FR2730492B1 - Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2730492B1
FR2730492B1 FR9501490A FR9501490A FR2730492B1 FR 2730492 B1 FR2730492 B1 FR 2730492B1 FR 9501490 A FR9501490 A FR 9501490A FR 9501490 A FR9501490 A FR 9501490A FR 2730492 B1 FR2730492 B1 FR 2730492B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
transferase inhibitors
farnesyl transferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9501490A
Other languages
English (en)
Other versions
FR2730492A1 (fr
Inventor
Francois Clerc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9501490A priority Critical patent/FR2730492B1/fr
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to KR1019970705444A priority patent/KR19980702049A/ko
Priority to CA002210953A priority patent/CA2210953A1/fr
Priority to EP96903062A priority patent/EP0808329A1/fr
Priority to CZ972499A priority patent/CZ249997A3/cs
Priority to PL96321710A priority patent/PL321710A1/xx
Priority to SK1088-97A priority patent/SK108897A3/sk
Priority to BR9607318A priority patent/BR9607318A/pt
Priority to PCT/FR1996/000199 priority patent/WO1996024612A1/fr
Priority to AU47228/96A priority patent/AU4722896A/en
Priority to JP8524038A priority patent/JPH10513468A/ja
Priority to CN96191866A priority patent/CN1173873A/zh
Priority to TR97/00726T priority patent/TR199700726T1/xx
Priority to ZA961073A priority patent/ZA961073B/xx
Publication of FR2730492A1 publication Critical patent/FR2730492A1/fr
Application granted granted Critical
Publication of FR2730492B1 publication Critical patent/FR2730492B1/fr
Priority to MXPA/A/1997/005969A priority patent/MXPA97005969A/xx
Priority to NO973607A priority patent/NO973607L/no
Priority to FI973279A priority patent/FI973279A/fi
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
FR9501490A 1995-02-09 1995-02-09 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2730492B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR9501490A FR2730492B1 (fr) 1995-02-09 1995-02-09 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
TR97/00726T TR199700726T1 (xx) 1995-02-09 1996-02-07 Farnezil transferaz �nleyiciler ve m�stahzarlar�.
EP96903062A EP0808329A1 (fr) 1995-02-09 1996-02-07 Inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
CZ972499A CZ249997A3 (en) 1995-02-09 1996-02-07 Novel inhibitors of farnesyl transferase, process of their preparation and pharmaceutical compositions containing such inhibitors
PL96321710A PL321710A1 (en) 1995-02-09 1996-02-07 Novel inhibitors of farnseferase, their production and pharmaceutic compositions containing them
SK1088-97A SK108897A3 (en) 1995-02-09 1996-02-07 Novel farnesyl transferase inhibitors, preparation thereof, and pharmaceutical compositions containing same
BR9607318A BR9607318A (pt) 1995-02-09 1996-02-07 Peptidos e composição farmacêutica
PCT/FR1996/000199 WO1996024612A1 (fr) 1995-02-09 1996-02-07 Inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
KR1019970705444A KR19980702049A (ko) 1995-02-09 1996-02-07 신규한 파르네실 트랜스퍼라아제 억제제, 이의 제조방법 및 이를 함유하는 약학 조성물
JP8524038A JPH10513468A (ja) 1995-02-09 1996-02-07 ファルネシル転移酵素阻害剤、これらの調製、及びこれらを含む製薬学的組成
CN96191866A CN1173873A (zh) 1995-02-09 1996-02-07 新的法呢基转移酶抑制剂,其制法及其药物组合物
CA002210953A CA2210953A1 (fr) 1995-02-09 1996-02-07 Inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
AU47228/96A AU4722896A (en) 1995-02-09 1996-02-07 Novel farnesyl transferase inhibitors, preparation thereof, and pharmaceutical compositions containing same
ZA961073A ZA961073B (en) 1995-02-09 1996-02-09 New farnesyl transferase inhibitors their preparation and the pharmaceutical compositions which contain them
MXPA/A/1997/005969A MXPA97005969A (en) 1995-02-09 1997-08-05 New farnesil inhibitors transfer your preparation and the pharmaceutical compositions that contain them
NO973607A NO973607L (no) 1995-02-09 1997-08-05 Nye farnesyltransferaseinhibitorer, deres fremstilling og preparater inneholdende inhibitorene
FI973279A FI973279A (fi) 1995-02-09 1997-08-08 Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset koostumukset

