LUC00100I2 - - Google Patents
Download PDFInfo
- Publication number
- LUC00100I2 LUC00100I2 LU00100C LUC00100C LUC00100I2 LU C00100 I2 LUC00100 I2 LU C00100I2 LU 00100 C LU00100 C LU 00100C LU C00100 C LUC00100 C LU C00100C LU C00100 I2 LUC00100 I2 LU C00100I2
- Authority
- LU
- Luxembourg
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36400702P | 2002-03-13 | 2002-03-13 | |
PCT/US2003/007864 WO2003077914A1 (fr) | 2002-03-13 | 2003-03-13 | Utilisation de derives de benzimidazole alkyles n3 en tant qu'inhibiteurs de mek |
Publications (2)
Publication Number | Publication Date |
---|---|
LUC00100I1 LUC00100I1 (fr) | 2019-02-13 |
LUC00100I2 true LUC00100I2 (fr) | 2020-01-23 |
Family
ID=28041856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU00100C LUC00100I2 (fr) | 2002-03-13 | 2019-02-12 |
Country Status (35)
Country | Link |
---|---|
US (11) | US20030232869A1 (fr) |
EP (5) | EP2275102B1 (fr) |
JP (4) | JP4093966B2 (fr) |
KR (3) | KR100984595B1 (fr) |
CN (4) | CN100519539C (fr) |
AR (3) | AR038971A1 (fr) |
AT (1) | ATE449605T1 (fr) |
AU (2) | AU2003218157C1 (fr) |
BE (1) | BE2019C510I2 (fr) |
BR (1) | BR122018007328B8 (fr) |
CA (1) | CA2478374C (fr) |
CL (2) | CL2012002380A1 (fr) |
CY (3) | CY1109727T1 (fr) |
DE (1) | DE60330227D1 (fr) |
DK (4) | DK2130537T3 (fr) |
DO (4) | DOP2003000613A (fr) |
ES (5) | ES2335276T3 (fr) |
HK (3) | HK1070823A1 (fr) |
HU (2) | HUE025767T2 (fr) |
IL (4) | IL163995A0 (fr) |
IS (4) | IS2748B (fr) |
LT (1) | LTC1482932I2 (fr) |
LU (1) | LUC00100I2 (fr) |
MX (1) | MXPA04008893A (fr) |
NL (1) | NL300974I2 (fr) |
NZ (1) | NZ535158A (fr) |
PA (1) | PA8569301A1 (fr) |
PL (5) | PL401637A1 (fr) |
PT (4) | PT1482932E (fr) |
SG (3) | SG148857A1 (fr) |
SI (4) | SI3000810T1 (fr) |
TW (3) | TWI338685B (fr) |
UA (1) | UA77765C2 (fr) |
WO (1) | WO2003077914A1 (fr) |
ZA (1) | ZA200407220B (fr) |
Families Citing this family (239)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL401637A1 (pl) | 2002-03-13 | 2013-05-27 | Array Biopharma Inc. | N3 alkilowane pochodne benzimidazolu jako inhibitory MEK |
US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
EP1581527A4 (fr) * | 2002-12-13 | 2006-11-22 | Smithkline Beecham Corp | Mimetiques de la thrombopoietine |
EP1598079B1 (fr) * | 2003-02-26 | 2009-04-22 | Kowa Co., Ltd. | Traitement de la dermatite de contact allergique |
CA2532067C (fr) | 2003-07-24 | 2010-12-21 | Stephen Douglas Barrett | Benzimidazoles n-methyle-substitues |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7538120B2 (en) * | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
BRPI0414581C1 (pt) * | 2003-09-22 | 2021-05-25 | Mei Pharma Inc | composto, composição farmacêutica compreendendo o referido composto e uso do referido composto |
WO2005051302A2 (fr) * | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Inhibiteurs bicycliques de mek, et leurs procedes d'utilisation |
US7732616B2 (en) * | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
US7517994B2 (en) * | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
WO2005051304A2 (fr) | 2003-11-21 | 2005-06-09 | Array Biopharma Inc. | Inhibiteurs de la proteine kinase akt |
WO2005058341A2 (fr) * | 2003-12-11 | 2005-06-30 | Theravance, Inc. | Compositions a utiliser dans le traitement de maladies proliferatives cellulaires caracterisees par la presence d'une tyrosine kinase receptrice mutante |
DK1802579T3 (da) | 2004-10-20 | 2014-01-20 | Merck Serono Sa | Derivater af 3-arylaminopyridin |
ATE443063T1 (de) * | 2004-12-01 | 2009-10-15 | Merck Serono Sa | Ä1,2,4ütriazoloä4,3-aüpyridin-derivative zur behandlung hyperproliferativer erkrankungen |
US7429667B2 (en) | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
KR20080019236A (ko) | 2005-05-18 | 2008-03-03 | 어레이 바이오파마 인크. | Mek의 헤테로시클릭 억제제 및 그의 사용 방법 |
AR054623A1 (es) * | 2005-06-23 | 2007-07-04 | Astrazeneca Ab | PROCESO PARA PREPARAR DERIVADOS DE BENCIMIDAZOL Y COMPUESTOS INTERMEDIARIOS DE SíNTESIS DE LOS MISMOS. |
KR101357361B1 (ko) * | 2005-06-23 | 2014-02-03 | 아스트라제네카 아베 | 벤즈이미다졸 화합물의 SnAr 제조 방법 |
US8101799B2 (en) | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
NZ567140A (en) | 2005-10-07 | 2011-09-30 | Exelixis Inc | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
AU2012261703B2 (en) * | 2005-10-07 | 2015-08-13 | Exelixis, Inc. | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
AU2013203939B2 (en) * | 2005-10-07 | 2015-08-13 | Exelixis, Inc. | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
US7968108B2 (en) * | 2005-10-25 | 2011-06-28 | Metbro Distributing L.P. | Hydrogen cyanamide pesticide formulations |
US7572460B2 (en) * | 2005-10-25 | 2009-08-11 | Rodrigo Rodriguez-Kabana | Hydrogen cyanamide pesticide formulations |
TWI405756B (zh) * | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
WO2007071951A1 (fr) * | 2005-12-21 | 2007-06-28 | Astrazeneca Ab | Sel de tosylate du 6-(4-bromo-2-chlorophenylamino)-7-fluoro-n-(2-hydroxyethoxy)-3-methyl-3h-benzimidazole-5-carboxamide, inhibiteur de mek pouvant etre employe dans le traitement du cancer |
CA2534243A1 (fr) | 2006-01-25 | 2007-07-25 | Hydro Quebec | Particules d'oxyde metallique enrobees a faible taux de dissolution, procedes de preparation et utilisation dans les systemes electrochimiques |
