CN101389622B - 用作pi-3激酶抑制剂的嘧啶衍生物 - Google Patents
用作pi-3激酶抑制剂的嘧啶衍生物 Download PDFInfo
- Publication number
- CN101389622B CN101389622B CN2007800063742A CN200780006374A CN101389622B CN 101389622 B CN101389622 B CN 101389622B CN 2007800063742 A CN2007800063742 A CN 2007800063742A CN 200780006374 A CN200780006374 A CN 200780006374A CN 101389622 B CN101389622 B CN 101389622B
- Authority
- CN
- China
- Prior art keywords
- pyrimidine
- compound
- amine
- unsubstituted
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *CCc1c[s]c(N)n1 Chemical compound *CCc1c[s]c(N)n1 0.000 description 2
- LMMZXVJDJDOXEA-UHFFFAOYSA-N COc1cc2cc([N+]([O-])=O)cnc2cc1 Chemical compound COc1cc2cc([N+]([O-])=O)cnc2cc1 LMMZXVJDJDOXEA-UHFFFAOYSA-N 0.000 description 2
- WCUWHUUPGXCMMQ-UHFFFAOYSA-N NC(N1CCOCC1)=N Chemical compound NC(N1CCOCC1)=N WCUWHUUPGXCMMQ-UHFFFAOYSA-N 0.000 description 2
- YMJZAWIPQKVWDM-UHFFFAOYSA-N Bc(cnc(N)n1)c1OC Chemical compound Bc(cnc(N)n1)c1OC YMJZAWIPQKVWDM-UHFFFAOYSA-N 0.000 description 1
- WZNXEJSXXBACEB-UHFFFAOYSA-N C=CCNc(nccc1)c1F Chemical compound C=CCNc(nccc1)c1F WZNXEJSXXBACEB-UHFFFAOYSA-N 0.000 description 1
- SPSBENJFJRVTFF-UHFFFAOYSA-N C=CCNc1nccc(F)c1 Chemical compound C=CCNc1nccc(F)c1 SPSBENJFJRVTFF-UHFFFAOYSA-N 0.000 description 1
- FTUTUCGRIBWLGG-CQSZACIVSA-N CC(C)(C)OC(N(CC1)C[C@@H]1Oc1cc(-c2c(C(F)(F)F)cc(N)nc2)nc(N2CCOCC2)n1)=O Chemical compound CC(C)(C)OC(N(CC1)C[C@@H]1Oc1cc(-c2c(C(F)(F)F)cc(N)nc2)nc(N2CCOCC2)n1)=O FTUTUCGRIBWLGG-CQSZACIVSA-N 0.000 description 1
- WVYZDRRGQXGCSC-GFCCVEGCSA-N CC(C)(C)OC(N(CC1)C[C@@H]1Oc1cc(Cl)nc(N2CCOCC2)n1)=O Chemical compound CC(C)(C)OC(N(CC1)C[C@@H]1Oc1cc(Cl)nc(N2CCOCC2)n1)=O WVYZDRRGQXGCSC-GFCCVEGCSA-N 0.000 description 1
- OSKJHGOPHONCKP-UHFFFAOYSA-N CC(C)N(CC1)CCC1Oc(ccc([N+]([O-])=O)c1)c1OC Chemical compound CC(C)N(CC1)CCC1Oc(ccc([N+]([O-])=O)c1)c1OC OSKJHGOPHONCKP-UHFFFAOYSA-N 0.000 description 1
- WJKGLEPYSVEMMR-CYBMUJFWSA-N CC(N(CC1)C[C@@H]1Oc1cc(-c2c(C(F)(F)F)cc(N)nc2)nc(N2CCOCC2)n1)=O Chemical compound CC(N(CC1)C[C@@H]1Oc1cc(-c2c(C(F)(F)F)cc(N)nc2)nc(N2CCOCC2)n1)=O WJKGLEPYSVEMMR-CYBMUJFWSA-N 0.000 description 1
- YNMQQUCRKYWTKS-UHFFFAOYSA-N CC1NC(N)=CC(C(F)(F)F)=C1c1nc(N2CCOCC2)nc(Cl)c1 Chemical compound CC1NC(N)=CC(C(F)(F)F)=C1c1nc(N2CCOCC2)nc(Cl)c1 YNMQQUCRKYWTKS-UHFFFAOYSA-N 0.000 description 1
- GLNLFDLKKALVQA-GDNBJRDFSA-N CC[N](C)(CC)CCc1c[s]c(NC(C)N/C(/N)=C\C(C(F)(F)F)=C)n1 Chemical compound CC[N](C)(CC)CCc1c[s]c(NC(C)N/C(/N)=C\C(C(F)(F)F)=C)n1 GLNLFDLKKALVQA-GDNBJRDFSA-N 0.000 description 1
- UINDRJHZBAGQFD-UHFFFAOYSA-N CCc1ncc[n]1C Chemical compound CCc1ncc[n]1C UINDRJHZBAGQFD-UHFFFAOYSA-N 0.000 description 1
- XCGCQVZPKPJXMM-UHFFFAOYSA-N CNC(N1CCOCC1)=N Chemical compound CNC(N1CCOCC1)=N XCGCQVZPKPJXMM-UHFFFAOYSA-N 0.000 description 1
- WKGIMWHCYZIRAT-UHFFFAOYSA-N COc1cc([N+]([O-])=O)ccc1OC1CCNCC1 Chemical compound COc1cc([N+]([O-])=O)ccc1OC1CCNCC1 WKGIMWHCYZIRAT-UHFFFAOYSA-N 0.000 description 1
- VHKHDKZNEHKDNO-UHFFFAOYSA-N COc1ccc2ncc(N)cc2c1 Chemical compound COc1ccc2ncc(N)cc2c1 VHKHDKZNEHKDNO-UHFFFAOYSA-N 0.000 description 1
- YNXLSFXQTQKQEF-UHFFFAOYSA-N COc1ccnc(N)n1 Chemical compound COc1ccnc(N)n1 YNXLSFXQTQKQEF-UHFFFAOYSA-N 0.000 description 1
- ZAXYBSACYXUCEB-UHFFFAOYSA-N C[n](cc1)cc1NC(OCc1ccccc1)=O Chemical compound C[n](cc1)cc1NC(OCc1ccccc1)=O ZAXYBSACYXUCEB-UHFFFAOYSA-N 0.000 description 1
- FGYADSCZTQOAFK-UHFFFAOYSA-N C[n]1c(cccc2)c2nc1 Chemical compound C[n]1c(cccc2)c2nc1 FGYADSCZTQOAFK-UHFFFAOYSA-N 0.000 description 1
- XAUBEYHIVLSHOG-UHFFFAOYSA-N C[n]1c(nccc2)c2nc1 Chemical compound C[n]1c(nccc2)c2nc1 XAUBEYHIVLSHOG-UHFFFAOYSA-N 0.000 description 1
- KTGYDKACJATEDM-UHFFFAOYSA-N C[n]1cnc(-c2ccccc2)c1 Chemical compound C[n]1cnc(-c2ccccc2)c1 KTGYDKACJATEDM-UHFFFAOYSA-N 0.000 description 1
- FHQDWPCFSJMNCT-UHFFFAOYSA-N C[n]1cnc(CCN)c1 Chemical compound C[n]1cnc(CCN)c1 FHQDWPCFSJMNCT-UHFFFAOYSA-N 0.000 description 1
- UQFQONCQIQEYPJ-UHFFFAOYSA-N C[n]1nccc1 Chemical compound C[n]1nccc1 UQFQONCQIQEYPJ-UHFFFAOYSA-N 0.000 description 1
- HXQHRUJXQJEGER-UHFFFAOYSA-N C[n]1nnc2ccccc12 Chemical compound C[n]1nnc2ccccc12 HXQHRUJXQJEGER-UHFFFAOYSA-N 0.000 description 1
- OMAFFHIGWTVZOH-UHFFFAOYSA-N C[n]1nnnc1 Chemical compound C[n]1nnnc1 OMAFFHIGWTVZOH-UHFFFAOYSA-N 0.000 description 1
- UYDABCMRKBCMLZ-UHFFFAOYSA-N C[n]1nnnc1C(F)(F)F Chemical compound C[n]1nnnc1C(F)(F)F UYDABCMRKBCMLZ-UHFFFAOYSA-N 0.000 description 1
- HNOQAFMOBRWDKQ-UHFFFAOYSA-N Cc1cc(C)n[n]1C Chemical compound Cc1cc(C)n[n]1C HNOQAFMOBRWDKQ-UHFFFAOYSA-N 0.000 description 1
- LLPKQRMDOFYSGZ-UHFFFAOYSA-N Cc1cnc(C)[nH]1 Chemical compound Cc1cnc(C)[nH]1 LLPKQRMDOFYSGZ-UHFFFAOYSA-N 0.000 description 1
- HNJOAIYFUCQZAA-UHFFFAOYSA-N Cc1n[o]c(C)n1 Chemical compound Cc1n[o]c(C)n1 HNJOAIYFUCQZAA-UHFFFAOYSA-N 0.000 description 1
- UQNAZABNXOQHJA-UHFFFAOYSA-N Cc1nc(CCN(C)C)n[o]1 Chemical compound Cc1nc(CCN(C)C)n[o]1 UQNAZABNXOQHJA-UHFFFAOYSA-N 0.000 description 1
- XZGLNCKSNVGDNX-UHFFFAOYSA-N Cc1nnn[nH]1 Chemical compound Cc1nnn[nH]1 XZGLNCKSNVGDNX-UHFFFAOYSA-N 0.000 description 1
- ILLRAZLNZVSGBY-UHFFFAOYSA-N Nc(nc1)cc(C(F)(F)F)c1-c1nc(N2CCOCC2)nc(Cl)c1 Chemical compound Nc(nc1)cc(C(F)(F)F)c1-c1nc(N2CCOCC2)nc(Cl)c1 ILLRAZLNZVSGBY-UHFFFAOYSA-N 0.000 description 1
- KJCYBNURWMAKHV-LLVKDONJSA-N Nc(nc1)cc(C(F)(F)F)c1-c1nc(N2CCOCC2)nc(O[C@H]2CNCC2)c1 Chemical compound Nc(nc1)cc(C(F)(F)F)c1-c1nc(N2CCOCC2)nc(O[C@H]2CNCC2)c1 KJCYBNURWMAKHV-LLVKDONJSA-N 0.000 description 1
- WCCFLOQQACDOAX-UHFFFAOYSA-N Nc1nccc(F)c1 Chemical compound Nc1nccc(F)c1 WCCFLOQQACDOAX-UHFFFAOYSA-N 0.000 description 1
- WWEINXQNCAWBPD-UHFFFAOYSA-N Nc1ncccc1F Chemical compound Nc1ncccc1F WWEINXQNCAWBPD-UHFFFAOYSA-N 0.000 description 1
- ZOMPLGLSWKNRDO-UHFFFAOYSA-N O=C(CCCC1)N1c1cc(Cl)nc(N2CCOCC2)n1 Chemical compound O=C(CCCC1)N1c1cc(Cl)nc(N2CCOCC2)n1 ZOMPLGLSWKNRDO-UHFFFAOYSA-N 0.000 description 1
- AJJXRNSATOGXHR-UHFFFAOYSA-N OC(CCCCNc1cc(Cl)nc(N2CCOCC2)n1)=O Chemical compound OC(CCCCNc1cc(Cl)nc(N2CCOCC2)n1)=O AJJXRNSATOGXHR-UHFFFAOYSA-N 0.000 description 1
- XCHQPQVLYGBMFD-UHFFFAOYSA-N Oc1nc(N2CCOCC2)nc(O)c1 Chemical compound Oc1nc(N2CCOCC2)nc(O)c1 XCHQPQVLYGBMFD-UHFFFAOYSA-N 0.000 description 1
- DWGNYHYXTUHLFJ-UHFFFAOYSA-N Oc1nc(N2CCOCC2)nc(O)c1F Chemical compound Oc1nc(N2CCOCC2)nc(O)c1F DWGNYHYXTUHLFJ-UHFFFAOYSA-N 0.000 description 1
- CWBIJDQUYFAUKV-UHFFFAOYSA-N [O-][N+](c1cnc(ccc(O)c2)c2c1)=O Chemical compound [O-][N+](c1cnc(ccc(O)c2)c2c1)=O CWBIJDQUYFAUKV-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Description
化合物 | 60mg/kg | 100mg/kg |
91,于8hr | >50% | |
183,于8hr | 50-75% | |
103,于8hr | <50% | |
10,于10hr | >75% | >75% |
84,于10hr | 50-75% | |
76,于10hr | >75% | >75% |
66,于10hr | <50% |
Claims (32)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76078906P | 2006-01-20 | 2006-01-20 | |
US60/760,789 | 2006-01-20 | ||
PCT/US2007/001708 WO2007084786A1 (en) | 2006-01-20 | 2007-01-22 | Pyrimidine derivatives used as pi-3 kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101389622A CN101389622A (zh) | 2009-03-18 |
CN101389622B true CN101389622B (zh) | 2013-04-17 |
Family
ID=37951939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800063742A Active CN101389622B (zh) | 2006-01-20 | 2007-01-22 | 用作pi-3激酶抑制剂的嘧啶衍生物 |
