IT1256623B
(en)
*
|
1992-12-04 |
1995-12-12 |
Federico Arcamone |
TACHYCHININ ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS
|
US5635510A
(en)
*
|
1993-05-06 |
1997-06-03 |
Merrell Pharmaceuticals Inc. |
Substituted pyrrolidin-3-yl-alkyl-piperidines
|
CA2198084C
(en)
|
1994-08-25 |
2000-03-28 |
Timothy P. Burkholder |
Novel substituted piperidines useful for the treatment of allergic diseases
|
AU700693B2
(en)
*
|
1995-04-13 |
1999-01-14 |
Aventis Pharmaceuticals Inc. |
Novel substituted piperazine derivatives having tachykinin receptor antagonists activity
|
US6211199B1
(en)
|
1995-11-17 |
2001-04-03 |
Aventis Pharmaceuticals Inc. |
Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
|
US6423704B2
(en)
|
1995-12-20 |
2002-07-23 |
Aventis Pharmaceuticals Inc. |
Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
|
US6194406B1
(en)
|
1995-12-20 |
2001-02-27 |
Aventis Pharmaceuticals Inc. |
Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
|
US5998439A
(en)
*
|
1996-02-21 |
1999-12-07 |
Hoescht Marion Roussel, Inc. |
Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
|
US5922737A
(en)
*
|
1996-02-21 |
1999-07-13 |
Hoechst Marion Roussel, Inc. |
Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
|
US5932571A
(en)
*
|
1996-02-21 |
1999-08-03 |
Hoechst Marion Roussel, Inc. |
Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
|
AU3255697A
(en)
*
|
1996-06-12 |
1998-01-07 |
F. Hoffmann-La Roche Ag |
A process for the manufacture of 1-(amino-alkyl)-indoles
|
DE19624704A1
(en)
|
1996-06-20 |
1998-01-08 |
Klinge Co Chem Pharm Fab |
New pyridylalkanoic acid amides
|
DE19624659A1
(en)
|
1996-06-20 |
1998-01-08 |
Klinge Co Chem Pharm Fab |
New pyridylalkene and pyridylalkanoic acid amides
|
US6451816B1
(en)
|
1997-06-20 |
2002-09-17 |
Klinge Pharma Gmbh |
Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
|
DE19756261A1
(en)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
New aryl-substituted pyridylalkane, alkene and alkyarboxylic acid amides
|
DE19756235A1
(en)
*
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
New piperidinyl-substituted pyridylalkane alkene and alkane carboxylic acid amides
|
DE19756212A1
(en)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
New cyclic imide-substituted pyridylalkane, alkene and alkyarboxylic acid amides
|
US6903118B1
(en)
|
1997-12-17 |
2005-06-07 |
Klinge Pharma Gmbh |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
|
US6344450B1
(en)
|
1999-02-09 |
2002-02-05 |
Bristol-Myers Squibb Company |
Lactam compounds and their use as inhibitors of serine proteases and method
|
JP2002536411A
(en)
|
1999-02-09 |
2002-10-29 |
ブリストル−マイヤーズ スクイブ カンパニー |
Lactam inhibitors of factor Xa and methods
|
EP1031564A1
(en)
|
1999-02-26 |
2000-08-30 |
Klinge Pharma GmbH |
Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
|
ES2304984T3
(en)
|
1999-11-03 |
2008-11-01 |
Amr Technology, Inc. |
TETRA-HYDROISOQUINOLINAS OF ARILICA AND HETEROARILICA SUBSTITUTION AND ITS USE TO BLOCK THE RECOVERY OF NOREPINEFRINE, DOPAMINE AND SEROTONINE.
