DE69315920T2 - Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung - Google Patents
Kondensierte heterozyklische Verbindungen, deren Herstellung und VerwendungInfo
- Publication number
- DE69315920T2 DE69315920T2 DE69315920T DE69315920T DE69315920T2 DE 69315920 T2 DE69315920 T2 DE 69315920T2 DE 69315920 T DE69315920 T DE 69315920T DE 69315920 T DE69315920 T DE 69315920T DE 69315920 T2 DE69315920 T2 DE 69315920T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- optionally substituted
- substituted
- hydrogen atom
- hydrocarbon group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23748192 | 1992-09-04 | ||
JP10332893 | 1993-04-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69315920D1 DE69315920D1 (de) | 1998-02-05 |
DE69315920T2 true DE69315920T2 (de) | 1998-06-10 |
Family
ID=26443975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69315920T Expired - Fee Related DE69315920T2 (de) | 1992-09-04 | 1993-09-02 | Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung |
Country Status (13)
Country | Link |
---|---|
US (2) | US5482967A (de) |
EP (1) | EP0585913B1 (de) |
KR (1) | KR940007003A (de) |
CN (1) | CN1090274A (de) |
AT (1) | ATE161530T1 (de) |
AU (1) | AU667739B2 (de) |
CA (1) | CA2105518C (de) |
DE (1) | DE69315920T2 (de) |
FI (1) | FI933857A (de) |
HU (1) | HUT67284A (de) |
IL (1) | IL106908A0 (de) |
NO (1) | NO179904C (de) |
NZ (1) | NZ248583A (de) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0634169B1 (de) * | 1993-06-29 | 2000-01-05 | Takeda Chemical Industries, Ltd. | Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose |
EP0634402A1 (de) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinon-Derivate, ihre Herstellung und Verwendung |
AU674613B2 (en) * | 1993-09-28 | 1997-01-02 | Otsuka Pharmaceutical Co., Ltd. | Quinoxaline derivative as antidiabetic agent |
TW263498B (de) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
DE69533408T2 (de) * | 1994-05-27 | 2005-09-08 | Glaxosmithkline S.P.A. | Chinolinderivate als Tachykinin NK3 Rezeptor Antagonisten |
FR2725900B1 (fr) * | 1994-10-21 | 1997-07-18 | Sanofi Sa | Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice |
US5770590A (en) * | 1995-03-24 | 1998-06-23 | Takeda Chemical Industries, Ltd. | Cyclic compounds, their prudiction and use |
EP0733632B1 (de) * | 1995-03-24 | 2003-06-04 | Takeda Chemical Industries, Ltd. | Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten |
GB9524104D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
ID18046A (id) * | 1996-08-20 | 1998-02-19 | Takeda Chemical Industries Ltd | Senyawa siklik campuran, pembuatan dan penngunaannya. |
WO1998008836A1 (fr) | 1996-08-27 | 1998-03-05 | Shionogi & Co., Ltd. | Derives de chromene-3-carboxylate |
KR20000057548A (ko) * | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
AU6230098A (en) * | 1997-02-27 | 1998-09-18 | Tanabe Seiyaku Co., Ltd. | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors |
DE19755480A1 (de) * | 1997-12-13 | 1999-06-24 | Gruenenthal Gmbh | Substituierte heterocyclische Benzocycloalkene und ihre Verwendung als analgetisch wirksame Substanzen |
FR2772761B1 (fr) * | 1997-12-23 | 2000-05-26 | Lipha | Nouveaux derives de n-phenylamide et n-pyridylamide, leur procede de preparation et compositions pharmaceutiques les contenant |
RU2219924C2 (ru) * | 1998-04-14 | 2003-12-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ лечения нейропсихиатрических расстройств |
RU2309953C2 (ru) | 1999-11-03 | 2007-11-10 | Эймр Текнолоджи, Инк. | Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
FR2801310B1 (fr) * | 1999-11-24 | 2004-04-16 | Adir | NOUVEAUX DERIVES DE DIHYDROFURO-[3,4-b]QUINOLEIN-1-ONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
BR0112350A (pt) | 2000-07-11 | 2003-06-24 | Albany Molecular Res Inc | Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico |
PL360398A1 (en) * | 2000-07-13 | 2004-09-06 | Takeda Chemical Industries, Ltd. | Lipid-rich plaque inhibitors |
CA2421819C (en) * | 2000-09-20 | 2010-03-09 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
AU2002221116A1 (en) * | 2000-12-11 | 2002-06-24 | Takeda Chemical Industries Ltd. | Medicinal compositions having improved water-solubility |
BR0206831A (pt) | 2001-02-02 | 2004-07-06 | Takeda Chemical Industries Ltd | Composto, cristal, agente farmacêutico, agentes para profilaxia ou tratamento de diabetes, de complicações diabéticas, de tolerância prejudicada à glucose e de obesidade, inibidor de peptidase, uso de um composto, e, método de produção de um composto |