Country Status (40)
Country | Link |
---|---|
US (2) | US8217035B2 (zh) |
EP (2) | EP1984350B1 (zh) |
JP (1) | JP5161110B2 (zh) |
KR (1) | KR101353829B1 (zh) |
CN (1) | CN101389622B (zh) |
AR (2) | AR059087A1 (zh) |
AT (1) | ATE478064T1 (zh) |
AU (1) | AU2007206048B2 (zh) |
CA (1) | CA2636993C (zh) |
CR (1) | CR10163A (zh) |
CY (1) | CY1111091T1 (zh) |
DE (1) | DE602007008529D1 (zh) |
DK (2) | DK1984350T3 (zh) |
EA (1) | EA018083B1 (zh) |
EC (1) | ECSP088630A (zh) |
ES (2) | ES2427624T3 (zh) |
GE (1) | GEP20115147B (zh) |
GT (1) | GT200800143A (zh) |
HK (1) | HK1122031A1 (zh) |
HN (1) | HN2008001144A (zh) |
HR (2) | HRP20100603T1 (zh) |
IL (1) | IL192763A (zh) |
JO (1) | JO2660B1 (zh) |
MA (1) | MA30208B1 (zh) |
ME (2) | ME00012B (zh) |
MY (1) | MY144233A (zh) |
NO (1) | NO342183B1 (zh) |
NZ (1) | NZ569771A (zh) |
PE (1) | PE20071322A1 (zh) |
PL (2) | PL1984350T3 (zh) |
PT (2) | PT2261223E (zh) |
RS (2) | RS52928B (zh) |
SI (2) | SI2261223T1 (zh) |
SM (1) | SMP200800048B (zh) |
SV (1) | SV2008002984A (zh) |
TN (1) | TNSN08305A1 (zh) |
TW (2) | TWI385170B (zh) |
UA (1) | UA96284C2 (zh) |
WO (1) | WO2007084786A1 (zh) |
ZA (1) | ZA200806017B (zh) |
Families Citing this family (322)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
TW200808739A (en) | 2006-04-06 | 2008-02-16 | Novartis Vaccines & Diagnostic | Quinazolines for PDK1 inhibition |
CA2660758A1 (en) | 2006-08-24 | 2008-02-27 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
US7888352B2 (en) | 2006-12-07 | 2011-02-15 | Piramed Limited | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
CA2675558A1 (en) * | 2007-02-06 | 2008-08-14 | Novartis Ag | Pi 3-kinase inhibitors and methods of their use |
EP2142536B1 (en) | 2007-04-20 | 2015-10-21 | Probiodrug AG | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
EP2155689B1 (en) | 2007-05-31 | 2015-07-08 | Boehringer Ingelheim International GmbH | Ccr2 receptor antagonists and uses thereof |
EA018708B1 (ru) | 2007-07-09 | 2013-10-30 | Астразенека Аб | ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K |
WO2009017838A2 (en) * | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
WO2009066084A1 (en) * | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
AU2009221164B2 (en) * | 2008-03-05 | 2012-07-26 | Novartis Ag | Use of pyrimidine derivatives for the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members |
AU2012203914C1 (en) * | 2008-03-26 | 2013-11-28 | Novartis Ag | 5imidazoquinolines and pyrimidine derivatives as potent modulators of VEGF-driven angiogenic processes |
BRPI0909082A2 (pt) * | 2008-03-26 | 2019-02-26 | Novartis Ag | imidazoquinolinas e derivados de pirimidina como moduladores potentes de processos angiogênicos acionados por vegf |
WO2009120094A2 (en) * | 2008-03-27 | 2009-10-01 | Auckland Uniservices Limited | Substituted pyrimidines and triazines and their use in cancer therapy |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
CA2723961C (en) | 2008-05-21 | 2017-03-21 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
EP2310391A1 (en) * | 2008-06-27 | 2011-04-20 | S*BIO Pte Ltd | Pyrazine substituted purines |
MX336723B (es) * | 2008-07-11 | 2016-01-28 | Novartis Ag | Combinacion de (a) un inhibidor de fosfoinositido 3-cinasa y (b) un modulador de la ruta de ras/raf/mek. |
PE20110196A1 (es) * | 2008-07-29 | 2011-04-03 | Boehringer Ingelheim Int | 5-alquinil-pirimidinas |
US20100068204A1 (en) * | 2008-09-12 | 2010-03-18 | Wyeth | 4-aryloxyquinolin-2(1h)-ones as mtor kinase and pi3 kinase inhibitors, for use as anti-cancer agents |
MX340304B (es) * | 2008-10-01 | 2016-07-05 | Novartis Ag * | Antagonismo de smoothened para el tratamiento de los trastornos relacionados con la senda de hedgehog. |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
EP2349275B1 (en) * | 2008-10-31 | 2017-03-08 | Novartis AG | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor. |
EP2356117B1 (en) * | 2008-11-20 | 2012-09-26 | Genentech, Inc. | Pyrazolopyridine pi3k inhibitor compounds and methods of use |
MA33085B1 (fr) | 2008-12-19 | 2012-03-01 | Boehringer Ingelheim Int | Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives |
EP2404918B1 (en) | 2009-03-05 | 2016-11-30 | Daiichi Sankyo Company, Limited | Pyridine derivative as ppary inhibitor |
NZ595372A (en) | 2009-03-27 | 2013-11-29 | Vetdc Inc | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
AU2010234360A1 (en) * | 2009-04-09 | 2011-09-29 | Oncothyreon, Incorporated | Methods and compositions of PI-3 kinase inhibitors for treating fibrosis |
UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
CA2760179A1 (en) * | 2009-05-15 | 2010-11-18 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and an antidiabetic compound |
SG175708A1 (en) * | 2009-05-27 | 2011-12-29 | Genentech Inc | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
EP2451802A1 (en) | 2009-07-07 | 2012-05-16 | Pathway Therapeutics, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
US20120065166A1 (en) * | 2009-08-12 | 2012-03-15 | Virginia Espina | Bone Modulators And Methods Therewith |
CN101993416B (zh) * | 2009-08-27 | 2013-09-11 | 中国科学院上海药物研究所 | 喹啉类化合物、其制备方法、包含该化合物的药物组合物及该化合物的用途 |
CA2773848A1 (en) * | 2009-09-09 | 2011-03-17 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
EA201270568A1 (ru) | 2009-10-16 | 2012-11-30 | Риб-Экс Фармасьютикалз, Инк. | Антимикробные композиции и способы их получения и применения |
CA2777741A1 (en) * | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
JP5632014B2 (ja) | 2009-12-17 | 2014-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト及びこれらの使用 |
GB201004200D0 (en) | 2010-03-15 | 2010-04-28 | Univ Basel | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
WO2011151251A1 (en) | 2010-06-01 | 2011-12-08 | Boehringer Ingelheim International Gmbh | New ccr2 antagonists |
SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
EP2615081A1 (en) | 2010-09-07 | 2013-07-17 | Daiichi Sankyo Company, Limited | Process for preparing benzoic acid esters |
KR20130119928A (ko) * | 2010-10-01 | 2013-11-01 | 노파르티스 아게 | 피리미딘 유도체의 제조 방법 |
CA2810900A1 (en) * | 2010-10-14 | 2012-04-19 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in egfr-driven cancers |
ES2498293T3 (es) * | 2010-11-12 | 2014-09-24 | Bayer Intellectual Property Gmbh | Procedimiento para la preparación de 2,2-difluoroetilamina partiendo de prop-2-en-1-amina |
BR112013011728A2 (pt) | 2010-11-12 | 2016-08-16 | Univ Texas | terapia de combinação com dexametasona |
JP2014500308A (ja) * | 2010-12-21 | 2014-01-09 | ノバルティス アーゲー | Vps34阻害剤としてのビヘテロアリール化合物 |
CA2826387A1 (en) * | 2011-02-11 | 2012-08-16 | Dana Farber Cancer Institute, Inc. | Method of inhibiting hamartoma tumor cells |
CZ305457B6 (cs) * | 2011-02-28 | 2015-09-30 | Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. | Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití |
WO2012135160A1 (en) | 2011-03-28 | 2012-10-04 | Pathway Therapeutics Inc. | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
ES2676180T3 (es) | 2011-07-01 | 2018-07-17 | Novartis Ag | Terapia de combinación que comprende un inhibidor de CDK4/6 y un inhibidor de PI3K para el uso en el tratamiento de cáncer |
