JP6215938B2 - プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物 - Google Patents

プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物 Download PDF

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JP6215938B2
JP6215938B2 JP2015526540A JP2015526540A JP6215938B2 JP 6215938 B2 JP6215938 B2 JP 6215938B2 JP 2015526540 A JP2015526540 A JP 2015526540A JP 2015526540 A JP2015526540 A JP 2015526540A JP 6215938 B2 JP6215938 B2 JP 6215938B2
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alkyl
hydrogen
specific cases
halo
compound
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JP2015524468A (ja
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シャオ シュ，
シャオ シュ，
シャオボ ワン，
シャオボ ワン，
ロン マオ，
ロン マオ，
リ ザオ，
リ ザオ，
ビアオ シ，
ビアオ シ，
Original Assignee
エイシア バイオサイエンシーズ インコーポレイテッド
エイシア バイオサイエンシーズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
JP2015526540A 2012-08-06 2013-07-11 プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物 Active JP6215938B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261680231P 2012-08-06 2012-08-06
US61/680,231 2012-08-06
US13/843,554 2013-03-15
US13/843,554 US9034885B2 (en) 2012-01-13 2013-03-15 EGFR modulators and uses thereof
US201361814147P 2013-04-19 2013-04-19
US61/814,147 2013-04-19
US13/917,514 2013-06-13
US13/917,514 US8685988B2 (en) 2012-08-06 2013-06-13 EGFR modulators and uses thereof
PCT/US2013/050163 WO2014025486A1 (fr) 2012-08-06 2013-07-11 Nouveaux composés de pyrrolopyrimidine utilisés en tant qu'inhibiteurs des protéines kinases

Related Child Applications (1)

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JP2017005935A Division JP2017061581A (ja) 2012-08-06 2017-01-17 プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物

Publications (2)

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JP2015524468A JP2015524468A (ja) 2015-08-24
JP6215938B2 true JP6215938B2 (ja) 2017-10-18

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JP2015526540A Active JP6215938B2 (ja) 2012-08-06 2013-07-11 プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物
JP2017005935A Withdrawn JP2017061581A (ja) 2012-08-06 2017-01-17 プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物

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JP2017005935A Withdrawn JP2017061581A (ja) 2012-08-06 2017-01-17 プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物

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EP (2) EP2880035B9 (fr)
JP (2) JP6215938B2 (fr)
KR (1) KR102181365B1 (fr)
CN (2) CN107266453B (fr)
AU (1) AU2013300106B2 (fr)
BR (1) BR112015002709B1 (fr)
CA (1) CA2881275C (fr)
CY (1) CY1120844T1 (fr)
DK (1) DK2880035T3 (fr)
ES (2) ES2618007T3 (fr)
HK (1) HK1210471A1 (fr)
HR (1) HRP20170311T1 (fr)
HU (1) HUE031955T2 (fr)
IN (1) IN2015DN00914A (fr)
LT (1) LT2880035T (fr)
MX (1) MX361992B (fr)
NZ (1) NZ629807A (fr)
PT (1) PT2880035T (fr)
RU (2) RU2018104702A (fr)
SG (1) SG11201500872SA (fr)
WO (1) WO2014025486A1 (fr)
ZA (2) ZA201500762B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015503625A (ja) * 2012-01-13 2015-02-02 エイシア バイオサイエンシーズ インコーポレイテッド 抗がん剤としての複素環式化合物およびその使用
US10449196B2 (en) 2012-08-06 2019-10-22 ACEA Therapeutics, Inc. EGFR modulators and uses thereof
US10533011B2 (en) 2015-10-09 2020-01-14 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
US10562918B2 (en) 2013-07-11 2020-02-18 ACEA Therapeutics, Inc. Heterocyclic compounds and uses thereof
US11498922B2 (en) 2017-04-07 2022-11-15 ACEA Therapeutics, Inc. Pharmaceutical composition comprising N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenylacrylamide

