RU95104898A - Имидазолсодержащие ингибиторы фарнезид-протеинтрансферазы, способ лечения связанных с ней заболеваний - Google Patents

Имидазолсодержащие ингибиторы фарнезид-протеинтрансферазы, способ лечения связанных с ней заболеваний

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Publication number
RU95104898A
RU95104898A RU95104898/04A RU95104898A RU95104898A RU 95104898 A RU95104898 A RU 95104898A RU 95104898/04 A RU95104898/04 A RU 95104898/04A RU 95104898 A RU95104898 A RU 95104898A RU 95104898 A RU95104898 A RU 95104898A
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RU
Russia
Prior art keywords
independently
gis
phenyl
represented
alkyl
Prior art date
Application number
RU95104898/04A
Other languages
English (en)
Inventor
Т.Хант Джон
Us]
Original Assignee
Бристоль-Мейерз Сквибб Компани (US)
Бристоль-Мейерз Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристоль-Мейерз Сквибб Компани (US), Бристоль-Мейерз Сквибб Компани filed Critical Бристоль-Мейерз Сквибб Компани (US)
Publication of RU95104898A publication Critical patent/RU95104898A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Ингибирование фарнезил-трансферазы, которая представляет собой фермент, ответственный за экспрессию онкогена ras, осуществляют с помощью соединений общей формулы, данной в описании, или их энантиомеров, диастереомеров, фармацевтически приемлемых солей, пролекарственных предшественников, и сольватов.

Claims (1)

  1. Ингибирование фарнезил-трансферазы, которая представляет собой фермент, ответственный за экспрессию онкогена ras, осуществляют с помощью соединений общей формулы, данной в описании, или их энантиомеров, диастереомеров, фармацевтически приемлемых солей, пролекарственных предшественников, и сольватов.
RU95104898/04A 1994-03-31 1995-03-30 Имидазолсодержащие ингибиторы фарнезид-протеинтрансферазы, способ лечения связанных с ней заболеваний RU95104898A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22115394A 1994-03-31 1994-03-31
US29291694A 1994-08-19 1994-08-19
US292916 1994-08-19
US221153 1994-08-19

Publications (1)

Publication Number Publication Date
RU95104898A true RU95104898A (ru) 1996-12-27

Family

ID=26915545

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95104898/04A RU95104898A (ru) 1994-03-31 1995-03-30 Имидазолсодержащие ингибиторы фарнезид-протеинтрансферазы, способ лечения связанных с ней заболеваний

Country Status (13)

Country Link
EP (1) EP0675112A1 (ru)
JP (1) JPH07304750A (ru)
KR (1) KR950032174A (ru)
CN (1) CN1112117A (ru)
AU (1) AU1615895A (ru)
CA (1) CA2146059A1 (ru)
CZ (1) CZ82195A3 (ru)
FI (1) FI951554A (ru)
HU (1) HUT72440A (ru)
IL (1) IL113196A0 (ru)
NO (1) NO951266L (ru)
PL (1) PL307950A1 (ru)
RU (1) RU95104898A (ru)

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AU1615895A (en) 1995-10-12
HU9500934D0 (en) 1995-05-29
IL113196A0 (en) 1995-06-29
PL307950A1 (en) 1995-10-02
HUT72440A (en) 1996-04-29
FI951554A (fi) 1995-10-01
NO951266D0 (no) 1995-03-31
CN1112117A (zh) 1995-11-22
EP0675112A1 (en) 1995-10-04
NO951266L (no) 1995-10-02
JPH07304750A (ja) 1995-11-21
KR950032174A (ko) 1995-12-20
CZ82195A3 (en) 1996-09-11
FI951554A0 (fi) 1995-03-31
CA2146059A1 (en) 1995-10-01

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