WO2013010839A1 (en) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Novel and selective ccr2 antagonists |
ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
KR20140072028A (ko) | 2011-08-31 | 2014-06-12 | 노파르티스 아게 | Pi3k- 및 mek-억제제의 상승작용적 조합물 |
CN103764130A (zh) * | 2011-09-01 | 2014-04-30 | 诺华股份有限公司 | 用于治疗骨癌或者预防原发性癌细胞转移性播散入骨中的pi3k抑制剂 |
PE20141581A1 (es) | 2011-09-27 | 2014-11-14 | Novartis Ag | 3-pirmidin-4-il-oxazolidin-2-onas como inhibidores de la idh mutante |
US20140235630A1 (en) * | 2011-09-30 | 2014-08-21 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for the treatment of proliferative diseases |
SG11201400543TA (en) * | 2011-10-28 | 2014-08-28 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
KR20140091695A (ko) | 2011-11-15 | 2014-07-22 | 노파르티스 아게 | 포스포이노시티드 3-키나제 억제제와 야누스 키나제 2-신호 전달자 및 전사 활성화제 5 경로의 조절제의 조합물 |
UY34632A (es) * | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
SG10201704095UA (en) | 2012-04-24 | 2017-06-29 | Vertex Pharma | Dna-pk inhibitors |
WO2013169401A1 (en) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
JP6381523B2 (ja) * | 2012-05-16 | 2018-08-29 | ノバルティス アーゲー | Pi−3キナーゼ阻害剤の投与レジメン |
KR20160027219A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
CN104349771A (zh) | 2012-06-06 | 2015-02-11 | 诺华股份有限公司 | 用于***疾病的17α-羟化酶(C17,20-裂解酶)抑制剂和特定PI-3K抑制剂的组合 |
WO2013192367A1 (en) | 2012-06-22 | 2013-12-27 | Novartis Ag | Neuroendocrine tumor treatment |
WO2014006115A1 (en) | 2012-07-06 | 2014-01-09 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction |
CN104582707B (zh) * | 2012-07-23 | 2017-09-26 | 斯法尔制药私人有限公司 | 三嗪化合物 |
CN105050623B (zh) * | 2012-08-16 | 2018-06-12 | 诺华股份有限公司 | Pi3k抑制剂和c-met抑制剂的组合 |
CN102952086B (zh) * | 2012-09-28 | 2013-08-28 | 天津科创医药中间体技术生产力促进有限公司 | 一种2-吗啉基取代嘧啶类化合物的制备方法 |
US9394257B2 (en) | 2012-10-16 | 2016-07-19 | Tolero Pharmaceuticals, Inc. | PKM2 modulators and methods for their use |
WO2014064058A1 (en) | 2012-10-23 | 2014-05-01 | Novartis Ag | Improved process for manufacturing 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
BR112015011147A8 (pt) | 2012-11-16 | 2019-10-01 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso do referido composto |
WO2014093230A2 (en) * | 2012-12-10 | 2014-06-19 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
EP2742940B1 (en) | 2012-12-13 | 2017-07-26 | IP Gesellschaft für Management mbH | Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily |
CN104245693B (zh) * | 2012-12-14 | 2016-08-24 | 上海恒瑞医药有限公司 | 嘧啶类衍生物及其可药用盐、其制备方法及其在医药上的应用 |
PT2958943T (pt) | 2013-02-20 | 2019-12-17 | Novartis Ag | Tratamento do cancro usando recetor de antigénios quiméricos anti-egfrviii humanizados |
GB201303109D0 (en) * | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
WO2014136048A1 (en) * | 2013-03-06 | 2014-09-12 | Novartis Ag | Formulations of organic compounds |
CN107200749B (zh) | 2013-03-12 | 2019-09-03 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
US9498532B2 (en) | 2013-03-13 | 2016-11-22 | Novartis Ag | Antibody drug conjugates |
ES2665619T3 (es) | 2013-03-14 | 2018-04-26 | Novartis Ag | 3-Pirimidin-4-il-oxazolidin-2-onas como inhibidores de IDH mutante |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
US10202356B2 (en) | 2013-03-14 | 2019-02-12 | Tolero Pharmaceuticals, Inc. | JAK2 and ALK2 inhibitors and methods for their use |
CN105007950B (zh) | 2013-03-15 | 2019-01-15 | 诺华股份有限公司 | 抗体药物缀合物 |
SG10201906270VA (en) | 2013-03-21 | 2019-08-27 | Novartis Ag | Combination therapy comprising a b-raf inhibitor and a second inhibitor |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
CN105164114B (zh) * | 2013-05-01 | 2018-03-23 | 豪夫迈·罗氏有限公司 | C‑连接的杂环烷基取代的嘧啶类和它们的用途 |
CN110003178B (zh) * | 2013-05-01 | 2022-02-25 | 豪夫迈·罗氏有限公司 | 二杂芳基化合物及其用途 |
RU2672555C2 (ru) * | 2013-05-07 | 2018-11-16 | Новартис Аг | Комбинация ингибитора pi3 киназы с паклитакселом для использования при лечении или предотвращении рака головы и шеи |
KR20160018531A (ko) | 2013-06-11 | 2016-02-17 | 노파르티스 아게 | Pi3k 억제제 및 미세관 탈안정화제의 제약 조합물 |
JP2016522247A (ja) | 2013-06-18 | 2016-07-28 | ノバルティス アーゲー | 組合せ医薬 |
WO2015019320A1 (en) | 2013-08-08 | 2015-02-12 | Novartis Ag | Pim kinase inhibitor combinations |
BR112016002465B1 (pt) | 2013-08-14 | 2022-09-20 | Novartis Ag | Combinação farmacêutica e seu uso |
WO2015022657A1 (en) | 2013-08-16 | 2015-02-19 | Novartis Ag | Pharmaceutical combinations |
MX2016003046A (es) | 2013-09-09 | 2016-09-08 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
KR20160070066A (ko) | 2013-09-09 | 2016-06-17 | 멜린타 테라퓨틱스, 인크. | 항균 화합물, 및 이의 제조 방법 및 이용 방법 |
CN103483345B (zh) * | 2013-09-25 | 2016-07-06 | 中山大学 | Pi3k激酶抑制剂、包含其的药物组合物及其应用 |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
EP3057953B1 (en) | 2013-10-17 | 2018-08-15 | Vertex Pharmaceuticals Incorporated | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
US20160331755A1 (en) * | 2014-01-15 | 2016-11-17 | Samit Hirawat | Pharmaceutical Combinations |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
CA2940666C (en) | 2014-02-28 | 2022-08-23 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
CN106103484B (zh) | 2014-03-14 | 2021-08-20 | 诺华股份有限公司 | 针对lag-3的抗体分子及其用途 |
RU2688665C2 (ru) | 2014-04-22 | 2019-05-22 | Университет Базель | Новый способ получения производных триазина, пиримидина и пиридина |
WO2016001789A1 (en) * | 2014-06-30 | 2016-01-07 | Pfizer Inc. | Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer |
WO2016001341A1 (en) * | 2014-07-03 | 2016-01-07 | F. Hoffmann-La Roche Ag | Sulfonylaminopyridine compounds, compositions and methods of use |
WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
US11311512B2 (en) | 2014-08-12 | 2022-04-26 | Monash University | Lymph directing prodrugs |
TN2016000577A1 (en) | 2014-08-12 | 2018-04-04 | Novartis Ag | Anti-cdh6 antibody drug conjugates |
CN105330699B (zh) * | 2014-08-13 | 2018-12-04 | 山东汇睿迪生物技术有限公司 | 一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用 |
CN104151256B (zh) * | 2014-08-14 | 2016-08-24 | 西安交通大学 | 二取代苯甲酰胺类化合物及其合成方法和应用 |
US9993551B2 (en) | 2014-09-13 | 2018-06-12 | Novartis Ag | Combination therapies of EGFR inhibitors |
CN105461714B (zh) * | 2014-09-29 | 2017-11-28 | 山东轩竹医药科技有限公司 | 并环类pi3k抑制剂 |
KR20170066546A (ko) | 2014-10-03 | 2017-06-14 | 노파르티스 아게 | 조합 요법 |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
CU20170052A7 (es) | 2014-10-14 | 2017-11-07 | Dana Farber Cancer Inst Inc | Moléculas de anticuerpo que se unen a pd-l1 |
MA40933A (fr) | 2014-11-11 | 2017-09-19 | Piqur Therapeutics Ag | Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines |
JP6831783B2 (ja) | 2014-11-14 | 2021-02-17 | ノバルティス アーゲー | 抗体薬物コンジュゲート |
CN105085476B (zh) * | 2014-11-24 | 2018-03-09 | 苏州晶云药物科技有限公司 | 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺二盐酸盐的晶型及其制备方法 |
JP6847835B2 (ja) * | 2014-12-12 | 2021-03-24 | ザ ジェネラル ホスピタル コーポレイション | 乳がん脳転移の処置 |
AU2015366357B2 (en) * | 2014-12-17 | 2018-07-19 | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. | 2-morpholin-4,6-disubstituted pyrimidine derivative, and preparation method and pharmaceutical use thereof |
EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