GB0601962D0 (en) | 2006-01-31 | 2006-03-15 | Ucb Sa | Therapeutic agents |
WO2007121269A2 (fr) | 2006-04-11 | 2007-10-25 | Ardea Biosciences, Inc. | N-aryl-n'alkyle sulfamides utilisés comme inhibiteurs de mek |
ATE483463T1 (de) | 2006-04-18 | 2010-10-15 | Ardea Biosciences Inc | Pyridonsulfonamide und pyridonsulfamide als mek- hemmer |
ATE493418T1 (de) | 2006-07-06 | 2011-01-15 | Array Biopharma Inc | Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren |
SI2054418T1 (sl) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji |
BRPI0713555A2 (pt) | 2006-07-06 | 2012-03-20 | Array Biopharma, Inc. | ciclopenta [d] pirimidinas como inibidores de akt protéina cinase |
US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2008016123A1 (fr) * | 2006-08-03 | 2008-02-07 | Takeda Pharmaceutical Company Limited | INHIBITEUR DE LA GSK-3β |
CN101583616B (zh) * | 2006-08-21 | 2012-05-30 | 健泰科生物技术公司 | 氮杂苯并噻吩基化合物及使用方法 |
BRPI0714635A2 (pt) * | 2006-08-21 | 2013-06-18 | Genentech Inc | compostos, composiÇço farmacÊutica, mÉtodo para inibir, o crescimento celular anormal ou tratar uma disfunÇço hiperproliferativa, mÉtodo para tratar uma doenÇa inflamatària e mÉtodo para tratar uma doenÇa autoimune |
BRPI0714629A2 (pt) * | 2006-08-21 | 2013-05-07 | Genentech Inc | composto, composiÇço farmacÊutica, mÉtodo para inibir o crescimento celular, mÉtodo para tratar uma doenÇa inflamatària e mÉtodo para trataruma doenÇa auto-imune, lesço àsseo destrutiva, distérbios proliferativos, doenÇas infecciosas, doenÇas virais, doenÇas fibràticas ou doenÇas neurodegenerativas |
US7999006B2 (en) | 2006-12-14 | 2011-08-16 | Exelixis, Inc. | Methods of using MEK inhibitors |
JO2985B1 (ar) | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
JP2010523634A (ja) * | 2007-04-13 | 2010-07-15 | アストラゼネカ アクチボラグ | Azd2171およびazd6244またはmek阻害剤iiを含む併用療法 |
US8509487B2 (en) * | 2007-04-19 | 2013-08-13 | Avago Technologies General Ip (Singapore) Pte. Ltd. | System and method for optically measuring a parameter of an object |
EP2164850B1 (fr) | 2007-06-12 | 2016-01-13 | Genentech, Inc. | Azaindoles n-substitués et procédés d'utilisation |
CN101918373B (zh) * | 2007-07-05 | 2013-06-05 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
KR20150089099A (ko) | 2007-07-05 | 2015-08-04 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제로서의 피리미딜 시클로펜탄 |
GB0714384D0 (en) | 2007-07-23 | 2007-09-05 | Ucb Pharma Sa | theraputic agents |
WO2009050506A2 (fr) * | 2007-10-15 | 2009-04-23 | Astrazeneca Ab | Combinaison 059 |
ES2456966T3 (es) | 2007-11-12 | 2014-04-24 | Takeda Pharmaceutical Company Limited | Inhibidores de MAPK/ERK cinasa |
CN101945870B (zh) | 2007-12-19 | 2012-10-03 | 健泰科生物技术公司 | 5-苯氨基咪唑并吡啶和使用方法 |
CN101903387B (zh) | 2007-12-19 | 2014-05-21 | 健泰科生物技术公司 | 8-苯氨基咪唑并吡啶和它们在制备抗癌剂和/或抗炎剂中的用途 |
CA2707650A1 (fr) | 2007-12-20 | 2009-07-02 | F. Hoffmann-La Roche Ag | Hydantoines substituees en tant qu'inhibiteurs de la mek kinase |
CN101945875B (zh) | 2007-12-21 | 2013-04-24 | 健泰科生物技术公司 | 氮杂吲嗪及其使用方法 |
JP5346345B2 (ja) * | 2008-01-09 | 2013-11-20 | アレイ バイオファーマ、インコーポレイテッド | Aktタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン類 |
WO2009089453A1 (fr) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrimidyl cyclopentane hydroxylé en tant qu'inhibiteur de protéine kinase akt |
WO2009093008A1 (fr) | 2008-01-21 | 2009-07-30 | Ucb Pharma S.A. | Dérivés de thiénopyridine utilisés comme inhibiteurs de mek |
SA109300195B1 (ar) | 2008-03-28 | 2013-04-20 | Astrazeneca Ab | تركيبة صيدلانية جديدة مضادة للسرطان |
GB0811304D0 (en) | 2008-06-19 | 2008-07-30 | Ucb Pharma Sa | Therapeutic agents |
WO2009157167A1 (fr) | 2008-06-23 | 2009-12-30 | パナソニック株式会社 | Appareil de station de base de communication sans fil et procédé d'attribution de signal de référence |
EP2310373A1 (fr) | 2008-07-01 | 2011-04-20 | Genentech, Inc. | Hétérocycles bicycliques en tant qu'inhibiteurs de mek kinase |
RU2495028C2 (ru) | 2008-07-01 | 2013-10-10 | Дженентек, Инк. | Изоиндолоны и способы их применения |
PE20110665A1 (es) | 2008-08-04 | 2011-09-23 | Merck Patent Gmbh | Compuestos derivados de n-cichohexil-3-(fenilamino)-isonicotinamida como inhibidores de mek |
CN101653607B (zh) * | 2008-08-19 | 2013-02-13 | 鼎泓国际投资(香港)有限公司 | 含有肝细胞生长因子受体抑制剂和丝裂原细胞外激酶抑制剂的药物组合物及其用途 |
EP2358202B1 (fr) * | 2008-11-03 | 2016-06-15 | Merck Sharp & Dohme Corp. | Benzimidazole et aza-benzimidazole carboxamides |
JP5746630B2 (ja) | 2008-11-10 | 2015-07-08 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換スルホンアミドフェノキシベンズアミド |
JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
WO2011047795A1 (fr) | 2009-10-21 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Benzosulfonamides substitués |
CA2777304A1 (fr) | 2009-10-21 | 2011-04-28 | Marion Hitchcock | Benzosulfonamides substitues |
EP2491014A1 (fr) | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Dérivés d'halogénophénoxybenzamide substitués |
WO2011095807A1 (fr) | 2010-02-07 | 2011-08-11 | Astrazeneca Ab | Combinaisons d'inhibiteurs de mek et de hh |
EP2560640A1 (fr) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Thérapie anticancéreuse à l'aide d'une combinaison d'un composé inhibiteur de hsp90 et d'un inhibiteur d'egfr |
