |
2008-09-23 |
Inex Pharmaceuticals Corporation |
Liposomal encapsulated nucleic acid-complexes
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
CA2361201A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
JP2002536968A
(ja)
|
1999-01-29 |
2002-11-05 |
イムクローン システムズ インコーポレイティド |
Kdrに特異的な抗体およびその使用
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
GB9904387D0
(en)
|
1999-02-25 |
1999-04-21 |
Pharmacia & Upjohn Spa |
Antitumour synergistic composition
|
ATE408699T1
(de)
|
1999-03-10 |
2008-10-15 |
Phogen Ltd |
Verabreichung von nukleinsäuren und proteinen an zellen
|
EP1187633A4
(en)
|
1999-04-08 |
2005-05-11 |
Arch Dev Corp |
USE OF ANTI-VEGF ANTIBODY FOR INCREASING IRRADIATION IN CANCER THERAPY
|
MXPA02000402A
(es)
|
1999-07-14 |
2002-07-30 |
Alza Corp |
Lipopolimeros neutros y composiciones liposomales que contienen los mismos.
|
WO2001029058A1
(en)
|
1999-10-15 |
2001-04-26 |
University Of Massachusetts |
Rna interference pathway genes as tools for targeted genetic interference
|
US6545004B1
(en)
|
1999-10-27 |
2003-04-08 |
Cytokinetics, Inc. |
Methods and compositions utilizing quinazolinones
|
NZ518480A
(en)
|
1999-10-27 |
2004-02-27 |
Cytokinetics Inc |
Methods and compositions utilizing quinazolinones
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
US6401406B1
(en)
|
2000-02-11 |
2002-06-11 |
Domald K. Komara |
Retainment device for concrete block inspection plates
|
US20050032733A1
(en)
*
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
US7365196B2
(en)
|
2000-03-20 |
2008-04-29 |
Merck Sharp & Dohme Ltd. |
Sulphonamido-substituted bridged bicycloalkyl derivatives
|
GB0012671D0
(en)
|
2000-05-24 |
2000-07-19 |
Merck Sharp & Dohme |
Therapeutic agents
|
EP1313752B1
(en)
|
2000-09-01 |
2011-04-20 |
Ribozyme Pharmaceuticals, Inc. |
Methods for synthesizing nucleoside derivatives
|
US6998115B2
(en)
|
2000-10-10 |
2006-02-14 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
GB0025173D0
(en)
|
2000-10-13 |
2000-11-29 |
Merck Sharp & Dohme |
Therapeutic agents
|
EP1334085B1
(en)
|
2000-11-02 |
2005-08-24 |
Merck Sharp & Dohme Ltd. |
Sulfamides as gamma-secretase inhibitors
|
UA74849C2
(en)
|
2000-11-17 |
2006-02-15 |
Lilly Co Eli |
Lactam
|
US20020130430A1
(en)
|
2000-12-29 |
2002-09-19 |
Castor Trevor Percival |
Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
|
US20050164220A1
(en)
|
2001-03-19 |
2005-07-28 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke: method of treatment
|
WO2004028341A2
(en)
|
2001-03-19 |
2004-04-08 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke; methods of treatment
|
GB0108592D0
(en)
|
2001-04-05 |
2001-05-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB0108591D0
(en)
|
2001-04-05 |
2001-05-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
US6960584B2
(en)
|
2001-04-10 |
2005-11-01 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
JP4361276B2
(ja)
|
2001-04-10 |
2009-11-11 |
メルク エンド カムパニー インコーポレーテッド |
Akt活性の阻害物質
|
WO2002083140A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
US20040106540A1
(en)
|
2001-04-10 |
2004-06-03 |
Barnett Stanley F |
Method of treating cancer
|
US20030077829A1
(en)
|
2001-04-30 |
2003-04-24 |
Protiva Biotherapeutics Inc.. |
Lipid-based formulations
|
US20080161256A1
(en)
*
|
2001-05-18 |