NZ731664A (en) | 2014-12-23 | 2024-02-23 | Novartis Ag | Triazolopyrimidine compounds and uses thereof |
CN105832741A (zh) * | 2015-01-16 | 2016-08-10 | 复旦大学 | Pi3k抑制剂与紫杉醇的药物组合物及其在制备抗肿瘤药物中的应用 |
TWI788655B (zh) | 2015-02-27 | 2023-01-01 | 美商林伯士拉克許米公司 | 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途 |
JP2018510138A (ja) | 2015-02-27 | 2018-04-12 | カーテナ ファーマシューティカルズ,インク. | Olig2活性の阻害 |
MY190404A (en) | 2015-03-10 | 2022-04-21 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
SG11201707346RA (en) | 2015-03-11 | 2017-10-30 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
US9481665B2 (en) * | 2015-03-13 | 2016-11-01 | Yong Xu | Process for preparing PI3K inhibitor buparsilib |
JP6695353B2 (ja) | 2015-03-25 | 2020-05-20 | ノバルティス アーゲー | Fgfr4阻害剤としてのホルミル化n−複素環式誘導体 |
EP3273959A1 (en) * | 2015-03-25 | 2018-01-31 | Novartis Ag | Pharmaceutical combinations |
WO2016203432A1 (en) | 2015-06-17 | 2016-12-22 | Novartis Ag | Antibody drug conjugates |
WO2017004134A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
WO2017004537A1 (en) | 2015-07-02 | 2017-01-05 | Centrexion Therapeutics Corporation | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
SI3317301T1 (sl) | 2015-07-29 | 2021-10-29 | Novartis Ag | Kombinirane terapije, ki obsegajo molekule protitelesa na LAG-3 |
JP2018528206A (ja) | 2015-08-28 | 2018-09-27 | ノバルティス アーゲー | Mdm2阻害剤およびその組み合わせ物 |
CN105001151B (zh) * | 2015-08-28 | 2017-07-14 | 苏州明锐医药科技有限公司 | 布帕尼西中间体及其制备方法 |
US10023571B2 (en) | 2015-09-02 | 2018-07-17 | Nimbus Lakshimi, Inc. | TYK2 inhibitors and uses thereof |
AU2016318229A1 (en) | 2015-09-08 | 2018-03-29 | Monash University | Lymph directing prodrugs |
US10683308B2 (en) | 2015-09-11 | 2020-06-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
JP6800968B2 (ja) | 2015-10-23 | 2020-12-16 | ナビター ファーマシューティカルズ, インコーポレイテッド | セストリン−gator2相互作用のモジュレーターおよびその使用 |
MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
AU2016347881A1 (en) | 2015-11-02 | 2018-05-10 | Novartis Ag | Dosage regimen for a phosphatidylinositol 3-kinase inhibitor |
BR112018008904A2 (pt) | 2015-11-03 | 2018-11-27 | Janssen Biotech Inc | anticorpos que se ligam especificamente a tim-3 e seus usos |
RU2018123524A (ru) | 2015-12-03 | 2020-01-09 | Новартис Аг | Фармацевтическая диагностика |
EP3389664A4 (en) | 2015-12-14 | 2020-01-08 | Raze Therapeutics Inc. | MTHFD2 CAFFEIN INHIBITORS AND USES THEREOF |
CN106883185B (zh) * | 2015-12-15 | 2021-07-09 | 重庆博腾制药科技股份有限公司 | 一种4-氯-2-三氟甲基嘧啶的制备方法 |
CA3007671A1 (en) | 2015-12-17 | 2017-06-22 | Novartis Ag | Antibody molecules to pd-1 and uses thereof |
US11014882B2 (en) | 2016-03-09 | 2021-05-25 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
PT3426243T (pt) | 2016-03-09 | 2021-08-19 | Raze Therapeutics Inc | Inibidores de 3-fosfoglicerato desidrogenase e utilizações dos mesmos |
JP2019510785A (ja) | 2016-04-08 | 2019-04-18 | エックス4 ファーマシューティカルズ, インコーポレイテッド | 癌を処置する方法 |
EP3231799A1 (en) * | 2016-04-14 | 2017-10-18 | Universität Basel | 4-(azetidin-1-yl)pyrimidine derivatives with anti-mitotic and anti-proliferative activity |
CN109414415B (zh) | 2016-05-18 | 2023-05-02 | 拓客股份有限公司 | 皮肤病变的治疗 |
SG11201809792TA (en) * | 2016-05-18 | 2018-12-28 | Piqur Therapeutics Ag | Treatment of neurological disorders |
CN108430987B (zh) * | 2016-06-02 | 2021-06-18 | 上海海雁医药科技有限公司 | Pi3k抑制剂及其药学上可接受的盐和多晶型物及其应用 |
CN109906224B (zh) | 2016-06-20 | 2022-02-25 | 诺华股份有限公司 | ***吡啶化合物及其应用 |
WO2017221100A1 (en) | 2016-06-20 | 2017-12-28 | Novartis Ag | Imidazopyrimidine compounds useful for the treatment of cancer |
US11091489B2 (en) | 2016-06-20 | 2021-08-17 | Novartis Ag | Crystalline forms of a triazolopyrimidine compound |
WO2017223243A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
EP3471726A4 (en) | 2016-06-21 | 2019-10-09 | X4 Pharmaceuticals, Inc. | CXCR4 INHIBITORS AND USES THEREOF |
US10759796B2 (en) | 2016-06-21 | 2020-09-01 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
CN106905294A (zh) * | 2016-07-08 | 2017-06-30 | 苏州科睿思制药有限公司 | 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺的晶型及其制备方法 |
TW201815418A (zh) | 2016-09-27 | 2018-05-01 | Vertex Pharma | 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法 |
JP2019536471A (ja) | 2016-09-27 | 2019-12-19 | セロ・セラピューティクス・インコーポレイテッドCERO Therapeutics, Inc. | キメラエンガルフメント受容体分子 |
EP3526222B1 (en) | 2016-10-14 | 2022-08-17 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
EP3528816A4 (en) | 2016-10-21 | 2020-04-08 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
WO2018089499A1 (en) | 2016-11-08 | 2018-05-17 | Navitor Pharmaceuticals, Inc. | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF |
WO2018092064A1 (en) | 2016-11-18 | 2018-05-24 | Novartis Ag | Combinations of mdm2 inhibitors and bcl-xl inhibitors |
CA3043768A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
US11091451B2 (en) | 2016-12-05 | 2021-08-17 | Raze Therapeutics, Inc. | SHMT inhibitors and uses thereof |
JP2020502238A (ja) | 2016-12-23 | 2020-01-23 | バイスクルアールディー・リミテッド | 新規連結構造を有するペプチド誘導体 |
EP3565638B8 (en) | 2017-01-06 | 2024-04-10 | BicycleRD Limited | Bicycle conjugate for treating cancer |
JOP20190187A1 (ar) | 2017-02-03 | 2019-08-01 | Novartis Ag | مترافقات عقار جسم مضاد لـ ccr7 |
EP3592868B1 (en) | 2017-03-06 | 2022-11-23 | Novartis AG | Methods of treatment of cancer with reduced ubb expression |
TWI783978B (zh) | 2017-03-08 | 2022-11-21 | 美商林伯士拉克許米公司 | Tyk2抑制劑、其用途及生產方法 |
EP3375784A1 (en) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
EP3375778A1 (en) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidine derivatives |
GB201705263D0 (en) * | 2017-03-31 | 2017-05-17 | Probiodrug Ag | Novel inhibitors |
WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
WO2018191146A1 (en) | 2017-04-10 | 2018-10-18 | Navitor Pharmaceuticals, Inc. | Heteroaryl rheb inhibitors and uses thereof |
WO2018200625A1 (en) | 2017-04-26 | 2018-11-01 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-gator2 interaction and uses thereof |
US10857196B2 (en) | 2017-04-27 | 2020-12-08 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
MX2019013862A (es) | 2017-05-23 | 2020-01-20 | Mei Pharma Inc | Terapia de combinacion. |
WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
US20200362058A1 (en) | 2017-05-24 | 2020-11-19 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use |
US20200270334A1 (en) | 2017-05-24 | 2020-08-27 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
JP7433910B2 (ja) | 2017-06-22 | 2024-02-20 | ノバルティス アーゲー | Cd73に対する抗体分子及びその使用 |
WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES |
WO2019002842A1 (en) | 2017-06-26 | 2019-01-03 | Bicyclerd Limited | BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF |
JP7216705B2 (ja) | 2017-07-28 | 2023-02-02 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用方法 |
EP3668887A1 (en) | 2017-08-14 | 2020-06-24 | Bicyclerd Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
WO2019034868A1 (en) | 2017-08-14 | 2019-02-21 | Bicyclerd Limited | CONJUGATES PEPTIDE BICYCLIC-LIGAND PPR-A AND USES THEREOF |
MX2020001727A (es) | 2017-08-14 | 2020-03-20 | Mei Pharma Inc | Terapia de combinacion. |
US10800774B2 (en) * | 2017-08-17 | 2020-10-13 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ATR kinase |