WO2011131748A2 (fr) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Nouveaux inhibiteurs |
CN103080107A (zh) | 2010-06-25 | 2013-05-01 | 诺瓦提斯公司 | 作为蛋白激酶抑制剂的杂芳基化合物和组合物 |
CN103221043B (zh) | 2010-08-05 | 2016-04-06 | 卡斯西部储备大学 | 用于治疗神经元连接发育障碍的erk抑制剂 |
HUE033209T2 (hu) | 2010-10-06 | 2017-11-28 | Glaxosmithkline Llc | PI3 kináz inhibitor hatású benzimidazol-származékok |
US9045429B2 (en) | 2010-10-29 | 2015-06-02 | Bayer Intellectual Property Gmbh | Substituted phenoxypyridines |
CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
KR20140063501A (ko) | 2010-12-22 | 2014-05-27 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
PL2655375T3 (pl) | 2010-12-23 | 2015-05-29 | Sanofi Sa | Pochodne pirymidynonu, ich wytwarzanie i ich farmaceutyczne zastosowanie |
EP2694073B1 (fr) | 2011-04-01 | 2018-08-08 | Genentech, Inc. | Combinaisons de inhibiteurs d'akt et mek pour le traitement du cancer |
CN107233343A (zh) | 2011-04-01 | 2017-10-10 | 基因泰克公司 | Akt抑制剂化合物和化疗剂的组合以及使用方法 |
WO2012145503A1 (fr) | 2011-04-21 | 2012-10-26 | Novartis Ag | Combinaisons pharmaceutiques |
WO2012162293A1 (fr) * | 2011-05-23 | 2012-11-29 | Synta Pharmaceuticals Corp. | Polythérapie de composés inhibiteurs de hsp90 avec inhibiteurs de mek |
ES2597052T3 (es) | 2011-05-25 | 2017-01-13 | Université Paris Descartes | Inhibidores de ERK para su uso en el tratamiento de atrofia muscular espinal |
EP3812387A1 (fr) | 2011-07-21 | 2021-04-28 | Sumitomo Dainippon Pharma Oncology, Inc. | Inhibiteurs de protéine kinase hétérocycliques |
UA117220C2 (uk) * | 2011-08-01 | 2018-07-10 | Дженентек, Інк. | Способи лікування раку з використанням антагоністів, що зв'язуються з віссю pd-1, і інгібіторів mek |
US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
CN103764144B (zh) * | 2011-08-31 | 2016-07-20 | 诺华股份有限公司 | Pi3k抑制剂与mek抑制剂的协同组合 |
CA2845571A1 (fr) * | 2011-09-01 | 2013-03-07 | Novartis Ag | Utilisation d'un compose organique dans le traitement du syndrome de noonan |
EP2570127A1 (fr) | 2011-09-16 | 2013-03-20 | Sanofi | Compositions et procédés pour traiter le cancer avec un inhibiteur bêta PI3KB et un inhibiteur de la voie MAPK, incluant des inhibiteurs MEK et RAF |
JP2014530243A (ja) | 2011-10-14 | 2014-11-17 | アレイ バイオファーマ、インコーポレイテッド | Arry−380の多形体、選択的herb2阻害剤、およびそれらを含有する薬学的組成物 |
EP2773345A1 (fr) | 2011-11-02 | 2014-09-10 | Synta Pharmaceuticals Corp. | Thérapie anticancéreuse utilisant une combinaison d'inhibiteurs de hsp 90 et d'inhibiteurs de topoisomérase i |
WO2013067165A1 (fr) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Polythérapie d'inhibiteurs de hsp 90 avec des agents contenant du platine |
EP2780010A1 (fr) | 2011-11-14 | 2014-09-24 | Synta Pharmaceuticals Corp. | Association thérapeutique d'inhibiteurs de hsp90 et d'inhibiteurs de braf |
AU2012340766B2 (en) | 2011-11-23 | 2018-05-10 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
WO2013082511A1 (fr) | 2011-12-02 | 2013-06-06 | Genentech, Inc. | Procédés pour surmonter la résistance tumorale aux antagonistes de vegf |
US10023862B2 (en) | 2012-01-09 | 2018-07-17 | Arrowhead Pharmaceuticals, Inc. | Organic compositions to treat beta-catenin-related diseases |
WO2013109142A1 (fr) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Inhibition de la voie des mapk/erk et pdk combinée dans des cas de néoplasie |
CN103204822B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
GB201201332D0 (en) | 2012-01-26 | 2012-03-14 | Imp Innovations Ltd | Method |
CN104487089B (zh) * | 2012-03-20 | 2018-08-28 | 诺华股份有限公司 | Mek抑制剂和igfir抑制剂的组合疗法 |
WO2013152425A1 (fr) | 2012-04-09 | 2013-10-17 | Switch Materials , Inc. | Matériaux de commutation, et compositions et procédés pour les fabriquer |
WO2013177676A1 (fr) | 2012-05-29 | 2013-12-05 | Switch Materials Inc. | Filtre optique comprenant une couche à transmittance variable |
CA2874905A1 (fr) | 2012-05-31 | 2013-12-05 | Bayer Pharma Aktiengesellschaft | Biomarqueurs pour la determination de la reponse efficace de traitements de patients atteints d'un carcinome hepatocellulaire (hcc) |
AR091876A1 (es) * | 2012-07-26 | 2015-03-04 | Novartis Ag | Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas |
MX367970B (es) | 2012-08-17 | 2019-09-11 | Hoffmann La Roche | Tratamientos de combinación para melanoma que comprenden la administración de cobimetinib y vemurafinib. |
LT2903968T (lt) | 2012-10-02 | 2017-02-27 | Gilead Sciences, Inc. | Histondemetilazių inhibitoriai |
SI2909188T1 (en) | 2012-10-12 | 2018-07-31 | Exelixis, Inc. | A novel process for the manufacture of compounds for use in the treatment of cancer |
EP2909181B1 (fr) | 2012-10-16 | 2017-08-09 | Tolero Pharmaceuticals, Inc. | Modulateurs de pkm2 et procédés pour les utiliser |
ES2772498T3 (es) * | 2012-10-19 | 2020-07-07 | Array Biopharma Inc | Preparación de un inhibidor mek y formulación que comprende el mismo |
US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
US9446043B2 (en) | 2012-11-29 | 2016-09-20 | Novartis Ag | Pharmaceutical combinations |
WO2014097125A1 (fr) | 2012-12-20 | 2014-06-26 | Novartis Ag | Combinaison pharmaceutique comprenant du binimétinib |
EP2752191A1 (fr) | 2013-01-07 | 2014-07-09 | Sanofi | Compositions et procédés utilisant un antagoniste de hdm2 et un inhibiteur de mek |