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013013188A1 (fr) 2011-07-21 2013-01-24 Tolero Pharmaceuticals, Inc. Inhibiteurs de protéine kinase hétérocycliques
US9464089B2 (en) 2012-01-13 2016-10-11 Acea Biosciences Inc. Heterocyclic compounds and uses thereof
SG11201505446WA (en) 2013-01-16 2015-08-28 Signal Pharm Llc Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
WO2014151871A2 (fr) * 2013-03-14 2014-09-25 Tolero Pharmaceuticals, Inc. Inhibiteurs de jak2 et alk2 et leurs procédés d'utilisation
WO2015127234A1 (fr) * 2014-02-20 2015-08-27 Board Of Regents, The University Of Texas System Utilisation d'ibrutinib pour le traitement du cancer à mutation de l'egfr
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
KR20170024120A (ko) 2014-07-14 2017-03-06 시그날 파마소티칼 엘엘씨 치환된 피롤로피리미딘 화합물을 사용한 암의 치료방법, 이의 조성물
CA2976109A1 (fr) 2015-02-13 2016-08-18 Dana-Farber Cancer Institute, Inc. Pyrrolopyrimidine substituee, pyrazolopyrimidine et derives de purine, et utilisation connexe comme inhibiteurs de lrrk2
JP2018104290A (ja) * 2015-04-28 2018-07-05 アステラス製薬株式会社 ピラジンカルボキサミド化合物を有効成分とする医薬組成物
WO2016173438A1 (fr) * 2015-04-29 2016-11-03 南京明德新药研发股份有限公司 Composé aryl-pyrimidine tricyclique ou à cycle fusionné utilisé comme inhibiteur de kinase
WO2017011720A1 (fr) * 2015-07-16 2017-01-19 Signal Pharmaceuticals, Llc 4-((4(cyclopentyloxy)-5-méthylbenzo[d]oxazol-6-yl)-17h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-méthoxy-n-méthylbenzamide sous forme solide, compositions correspondantes et procédés d'utilisation correspondants
CN105646496B (zh) * 2016-01-20 2018-07-20 华侨大学 一种7H-吡咯并[2,3-d]嘧啶衍生物、其合成方法及应用
CN107540661A (zh) * 2016-06-24 2018-01-05 正大天晴药业集团股份有限公司 作为egfr抑制剂的苯胺嘧啶化合物的结晶
CN107663208B (zh) * 2016-07-27 2021-10-15 南京圣和药业股份有限公司 一种新型egfr激酶抑制剂的药用盐及其制备方法与用途
CN107663207B (zh) * 2016-07-27 2021-07-30 南京圣和药业股份有限公司 一种egfr激酶抑制剂的甲磺酸盐结晶及制备方法
CN107955019B (zh) * 2016-10-17 2021-09-14 广东众生药业股份有限公司 一种egfr抑制剂的盐型、晶型及其制备方法
CN106749266B (zh) * 2016-11-14 2019-01-22 山东大学 吡咯并[2,3-d]嘧啶类化合物的高效制备方法
CN108299419B (zh) * 2017-01-11 2022-04-26 南京圣和药业股份有限公司 一种新型egfr激酶抑制剂的几种新晶型及其制备方法
JP7164203B2 (ja) 2017-02-08 2022-11-01 中国医▲薬▼研究▲開▼▲発▼中心有限公司 ピロロ芳香族複素環化合物及びその製造方法並びに医薬用途
CN109422751B (zh) * 2017-09-03 2022-04-22 上海美志医药科技有限公司 一类具有降解酪氨酸蛋白激酶jak3活性的化合物
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
AU2018394997B2 (en) * 2017-12-28 2021-02-04 Daewoong Pharmaceutical Co., Ltd. Oxy-fluoropiperidine derivative as kinase inhibitor
KR102577242B1 (ko) * 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체
KR102577241B1 (ko) * 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체
WO2019195753A1 (fr) 2018-04-05 2019-10-10 Tolero Pharmaceuticals, Inc. Inhibiteurs de kinases axl et leur utilisation
CA3095580A1 (fr) 2018-04-13 2019-10-17 Sumitomo Dainippon Pharma Oncology, Inc. Inhibiteurs de kinase pim pour le traitement de neoplasmes myeloproliferatifs et de fibrose associee au cancer
CN108530450B (zh) * 2018-05-03 2021-03-30 赖建智 具有egfr抑制活性的化合物、制备方法及其在疾病治疗中的应用
JP2021530554A (ja) 2018-07-26 2021-11-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 異常なａｃｖｒ１発現を伴う疾患を処置するための方法およびそこで使用するためのａｃｖｒ１阻害剤
EP3613738A1 (fr) * 2018-08-23 2020-02-26 Lead Discovery Center GmbH 4-substitué pyrrolo[2,3-b] pyridine en tant que modulateurs erbb utiles pour le traitement du cancer
AU2020221247A1 (en) 2019-02-12 2021-08-05 Sumitomo Pharma Oncology, Inc. Formulations comprising heterocyclic protein kinase inhibitors
CN111747950B (zh) * 2019-03-29 2024-01-23 深圳福沃药业有限公司 用于治疗癌症的嘧啶衍生物
CN110407840A (zh) * 2019-08-15 2019-11-05 重庆化工职业学院 一种艾维替尼的制备方法
JP7473642B2 (ja) * 2019-11-13 2024-04-23 ジャージアン・ロングチャーム・バイオ－テック・ファーマ・カンパニー・リミテッド Ｂｔｋ阻害剤としてのピロロピリミジン系化合物およびその使用
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
WO2021147952A1 (fr) * 2020-01-21 2021-07-29 江苏先声药业有限公司 Composé pyrimidopyrrole
CN111848631B (zh) * 2020-08-28 2022-04-19 四川大学华西医院 一种靶向EGFR突变的吡咯并[2,3-d]嘧啶衍生物及其制备方法和用途
WO2022140246A1 (fr) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Procédés et composés destinés à l'autophagie ciblée
CN114957248B (zh) * 2022-05-09 2023-12-29 南开大学 一种吡咯并嘧啶化合物及其制备方法、药物组合物和应用
CN115611989B (zh) * 2022-10-09 2023-08-01 武汉理工大学 机械活化淀粉衍生物抑制剂的优化制备方法及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563905A (en) 1992-09-24 1996-10-08 Hughes Aircraft Company Network communication system having time-sliced protocol
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US7468255B2 (en) 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7732127B2 (en) 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
AU2003267998A1 (en) 2002-07-20 2004-02-09 Acea Biosciences, Inc. Impedance based devices and methods for use in assays
CA2550274A1 (fr) 2003-11-12 2005-05-26 Acea Biosciences, Inc. Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules
ES2381962T3 (es) * 2005-09-21 2012-06-04 4Sc Ag Nuevos sulfonilpirroles como inhibidores de las HDAC
EP2440559B1 (fr) * 2009-05-05 2018-01-10 Dana-Farber Cancer Institute, Inc. Inhibiteurs d'egfr et procédés de traitement de troubles
WO2011079231A1 (fr) * 2009-12-23 2011-06-30 Gatekeeper Pharmaceutical, Inc. Composés qui modulent l'activité egfr et des procédés pour traiter ou prévenir des affections avec ceux-ci