EP4306524A2 (en) | 2017-08-29 | 2024-01-17 | PureTech LYT, Inc. | Lymphatic system-directing lipid prodrugs |
US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
CA3073073A1 (en) | 2017-09-08 | 2019-03-14 | F. Hoffmann-La Roche Ag | Diagnostic and therapeutic methods for cancer |
US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
IL307995A (en) | 2017-09-22 | 2023-12-01 | Kymera Therapeutics Inc | Protein compounds and their uses |
CA3073421A1 (en) | 2017-09-26 | 2019-04-04 | Daniel Mark COREY | Chimeric engulfment receptor molecules and methods of use |
CN109651341A (zh) * | 2017-10-11 | 2019-04-19 | 上海医药工业研究院 | 二吗啉氰基嘧(吡)啶类衍生物及作为抗肿瘤药物应用 |
US11351156B2 (en) | 2017-10-13 | 2022-06-07 | Inserm | Combination treatment of pancreatic cancer |
WO2019101871A1 (en) | 2017-11-23 | 2019-05-31 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | A new marker for predicting the sensitivity to pi3k inhibitors |
US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
WO2019126378A1 (en) | 2017-12-19 | 2019-06-27 | Ariya Therapeutics, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
US11667651B2 (en) | 2017-12-22 | 2023-06-06 | Hibercell, Inc. | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
EP3728230A1 (en) * | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors |
MX2020006812A (es) | 2017-12-26 | 2020-11-06 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. |
US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
EP3746075A4 (en) | 2018-01-29 | 2021-09-08 | Merck Patent GmbH | GCN2 INHIBITORS AND THEIR USES |
KR20200115620A (ko) | 2018-01-29 | 2020-10-07 | 메르크 파텐트 게엠베하 | Gcn2 억제제 및 이의 용도 |
WO2019169001A1 (en) | 2018-02-27 | 2019-09-06 | Artax Biopharma Inc. | Chromene derivatives as inhibitors of tcr-nck interaction |
US20210087251A1 (en) | 2018-03-28 | 2021-03-25 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
RU2020135107A (ru) | 2018-03-28 | 2022-04-29 | Серо Терапьютикс, Инк. | Клеточные иммунотерапевтические композиции и их применения |
US20210024607A1 (en) | 2018-03-28 | 2021-01-28 | Cero Therapeutics, Inc. | Expression vectors for chimeric engulfment receptors, genetically modified host cells, and uses thereof |
MX2020010437A (es) | 2018-04-05 | 2021-01-29 | Sumitomo Pharma Oncology Inc | Inhibidores de axl cinasa y uso de los mismos. |
CN111936469A (zh) * | 2018-04-06 | 2020-11-13 | 日本曹达株式会社 | (杂)芳基磺酰胺化合物和有害生物防除剂 |
US11236079B2 (en) | 2018-04-10 | 2022-02-01 | Neuropore Therapies, Inc. | Morpholine derivates as inhibitors of Vps34 |
MX2020010576A (es) * | 2018-04-10 | 2021-03-02 | Neuropore Therapies Inc | Derivados tri sustituidos de arilo y heteroarilo como moduladores de p13-kinasa y rutas de autofagia. |
CA3097774A1 (en) | 2018-04-24 | 2019-10-31 | Vertex Pharmaceuticals Incorporated | Pteridinone compounds and uses thereof |
ES2919572T3 (es) | 2018-04-24 | 2022-07-27 | Merck Patent Gmbh | Compuestos antiproliferación y usos de los mismos |
TW202015726A (zh) | 2018-05-30 | 2020-05-01 | 瑞士商諾華公司 | Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法 |
US20210214459A1 (en) | 2018-05-31 | 2021-07-15 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
JP7382353B2 (ja) | 2018-06-15 | 2023-11-16 | ヤンセン ファーマシューティカ エヌ.ベー. | ラパマイシン類似体およびその使用 |
CN108864067B (zh) * | 2018-06-20 | 2020-05-12 | 郑州大学 | 一种2-炔丙巯基-5-氰基嘧啶类衍生物及其制备方法和应用 |
GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
CA3103995A1 (en) | 2018-07-26 | 2020-01-30 | Sumitomo Dainippon Pharma Oncology, Inc. | Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same |
LT3837256T (lt) | 2018-08-17 | 2023-06-12 | Novartis Ag | Karbamido junginiai ir kompozicijos kaip smarca2 / brm atfazės inhibitoriai |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
EP3846793B1 (en) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
WO2020081508A1 (en) | 2018-10-15 | 2020-04-23 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
CN112955459A (zh) | 2018-10-23 | 2021-06-11 | 拜斯科技术开发有限公司 | 双环肽配体和其用途 |
AU2019364542A1 (en) | 2018-10-24 | 2021-06-10 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
EP3873532A1 (en) | 2018-10-31 | 2021-09-08 | Novartis AG | Dc-sign antibody drug conjugates |
US11352350B2 (en) | 2018-11-30 | 2022-06-07 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
AU2019389025A1 (en) | 2018-11-30 | 2021-06-17 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
EP3670659A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Biomarkers, and uses in treatment of viral infections, inflammations, or cancer |
BR112021011894A2 (pt) | 2018-12-21 | 2021-09-08 | Daiichi Sankyo Company, Limited | Composição farmacêutica |
BR112021011900A2 (pt) | 2018-12-21 | 2021-09-08 | Novartis Ag | Anticorpos para pmel17 e conjugados dos mesmos |
CN109705033B (zh) * | 2019-01-22 | 2021-03-30 | 杭州壹瑞医药科技有限公司 | N-杂芳基磺酰胺类衍生物及制备和应用 |
CN109651297B (zh) * | 2019-01-22 | 2022-05-27 | 杭州壹瑞医药科技有限公司 | 一种n-苄基-n-芳基磺酰胺类衍生物及制备和应用 |
CN113348021A (zh) | 2019-01-23 | 2021-09-03 | 林伯士拉克许米公司 | Tyk2抑制剂和其用途 |
EP3924351A4 (en) | 2019-02-12 | 2022-12-21 | Sumitomo Pharma Oncology, Inc. | FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS |
WO2020165600A1 (en) | 2019-02-14 | 2020-08-20 | Bicycletx Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
AU2020245437A1 (en) | 2019-03-22 | 2021-09-30 | Sumitomo Pharma Oncology, Inc. | Compositions comprising PKM2 modulators and methods of treatment using the same |
JP2022528887A (ja) | 2019-04-02 | 2022-06-16 | バイスクルテクス・リミテッド | バイシクルトキシンコンジュゲートおよびその使用 |
KR20220006139A (ko) | 2019-04-05 | 2022-01-14 | 카이메라 쎄라퓨틱스 인코포레이티드 | Stat 분해제 및 이의 용도 |
JP2022534425A (ja) | 2019-05-31 | 2022-07-29 | イケナ オンコロジー, インコーポレイテッド | Tead阻害剤およびその使用 |
WO2021001431A1 (en) | 2019-07-02 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3ka-selective inhibitors for treating metastatic disease in patients suffering from pancreatic cancer |
WO2021001427A1 (en) | 2019-07-02 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prophylactic treatment of cancer in patients suffering from pancreatitis |
EP3993707A1 (en) | 2019-07-02 | 2022-05-11 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of ultrafast elasticity imaging for detecting pancreatic cancers |
WO2021003417A1 (en) | 2019-07-03 | 2021-01-07 | Sumitomo Dainippon Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof |
AU2020345962A1 (en) | 2019-09-11 | 2022-03-31 | Vincere Biosciences, Inc. | USP30 inhibitors and uses thereof |
JP2022547719A (ja) | 2019-09-13 | 2022-11-15 | ニンバス サターン, インコーポレイテッド | Hpk1アンタゴニストおよびその使用 |
JP2022548881A (ja) | 2019-09-18 | 2022-11-22 | ノバルティス アーゲー | Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法 |
EP4038097A1 (en) | 2019-10-03 | 2022-08-10 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
US11723890B2 (en) | 2019-11-01 | 2023-08-15 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mTORC1 modulator |
CN115209897A (zh) | 2019-12-05 | 2022-10-18 | 安纳库利亚治疗公司 | 雷帕霉素类似物及其用途 |
IL293917A (en) | 2019-12-17 | 2022-08-01 | Kymera Therapeutics Inc | Iraq joints and their uses |
US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
CA3162502A1 (en) | 2019-12-23 | 2021-07-01 | Yi Zhang | Smarca degraders and uses thereof |