US20140242595A1 (en) | 2013-02-22 | 2014-08-28 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
WO2014133071A1 (fr) | 2013-02-27 | 2014-09-04 | 第一三共株式会社 | Procédé de prédiction de la réactivité à un composé inhibant la voie de transduction du signal de mapk |
PL2961736T3 (pl) | 2013-02-27 | 2018-08-31 | Gilead Sciences, Inc. | Inhibitory demetylaz histonowych |
EP2970205B1 (fr) | 2013-03-14 | 2019-05-08 | Tolero Pharmaceuticals, Inc. | Inhibiteurs de jak2 et alk2 et leurs procédés d'utilisation |
MA38522A1 (fr) * | 2013-03-21 | 2017-10-31 | Novartis Ag | Thérapie de combinaison comprenant un inhibiteur de b-raf et un second inhibiteur. |
AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
WO2015041534A1 (fr) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk en combinaison avec raf/erk/mek |
WO2015041533A1 (fr) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | Association de rock et de la voie mapk |
US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
MA39189A1 (fr) | 2013-12-19 | 2017-06-30 | Actelion Pharmaceuticals Ltd | Dérivés de 1h-indazole et de 1h-indole antibactériens |
CN104788365B (zh) * | 2014-01-16 | 2018-08-10 | 上海艾力斯医药科技有限公司 | 异烟酰胺衍生物、其制备方法及应用 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
AU2015227184B2 (en) | 2014-03-04 | 2021-05-20 | Fate Therapeutics, Inc. | Improved reprogramming methods and cell culture platforms |
AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
TWI697500B (zh) | 2014-03-14 | 2020-07-01 | 瑞士商諾華公司 | 針對lag-3之抗體分子及其用途 |
EP3126345A1 (fr) | 2014-03-31 | 2017-02-08 | Gilead Sciences, Inc. | Inhibiteurs d'histones déméthylases |
US20170107486A1 (en) | 2014-04-21 | 2017-04-20 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
ES2687040T3 (es) | 2014-05-16 | 2018-10-23 | Idorsia Pharmaceuticals Ltd | Derivados antibacterianos de quinazolin4(3H)ona |
US10023879B2 (en) | 2014-06-04 | 2018-07-17 | Fate Therapeutics, Inc. | Minimal volume reprogramming of mononuclear cells |
JP6673896B2 (ja) | 2014-07-15 | 2020-03-25 | ジェネンテック, インコーポレイテッド | Pd−1軸結合アンタゴニスト及びmek阻害剤を使用した癌を処置するための組成物 |
AR101692A1 (es) | 2014-08-27 | 2017-01-04 | Epitherapeutics Aps | Compuestos y métodos para inhibir histonas demetilasas |
CA2960824A1 (fr) | 2014-09-13 | 2016-03-17 | Novartis Ag | Therapies combinees d'inhibiteurs d'alk |
ES2774448T3 (es) | 2014-10-03 | 2020-07-21 | Novartis Ag | Terapias de combinación |
WO2016057367A1 (fr) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Biomarqueurs à base d'angiopoïétine -2 utilisés pour la prédiction de la réponse de point de contrôle anti-immunitaire |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
CN114920840A (zh) | 2014-10-14 | 2022-08-19 | 诺华股份有限公司 | 针对pd-l1的抗体分子及其用途 |
US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
US20170340733A1 (en) | 2014-12-19 | 2017-11-30 | Novartis Ag | Combination therapies |
HUE043060T2 (hu) | 2014-12-23 | 2019-07-29 | Novartis Ag | Triazolopirimidin-vegyületek és alkalmazásaik |
SG10202101358XA (en) | 2015-01-26 | 2021-03-30 | Fate Therapeutics Inc | Methods and compositions for inducing hematopoietic cell differentiation |
CN105566225A (zh) * | 2015-02-16 | 2016-05-11 | 苏州晶云药物科技有限公司 | 一种口服丝裂原活化蛋白激酶抑制剂的晶型及其制备方法 |
JP2016155776A (ja) * | 2015-02-24 | 2016-09-01 | 学校法人兵庫医科大学 | 抗腫瘍効果増強剤および抗腫瘍剤 |
TN2017000375A1 (en) | 2015-03-10 | 2019-01-16 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene" -dependent signalling |
CN107667092B (zh) | 2015-03-25 | 2021-05-28 | 诺华股份有限公司 | 作为fgfr4抑制剂的甲酰化n-杂环衍生物 |
MA41866A (fr) | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | Molécules à auto-assemblage pour l'administration ciblée de médicaments |
EP3316902A1 (fr) | 2015-07-29 | 2018-05-09 | Novartis AG | Polythérapies comprenant des molécules d'anticorps contre tim -3 |
EP3317301B1 (fr) | 2015-07-29 | 2021-04-07 | Novartis AG | Polythérapies comprenant des molécules d'anticorps dirigées contre lag-3 |
AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
WO2017033113A1 (fr) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Associations thérapeutiques d'un inhibiteur de mek et d'un inhibiteur de btk |
CN111821306A (zh) | 2015-08-28 | 2020-10-27 | 诺华股份有限公司 | Mdm2抑制剂和其组合 |
AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
CN117737124A (zh) | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
MX2018005550A (es) | 2015-11-03 | 2019-07-18 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a tim-3 y sus usos. |
CN115806940A (zh) | 2015-11-04 | 2023-03-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
WO2017078807A1 (fr) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Procédés et compositions pour induire la différenciation de cellules hématopoïétiques |
JP2019503349A (ja) | 2015-12-17 | 2019-02-07 | ノバルティス アーゲー | Pd−1に対する抗体分子およびその使用 |
US11413309B2 (en) | 2016-01-20 | 2022-08-16 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
AU2017210031C1 (en) | 2016-01-20 | 2020-11-26 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
AR108257A1 (es) | 2016-05-02 | 2018-08-01 | Mei Pharma Inc | Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas |
CN109890386B (zh) | 2016-06-03 | 2022-05-24 | 阵列生物制药公司 | 药物组合 |
EP3472168B1 (fr) | 2016-06-20 | 2024-01-10 | Novartis AG | Formes cristallines d'un composé de triazolopyrimidine |
