JOP20190009A1 - أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها - Google Patents
أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامهاInfo
- Publication number
- JOP20190009A1 JOP20190009A1 JOP/2019/0009A JOP20190009A JOP20190009A1 JO P20190009 A1 JOP20190009 A1 JO P20190009A1 JO P20190009 A JOP20190009 A JO P20190009A JO P20190009 A1 JOP20190009 A1 JO P20190009A1
- Authority
- JO
- Jordan
- Prior art keywords
- polypeptide
- extracellular domain
- alpha
- human
- sirp
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/00—Immunoglobulins specific features
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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Abstract
<strong>يتعلق الاختراع الحالي، ضمن أشياء اخرى، بأجسام مضاد معزولة تربط نطاق خارج الخلية لبولي ببتيد</strong> <span dir="LTR">SIRP- alpha v1</span><strong> بشري (على سبيل المثال، نطاق </strong><span dir="LTR">D1</span><strong>)، نطاق خارج الخلية لبولي ببتيد </strong><span dir="LTR">SIRP- alpha v2</span><strong> بشري، أو كلاهما. في بعض النماذج، تربط الأجسام المضادة أيضاً نطاق خارج الخلية لبولي ببتيد </strong><span dir="LTR">SIRP- alpha</span><strong> قرد، نطاق خارج الخلية لبولي ببتيد </strong><span dir="LTR">SIRP- alpha</span><strong> فأري، نطاق خارج الخلية لبولي ببتيد </strong><span dir="LTR">SIRP-beta</span><strong> بشري، و/ أو نطاق خارج الخلية لبولي ببتيد </strong> <span dir="LTR">SIRP-</span><span dir="LTR">-gama</span><strong>بشري. في بعض النماذج، تمنع الأجسام المضادة أو لا تربط بين نطاق خارج الخلية لبولي ببتيد </strong><span dir="LTR">SIRP- alpha</span><strong> بشري ونطاق </strong><span dir="LTR">IgSF</span><strong> لبولي ببتيد </strong><span dir="LTR">CD47</span><strong> بشري، بينما في بعض النماذج، تخفض الأجسام المضادة ألفة بولي ببتيد </strong><span dir="LTR">SIRP- alpha</span><strong> بشري لربط نطاق </strong><span dir="LTR">IgSF</span><strong> لبولي ببتيد </strong><span dir="LTR">CD47</span><strong> بشري. يتم في هذه الوثيقة أيضاً تقديم طرق، بولي نيوكليوتيدات، نواقل، وخلايا مضيفة متعلقة بها.</strong>
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662397752P | 2016-09-21 | 2016-09-21 | |
US201762515480P | 2017-06-05 | 2017-06-05 | |
PCT/US2017/052592 WO2018057669A1 (en) | 2016-09-21 | 2017-09-20 | Antibodies against signal-regulatory protein alpha and methods of use |
Publications (1)
Publication Number | Publication Date |
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JOP20190009A1 true JOP20190009A1 (ar) | 2019-01-27 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JOP/2019/0009A JOP20190009A1 (ar) | 2016-09-21 | 2017-06-16 | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
Country Status (32)
Country | Link |
---|---|
US (4) | US11401338B2 (ar) |
EP (2) | EP4119580A1 (ar) |
JP (2) | JP7181874B2 (ar) |
KR (1) | KR102601298B1 (ar) |
CN (2) | CN117756937A (ar) |
AU (1) | AU2017332285A1 (ar) |
BR (1) | BR112019003027A2 (ar) |
CA (1) | CA3034480A1 (ar) |
CL (2) | CL2019000668A1 (ar) |