WO2021159993A1 (en) * | 2020-02-14 | 2021-08-19 | Pharmablock Sciences (Nanjing) , Inc. | Inhibitors of interleukin-1 receptor associated kinase (irak) /fms-like receptor tyrosine kinase (flt3), pharmaceutical products thereof, and methods thereof |
TW202146393A (zh) | 2020-03-03 | 2021-12-16 | 美商皮克醫療公司 | Eif4e抑制劑及其用途 |
EP4121043A1 (en) | 2020-03-19 | 2023-01-25 | Kymera Therapeutics, Inc. | Mdm2 degraders and uses thereof |
US20230181756A1 (en) | 2020-04-30 | 2023-06-15 | Novartis Ag | Ccr7 antibody drug conjugates for treating cancer |
TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
KR20210158019A (ko) | 2020-06-23 | 2021-12-30 | 주식회사 온코빅스 | 포스파티딜이노시톨 3-키나제(pi3k) 억제제로써 pten 과오종 증후군에 의한 종양 세포의 성장 또는 증식을 억제하는데 유용한 신규한 피리미딘 유도체 및 이의 약제학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 약제학적 조성물 |
AR123185A1 (es) | 2020-08-10 | 2022-11-09 | Novartis Ag | Compuestos y composiciones para inhibir ezh2 |
WO2022036285A1 (en) | 2020-08-14 | 2022-02-17 | Cero Therapeutics, Inc. | Compositions and methods for treating cancer with chimeric tim receptors in combination with inhibitors of poly (adp-ribose) polymerase |
WO2022036265A1 (en) | 2020-08-14 | 2022-02-17 | Cero Therapeutics, Inc. | Chimeric tim receptors and uses thereof |
WO2022036287A1 (en) | 2020-08-14 | 2022-02-17 | Cero Therapeutics, Inc. | Anti-cd72 chimeric receptors and uses thereof |
CN116234931A (zh) | 2020-08-17 | 2023-06-06 | 拜斯科技术开发有限公司 | 对nectin-4具有特异性的双环缀合物及其用途 |
WO2022043558A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
WO2022043556A1 (en) | 2020-08-31 | 2022-03-03 | Novartis Ag | Stable radiopharmaceutical composition |
WO2022043557A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
TW202227089A (zh) | 2020-11-30 | 2022-07-16 | 大陸商杭州阿諾生物醫藥科技有限公司 | 用於治療pik3ca突變癌症的組合療法 |
WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
EP4255895A1 (en) | 2020-12-02 | 2023-10-11 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk﹘5抑制劑和彼之用途 |
US20230113202A1 (en) | 2021-02-02 | 2023-04-13 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
CN116888116A (zh) | 2021-02-02 | 2023-10-13 | 里米诺生物科学有限公司 | Gpr84拮抗剂和其用途 |
TW202245789A (zh) | 2021-02-15 | 2022-12-01 | 美商凱麥拉醫療公司 | Irak4降解劑及其用途 |
CN117203223A (zh) | 2021-02-26 | 2023-12-08 | 凯洛尼亚疗法有限公司 | 淋巴细胞靶向慢病毒载体 |
EP4301756A1 (en) | 2021-03-05 | 2024-01-10 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
KR20230158659A (ko) * | 2021-03-18 | 2023-11-21 | 쑤저우 궈쾅 팜테크 코포레이션 리미티드 | Ctla-4 소분자 분해제 및 그 응용 |
TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
WO2022221720A1 (en) | 2021-04-16 | 2022-10-20 | Novartis Ag | Antibody drug conjugates and methods for making thereof |
AU2022258968A1 (en) | 2021-04-16 | 2023-10-19 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023010097A1 (en) | 2021-07-28 | 2023-02-02 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
US20230134932A1 (en) | 2021-08-25 | 2023-05-04 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
WO2023028235A1 (en) | 2021-08-25 | 2023-03-02 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
WO2023107603A1 (en) * | 2021-12-08 | 2023-06-15 | Kineta, Inc. | Pyrimidines and methods of their use |
WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
CN114213340B (zh) | 2022-02-22 | 2022-06-07 | 北京蓝晶微生物科技有限公司 | 2,4-二氨基嘧啶氧化物的制备方法 |
CN114591326B (zh) * | 2022-02-28 | 2024-02-27 | 上海筛杰生物医药有限公司 | Cct-251921的中间体及其制备方法 |
WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023211889A1 (en) | 2022-04-25 | 2023-11-02 | Ikena Oncology, Inc. | Polymorphic compounds and uses thereof |
US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
WO2024028365A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Substituted pyridone gpr84 antagonists and uses thereof |
WO2024028363A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Heteroaryl carboxamide and related gpr84 antagonists and uses thereof |
WO2024028364A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Aryl-triazolyl and related gpr84 antagonists and uses thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004048365A1 (en) * | 2002-11-21 | 2004-06-10 | Chiron Corporation | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer |
WO2005028444A1 (en) * | 2003-09-24 | 2005-03-31 | Novartis Ag | 1,4-disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases |
WO2006005914A1 (en) * | 2004-07-09 | 2006-01-19 | Astrazeneca Ab | 2, 4, 6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer |
Family Cites Families (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB581334A (en) | 1943-09-29 | 1946-10-09 | Francis Henry Swinden Curd | New pyrimidine compounds |
DE2341925A1 (de) | 1973-08-20 | 1975-03-06 | Thomae Gmbh Dr K | Neue pyrimidinderivate und verfahren zu ihrer herstellung |
AT340933B (de) * | 1973-08-20 | 1978-01-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze |
JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | 1,2‐ジアミノシクロヘキサン異性体のシス白金(2)錯体 |
US4323581A (en) | 1978-07-31 | 1982-04-06 | Johnson & Johnson | Method of treating carcinogenesis |
US4329726A (en) * | 1978-12-01 | 1982-05-11 | Raychem Corporation | Circuit protection devices comprising PTC elements |
IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
EP0303697B1 (en) | 1987-03-09 | 1997-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance k-252 |
US4994386A (en) | 1987-07-13 | 1991-02-19 | Pharmacia Diagnostics, Inc. | Production of HBLV virus in the HSB-2 cell line |
US4904768A (en) | 1987-08-04 | 1990-02-27 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-phosphate derivatives |
JP2766360B2 (ja) | 1988-02-04 | 1998-06-18 | 協和醗酵工業株式会社 | スタウロスポリン誘導体 |
US4929726A (en) | 1988-02-09 | 1990-05-29 | Georgia State University Foundation, Inc. | Novel diazines and their method of preparation |
US5238944A (en) | 1988-12-15 | 1993-08-24 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine |
US4929624A (en) | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
GB9012311D0 (en) | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
US6410010B1 (en) | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
US5451700A (en) | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
US5268376A (en) | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
AU2866992A (en) | 1991-10-10 | 1993-05-03 | Schering Corporation | 4'-(n-substituted-n-oxide)staurosporine derivatives |
US5266575A (en) | 1991-11-06 | 1993-11-30 | Minnesota Mining And Manufacturing Company | 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines |
JPH07505124A (ja) | 1991-11-08 | 1995-06-08 | ザ ユニバーシティ オブ サザン カリフォルニア | ニューロトロフィン活性増強のためのk−252化合物を含む組成物 |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
US5948898A (en) | 1992-03-16 | 1999-09-07 | Isis Pharmaceuticals, Inc. | Methoxyethoxy oligonucleotides for modulation of protein kinase C expression |
US5756494A (en) | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5621100A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
JP3608788B2 (ja) | 1992-08-31 | 2005-01-12 | ルドヴィグ・インスティテュート・フォー・キャンサー・リサーチ | Mage−3遺伝子から誘導されてhla−a1により提示される単離されたノナペプチドおよびそれらの用途 |
DE69331228D1 (en) | 1992-09-21 | 2002-01-10 | Kyowa Hakko Kogyo Kk | Heilmittel für thrombozytopenia |