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9501490A FR2730492B1 (fr) 1995-02-09 1995-02-09 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2730492A1 FR2730492A1 (fr) 1996-08-14
FR2730492B1 true FR2730492B1 (fr) 1997-03-14

Family

ID=9475981

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9501490A Expired - Fee Related FR2730492B1 (fr) 1995-02-09 1995-02-09 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Country Status (16)

Country Link
EP (1) EP0808329A1 (fr)
JP (1) JPH10513468A (fr)
KR (1) KR19980702049A (fr)
CN (1) CN1173873A (fr)
AU (1) AU4722896A (fr)
BR (1) BR9607318A (fr)
CA (1) CA2210953A1 (fr)
CZ (1) CZ249997A3 (fr)
FI (1) FI973279A (fr)
FR (1) FR2730492B1 (fr)
NO (1) NO973607L (fr)
PL (1) PL321710A1 (fr)
SK (1) SK108897A3 (fr)
TR (1) TR199700726T1 (fr)
WO (1) WO1996024612A1 (fr)
ZA (1) ZA961073B (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2730491B1 (fr) * 1995-02-09 1997-03-14 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
US6015817A (en) * 1996-12-05 2000-01-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5972966A (en) * 1996-12-05 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5932590A (en) * 1996-12-05 1999-08-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
FR2796943A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique
FR2796946A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromanes, leur preparation et leur utilisation en therapeutique
WO2006123182A2 (fr) 2005-05-17 2006-11-23 Merck Sharp & Dohme Limited Sulfones de cyclohexyle pour le traitement du cancer
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2008039327A2 (fr) 2006-09-22 2008-04-03 Merck & Co., Inc. Procédé de traitement utilisant des inhibiteurs de synthèse d'acide gras
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AU2008204380B2 (en) 2007-01-10 2013-08-15 Msd Italia S.R.L. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
CN101679266B (zh) 2007-03-01 2015-05-06 诺华股份有限公司 Pim激酶抑制剂及其应用方法
BRPI0812159A2 (pt) 2007-05-21 2017-05-02 Novartis Ag inibidores de csf-1r, composições e métodos de uso
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
EP2413932A4 (fr) 2009-04-01 2012-09-19 Merck Sharp & Dohme Inhibiteurs de l'activité akt
JP6073677B2 (ja) 2009-06-12 2017-02-01 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 縮合複素環式化合物およびそれらの使用
BR112012008849A2 (pt) 2009-10-14 2015-09-22 Schering Corp composto, composição farmacêutica, e, uso de um composto
BR112012023021A2 (pt) 2010-03-16 2016-05-31 Dana Farber Cancer Inst Inc compostos de indazol e seus usos
EP2584903B1 (fr) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
JP6043285B2 (ja) 2010-08-02 2016-12-14 サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害
HUE044815T2 (hu) 2010-08-17 2019-11-28 Sirna Therapeutics Inc Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával
EP2608669B1 (fr) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. Nouveaux dérivés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de mtor
EP2613782B1 (fr) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk
WO2012036997A1 (fr) 2010-09-16 2012-03-22 Schering Corporation Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
WO2012087772A1 (fr) 2010-12-21 2012-06-28 Schering Corporation Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
US20140045847A1 (en) 2011-04-21 2014-02-13 Piramal Enterprises Limited Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
WO2013063214A1 (fr) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Nouveaux composés qui sont des inhibiteurs d'erk
WO2013074986A1 (fr) 2011-11-17 2013-05-23 Dana-Farber Cancer Institute, Inc. Inhibiteurs de la kinase c-jun-n-terminale (jnk)
EP3919620A1 (fr) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Compositions d'acide nucléique interférent court (sina)
US9233979B2 (en) 2012-09-28 2016-01-12 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
US10112927B2 (en) 2012-10-18 2018-10-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
US9758522B2 (en) 2012-10-19 2017-09-12 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
BR112015012295A8 (pt) 2012-11-28 2023-03-14 Merck Sharp & Dohme Uso de um inibidor de wee1, e, kit para identificar um paciente com câncer
BR112015013611A2 (pt) 2012-12-20 2017-11-14 Merck Sharp & Dohme composto, e, composição farmacêutica
EP2951180B1 (fr) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
EP3041938A1 (fr) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Polynucléotides circulaires
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド サイクリン依存性キナーゼ7(cdk7)の多環阻害剤
WO2015058126A1 (fr) 2013-10-18 2015-04-23 Syros Pharmaceuticals, Inc. Composés hétéroaromatiques utiles dans le traitement de maladies prolifératives
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164614A1 (fr) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Inhibiteurs de janus kinase et leurs utilisations
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
AU2015371251B2 (en) 2014-12-23 2020-06-11 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2016160617A2 (fr) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibiteurs de kinases cycline-dépendantes
EP3307728A4 (fr) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Thérapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases
EP3347018B1 (fr) 2015-09-09 2021-09-01 Dana-Farber Cancer Institute, Inc. Inhibiteurs de kinases cycline-dépendantes
JOP20190055A1 (ar) 2016-09-26 2019-03-24 Merck Sharp & Dohme أجسام مضادة ضد cd27
JP7160833B2 (ja) 2017-04-13 2022-10-25 サイロパ ビー.ブイ. 抗sirpアルファ抗体
WO2019094311A1 (fr) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
WO2019148412A1 (fr) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anticorps bispécifiques anti-pd-1/lag3
EP3833667B1 (fr) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
WO2020033282A1 (fr) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
CA2072033A1 (fr) * 1991-06-28 1992-12-29 Jackson B. Gibbs Inhibiteur de la farnesyl-proteine-transferase ne se rapportant pas a un substrat
CA2118985A1 (fr) * 1993-04-02 1994-10-03 Dinesh V. Patel Inhibiteurs heterocycliques de la farnesyl proteine transferase
JPH09500615A (ja) * 1993-05-14 1997-01-21 ジェネンテク,インコーポレイテッド Ras−ファルネシル転移酵素阻害剤
US5439918A (en) * 1994-03-14 1995-08-08 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase

Also Published As

Publication number Publication date
CZ249997A3 (en) 1997-11-12
JPH10513468A (ja) 1998-12-22
NO973607D0 (no) 1997-08-05
CA2210953A1 (fr) 1996-08-15
NO973607L (no) 1997-08-05
CN1173873A (zh) 1998-02-18
FR2730492A1 (fr) 1996-08-14
FI973279A0 (fi) 1997-08-08
MX9705969A (es) 1997-11-29
TR199700726T1 (xx) 1998-01-21
WO1996024612A1 (fr) 1996-08-15
KR19980702049A (ko) 1998-07-15
AU4722896A (en) 1996-08-27
EP0808329A1 (fr) 1997-11-26
BR9607318A (pt) 1997-12-30
PL321710A1 (en) 1997-12-22
ZA961073B (en) 1996-08-20
FI973279A (fi) 1997-08-08
SK108897A3 (en) 1997-12-10

Similar Documents

Publication Publication Date Title
FR2736641B1 (fr) Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2730491B1 (fr) Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2736638B1 (fr) Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2730492B1 (fr) Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2742751B1 (fr) Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2727411B1 (fr) Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
DZ2009A1 (fr) Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2676446B1 (fr) Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2683531B1 (fr) Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
ZA96258B (en) New farnesyl tranferase inhibitors their preparation and the pharmaceutical compositions which contain them
FR2642069B1 (fr) Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2779724B1 (fr) Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757166B1 (fr) Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2687151B1 (fr) Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2745814B1 (fr) Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732342B1 (fr) Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2712288B1 (fr) Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2712289B1 (fr) Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2721021B1 (fr) Nouveaux inhibiteurs de farnésyl transférase, leur préparation et les compositions pharmaceutique qui les contiennent.
FR2705097B1 (fr) Nouveaux dérivés du lupane, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2705094B1 (fr) Nouveaux dérivés du lupane, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2721023B1 (fr) Nouveaux Taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2757855B1 (fr) Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2733498B1 (fr) Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
ST Notification of lapse