WO2017221092A1 (fr) | 2016-06-20 | 2017-12-28 | Novartis Ag | Composés de triazolopyridine et leurs utilisations |
CN109790166A (zh) | 2016-06-20 | 2019-05-21 | 诺华股份有限公司 | 咪唑并吡啶化合物用于治疗癌症 |
WO2018009466A1 (fr) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Composés dinucléotidiques cycliques d'acide nucléique bloqué et leurs utilisations |
WO2018065924A1 (fr) * | 2016-10-04 | 2018-04-12 | Sun Pharmaceutical Industries Limited | Intermédiaires d'inhibiteurs de la protéine kinase kinase activée par mitogène (map2k ou mek) et leur procédé de préparation |
WO2018092064A1 (fr) | 2016-11-18 | 2018-05-24 | Novartis Ag | Combinaisons d'inhibiteurs de mdm2 et d'inhibiteurs de bcl-xl |
CN108084078B (zh) * | 2016-11-24 | 2021-07-30 | 中山大学 | 一种治疗银屑病性关节炎疾病的药物阿普斯特的合成方法 |
WO2018106595A1 (fr) | 2016-12-05 | 2018-06-14 | Fate Therapeutics, Inc. | Compositions et procédés pour la modulation de cellules immunitaires dans des immunothérapies adoptives |
EP3372624A1 (fr) | 2017-03-06 | 2018-09-12 | Henkel AG & Co. KGaA | Composition à un composant à base de composés ayant au moins deux unités de carbonate cyclique exo-vinylène |
UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
CN109438362B (zh) * | 2017-11-14 | 2020-07-21 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的苯并咪唑化合物及包含该化合物的组合物 |
JP2021503478A (ja) | 2017-11-16 | 2021-02-12 | ノバルティス アーゲー | 組み合わせ治療 |
TW201938165A (zh) | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | 治療癌症的方法及組合療法 |
MX2020009762A (es) | 2018-03-19 | 2021-01-08 | Taiho Pharmaceutical Co Ltd | Composicion farmaceutica que incluye alquil sulfato de sodio. |
BR112020020246A8 (pt) | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
MX2020012598A (es) | 2018-05-24 | 2021-05-27 | Janssen Biotech Inc | Agentes aglutinantes del psma y usos de estos. |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
WO2020021465A1 (fr) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Procédé de traitement de tumeurs neuroendocrines |
KR102643582B1 (ko) | 2018-07-25 | 2024-03-05 | 어드밴스드 엑셀러레이터 어플리케이션즈 | 안정한 농축 방사성 핵종 복합체 용액 |
CN112512597A (zh) | 2018-07-26 | 2021-03-16 | 大日本住友制药肿瘤公司 | 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂 |
JP7328323B2 (ja) | 2018-08-17 | 2023-08-16 | ノバルティス アーゲー | SMARCA2/BRM ATPase阻害剤としての尿素化合物及び組成物 |
WO2020064693A1 (fr) | 2018-09-25 | 2020-04-02 | Advanced Accelerator Applications (Italy) Srl | Polythérapie |
CN113473978A (zh) | 2018-11-20 | 2021-10-01 | 恩福莱克逊治疗有限公司 | 用于治疗皮肤疾病氰基芳烃-苯胺化合物 |
JP2022514315A (ja) | 2018-12-20 | 2022-02-10 | ノバルティス アーゲー | 3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体を含む投与計画及び薬剤組み合わせ |
TW202038957A (zh) | 2018-12-21 | 2020-11-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與激酶抑制劑之組合 |
CA3127502A1 (fr) | 2019-02-12 | 2020-08-20 | Sumitomo Dainippon Pharma Oncology, Inc. | Formulations comprenant des inhibiteurs de proteine kinase heterocycliques |
CN113329792A (zh) | 2019-02-15 | 2021-08-31 | 诺华股份有限公司 | 取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
WO2020165833A1 (fr) | 2019-02-15 | 2020-08-20 | Novartis Ag | Dérivés de 3-(1-oxo-5-(pipéridin-4-yl)isoindolin-2-yl)pipéridine-2,6-dione et leurs utilisations |
JP2022526713A (ja) | 2019-03-21 | 2022-05-26 | オンクセオ | がんの処置のための、キナーゼ阻害剤と組み合わせたDbait分子 |
KR20210141621A (ko) | 2019-03-22 | 2021-11-23 | 스미토모 다이니폰 파마 온콜로지, 인크. | Pkm2 조정제를 포함하는 조성물 및 그를 사용한 치료 방법 |
WO2020212832A1 (fr) * | 2019-04-16 | 2020-10-22 | Alembic Pharmaceuticals Limited | Procédé de préparation de composés de benzimidazole |
MA55717A (fr) | 2019-04-19 | 2022-02-23 | Janssen Biotech Inc | Méthodes de traitement du cancer de la prostate avec un anticorps anti-psma/cd3 |
TWI817018B (zh) | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療braf相關的疾病和失調症之化合物 |
JP2022539208A (ja) | 2019-07-03 | 2022-09-07 | スミトモ ファーマ オンコロジー, インコーポレイテッド | チロシンキナーゼ非受容体1(tnk1)阻害剤およびその使用 |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021116901A1 (fr) * | 2019-12-09 | 2021-06-17 | Biocon Limited | Formes de binimétinib et procédé de préparation correspondant |
EP4077389A1 (fr) | 2019-12-20 | 2022-10-26 | Novartis AG | Combinaison d'anticorps anti-tim-3 mbg453 et d'anticorps anti-tgf-bêta nis793, avec ou sans décitabine ou l'anticorps anti pd-1 spartalizumab, pour le traitement de la myélofibrose et du syndrome myélodysplasique |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
WO2021185291A1 (fr) * | 2020-03-17 | 2021-09-23 | 南京明德新药研发有限公司 | Régulateur de protéolyse et son procédé d'utilisation |
EP4134081A1 (fr) | 2020-04-10 | 2023-02-15 | Taiho Pharmaceutical Co., Ltd. | Thérapie contre le cancer à l'aide d'un composé d'alcynyle benzène 3,5-disubstitué et un inhibiteur de mek |
IL298300A (en) | 2020-06-09 | 2023-01-01 | Array Biopharma Inc | 4-oxo-3,4-dihydroquinazolinone compounds for the treatment of braf-related diseases and disorders |
KR20230027056A (ko) | 2020-06-23 | 2023-02-27 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 |
AR123185A1 (es) | 2020-08-10 | 2022-11-09 | Novartis Ag | Compuestos y composiciones para inhibir ezh2 |
US20230321285A1 (en) | 2020-08-31 | 2023-10-12 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