CA2145985C (en) | 1992-10-28 | 2003-09-16 | Napoleone Ferrara | Vascular endothelial cell growth factor antagonists |
US5395937A (en) | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
JPH09500128A (ja) | 1993-07-15 | 1997-01-07 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | イミダゾ〔4,5−c〕ピリジン−4−アミン |
US5352784A (en) | 1993-07-15 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
US5478932A (en) | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
AU1339895A (en) | 1993-12-23 | 1995-07-10 | Eli Lilly And Company | Protein kinase c inhibitors |
US5587459A (en) | 1994-08-19 | 1996-12-24 | Regents Of The University Of Minnesota | Immunoconjugates comprising tyrosine kinase inhibitors |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5482936A (en) | 1995-01-12 | 1996-01-09 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-C]quinoline amines |
EP2295415A1 (en) | 1995-03-30 | 2011-03-16 | OSI Pharmaceuticals, Inc. | Quinazoline derivatives |
JP3145410B2 (ja) | 1995-04-13 | 2001-03-12 | 大鵬薬品工業株式会社 | 新規な4,6−ジアリールピリミジン誘導体及びその塩 |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
WO1997007081A2 (en) | 1995-08-11 | 1997-02-27 | Yale University | Glycosylated indolocarbazole synthesis |
FR2741881B1 (fr) | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
CA2231105C (en) | 1995-12-08 | 2005-09-13 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives |
KR100447918B1 (ko) | 1996-07-25 | 2005-09-28 | 동아제약주식회사 | 대장을포함한위장관보호작용을갖는플라본및플라바논화합물 |
IL128124A0 (en) | 1996-08-02 | 1999-11-30 | Genesense Technologies Inc | Antitumor antisense sequences directed against r1 and r2 components of ribonucleotide reductase |
JP3734907B2 (ja) * | 1996-12-19 | 2006-01-11 | 富士写真フイルム株式会社 | 現像処理方法 |
CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
US6126965A (en) | 1997-03-21 | 2000-10-03 | Georgetown University School Of Medicine | Liposomes containing oligonucleotides |
CA2294244A1 (en) | 1997-07-12 | 1999-01-21 | Cancer Research Campaign Technology Limited | Cyclin dependent kinase inhibiting purine derivatives |
AU727013B2 (en) * | 1997-07-24 | 2000-11-30 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compound and antitumor agent comprising the same as effective component |
US6166037A (en) | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
US6150362A (en) * | 1997-12-12 | 2000-11-21 | Henkin; Jack | Triazine angiogenesis inhibitors |
GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
DK0930302T3 (da) * | 1998-01-16 | 2003-07-21 | Hoffmann La Roche | Benzosulfonderivater |
HUP0103617A2 (hu) | 1998-05-29 | 2002-02-28 | Sugen, Inc. | Protein kinázt gátló, pirrolilcsoporttal helyettesített 2-indolszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása |
DE69919707T2 (de) | 1998-06-19 | 2005-09-01 | Chiron Corp., Emeryville | Glycogen synthase kinase 3 inhibitoren |
US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
US20030083242A1 (en) | 1998-11-06 | 2003-05-01 | Alphonse Galdes | Methods and compositions for treating or preventing peripheral neuropathies |
US6495558B1 (en) * | 1999-01-22 | 2002-12-17 | Amgen Inc. | Kinase inhibitors |
AU768201B2 (en) | 1999-01-22 | 2003-12-04 | Amgen, Inc. | Kinase inhibitors |
GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
NZ514675A (en) | 1999-05-04 | 2004-05-28 | Schering Corp | Piperidine derivatives useful as CCR5 antagonists |
PL203116B1 (pl) | 1999-05-04 | 2009-08-31 | Schering Corp | Piperazynopiperydynowa pochodna użyteczna jako antagonista CCR5, zawierająca ją kompozycja farmaceutyczna i jej zastosowanie |
EP1189641B1 (en) | 1999-06-25 | 2009-07-29 | Genentech, Inc. | HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
US6498165B1 (en) | 1999-06-30 | 2002-12-24 | Merck & Co., Inc. | Src kinase inhibitor compounds |
CA2376951A1 (en) | 1999-06-30 | 2001-01-04 | Peter J. Sinclair | Src kinase inhibitor compounds |
AU6605200A (en) | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
CA2379035A1 (en) | 1999-07-13 | 2001-01-18 | Shiro Akinaga | Staurosporin derivatives |
WO2001005783A1 (en) | 1999-07-15 | 2001-01-25 | Pharmacopeia, Inc. | Bradykinin b1 receptor antagonists |
UA72946C2 (uk) | 1999-11-05 | 2005-05-16 | Астразенека Аб | Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf) |
CA2399358C (en) | 2000-02-15 | 2006-03-21 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
EP1274705A1 (en) | 2000-03-29 | 2003-01-15 | Cyclacel Limited | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders |
WO2001079255A1 (en) | 2000-04-12 | 2001-10-25 | Genaera Corporation | A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group |
CN100345830C (zh) | 2000-04-27 | 2007-10-31 | 安斯泰来制药有限公司 | 稠合杂芳基衍生物 |
WO2001083460A1 (fr) | 2000-04-28 | 2001-11-08 | Tanabe Seiyaku Co., Ltd. | Composes cycliques |
WO2002000647A1 (en) * | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
IL153111A0 (en) | 2000-06-30 | 2003-06-24 | Glaxo Group Ltd | Quinazoline ditosylate salt compounds |
AU9502601A (en) | 2000-09-06 | 2002-03-22 | Chiron Corp | Inhibitors of glycogen synthase kinase 3 |
KR100732206B1 (ko) | 2000-09-11 | 2007-06-27 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 티로신 키나제 억제제로서의 퀴놀리논 유도체 |
AU2001292670A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6677450B2 (en) | 2000-10-06 | 2004-01-13 | Bristol-Myers Squibb Company | Topoisomerase inhibitors |
SE0004053D0 (sv) | 2000-11-06 | 2000-11-06 | Astrazeneca Ab | N-type calcium channel antagonists for the treatment of pain |
BR0116411A (pt) | 2000-12-21 | 2003-11-11 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
JP4323167B2 (ja) | 2001-01-16 | 2009-09-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 分泌タンパク質を発現する細胞の単離 |
EP1363890A4 (en) | 2001-02-07 | 2009-06-10 | Ore Pharmaceuticals Inc | MELANOCORTIN-4-RECEPTOR BINDING COMPOUNDS AND METHOD FOR THEIR APPLICATION |
WO2002062826A1 (fr) | 2001-02-07 | 2002-08-15 | Vadim Viktorovich Novikov | Procede de fabrication des peptides |
JP2004531571A (ja) * | 2001-05-25 | 2004-10-14 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン生産のインヒビターとしてのカルバメート及びオキサミド化合物 |
JP2005500294A (ja) | 2001-06-19 | 2005-01-06 | ブリストル−マイヤーズ スクイブ カンパニー | ホスホジエステラーゼ7に対するピリミジン阻害剤 |
WO2003004505A1 (en) | 2001-07-02 | 2003-01-16 | Debiopharm S.A. | Oxaliplatin active substance with a very low content of oxalic acid |
US6603000B2 (en) * | 2001-07-11 | 2003-08-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis for heteroarylamine compounds |
KR100484504B1 (ko) | 2001-09-18 | 2005-04-20 | 학교법인 포항공과대학교 | 쿠커비투릴 유도체를 주인 분자로서 포함하고 있는 내포화합물 및 이를 포함한 약제학적 조성물 |
WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
US20030134846A1 (en) | 2001-10-09 | 2003-07-17 | Schering Corporation | Treatment of trypanosoma brucei with farnesyl protein transferase inhibitors |
EP1485082A4 (en) | 2002-02-19 | 2009-12-30 | Xenoport Inc | PROCESS FOR THE SYNTHESIS OF PROMEDICAMENTS FROM 1-ACYL-ALKYL DERIVATIVES AND CORRESPONDING COMPOSITIONS |
AU2003218215A1 (en) * | 2002-03-15 | 2003-09-29 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines as inhibitors of protein kinases |
DE60332433D1 (de) * | 2002-03-15 | 2010-06-17 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
