JPH11504007A - 抗体精製 - Google Patents
抗体精製Info
- Publication number
- JPH11504007A JPH11504007A JP8531774A JP53177496A JPH11504007A JP H11504007 A JPH11504007 A JP H11504007A JP 8531774 A JP8531774 A JP 8531774A JP 53177496 A JP53177496 A JP 53177496A JP H11504007 A JPH11504007 A JP H11504007A
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibodies
- buffer
- column
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.抗体を含有する混合物を疎水相互作用クロマトグラフィーカラムに添加し 、そのカラムから約2.5〜4.5のpHを持つ緩衝液で抗体を溶出させることからなる 抗体の精製法。 2.カラムに添加する混合物のpHが約2.5〜4.5である請求項1の方法。 3.カラムに添加する混合物が約0〜0.25Mの塩濃度を持つ請求項1の方法。 4.カラムに添加する混合物が約0〜0.1Mの塩濃度を持つ請求項3の方法。 5.緩衝液が約0〜0.25Mの塩濃度を持つ請求項1の方法。 6.緩衝液が約0〜0.1Mの塩濃度を持つ請求項5の方法。 7.抗体がキメラである請求項1の方法。 8.抗体が擬人化されている請求項7の方法。 9.抗体が抗体断片からなる請求項1の方法。 10.抗体断片がF(ab')2断片からなる請求項9の方法。 11.緩衝液が約2.8〜3.5のpHを持つ請求項1の方法。 12.緩衝液が約3.1のpHを持つ請求項11の方法。 13.疎水相互作用クロマトグラフィーカラムがフェニルアガロースカラムで ある請求項1の方法。 14.精製される抗体が正しくジスルフィド結合している請求項1の方法。 15.不適切にジスルフィド結合した抗体から抗体を精製する請求項1の方法 。 16.不適切にジスルフィド結合した抗体が抗体断片である請求項15の方法 。 17.生理学的に許容できる担体中の請求項1の方法によって製造される抗体 からなる組成物。 18.抗体断片を含む請求項17の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/425,763 | 1995-04-20 | ||
US08/425,763 US5641870A (en) | 1995-04-20 | 1995-04-20 | Low pH hydrophobic interaction chromatography for antibody purification |
PCT/US1996/004683 WO1996033208A1 (en) | 1995-04-20 | 1996-04-05 | Antibody purification by low-ph hydrophobic interaction chromatoggraphy |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006135062A Division JP4091087B2 (ja) | 1995-04-20 | 2006-05-15 | 抗体精製 |
JP2006135061A Division JP4153533B2 (ja) | 1995-04-20 | 2006-05-15 | 抗体精製 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11504007A true JPH11504007A (ja) | 1999-04-06 |
JP4042868B2 JP4042868B2 (ja) | 2008-02-06 |
Family
ID=23687930
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53177496A Expired - Lifetime JP4042868B2 (ja) | 1995-04-20 | 1996-04-05 | 抗体精製 |
JP2006135061A Expired - Lifetime JP4153533B2 (ja) | 1995-04-20 | 2006-05-15 | 抗体精製 |
JP2006135062A Expired - Lifetime JP4091087B2 (ja) | 1995-04-20 | 2006-05-15 | 抗体精製 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006135061A Expired - Lifetime JP4153533B2 (ja) | 1995-04-20 | 2006-05-15 | 抗体精製 |
JP2006135062A Expired - Lifetime JP4091087B2 (ja) | 1995-04-20 | 2006-05-15 | 抗体精製 |
Country Status (16)
Country | Link |
---|---|
US (5) | US5641870A (ja) |
EP (2) | EP1752465B1 (ja) |
JP (3) | JP4042868B2 (ja) |
AT (2) | ATE510854T1 (ja) |
AU (1) | AU721736B2 (ja) |
CA (1) | CA2214633C (ja) |
DE (1) | DE69636733T2 (ja) |
DK (2) | DK1752465T3 (ja) |
ES (2) | ES2277344T3 (ja) |
HK (1) | HK1099310A1 (ja) |
IL (1) | IL117942A (ja) |
MX (1) | MX9707909A (ja) |
NZ (2) | NZ306718A (ja) |
PT (1) | PT821695E (ja) |
WO (1) | WO1996033208A1 (ja) |
ZA (1) | ZA962885B (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010516773A (ja) * | 2007-01-22 | 2010-05-20 | ジェネンテック, インコーポレイテッド | 多価電解質沈殿物及びタンパク質の精製 |
JP2015503524A (ja) * | 2011-12-22 | 2015-02-02 | ジェネンテック, インコーポレイテッド | イオン交換膜クロマトグラフィー |
WO2019088143A1 (ja) * | 2017-11-01 | 2019-05-09 | 中外製薬株式会社 | 生物活性が低下した抗体バリアントおよびアイソフォーム |
US11214623B2 (en) | 2014-09-26 | 2022-01-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody capable of neutralizing substance having activity alternative to function of coagulation factor VIII (FVIII) |
US11248053B2 (en) | 2007-09-26 | 2022-02-15 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
US11352438B2 (en) | 2016-09-06 | 2022-06-07 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X |
US11649262B2 (en) | 2015-12-28 | 2023-05-16 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
Families Citing this family (1112)
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SG43125A1 (en) * | 1993-10-27 | 1997-10-17 | Molex Inc | Shunted electrical connector |
US5641870A (en) * | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US20040121415A1 (en) * | 1996-12-10 | 2004-06-24 | King David John | Monovalent antibody fragments |
US8088386B2 (en) | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
AU760048B2 (en) | 1998-05-06 | 2003-05-08 | Genentech Inc. | Protein purification by ion exchange chromatography |
SI1308456T1 (sl) * | 1998-05-06 | 2008-02-29 | Genentech Inc | Ciscenje protiteles z ionsko izmenjevalno kromatografijo |
AU2003200708B2 (en) * | 1998-05-06 | 2007-01-04 | Genentech, Inc. | Protein purification |
CN100340575C (zh) | 1999-06-25 | 2007-10-03 | 杰南技术公司 | 人源化抗ErbB2抗体及其在制备药物中的应用 |
EP2283867B1 (en) | 1999-06-25 | 2014-05-21 | ImmunoGen, Inc. | Methods of treatment using anti-ERBB antibody-maytansinoid conjugates |
JP2001066308A (ja) * | 1999-07-29 | 2001-03-16 | Gsf Forschungszentrum Fuer Umwelt & Gesundheit Gmbh | IgG抗体の不可逆的損傷の検出 |
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US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
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