BR112016013896A2 - métodos de tratamento de câncer positivo para her2 usando antagonistas de ligação do eixo de pd-1 e anticorpos anti-her2 - Google Patents
métodos de tratamento de câncer positivo para her2 usando antagonistas de ligação do eixo de pd-1 e anticorpos anti-her2Info
- Publication number
- BR112016013896A2 BR112016013896A2 BR112016013896A BR112016013896A BR112016013896A2 BR 112016013896 A2 BR112016013896 A2 BR 112016013896A2 BR 112016013896 A BR112016013896 A BR 112016013896A BR 112016013896 A BR112016013896 A BR 112016013896A BR 112016013896 A2 BR112016013896 A2 BR 112016013896A2
- Authority
- BR
- Brazil
- Prior art keywords
- her2
- axis binding
- cancer treatment
- treatment methods
- positive cancer
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 101150029707 ERBB2 gene Proteins 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
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- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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Abstract
a invenção fornece composições e métodos para tratar cânceres positivos para her2. o método compreende administrar um antagonista da ligação do eixo de pd-1 e um anticorpo direcionado para her2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361917264P | 2013-12-17 | 2013-12-17 | |
PCT/US2014/070992 WO2015095418A1 (en) | 2013-12-17 | 2014-12-17 | Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016013896A2 true BR112016013896A2 (pt) | 2017-10-10 |
Family
ID=52293262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112016013896A BR112016013896A2 (pt) | 2013-12-17 | 2014-12-17 | métodos de tratamento de câncer positivo para her2 usando antagonistas de ligação do eixo de pd-1 e anticorpos anti-her2 |
Country Status (27)
Country | Link |
---|---|
US (9) | US10570213B2 (pt) |
EP (4) | EP3083692B1 (pt) |
JP (5) | JP2017507900A (pt) |
KR (4) | KR20240017102A (pt) |
CN (3) | CN112353943A (pt) |
AU (3) | AU2014364601A1 (pt) |
BR (1) | BR112016013896A2 (pt) |
CA (2) | CA2931812A1 (pt) |
DK (1) | DK3083686T4 (pt) |
ES (1) | ES2763429T5 (pt) |
FI (1) | FI3083686T4 (pt) |
HK (1) | HK1225634A1 (pt) |
HR (1) | HRP20192288T4 (pt) |
HU (1) | HUE047699T2 (pt) |
IL (3) | IL296657A (pt) |
LT (1) | LT3083686T (pt) |
MX (3) | MX2016007972A (pt) |
MY (1) | MY189089A (pt) |
NZ (2) | NZ760065A (pt) |
PL (1) | PL3083686T5 (pt) |
PT (1) | PT3083686T (pt) |
RS (1) | RS59659B2 (pt) |
RU (1) | RU2719487C2 (pt) |
SG (4) | SG10202002334PA (pt) |
SI (1) | SI3083686T2 (pt) |
WO (2) | WO2015095418A1 (pt) |
ZA (1) | ZA201603753B (pt) |
Families Citing this family (124)
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TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
KR20210060670A (ko) | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도 |
KR101681818B1 (ko) | 2011-08-23 | 2016-12-01 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
CA2879768A1 (en) | 2012-10-08 | 2014-04-17 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
CN110845618A (zh) | 2013-02-26 | 2020-02-28 | 罗切格利卡特公司 | 双特异性t细胞活化抗原结合分子 |
RS59992B1 (sr) | 2013-02-26 | 2020-04-30 | Roche Glycart Ag | Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije specifični za cd3 i cea |
BR112015024926A2 (pt) | 2013-04-16 | 2017-10-10 | Genentech Inc | composições, artigo de fabricação, métodos para tratar um paciente com câncer, para avaliar uma composição, para avaliar a atividade biológica, para produzir uma composição e para avaliar a fragmentação de uma composição e variante de pertuzumabe |
ES2822665T3 (es) * | 2013-05-31 | 2021-05-04 | Merck Sharp & Dohme | Terapias de combinación para el cáncer |
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- 2014-12-17 EP EP14833308.1A patent/EP3083692B1/en active Active
- 2014-12-17 HU HUE14824700A patent/HUE047699T2/hu unknown
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- 2014-12-17 IL IL296657A patent/IL296657A/en unknown
- 2014-12-17 RU RU2016126662A patent/RU2719487C2/ru active
- 2014-12-17 DK DK14824700.0T patent/DK3083686T4/da active
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