WO2022043556A1 (fr) | 2020-08-31 | 2022-03-03 | Novartis Ag | Composition pharmaceutique stable |
EP4204020A1 (fr) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Méthode de traitement de cancers exprimant le psma |
MX2023003867A (es) | 2020-10-05 | 2023-04-18 | Pf Medicament | Combinacion de encorafenib y binimetinib a manera de tratamiento adyuvante contra melanoma resecado en etapa ii. |
TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk﹘5抑制劑和彼之用途 |
CN112679438A (zh) * | 2020-12-31 | 2021-04-20 | 武汉九州钰民医药科技有限公司 | 制备司美替尼的方法 |
CN112759552A (zh) * | 2020-12-31 | 2021-05-07 | 武汉九州钰民医药科技有限公司 | 司美替尼的合成方法 |
CN117136056A (zh) * | 2021-01-21 | 2023-11-28 | 恩福莱克逊治疗有限公司 | 吡咯并吡啶-苯胺化合物的制备方法 |
AU2022214491A1 (en) | 2021-01-28 | 2023-09-14 | Janssen Biotech, Inc. | Psma binding proteins and uses thereof |
CN117794929A (zh) | 2021-02-02 | 2024-03-29 | 法国施维雅药厂 | 选择性bcl-xl protac化合物及使用方法 |
WO2022195551A1 (fr) | 2021-03-18 | 2022-09-22 | Novartis Ag | Biomarqueurs pour le cancer et leurs méthodes d'utilisation |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
KR20230170039A (ko) | 2021-04-13 | 2023-12-18 | 뉴베일런트, 아이엔씨. | Egfr 돌연변이를 지니는 암을 치료하기 위한 아미노-치환된 헤테로사이클 |
EP4322953A1 (fr) * | 2021-04-15 | 2024-02-21 | Ideaya Biosciences, Inc. | Polythérapie comprenant un inhibiteur de pkc et un inhibiteur de mek |
AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
TW202313046A (zh) | 2021-06-09 | 2023-04-01 | 瑞士商赫孚孟拉羅股份公司 | 用於癌症治療之組合療法 |
WO2022262699A1 (fr) * | 2021-06-17 | 2022-12-22 | 深圳市塔吉瑞生物医药有限公司 | Composé de benzimidazole substitué, composition le contenant et utilisation associée |
AU2022306297A1 (en) | 2021-07-09 | 2024-02-08 | Plexium, Inc. | Aryl compounds and pharmaceutical compositions that modulate ikzf2 |
CA3230652A1 (fr) | 2021-11-04 | 2023-05-11 | F. Hoffmann-La Roche Ag | Nouvelle utilisation d'un compose quinazolinone pour le traitement du cancer |
WO2023084489A1 (fr) | 2021-11-15 | 2023-05-19 | Pfizer Inc. | Procédés de traitement de la maladie à coronavirus 2019 |
TW202342018A (zh) | 2022-03-04 | 2023-11-01 | 美商奇奈特生物製藥公司 | Mek激酶抑制劑 |
WO2023225336A1 (fr) | 2022-05-20 | 2023-11-23 | Novartis Ag | Conjugués anticorps-médicament inhibiteurs de met bcl-xl et leurs procédés d'utilisation |
WO2023225320A1 (fr) | 2022-05-20 | 2023-11-23 | Novartis Ag | Conjugués anticorps-médicament inhibiteurs de bcl-xl et méthodes d'utilisation associées |
WO2023238000A1 (fr) * | 2022-06-06 | 2023-12-14 | Glenmark Life Sciences Limited | Procédé de préparation de sélumétinib et de sels de celui-ci |
Family Cites Families (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1980001113A1 (fr) | 1978-11-20 | 1980-05-29 | Braun Ag | Garde-temps, en particulier horloge pilotee a quartz |
GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
US5250554A (en) * | 1989-10-24 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives useful as angiotensin II inhibitors |
IL95975A (en) | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
US5218356A (en) * | 1991-05-31 | 1993-06-08 | Guenther Knapp | Wireless indoor data relay system |
US5216003A (en) * | 1992-01-02 | 1993-06-01 | G. D. Searle & Co. | Diacid-containing benzimidazole compounds for treatment of neurotoxic injury |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
EP0710654A4 (fr) | 1993-07-23 | 1996-08-28 | Green Cross Corp | Derive de triazole et son utilisation pharmaceutique |
EP0639573A1 (fr) | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Hétérocycles à cinq chaînons benzocondensés, procédé pour leur préparation, leur utilisation comme médicament et comme diagnostique aussi bien que les produits pharmaceutiques le contenant |
NZ270985A (en) | 1994-04-29 | 1997-06-24 | Lilly Co Eli | Substituted benzimidazole derivatives; medicaments and preparation of medicaments |
US5520187A (en) * | 1994-11-25 | 1996-05-28 | General Electric Company | Ultrasonic probe with programmable multiplexer for imaging systems with different channel counts |
US5525625A (en) | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
CA2218503C (fr) | 1995-04-20 | 2001-07-24 | Pfizer Inc. | Derives d'acide hydroxamique arylsufonyle en tant qu'inhibiteurs de mmp et de tnf |
US5972980A (en) * | 1995-10-05 | 1999-10-26 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
DK0780386T3 (da) | 1995-12-20 | 2003-02-03 | Hoffmann La Roche | Matrixmetalloproteaseinhibitorer |
GB9600344D0 (en) * | 1996-01-09 | 1996-03-13 | Lilly Co Eli | Benzimidzolyl neuropeptide y receptor antagonists |
TR199900066T2 (xx) | 1996-07-18 | 1999-04-21 | Pfizer Inc. | Matriks metalloproteazlar�n fosfinat bazl� inhibit�rleri |
IL128189A0 (en) | 1996-08-23 | 1999-11-30 | Pfizer | Arylsulfonylamino hydroxamic acid derivatives |
US6077864A (en) | 1997-01-06 | 2000-06-20 | Pfizer Inc. | Cyclic sulfone derivatives |
PL335027A1 (en) | 1997-02-03 | 2000-03-27 | Pfizer Prod Inc | Derivatives of arylsulphonylamino hydroxamic acid |
CA2279863A1 (fr) | 1997-02-07 | 1998-08-13 | Pfizer Inc. | Derives du n-hxdroxy-beta-sulfonyl-propionamide et leur utilisation comme inhibiteurs des metalloproteases matrices |
BR9807678A (pt) | 1997-02-11 | 2000-02-15 | Pfizer | Derivados de ácidos arilsulfonil-hidroxâmicos |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