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015503625A (ja) * 2012-01-13 2015-02-02 エイシア バイオサイエンシーズ インコーポレイテッド 抗がん剤としての複素環式化合物およびその使用
US10596174B2 (en) 2012-01-13 2020-03-24 ACEA Therapeutics, Inc. Pyrrolopyrimidine compounds as inhibitors of protein kinases
US10449196B2 (en) 2012-08-06 2019-10-22 ACEA Therapeutics, Inc. EGFR modulators and uses thereof
US11007197B2 (en) 2012-08-06 2021-05-18 ACEA Therapeutics, Inc. EGFR modulators and uses thereof
US10562918B2 (en) 2013-07-11 2020-02-18 ACEA Therapeutics, Inc. Heterocyclic compounds and uses thereof
US10533011B2 (en) 2015-10-09 2020-01-14 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
US11498922B2 (en) 2017-04-07 2022-11-15 ACEA Therapeutics, Inc. Pharmaceutical composition comprising N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenylacrylamide

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Publication number Publication date
ES2618007T3 (es) 2017-06-20
WO2014025486A1 (fr) 2014-02-13
ZA201600648B (en) 2021-09-29
SG11201500872SA (en) 2015-03-30
KR102181365B1 (ko) 2020-11-23
EP2880035B9 (fr) 2017-05-17
IN2015DN00914A (fr) 2015-06-12
CN103748096B (zh) 2017-10-20
ZA201500762B (en) 2021-09-29
AU2013300106B2 (en) 2017-11-30
MX361992B (es) 2018-12-19
CA2881275C (fr) 2020-10-20
JP2017061581A (ja) 2017-03-30
RU2645672C2 (ru) 2018-02-27
CY1120844T1 (el) 2019-12-11
BR112015002709B1 (pt) 2022-09-20
CN103748096A (zh) 2014-04-23
MX2015001715A (es) 2015-07-06
DK2880035T3 (en) 2017-03-06
KR20150068949A (ko) 2015-06-22
EP3170825B1 (fr) 2019-04-10
RU2018104702A (ru) 2019-02-22
AU2013300106A1 (en) 2015-02-19
HUE031955T2 (en) 2017-08-28
LT2880035T (lt) 2017-03-27
NZ629807A (en) 2017-04-28
HRP20170311T1 (hr) 2017-04-21
EP2880035A1 (fr) 2015-06-10
BR112015002709A2 (pt) 2017-07-04
PT2880035T (pt) 2017-03-10
CN107266453B (zh) 2020-02-07
CN107266453A (zh) 2017-10-20
RU2015107831A (ru) 2016-09-27
EP2880035B1 (fr) 2016-12-07
EP3170825A1 (fr) 2017-05-24
CA2881275A1 (fr) 2014-02-13
ES2733576T3 (es) 2019-12-02
JP2015524468A (ja) 2015-08-24
HK1210471A1 (en) 2016-04-22

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