MX2022000164A - Inhibidores de tirosina cinasa no receptora 1 (tnk1) y usos de los mismos. - Google Patents

Inhibidores de tirosina cinasa no receptora 1 (tnk1) y usos de los mismos.

Info

Publication number
MX2022000164A
MX2022000164A MX2022000164A MX2022000164A MX2022000164A MX 2022000164 A MX2022000164 A MX 2022000164A MX 2022000164 A MX2022000164 A MX 2022000164A MX 2022000164 A MX2022000164 A MX 2022000164A MX 2022000164 A MX2022000164 A MX 2022000164A
Authority
MX
Mexico
Prior art keywords
tnk1
receptor
tyrosine kinase
inhibitors
kinase non
Prior art date
Application number
MX2022000164A
Other languages
English (en)
Inventor
Jeyaprakashnarayanan Seenisamy
Steven L Warner
David J Bearss
Adam Siddiqui-Jain
Clifford J Whatcott
Original Assignee
Sumitomo Pharma Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma Oncology Inc filed Critical Sumitomo Pharma Oncology Inc
Publication of MX2022000164A publication Critical patent/MX2022000164A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención se refiere a un compuesto de Formula I: (ver Fórmula), o una sal farmacéuticamente aceptable del mismo, en donde los valores para las variables (por ejemplo, X1, X2, R1, R2, R3, R4, R5, R6, R7, R8, m, n) son como se describen en la presente. Compuestos de Formula I, sales de los mismos farmacéuticamente aceptable, composiciones farmacéuticas de cualquiera de los anteriores, y combinaciones de cualquiera de los anteriores pueden ser usados para tratar enfermedades, trastornos y condiciones mediados por tirosina cinasa no receptora 1 (TNK1).
MX2022000164A 2019-07-03 2020-07-02 Inhibidores de tirosina cinasa no receptora 1 (tnk1) y usos de los mismos. MX2022000164A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962870415P 2019-07-03 2019-07-03
US201962888149P 2019-08-16 2019-08-16
US201962934167P 2019-11-12 2019-11-12
PCT/US2020/040737 WO2021003417A1 (en) 2019-07-03 2020-07-02 Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
MX2022000164A true MX2022000164A (es) 2022-04-01

Family

ID=71738312

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022000164A MX2022000164A (es) 2019-07-03 2020-07-02 Inhibidores de tirosina cinasa no receptora 1 (tnk1) y usos de los mismos.

Country Status (9)

Country Link
US (1) US11529350B2 (es)
EP (1) EP3994132A1 (es)
JP (1) JP2022539208A (es)
KR (1) KR20220028075A (es)
CN (1) CN114302878A (es)
AU (1) AU2020300619A1 (es)
CA (1) CA3145864A1 (es)
MX (1) MX2022000164A (es)
WO (1) WO2021003417A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3941463A1 (en) 2019-03-22 2022-01-26 Sumitomo Dainippon Pharma Oncology, Inc. Compositions comprising pkm2 modulators and methods of treatment using the same
WO2021003417A1 (en) 2019-07-03 2021-01-07 Sumitomo Dainippon Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
EP4274567A1 (en) * 2021-01-05 2023-11-15 Sumitomo Pharma Oncology, Inc. Forms and formulations of a tyrosine kinase non-receptor 1 (tnk1) inhibitor
CN116063307A (zh) * 2021-10-29 2023-05-05 中国药科大学 Shp2与cdk4/6双靶点抑制化合物合成及其制备方法与应用

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