US6506798B1 (en) * | 1997-07-01 | 2003-01-14 | Warner-Lambert Company | 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors |
US6310060B1 (en) | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
NZ501277A (en) | 1997-07-01 | 2002-12-20 | Warner Lambert Co | -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
US6821963B2 (en) * | 1997-07-01 | 2004-11-23 | Warner-Lambert Company | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors |
PT993439E (pt) | 1997-07-01 | 2004-12-31 | Warner Lambert Co | Derivados de acido 4-bromo ou 4-iodofenilaminobenzidroxamico e sua utilizacao como inibidores de mek |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
US6534503B1 (en) * | 1998-04-28 | 2003-03-18 | Lion Bioscience Ag | Melanocortin receptor-3 ligands to treat sexual dysfunction |
AUPP616498A0 (en) | 1998-09-25 | 1998-10-15 | University Of Queensland, The | Synthesis of cyclic peptides |
US6696440B1 (en) | 1999-01-07 | 2004-02-24 | Warner-Lambert Company | Treatment of asthma with MEK inhibitors |
WO2000040237A1 (fr) | 1999-01-07 | 2000-07-13 | Warner-Lambert Company | Methode antivirale utilisant des inhibiteurs de mek |
EP1144385B1 (fr) * | 1999-01-13 | 2005-08-17 | Warner-Lambert Company Llc | Les benzoheterocycles et leur utilisation comme inhibiteurs de mek |
JP2000204077A (ja) | 1999-01-13 | 2000-07-25 | Warner Lambert Co | ジアリ―ルアミン |
OA11819A (en) | 1999-01-13 | 2005-08-17 | Warner Lambert Co | 1-Heterocycle substituted diarylamines. |
EP1144371B1 (fr) | 1999-01-13 | 2005-11-09 | Warner-Lambert Company Llc | Derives de benzenesulfonamide et leur utilisation comme inhibiteurs de mek |
EP1150950A2 (fr) | 1999-01-13 | 2001-11-07 | Warner-Lambert Company | Derives d'acide anthranilique |
CA2349467A1 (fr) | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Acides sulfo-hydroxamiques et sulfo-hydroxamates et leur utilisation comme inhibiteurs mk |
CA2348236A1 (fr) | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, et 4-arylthio diarylamines et leurs derives comme inhibiteurs selectifs de mek |
GB9910577D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
GB9912961D0 (en) | 1999-06-03 | 1999-08-04 | Pfizer Ltd | Metalloprotease inhibitors |
CA2378381A1 (fr) | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Traitement de douleurs chroniques au moyen d'inhibiteurs de mek |
HUP0202381A3 (en) | 1999-07-16 | 2004-12-28 | Warner Lambert Co | Method for treating chronic pain using mek inhibitors |
CA2377092A1 (fr) * | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Methode de traitement de la douleur chronique au moyen d'inhibiteurs de mek |
NZ515567A (en) | 1999-07-16 | 2004-03-26 | Warner Lambert Co | Method for treating chronic pain using MEK inhibitors |
US7030119B1 (en) * | 1999-07-16 | 2006-04-18 | Warner-Lambert Company | Method for treating chronic pain using MEK inhibitors |
WO2001021634A1 (fr) | 1999-09-21 | 2001-03-29 | Lion Bioscience Ag | Derives de benzimidazole et bibliotheques combinatoires contenant ces derives |
EP1339702A1 (fr) | 2000-03-15 | 2003-09-03 | Warner-Lambert Company | Diarylamines a substitution 5-amide, utilises en tant qu'inhibiteur de kinases erk mitogenes mek |
CA2403017A1 (fr) | 2000-03-15 | 2001-09-20 | Warner-Lambert Company | Diarylamines a substitution 5-amide, utilises en tant qu'inhibiteur de kinases erk mitogenes mek |
EE05450B1 (et) | 2000-07-19 | 2011-08-15 | Warner-Lambert Company | 4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine |
AP2001002249A0 (en) | 2000-08-25 | 2001-09-30 | Warner Lambert Co | Process for making N-ARYL-ANTHRANILIC acids and their derivatives. |
EP1337524A1 (fr) | 2000-11-02 | 2003-08-27 | AstraZeneca AB | Quinolines substituees comme agents antitumoraux |
AU2002221239A1 (en) * | 2000-12-07 | 2002-06-18 | Astrazeneca Ab | Therapeutic benzimidazole compounds |
US7102009B2 (en) * | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
AU2002336273A1 (en) * | 2001-03-09 | 2002-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds and their use as histamine h4 ligands. |
US20040039208A1 (en) | 2001-07-20 | 2004-02-26 | Chen Michael Huai Gu | Process for making n-aryl-anthranilic acids and their derivatives |
WO2003024899A2 (fr) * | 2001-09-17 | 2003-03-27 | Bristol-Myers Squibb Company | Acides hydroxamiques cycliques utilises comme inhibiteurs de metalloproteinases matricielles et/ou d'enzyme de conversion du tnf-$g(a) (tace) |
WO2003054180A1 (fr) | 2001-12-21 | 2003-07-03 | Warner-Lambert Company Llc | Peptides mek1 et mek2 modifies, cristal d'un complexe peptide/ligand/cofacteur contenant de tels peptides mek1 ou mek2 modifies et leurs procedes d'utilisation |
BR0307060A (pt) | 2002-01-23 | 2004-10-26 | Warner Lambert Co | ésteres hidroxamato do ácido n-(fenil 4-substituìdo)-antranìlico |
US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
PL401637A1 (pl) | 2002-03-13 | 2013-05-27 | Array Biopharma Inc. | N3 alkilowane pochodne benzimidazolu jako inhibitory MEK |
MXPA04008894A (es) * | 2002-03-13 | 2005-06-20 | Array Biopharma Inc | Derivados de bencimidazol n3 alquilados como inhibidores de mek. |
DE10238002A1 (de) * | 2002-08-20 | 2004-03-04 | Merck Patent Gmbh | Benzimidazolderivate |
