MX2021001804A - Compuestos de urea y composiciones como inhibidores de atpasa de smarca2/brm. - Google Patents

Compuestos de urea y composiciones como inhibidores de atpasa de smarca2/brm.

Info

Publication number
MX2021001804A
MX2021001804A MX2021001804A MX2021001804A MX2021001804A MX 2021001804 A MX2021001804 A MX 2021001804A MX 2021001804 A MX2021001804 A MX 2021001804A MX 2021001804 A MX2021001804 A MX 2021001804A MX 2021001804 A MX2021001804 A MX 2021001804A
Authority
MX
Mexico
Prior art keywords
smarca2
compositions
urea compounds
atpase inhibitors
brm
Prior art date
Application number
MX2021001804A
Other languages
English (en)
Inventor
Troy Douglas Smith
Christopher Adair
Julien Papillon
Katsumasa Nakajima
Rukundo Ntaganda
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2021001804A publication Critical patent/MX2021001804A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Se proporciona un compuesto de Fórmula (I), o una sal farmacéuticamente aceptable del mismo, que ha demostrado ser útil para el tratamiento de una enfermedad o un trastorno mediados por BRM y/o mediados por BRG1: (ver Fórmula) Fórmula (I) en donde R1 a R6 son como se define en la presente descripción.
MX2021001804A 2018-08-17 2019-08-12 Compuestos de urea y composiciones como inhibidores de atpasa de smarca2/brm. MX2021001804A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862765138P 2018-08-17 2018-08-17
PCT/IB2019/056847 WO2020035779A1 (en) 2018-08-17 2019-08-12 Urea compounds and compositions as smarca2/brm atpase inhibitors

Publications (1)

Publication Number Publication Date
MX2021001804A true MX2021001804A (es) 2021-04-19

Family

ID=68072895

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021001804A MX2021001804A (es) 2018-08-17 2019-08-12 Compuestos de urea y composiciones como inhibidores de atpasa de smarca2/brm.

Country Status (20)

Country Link
EP (2) EP4219488A1 (es)
JP (1) JP7328323B2 (es)
KR (1) KR20210047313A (es)
CN (1) CN112585136A (es)
AU (1) AU2019322325B2 (es)
BR (1) BR112021002632A2 (es)
CA (1) CA3107097A1 (es)
CY (1) CY1126039T1 (es)
DK (1) DK3837256T3 (es)
ES (1) ES2946060T3 (es)
FI (1) FI3837256T3 (es)
HR (1) HRP20230477T1 (es)
HU (1) HUE061963T2 (es)
LT (1) LT3837256T (es)
MX (1) MX2021001804A (es)
PL (1) PL3837256T3 (es)
PT (1) PT3837256T (es)
RS (1) RS64238B1 (es)
SI (1) SI3837256T1 (es)
WO (1) WO2020035779A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021512166A (ja) 2018-01-30 2021-05-13 フォグホーン セラピューティクス インコーポレイテッドＦｏｇｈｏｒｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 化合物及びその使用
AU2021213811A1 (en) 2020-01-29 2022-07-28 Foghorn Therapeutics Inc. Compounds and uses thereof
CN112979646B (zh) * 2021-03-08 2022-01-14 北京富龙康泰生物技术有限公司 一种咪唑并吡啶类衍生物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2779780A (en) 1955-03-01 1957-01-29 Du Pont 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
GB9823873D0 (en) * 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
JP2002532415A (ja) 1998-12-16 2002-10-02 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤による関節炎の治療
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
EE05450B1 (et) 2000-07-19 2011-08-15 Warner-Lambert Company 4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine
EP2308861B1 (en) 2002-03-08 2017-03-01 Eisai R&D Management Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
PT3000810T (pt) 2002-03-13 2017-10-25 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
MX2008002114A (es) 2005-07-21 2008-04-17 Ardea Biosciences Inc Inhibidores de n-(arilamino)-sulfonamida de mek.
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
BRPI0816769A2 (pt) 2007-09-12 2016-11-29 Hoffmann La Roche combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
ES2439705T3 (es) 2007-10-25 2014-01-24 Genentech, Inc. Proceso para la preparación de compuestos de tienopirimidina
MA41598A (fr) * 2015-02-25 2018-01-02 Constellation Pharmaceuticals Inc Composés thérapeutiques de pyridazine et leurs utilisations

Also Published As

Publication number Publication date
CY1126039T1 (el) 2023-11-15
KR20210047313A (ko) 2021-04-29
AU2019322325B2 (en) 2022-01-20
JP2021534147A (ja) 2021-12-09
US20210323956A1 (en) 2021-10-21
HUE061963T2 (hu) 2023-09-28
PT3837256T (pt) 2023-05-23
PL3837256T3 (pl) 2023-07-10
FI3837256T3 (fi) 2023-05-15
AU2019322325A1 (en) 2021-02-18
BR112021002632A2 (pt) 2021-05-11
EP4219488A1 (en) 2023-08-02
EP3837256A1 (en) 2021-06-23
DK3837256T3 (da) 2023-05-30
JP7328323B2 (ja) 2023-08-16
HRP20230477T1 (hr) 2023-07-21
CA3107097A1 (en) 2020-02-20
LT3837256T (lt) 2023-06-12
ES2946060T3 (es) 2023-07-12
SI3837256T1 (sl) 2023-07-31
RS64238B1 (sr) 2023-06-30
CN112585136A (zh) 2021-03-30
EP3837256B1 (en) 2023-03-08
WO2020035779A1 (en) 2020-02-20

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