CO (1) | CO2019003809A2 (ar) |
DK (1) | DK3515490T3 (ar) |
ES (1) | ES2932602T3 (ar) |
GE (2) | GEP20237480B (ar) |
HR (1) | HRP20221323T1 (ar) |
HU (1) | HUE060170T2 (ar) |
IL (2) | IL297891B1 (ar) |
JO (1) | JOP20190009A1 (ar) |
LT (1) | LT3515490T (ar) |
MA (1) | MA46290A (ar) |
MX (1) | MX2019003168A (ar) |
MY (1) | MY197854A (ar) |
PE (1) | PE20190575A1 (ar) |
PH (1) | PH12019500600A1 (ar) |
PL (1) | PL3515490T3 (ar) |
PT (1) | PT3515490T (ar) |
RS (1) | RS63658B1 (ar) |
SA (1) | SA519401371B1 (ar) |
SG (1) | SG10201912878UA (ar) |
SI (1) | SI3515490T1 (ar) |
UA (1) | UA126281C2 (ar) |
WO (1) | WO2018057669A1 (ar) |
ZA (1) | ZA201900937B (ar) |
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US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
EP3913051A1 (en) | 2015-08-07 | 2021-11-24 | ALX Oncology Inc. | Constructs having a sirp-alpha domain or variant thereof |
JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
CN110325549B (zh) | 2016-12-09 | 2024-03-08 | 艾利妥 | 抗SIRPα抗体及其使用方法 |
MA47494A (fr) * | 2017-02-17 | 2019-12-25 | Ose Immunotherapeutics | Nouvelles utilisations d'anticorps anti-sirpg |
WO2018190719A2 (en) | 2017-04-13 | 2018-10-18 | Aduro Biotech Holdings, Europe B.V. | Anti-sirp alpha antibodies |
CA3071860A1 (en) | 2017-08-02 | 2019-02-07 | Phanes Therapeutics, Inc. | Anti-cd47 antibodies and uses thereof |
US11292850B2 (en) | 2018-03-21 | 2022-04-05 | ALX Oncology Inc. | Antibodies against signal-regulatory protein α and methods of use |
US20210380698A1 (en) * | 2018-04-09 | 2021-12-09 | Origincell Therapeutics Co., Ltd. | Anti-pd-l1 antibody and use thereof |
CA3097193A1 (en) * | 2018-05-08 | 2019-11-14 | Phanes Therapeutics, Inc. | Anti-dll3 antibodies and uses thereof |
BR112020023844A2 (pt) | 2018-05-25 | 2021-04-13 | Alector Llc | Anticorpos, métodos de tratamento do câncer e de produção de um anticorpo, ácido nucleico, vetor, células hospedeiras e composição farmacêutica |
CN110577597B (zh) * | 2018-06-11 | 2021-10-22 | 康诺亚生物医药科技(成都)有限公司 | 一种阻断CD47和SIRPα相互作用的抗体 |
TW202035449A (zh) * | 2018-07-10 | 2020-10-01 | 國立大學法人神戶大學 | 抗SIRPα抗體 |
EP3833391A4 (en) * | 2018-08-08 | 2022-08-10 | Orionis Biosciences, Inc. | CHIMERIC PROTEINS TARGETED AT SIRP1alpha AND THEIR USES |
CN110878123B (zh) * | 2018-09-05 | 2022-08-23 | 华瑞同康生物技术(深圳)有限公司 | 一种抗tk1原核重组单链抗体及制备方法 |
CA3113798A1 (en) * | 2018-09-27 | 2020-04-02 | Celgene Corporation | Sirp.alpha. binding proteins and methods of use thereof |
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TW202035449A (zh) | 2018-07-10 | 2020-10-01 | 國立大學法人神戶大學 | 抗SIRPα抗體 |
US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
CA3119748A1 (en) | 2018-11-14 | 2020-05-22 | Arch Oncology, Inc. | Therapeutic sirp.alpha. antibodies |
MX2021005761A (es) | 2018-11-15 | 2021-08-11 | Byondis Bv | Anticuerpos anti-proteína alfa reguladora de señal (anti-sirpalfa) humanizados. |
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