EP1485381B8 (en) * | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazine as inhibitors of protein kinases |
WO2003078423A1 (en) * | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Compositions useful as inhibitors of protein kinases |
DE60329910D1 (de) | 2002-03-29 | 2009-12-17 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
US6900342B2 (en) | 2002-05-10 | 2005-05-31 | Dabur India Limited | Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof |
US6727272B1 (en) | 2002-07-15 | 2004-04-27 | Unitech Pharmaceuticals, Inc. | Leflunomide analogs for treating rheumatoid arthritis |
US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
AU2003288925A1 (en) | 2002-10-08 | 2004-05-04 | Massachusetts Institute Of Technology | Compounds for modulation of cholesterol transport |
AU2003300021A1 (en) | 2002-12-27 | 2004-07-29 | Chiron Corporation | Thiosemicarbazones as anti-virals and immunopotentiators |
WO2004064759A2 (en) | 2003-01-21 | 2004-08-05 | Chiron Corporation | Use of tryptanthrin compounds for immune potentiation |
EP1608622A4 (en) | 2003-03-24 | 2009-04-01 | Merck & Co Inc | BIARYLSUBSTITUTED 6-LOW HETEROCYCLES AS SODIUM CHANNEL BLOCKERS |
US7893096B2 (en) | 2003-03-28 | 2011-02-22 | Novartis Vaccines And Diagnostics, Inc. | Use of small molecule compounds for immunopotentiation |
US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
CA2531490A1 (en) | 2003-07-15 | 2005-02-03 | Neurogen Corporation | Substituted pyrimidin-4-ylamina analogues as vanilloid receptor ligands |
AU2004257289A1 (en) | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
GB0415364D0 (en) | 2004-07-09 | 2004-08-11 | Astrazeneca Ab | Pyrimidine derivatives |
EP1979325A1 (en) | 2006-01-11 | 2008-10-15 | AstraZeneca AB | Morpholino pyrimidine derivatives and their use in therapy |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
CA2675558A1 (en) * | 2007-02-06 | 2008-08-14 | Novartis Ag | Pi 3-kinase inhibitors and methods of their use |
CA2826387A1 (en) | 2011-02-11 | 2012-08-16 | Dana Farber Cancer Institute, Inc. | Method of inhibiting hamartoma tumor cells |
-
2007
- 2007-01-18 JO JO200713A patent/JO2660B1/en active
- 2007-01-19 TW TW096102123A patent/TWI385170B/zh active
- 2007-01-19 PE PE2007000060A patent/PE20071322A1/es active IP Right Grant
- 2007-01-19 TW TW101150766A patent/TW201315723A/zh unknown
- 2007-01-19 AR ARP070100237A patent/AR059087A1/es not_active Application Discontinuation
- 2007-01-22 RS RS20130353A patent/RS52928B/en unknown
- 2007-01-22 EA EA200801680A patent/EA018083B1/ru not_active IP Right Cessation
- 2007-01-22 PL PL07716906T patent/PL1984350T3/pl unknown
- 2007-01-22 CA CA2636993A patent/CA2636993C/en active Active
- 2007-01-22 DE DE602007008529T patent/DE602007008529D1/de active Active
- 2007-01-22 GE GEAP200710824A patent/GEP20115147B/en unknown
- 2007-01-22 DK DK07716906.8T patent/DK1984350T3/da active
- 2007-01-22 EP EP07716906A patent/EP1984350B1/en active Active
- 2007-01-22 KR KR1020087020198A patent/KR101353829B1/ko active IP Right Grant
- 2007-01-22 SI SI200731300T patent/SI2261223T1/sl unknown
- 2007-01-22 UA UAA200809431A patent/UA96284C2/ru unknown
- 2007-01-22 MY MYPI20082622A patent/MY144233A/en unknown
- 2007-01-22 EP EP10173136.2A patent/EP2261223B1/en active Active
- 2007-01-22 ME MEP-2008-39A patent/ME00012B/me unknown
- 2007-01-22 SM SM200800048T patent/SMP200800048B/it unknown
- 2007-01-22 JP JP2008551469A patent/JP5161110B2/ja active Active
- 2007-01-22 WO PCT/US2007/001708 patent/WO2007084786A1/en active Application Filing
- 2007-01-22 PT PT101731362T patent/PT2261223E/pt unknown
- 2007-01-22 PL PL10173136T patent/PL2261223T3/pl unknown
- 2007-01-22 SI SI200730406T patent/SI1984350T1/sl unknown
- 2007-01-22 ES ES10173136T patent/ES2427624T3/es active Active
- 2007-01-22 PT PT07716906T patent/PT1984350E/pt unknown
- 2007-01-22 AT AT07716906T patent/ATE478064T1/de active
- 2007-01-22 CN CN2007800063742A patent/CN101389622B/zh active Active
- 2007-01-22 ME MEP-39/08A patent/MEP3908A/xx unknown
- 2007-01-22 NZ NZ569771A patent/NZ569771A/en unknown
- 2007-01-22 US US12/161,537 patent/US8217035B2/en active Active
- 2007-01-22 ES ES07716906T patent/ES2351172T3/es active Active
- 2007-01-22 RS RSP-2010/0439A patent/RS51548B/en unknown
- 2007-01-22 DK DK10173136.2T patent/DK2261223T3/da active
- 2007-01-22 AU AU2007206048A patent/AU2007206048B2/en active Active
-
2008
- 2008-07-09 ZA ZA2008/06017A patent/ZA200806017B/en unknown
- 2008-07-10 IL IL192763A patent/IL192763A/en active IP Right Grant
- 2008-07-18 GT GT200800143A patent/GT200800143A/es unknown
- 2008-07-18 CR CR10163A patent/CR10163A/es unknown
- 2008-07-18 TN TNP2008000305A patent/TNSN08305A1/en unknown
- 2008-07-18 EC EC2008008630A patent/ECSP088630A/es unknown
- 2008-07-21 SV SV2008002984A patent/SV2008002984A/es unknown
- 2008-07-21 HN HN2008001144A patent/HN2008001144A/es unknown
- 2008-08-01 NO NO20083389A patent/NO342183B1/no unknown
- 2008-08-06 MA MA31157A patent/MA30208B1/fr unknown
-
2009
- 2009-03-17 HK HK09102514.4A patent/HK1122031A1/xx unknown
-
2010
- 2010-11-09 HR HR20100603T patent/HRP20100603T1/hr unknown
- 2010-11-12 CY CY20101101021T patent/CY1111091T1/el unknown
-
2012
- 2012-05-14 US US13/471,111 patent/US8563549B2/en active Active
-
2013
- 2013-08-22 HR HRP20130796TT patent/HRP20130796T1/hr unknown
-
2018
- 2018-06-01 AR ARP180101483A patent/AR112118A2/es unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004048365A1 (en) * | 2002-11-21 | 2004-06-10 | Chiron Corporation | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer |
WO2005028444A1 (en) * | 2003-09-24 | 2005-03-31 | Novartis Ag | 1,4-disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases |
WO2006005914A1 (en) * | 2004-07-09 | 2006-01-19 | Astrazeneca Ab | 2, 4, 6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101389622B (zh) | 用作pi-3激酶抑制剂的嘧啶衍生物 | |
ES2381895T3 (es) | Inhibidores de PI 3-quinasa y métodos para su uso | |
JP5303557B2 (ja) | キナーゼ阻害剤である2−ヘテロアリールアミノ−ピリミジン誘導体 | |
JP5599312B2 (ja) | 5−(4−(ハロアルコキシ)フェニル)ピリミジン−2−アミン化合物およびキナーゼ阻害剤としての組成物 | |
CN101501023A (zh) | 苯基取代的杂芳基衍生物及其作为抗肿瘤剂的用途 | |
JP2010533680A (ja) | 二環ヘテロアリール化合物およびそれらのキナーゼ阻害剤としての使用 | |
CN101384586A (zh) | Pi-3激酶抑制剂及其应用方法 | |
CN103664878A (zh) | 杂芳环及其衍生物类酪氨酸激酶抑制剂 | |
KR20150130491A (ko) | 피라졸로 화합물 및 그것의 용도 | |
KR20070090172A (ko) | 단백질 키나아제의 억제제로서 유용한피라졸로[1,5-a]피리미딘 | |
JP2013528591A (ja) | インダゾール | |
JP2008532988A (ja) | 細胞増殖の阻害剤としてのイミダゾロ−5−イル−2−アニロ−ピリミジン | |
CN101679378A (zh) | 用作激酶抑制剂的噻唑和吡唑 | |
BRPI0707189B1 (pt) | Derivados de pirimidina, sua composição e seu uso |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: NOVARTIS CO., LTD. Free format text: FORMER NAME: NOVARTIS AG |
|
CP01 | Change in the name or title of a patent holder |
Address after: Basel Patentee after: Novartis Ag Address before: Basel Patentee before: Novartis AG |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20090318 Assignee: Hangzhou Arnold Biomedical Technology Co.,Ltd. Assignor: NOVARTIS AG Contract record no.: X2021990000669 Denomination of invention: Pyrimidine derivatives used as PI-3 kinase inhibitors Granted publication date: 20130417 License type: Exclusive License Record date: 20211102 |