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
RU2301808C2
(en)
|
2000-07-11 |
2007-06-27 |
Эймр Текнолоджи, Инк. |
4-phenyl-substituted tetrahydroisoquinolines, pharmaceutical composition and method for treatment based on thereof
|
US6511973B2
(en)
|
2000-08-02 |
2003-01-28 |
Bristol-Myers Squibb Co. |
Lactam inhibitors of FXa and method
|
GB0326407D0
(en)
*
|
2003-11-12 |
2003-12-17 |
Glaxo Group Ltd |
Chemical compounds
|
GEP20094640B
(en)
|
2004-07-15 |
2009-03-10 |
Bristol Myers Squibb Co |
Aryl-and heteroaryl-substituted tetrahydro isoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
ATE550019T1
(en)
|
2005-05-17 |
2012-04-15 |
Merck Sharp & Dohme |
CIS-4-Ä(4-CHLOROPHENYL)SULFONYLÜ-4-(2,5-DIFLUOROPHENYL)CYCLOHEXANEPROPANE ACID FOR THE TREATMENT OF CANCER
|
BRPI0613403A2
(en)
|
2005-07-15 |
2009-02-10 |
Amr Technology Inc |
aryl and heteroaryl substituted tetrahydrobenzodiazepines and their use to block reuptake of norepinephrine, dopamine and serotonin
|
CA2624030A1
(en)
|
2005-09-29 |
2007-04-12 |
Tianying Jian |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
EP2083831B1
(en)
|
2006-09-22 |
2013-12-25 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
JP4611444B2
(en)
|
2007-01-10 |
2011-01-12 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー |
Amide substituted indazoles as poly (ADP-ribose) polymerase (PARP) inhibitors
|
EP2145884B1
(en)
|
2007-04-02 |
2014-08-06 |
Msd K.K. |
Indoledione derivative
|
US8389553B2
(en)
|
2007-06-27 |
2013-03-05 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
JP2010229034A
(en)
*
|
2007-07-26 |
2010-10-14 |
Dainippon Sumitomo Pharma Co Ltd |
Bicyclic pyrrole derivative
|
JP2011515343A
(en)
|
2008-03-03 |
2011-05-19 |
タイガー ファーマテック |
Tyrosine kinase inhibitor
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
US8691825B2
(en)
|
2009-04-01 |
2014-04-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of AKT activity
|
KR101830447B1
(en)
|
2009-05-12 |
2018-02-20 |
알바니 몰레큘라 리써치, 인크. |
7-([1,2,4]TRIAZOLO[1,5-α]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
|
EP2429295B1
(en)
|
2009-05-12 |
2013-12-25 |
Albany Molecular Research, Inc. |
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
|
JP5739415B2
(en)
|
2009-05-12 |
2015-06-24 |
ブリストル−マイヤーズ スクウィブ カンパニー |
(S) -7-([1,2,4] triazolo [1,5-a] pyridin-6-yl) -4- (3,4-dichlorophenyl) -1,2,3,4-tetrahydroisoquinoline Crystal forms and uses thereof
|
CN102638981B
(en)
|
2009-10-14 |
2015-07-22 |
默沙东公司 |
Substituted piperidines that increase p53 activity and the uses thereof
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
CA2805265A1
(en)
|
2010-08-02 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
|
EP2606134B1
(en)
|
2010-08-17 |
2019-04-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
EP2632472B1
(en)
|
2010-10-29 |
2017-12-13 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
JP2014514321A
(en)
|
2011-04-21 |
2014-06-19 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Insulin-like growth factor 1 receptor inhibitor
|
WO2013004766A1
(en)
|
2011-07-04 |
2013-01-10 |
Ferrari Giulio |
Nk-1 receptor antagonists for treating corneal neovascularisation
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
EP3453762B1
(en)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
US9233979B2
(en)
|
2012-09-28 |
2016-01-12 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
RU2660349C2
(en)
|
2012-11-28 |
2018-07-05 |
Мерк Шарп И Доум Корп. |
Compositions and methods for treatment of malignant tumour
|
BR112015013611A2
(en)
|
2012-12-20 |
2017-11-14 |
Merck Sharp & Dohme |
compound and pharmaceutical composition
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
CN105884675A
(en)
*
|
2014-09-24 |
2016-08-24 |
中国药科大学 |
N-substituted indole carboxylic acid derivative and its preparation method and medical use
|
EP3706742B1
(en)
|
2017-11-08 |
2023-03-15 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
US20210015834A1
(en)
|
2018-02-26 |
2021-01-21 |
Ospedale San Raffaele S.R.L. |
Nk-1 antagonists for use in the treatment of ocular pain
|
WO2020033284A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
EP4117673A1
(en)
|
2020-03-11 |
2023-01-18 |
Ospedale San Raffaele S.r.l. |
Treatment of stem cell deficiency
|