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US20040152727A1 (en) * | 2001-05-18 | 2004-08-05 | Hay Douglas William Pierre | Novel use |
CA2472419A1 (en) * | 2002-01-11 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Coumarin derivatives, process for their production and use thereof |
EP1484320A1 (de) * | 2002-02-13 | 2004-12-08 | Takeda Chemical Industries, Ltd. | Jnk-inhibitor |
FR2849653B1 (fr) * | 2003-01-08 | 2006-08-25 | B F B Etudes Et Rech S Experim | Derives de la coumarine ayant une affinite pour les recepteurs aux estrogenes, procede pour leur preparation et compositions pharmaceutiques en contenant |
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EP1904069B1 (de) | 2005-07-15 | 2018-06-13 | Albany Molecular Research, Inc. | Aryl- und heteroarylsubstituierte tetrahydrobenzazepine und verwendung damit zur wiederaufnahmeblockierung von norepinephrin, dopamin und serotonin |
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BR112012008849A2 (pt) | 2009-10-14 | 2015-09-22 | Schering Corp | composto, composição farmacêutica, e, uso de um composto |
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AU2016214102B2 (en) | 2015-02-03 | 2018-09-27 | Pfizer Inc. | Novel cyclopropabenzofuranyl pyridopyrazinediones |
TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
CN106946897B (zh) * | 2017-02-28 | 2018-10-23 | 牡丹江医学院 | 一种治疗胆囊炎的药物及其应用 |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
EP3833667B1 (de) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5-inhibitoren |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
US11731970B1 (en) | 2023-03-23 | 2023-08-22 | King Faisal University | Pyrrolo[2,3-b]quinoline compounds as antibacterial agents |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3509156A (en) * | 1967-12-08 | 1970-04-28 | American Home Prod | 1,2-dihydro-2-oxo-3-quinolineacetamides and related intermediates |
NO133758C (de) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
AU577105B2 (en) * | 1985-04-02 | 1988-09-15 | T.P.O. :Pharmachim: | Acylaminic penicillin derivatives |
IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
TW205037B (de) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
CA2075632C (en) * | 1990-02-10 | 2001-10-16 | Kanji Meguro | Chromene derivatives, their production and use |
JPH059179A (ja) * | 1990-09-27 | 1993-01-19 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及びacat阻害剤 |
ATE124408T1 (de) * | 1990-10-16 | 1995-07-15 | Takeda Chemical Industries Ltd | Heterozyklische aminderivate, deren herstellung und deren verwendung. |
IL99731A0 (en) * | 1990-10-18 | 1992-08-18 | Merck & Co Inc | Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them |
EP0634402A1 (de) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinon-Derivate, ihre Herstellung und Verwendung |
-
1993
- 1993-09-02 US US08/114,841 patent/US5482967A/en not_active Expired - Lifetime
- 1993-09-02 DE DE69315920T patent/DE69315920T2/de not_active Expired - Fee Related
- 1993-09-02 EP EP93114024A patent/EP0585913B1/de not_active Expired - Lifetime
- 1993-09-02 AT AT93114024T patent/ATE161530T1/de not_active IP Right Cessation
- 1993-09-02 NO NO933133A patent/NO179904C/no unknown
- 1993-09-03 HU HU9302499A patent/HUT67284A/hu unknown
- 1993-09-03 IL IL106908A patent/IL106908A0/xx unknown
- 1993-09-03 CA CA002105518A patent/CA2105518C/en not_active Expired - Fee Related
- 1993-09-03 AU AU46132/93A patent/AU667739B2/en not_active Ceased
- 1993-09-03 FI FI933857A patent/FI933857A/fi not_active Application Discontinuation
- 1993-09-04 KR KR1019930017737A patent/KR940007003A/ko not_active Application Discontinuation
- 1993-09-04 CN CN93118986A patent/CN1090274A/zh active Pending
- 1993-09-06 NZ NZ248583A patent/NZ248583A/en unknown
-
1995
- 1995-10-11 US US08/540,913 patent/US5700810A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FI933857A0 (fi) | 1993-09-03 |
US5482967A (en) | 1996-01-09 |
HUT67284A (en) | 1995-03-28 |
NO933133D0 (no) | 1993-09-02 |
HU9302499D0 (en) | 1993-11-29 |
AU667739B2 (en) | 1996-04-04 |
NZ248583A (en) | 1995-04-27 |
CA2105518A1 (en) | 1994-03-05 |
CA2105518C (en) | 2005-08-09 |
ATE161530T1 (de) | 1998-01-15 |
NO179904C (no) | 1997-01-08 |
EP0585913A2 (de) | 1994-03-09 |
NO933133L (no) | 1994-03-07 |
DE69315920D1 (de) | 1998-02-05 |
KR940007003A (ko) | 1994-04-26 |
NO179904B (no) | 1996-09-30 |
CN1090274A (zh) | 1994-08-03 |
EP0585913A3 (en) | 1994-05-25 |
US5700810A (en) | 1997-12-23 |
IL106908A0 (en) | 1993-12-28 |
EP0585913B1 (de) | 1997-12-29 |
AU4613293A (en) | 1994-03-10 |
FI933857A (fi) | 1994-05-17 |
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