2008-07-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
JP2004536614A
(ja)
|
2001-08-01 |
2004-12-09 |
ユニバーシティ オブ ユタ |
Pde3環状ヌクレオチド・ホスホジエステラーゼのアイソフォーム選択的な阻害剤および活性化剤
|
GB0119152D0
(en)
|
2001-08-06 |
2001-09-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2003013526A1
(en)
|
2001-08-08 |
2003-02-20 |
Merck & Co. Inc. |
Anticoagulant compounds
|
HUP0401241A3
(en)
|
2001-08-21 |
2008-03-28 |
Merck Sharp & Dohme |
Novel cyclohexyl sulphones, process for their preparation and pharmaceutical compositions containing them
|
US7514415B2
(en)
|
2002-08-01 |
2009-04-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
|
US20050191627A1
(en)
|
2001-09-28 |
2005-09-01 |
Incyte Corporation |
Enzymes
|
FR2830767B1
(fr)
|
2001-10-12 |
2004-03-12 |
Optis France Sa |
Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire
|
FR2830766B1
(fr)
|
2001-10-12 |
2004-03-12 |
Optis France Sa |
Dispositif de delivrance de medicaments par iontophorese transpalpebrale
|
US7060498B1
(en)
|
2001-11-28 |
2006-06-13 |
Genta Salus Llc |
Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
|
US7141540B2
(en)
|
2001-11-30 |
2006-11-28 |
Genta Salus Llc |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
|
JP4464136B2
(ja)
|
2001-12-06 |
2010-05-19 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有糸***キネシン阻害薬
|
WO2003050064A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
AU2002364128B2
(en)
|
2001-12-06 |
2008-03-06 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
EP1551812B1
(en)
|
2001-12-06 |
2009-03-04 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
EP1481077B1
(en)
|
2001-12-06 |
2009-11-04 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
WO2003052075A2
(en)
|
2001-12-14 |
2003-06-26 |
Incyte Genomics, Inc. |
Enzymes
|
EP1432724A4
(en)
|
2002-02-20 |
2006-02-01 |
Sirna Therapeutics Inc |
RNA inhibition mediated inhibition of MAP KINASE GENES
|
US7662952B2
(en)
*
|
2002-02-20 |
2010-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)
|
EP1492487B1
(en)
|
2002-03-08 |
2009-11-11 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
WO2003086403A1
(en)
|
2002-04-08 |
2003-10-23 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
JP4394960B2
(ja)
|
2002-04-08 |
2010-01-06 |
メルク エンド カムパニー インコーポレーテッド |
Akt活性阻害薬
|
AU2003226271B2
(en)
|
2002-04-08 |
2007-10-18 |
Merck Sharp & Dohme Corp. |
Fused quinoxaline derivatives as inhibitors of Akt activity
|
JP4394959B2
(ja)
|
2002-04-08 |
2010-01-06 |
メルク エンド カムパニー インコーポレーテッド |
Akt活性の阻害剤
|
US20060142178A1
(en)
|
2002-04-08 |
2006-06-29 |
Barnett Stanley F |
Method of treating cancer
|
GB0209997D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2003093252A1
(en)
|
2002-05-01 |
2003-11-13 |
Merck Sharp & Dohme Limited |
Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
|
GB0209995D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB0209991D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2483627A1
(en)
|
2002-05-23 |
2003-12-04 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
CA2485343A1
(en)
|
2002-05-23 |
2004-05-13 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
CN100421665C
(zh)
|
2002-06-14 |
2008-10-01 |
麦克公司 |
有丝***驱动蛋白抑制剂
|
ES2282647T3
(es)
|
2002-06-14 |
2007-10-16 |
MERCK & CO., INC. |
Inhibidores de cinesina mitotica.
