CA2912219C - Biomarqueurs pour predire et evaluer la reponse de sujets atteints de cancer de l'endometre a des composes a base de lenvatinib - Google Patents

Biomarqueurs pour predire et evaluer la reponse de sujets atteints de cancer de l'endometre a des composes a base de lenvatinib Download PDF

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Publication number
CA2912219C
CA2912219C CA2912219A CA2912219A CA2912219C CA 2912219 C CA2912219 C CA 2912219C CA 2912219 A CA2912219 A CA 2912219A CA 2912219 A CA2912219 A CA 2912219A CA 2912219 C CA2912219 C CA 2912219C
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Canada
Prior art keywords
lenvatinib
protein
ang2
concentration
endometrial cancer
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Active
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CA2912219A
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English (en)
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CA2912219A1 (fr
Inventor
Yasuhiro Funahashi
Tadashi Kadowaki
Pallavi SACHDEV
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Publication of CA2912219A1 publication Critical patent/CA2912219A1/fr
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57442—Specifically defined cancers of the uterus and endometrial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/515—Angiogenesic factors; Angiogenin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

La présente invention concerne des biomarqueurs qui prédisent si un sujet atteint d'un cancer de l'endomètre répondra ou non à un traitement comprenant du lenvatinib ou son sel pharmaceutiquement acceptable (par ex. le mésylate de lenvatinib). Les biomarqueur, les compositions et les procédés décrits ici sont utiles pour sélectionner des modalités thérapeutiques appropriées et traiter un sujet présentant, soupçonné de présenter ou présentant un risque de développer un cancer de l'endomètre.
CA2912219A 2013-05-14 2014-05-12 Biomarqueurs pour predire et evaluer la reponse de sujets atteints de cancer de l'endometre a des composes a base de lenvatinib Active CA2912219C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361823034P 2013-05-14 2013-05-14
US61/823034 2013-05-14
PCT/JP2014/063134 WO2014185540A1 (fr) 2013-05-14 2014-05-12 Biomarqueurs pour prédire et évaluer la réponse de sujets atteints de cancer de l'endomètre à des composés à base de lenvatinib

Publications (2)

Publication Number Publication Date
CA2912219A1 CA2912219A1 (fr) 2014-11-20
CA2912219C true CA2912219C (fr) 2021-11-16

Family

ID=50877624

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2912219A Active CA2912219C (fr) 2013-05-14 2014-05-12 Biomarqueurs pour predire et evaluer la reponse de sujets atteints de cancer de l'endometre a des composes a base de lenvatinib

Country Status (14)

Country Link
US (1) US10517861B2 (fr)
EP (1) EP2997377B1 (fr)
JP (1) JP6411379B2 (fr)
KR (1) KR102204279B1 (fr)
CN (1) CN105264380B (fr)
AU (1) AU2014266223B2 (fr)
CA (1) CA2912219C (fr)
ES (1) ES2687968T3 (fr)
IL (1) IL242519B (fr)
MX (1) MX368099B (fr)
NZ (1) NZ714049A (fr)
RU (1) RU2658601C2 (fr)
SG (1) SG11201509278XA (fr)
WO (1) WO2014185540A1 (fr)

Families Citing this family (14)

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ES2705950T3 (es) 2011-06-03 2019-03-27 Eisai R&D Man Co Ltd Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
MX368099B (es) 2013-05-14 2019-09-19 Eisai R&D Man Co Ltd Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib.
JO3783B1 (ar) 2014-08-28 2021-01-31 Eisai R&D Man Co Ltd مشتق كوينولين عالي النقاء وطريقة لإنتاجه
AU2015328411C1 (en) * 2014-10-06 2022-03-03 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
DK3263106T3 (da) 2015-02-25 2024-01-08 Eisai R&D Man Co Ltd Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat
CA2978226A1 (fr) * 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Association d'un antagoniste de pd-1 et d'un inhibiteur des tyrosines kinases vegfr/fgfr/ret pour traiter le cancer
MX2017014540A (es) 2015-05-29 2018-03-12 Eisai R&D Man Co Ltd Biomarcadores para una terapia combinada que comprende lenvatinib y everolimus.
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
JP2019515670A (ja) * 2016-04-15 2019-06-13 ジェネンテック， インコーポレイテッド がんをモニタリングし治療するための方法
TW201837467A (zh) 2017-03-01 2018-10-16 美商建南德克公司 用於癌症之診斷及治療方法
EP3860605B1 (fr) * 2018-10-04 2023-11-08 Synthon B.V. Composition pharmaceutique comprenant besylate de lenvatinib
WO2020071457A1 (fr) * 2018-10-05 2020-04-09 Eisai R&D Management Co., Ltd. Biomarqueurs pour une polythérapie comprenant du lenvatinib et de l'évérolimus
CN113533544A (zh) * 2020-04-16 2021-10-22 先声药业有限公司 一种甲磺酸仑伐替尼的有关物质检测方法
CN114441764B (zh) * 2021-12-24 2022-09-27 广州市妇女儿童医疗中心 Angiogenin作为先天性巨结肠肠炎早期预测及诊断标志物的应用

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SG11201509278XA (en) 2015-12-30
KR20160009551A (ko) 2016-01-26
CA2912219A1 (fr) 2014-11-20
EP2997377A1 (fr) 2016-03-23
AU2014266223A1 (en) 2015-11-26
MX2015015605A (es) 2016-07-07
EP2997377B1 (fr) 2018-07-18
JP2016522879A (ja) 2016-08-04
ES2687968T3 (es) 2018-10-30
US10517861B2 (en) 2019-12-31
CN105264380A (zh) 2016-01-20
IL242519B (en) 2018-02-28
RU2015148193A (ru) 2017-06-21
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US20160089366A1 (en) 2016-03-31
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