BR112013032552A2 - variantes de anticorpos monoclonais humanizados imunomoduladores - Google Patents

variantes de anticorpos monoclonais humanizados imunomoduladores

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Publication number
BR112013032552A2
BR112013032552A2 BR112013032552A BR112013032552A BR112013032552A2 BR 112013032552 A2 BR112013032552 A2 BR 112013032552A2 BR 112013032552 A BR112013032552 A BR 112013032552A BR 112013032552 A BR112013032552 A BR 112013032552A BR 112013032552 A2 BR112013032552 A2 BR 112013032552A2
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BR
Brazil
Prior art keywords
monoclonal antibody
antibody variants
immunomodulatory monoclonal
humanized
humanized immunomodulatory
Prior art date
Application number
BR112013032552A
Other languages
English (en)
Inventor
Schickler Michael
Rotem-Yehudar Rinat
Original Assignee
Curetech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curetech Ltd filed Critical Curetech Ltd
Publication of BR112013032552A2 publication Critical patent/BR112013032552A2/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
BR112013032552A 2011-07-24 2012-07-23 variantes de anticorpos monoclonais humanizados imunomoduladores BR112013032552A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161511055P 2011-07-24 2011-07-24
PCT/IL2012/050267 WO2013014668A1 (en) 2011-07-24 2012-07-23 Variants of humanized immunomodulatory monoclonal antibodies

Publications (1)

Publication Number Publication Date
BR112013032552A2 true BR112013032552A2 (pt) 2017-12-12

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BR112013032552A BR112013032552A2 (pt) 2011-07-24 2012-07-23 variantes de anticorpos monoclonais humanizados imunomoduladores

Country Status (12)

Country Link
US (2) US8686119B2 (pt)
EP (1) EP2734551B1 (pt)
JP (1) JP6240600B2 (pt)
KR (1) KR20140041598A (pt)
AU (1) AU2012288413B2 (pt)
BR (1) BR112013032552A2 (pt)
CA (1) CA2840018C (pt)
ES (1) ES2664622T3 (pt)
IL (1) IL230057A (pt)
LT (1) LT2734551T (pt)
RU (1) RU2604814C2 (pt)
WO (1) WO2013014668A1 (pt)

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