|
AU2003279750A1
(en)
|
2002-06-28 |
2004-01-19 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds
|
US6989442B2
(en)
|
2002-07-12 |
2006-01-24 |
Sirna Therapeutics, Inc. |
Deprotection and purification of oligonucleotides and their derivatives
|
ATE427352T1
(de)
*
|
2002-07-26 |
2009-04-15 |
Novartis Vaccines & Diagnostic |
Modifizierte kleine irns molekule und methoden zu deren anwendung
|
US8216609B2
(en)
|
2002-08-05 |
2012-07-10 |
Torrent Pharmaceuticals Limited |
Modified release composition of highly soluble drugs
|
GB0223039D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
GB0223038D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
GB0223040D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
AU2003287057B2
(en)
|
2002-10-18 |
2008-08-21 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
US8133903B2
(en)
|
2003-10-21 |
2012-03-13 |
Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center |
Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
|
US20040102360A1
(en)
|
2002-10-30 |
2004-05-27 |
Barnett Stanley F. |
Combination therapy
|
AU2003284981B2
(en)
|
2002-10-30 |
2009-05-28 |
Merck Sharp & Dohme Corp. |
Inhibitors of Akt activity
|
GB0225474D0
(en)
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB0225475D0
(en)
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2508956A1
(en)
|
2002-12-20 |
2004-07-15 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
US7622468B2
(en)
|
2002-12-20 |
2009-11-24 |
Merck & Co. Inc. |
Mitotic kinesin inhibitors
|
US7816337B2
(en)
|
2003-02-18 |
2010-10-19 |
Roche Madison Inc. |
Reversible attachment of a membrane active polymer to a polynucleotide
|
WO2004080887A1
(en)
|
2003-03-07 |
2004-09-23 |
Massachusetts Institute Of Technology |
Three dimensional mecrofabrication
|
GB0308318D0
(en)
|
2003-04-10 |
2003-05-14 |
Merck Sharp & Dohme |
Therapeutic agents
|
EP1620095A4
(en)
|
2003-04-24 |
2009-04-01 |
Merck & Co Inc |
INHIBITORS OF AKT ACTIVITY
|
JP4673300B2
(ja)
|
2003-04-24 |
2011-04-20 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Akt活性の阻害剤
|
ATE446752T1
(de)
|
2003-04-24 |
2009-11-15 |
Merck & Co Inc |
Hemmer der akt aktivität
|
CA2522431A1
(en)
|
2003-04-24 |
2004-11-11 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
JP4818114B2
(ja)
|
2003-05-16 |
2011-11-16 |
メルク シャープ エンド ドーム リミテッド |
γ−セクレターゼ阻害剤としてのシクロヘキシルスルホン類
|
US8350021B2
(en)
*
|
2003-06-12 |
2013-01-08 |
Alnylam Pharmaceuticals, Inc. |
Conserved HBV and HCV sequences useful for gene silencing
|
GB0318447D0
(en)
|
2003-08-05 |
2003-09-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
AU2004266612B2
(en)
|
2003-08-13 |
2010-06-10 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
AR045342A1
(es)
|
2003-08-15 |
2005-10-26 |
Merck & Co Inc |
Inhibidores de quinesina mitotica
|
AU2004266232B2
(en)
|
2003-08-15 |
2008-07-03 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
CN1835756A
(zh)
|
2003-08-15 |
2006-09-20 |
默克公司 |
有丝***驱动蛋白抑制剂
|
AU2004264533B2
(en)
|
2003-08-15 |
2009-01-22 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
US7514459B2
(en)
|
2003-09-24 |
2009-04-07 |
Merck Sharp & Dohme Ltd. |
Gamma-secretase inhibitors
|
CA2539752A1
(en)
|
2003-09-29 |
2005-04-07 |
Topigen Pharmaceutique Inc. |
Oligonucleotide compositions and methods for treating disease including inflammatory conditions
|
CA2544378A1
(en)
|
2003-11-03 |
2005-05-19 |
Glaxo Group Limited |
A fluid dispensing device
|
US20100145038A1
(en)
*
|
2003-11-24 |
2010-06-10 |
Merck & Co., Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
JP5059411B2
(ja)
|
2003-12-19 |
2012-10-24 |
ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド |
短鎖干渉rnaの細胞トランスフェクティング処方物、関連する組成物および作製方法ならびに使用
|
US7294640B2
(en)
|
2004-02-06 |
2007-11-13 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
JP2007532558A
(ja)
|
2004-04-09 |
2007-11-15 |
メルク エンド カムパニー インコーポレーテッド |
Akt活性の阻害剤
|
AU2005233569B2
(en)
|
2004-04-09 |
2010-08-19 |
Merck Sharp & Dohme Corp. |
Inhibitors of Akt activity
|
CA2564616C
(en)
|
2004-04-20 |
2016-08-30 |
Nastech Pharmaceutical Company Inc. |
Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
|
ATE450251T1
(de)
|
2004-05-17 |
2009-12-15 |
Tekmira Pharmaceuticals Corp |
Liposomale formulierungen mit dihydrosphingomyelin und verfahren zu ihrer verwendung
|
US20060019258A1
(en)
|
2004-07-20 |
2006-01-26 |
Illumina, Inc. |
Methods and compositions for detection of small interfering RNA and micro-RNA
|
JP4804467B2
(ja)
*
|
2004-08-23 |
2011-11-02 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
多重rnaポリメラーゼiiiプロモーター発現構築物
|
US20060062758A1
(en)
|
2004-09-21 |
2006-03-23 |
Nastech Pharmaceutical Comapny Inc. |
Tight junction modulator peptide PN159 for enhanced mucosal delivery of therapeutic compounds
|
EP1796732B1
(en)
*
|
2004-10-01 |
2013-10-30 |
Novartis Vaccines and Diagnostics, Inc. |
Modified small interfering rna molecules and methods of use
|
AU2005319306B9
(en)
*
|
2004-12-22 |
2012-04-05 |
Alnylam Pharmaceuticals, Inc. |
Conserved HBV and HCV sequences useful for gene silencing
|
US7404969B2
(en)
*
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
CN101142316A
(zh)
*
|
2005-03-09 |
2008-03-12 |
牧岩生命工学研究所 |
小干扰rna和包含它的用于治疗乙型肝炎的药物组合物
|
CA2622242A1
(en)
*
|
2005-09-12 |
2007-03-22 |
Somagenics Inc. |
Inhibition of viral gene expression using small interfering rna
|
MX2009001207A
(es)
|
2006-08-18 |
2009-02-11 |
Hoffmann La Roche |
Policonjugados para el suministro in vivo de polinucleotidos.
|
WO2008103276A2
(en)
*
|
2007-02-16 |
2008-08-28 |
Merck & Co., Inc. |
Compositions and methods for potentiated activity of biologicaly active molecules
|
WO2009038266A1
(en)
*
|
2007-09-17 |
2009-03-26 |
Mogam Biotechnology Research Institute |
Method for enhancing serum stability and lowering immune response of sirna down-regulating gene expression of hbv or hcv
|
DK2279254T3
(en)
|
2008-04-15 |
2017-09-18 |
Protiva Biotherapeutics Inc |
PRESENT UNKNOWN LIPID FORMS FOR NUCLEIC ACID ADMINISTRATION
|
CN101603042B
(zh)
*
|
2008-06-13 |
2013-05-01 |
厦门大学 |
可用于乙型肝炎病毒感染治疗的rna干扰靶点
|
CN101322847A
(zh)
*
|
2008-06-23 |
2008-12-17 |
淮安市第四人民医院 |
基于siRNA池干扰的复合载体介导的抗乙肝病毒基因药物
|
WO2010012244A1
(zh)
*
|
2008-08-01 |
2010-02-04 |
苏州瑞博生物技术有限公司 |
乙型肝炎病毒基因的小核酸干扰靶位点序列和小干扰核酸及组合物和应用
|
ES2475065T3
(es)
|
2008-10-09 |
2014-07-10 |
Tekmira Pharmaceuticals Corporation |
Aminol�pidos mejorados y métodos para la administración de ácidos nucleicos
|
WO2010048536A2
(en)
|
2008-10-23 |
2010-04-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for preparing lipids
|
KR102459839B1
(ko)
|
2008-11-10 |
2022-10-27 |
알닐람 파마슈티칼스 인코포레이티드 |
치료제 운반용 신규 지질 및 조성물
|
WO2010080724A1
(en)
*
|
2009-01-12 |
2010-07-15 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
EP3243504A1
(en)
|
2009-01-29 |
2017-11-15 |
Arbutus Biopharma Corporation |
Improved lipid formulation
|
SI3431076T1
(sl)
|
2009-06-10 |
2022-04-29 |
Arbutus Biopharma Corporation |
Izboljšana lipidna formulacija
|
NZ598943A
(en)
|
2009-10-16 |
2014-09-26 |
Glaxo Group Ltd |
Hbv antisense inhibitors
|
AU2011207062B2
(en)
|
2010-01-20 |
2015-07-02 |
Magna International Inc. |
Bi-metallic component and method of making the same
|
CA2807307C
(en)
|
2010-08-17 |
2021-02-09 |
Merck Sharp & Dohme Corp. |
Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
|
CN101948827A
(zh)
*
|
2010-08-19 |
2011-01-19 |
中国人民解放军第三〇二医院 |
一种低载量乙型肝炎病毒全基因组克隆的方法
|
CN111172162A
(zh)
*
|
2011-04-21 |
2020-05-19 |
葛兰素史克公司 |
乙型肝炎病毒(hbv)表达的调节
|
AU2012275355B2
(en)
|
2011-06-30 |
2017-05-11 |
Arrowhead Pharmaceuticals, Inc. |
Compositions and methods for inhibiting gene expression of Hepatitis B virus
|
CN102559657A
(zh)
*
|
2011-11-09 |
2012-07-11 |
中国人民解放军第三〇二医院 |
两片段连接法进行hbv全基因组克隆的方法
|