US20040127395A1 (en) * | 2002-09-06 | 2004-07-01 | Desai Pragnya J. | Use of histamine H4 receptor modulators for the treatment of allergy and asthma |
CN1694704A (zh) * | 2002-09-06 | 2005-11-09 | 詹森药业有限公司 | (1h-苯并咪唑-2-基)-(哌嗪基)-甲酮衍生物及其相关化合物作为组胺h4受体拮抗剂用于治疗炎性和过敏性疾病 |
US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
CA2532067C (fr) | 2003-07-24 | 2010-12-21 | Stephen Douglas Barrett | Benzimidazoles n-methyle-substitues |
DE102005032379A1 (de) | 2005-07-08 | 2007-01-11 | Conti Temic Microelectronic Gmbh | Zugangskontrollsystem für ein Kraftfahrzeug |
TWI405756B (zh) | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
WO2014097125A1 (fr) | 2012-12-20 | 2014-06-26 | Novartis Ag | Combinaison pharmaceutique comprenant du binimétinib |
-
2003
- 2003-03-13 PL PL401637A patent/PL401637A1/pl unknown
- 2003-03-13 UA UA20040907722A patent/UA77765C2/uk unknown
- 2003-03-13 DE DE60330227T patent/DE60330227D1/de not_active Expired - Lifetime
- 2003-03-13 KR KR1020047014182A patent/KR100984595B1/ko active IP Right Grant
- 2003-03-13 IL IL16399503A patent/IL163995A0/xx unknown
- 2003-03-13 NZ NZ535158A patent/NZ535158A/en not_active IP Right Cessation
- 2003-03-13 AU AU2003218157A patent/AU2003218157C1/en active Active
- 2003-03-13 AR ARP030100887A patent/AR038971A1/es active IP Right Grant
- 2003-03-13 EP EP10011691.2A patent/EP2275102B1/fr not_active Expired - Lifetime
- 2003-03-13 SI SI200332546T patent/SI3000810T1/sl unknown
- 2003-03-13 DO DO2003000613A patent/DOP2003000613A/es unknown
- 2003-03-13 SI SI200332449T patent/SI2275102T1/sl unknown
- 2003-03-13 ZA ZA200407220A patent/ZA200407220B/xx unknown
- 2003-03-13 PA PA20038569301A patent/PA8569301A1/es unknown
- 2003-03-13 KR KR1020107007539A patent/KR100984573B1/ko active IP Right Grant
- 2003-03-13 JP JP2003575967A patent/JP4093966B2/ja not_active Expired - Lifetime
- 2003-03-13 TW TW092105718A patent/TWI338685B/zh not_active IP Right Cessation
- 2003-03-13 SG SG200608672-2A patent/SG148857A1/en unknown
- 2003-03-13 CN CNB038107546A patent/CN100519539C/zh not_active Expired - Lifetime
- 2003-03-13 PL PL401638A patent/PL401638A1/pl unknown
- 2003-03-13 CN CN2008101903429A patent/CN101486682B/zh not_active Expired - Lifetime
- 2003-03-13 SG SG2011042850A patent/SG194238A1/en unknown
- 2003-03-13 PL PL401635A patent/PL233177B1/pl unknown
- 2003-03-13 WO PCT/US2003/007864 patent/WO2003077914A1/fr active Application Filing
- 2003-03-13 DK DK09011389.5T patent/DK2130537T3/da active
- 2003-03-13 EP EP15177189.6A patent/EP3000810B1/fr not_active Revoked
- 2003-03-13 PT PT03714148T patent/PT1482932E/pt unknown
- 2003-03-13 ES ES03714148T patent/ES2335276T3/es not_active Expired - Lifetime
- 2003-03-13 EP EP09011389A patent/EP2130537B1/fr not_active Expired - Lifetime
- 2003-03-13 EP EP09011388.7A patent/EP2130536B1/fr not_active Expired - Lifetime
- 2003-03-13 CN CN2009101492905A patent/CN101633644B/zh not_active Expired - Lifetime
- 2003-03-13 SI SI200332221T patent/SI2130537T1/sl unknown
- 2003-03-13 CA CA002478374A patent/CA2478374C/fr not_active Expired - Lifetime
- 2003-03-13 PT PT90113895T patent/PT2130537E/pt unknown
- 2003-03-13 US US10/387,879 patent/US20030232869A1/en not_active Abandoned
- 2003-03-13 PT PT100116912T patent/PT2275102E/pt unknown
- 2003-03-13 DK DK03714148.8T patent/DK1482932T3/da active
- 2003-03-13 KR KR1020107007537A patent/KR100984613B1/ko active Protection Beyond IP Right Term
- 2003-03-13 ES ES10011691.2T patent/ES2549159T3/es not_active Expired - Lifetime
- 2003-03-13 DK DK15177189.6T patent/DK3000810T3/en active
- 2003-03-13 ES ES09011389T patent/ES2394347T3/es not_active Expired - Lifetime
- 2003-03-13 TW TW099113379A patent/TWI343377B/zh not_active IP Right Cessation
- 2003-03-13 SG SG2013013339A patent/SG2013013339A/en unknown
- 2003-03-13 PL PL401636A patent/PL233493B1/pl unknown
- 2003-03-13 SI SI200331731T patent/SI1482932T1/sl unknown
- 2003-03-13 PT PT151771896T patent/PT3000810T/pt unknown
- 2003-03-13 MX MXPA04008893A patent/MXPA04008893A/es active IP Right Grant
- 2003-03-13 DK DK10011691.2T patent/DK2275102T3/en active
- 2003-03-13 EP EP03714148A patent/EP1482932B1/fr not_active Expired - Lifetime
- 2003-03-13 HU HUE10011691A patent/HUE025767T2/en unknown
- 2003-03-13 TW TW099113360A patent/TWI350285B/zh not_active IP Right Cessation
- 2003-03-13 ES ES15177189.6T patent/ES2635666T3/es not_active Expired - Lifetime
- 2003-03-13 AT AT03714148T patent/ATE449605T1/de active
- 2003-03-13 CN CN200910149291XA patent/CN101633645B/zh not_active Expired - Lifetime
- 2003-03-13 PL PL377628A patent/PL230179B1/pl unknown
- 2003-03-13 ES ES09011388T patent/ES2407849T3/es not_active Expired - Lifetime
- 2003-12-12 BR BR122018007328A patent/BR122018007328B8/pt active IP Right Grant
-
2004
- 2004-09-09 IL IL163995A patent/IL163995A/en active IP Right Grant
- 2004-09-09 IS IS7442A patent/IS2748B/is unknown
-
2005
- 2005-02-18 US US11/061,336 patent/US7425637B2/en not_active Expired - Lifetime
- 2005-04-26 HK HK05103569.0A patent/HK1070823A1/xx not_active IP Right Cessation
-
2007
- 2007-10-09 JP JP2007263512A patent/JP2008019277A/ja active Pending
-
2008
- 2008-01-29 JP JP2008017547A patent/JP5102642B2/ja not_active Expired - Lifetime
- 2008-03-18 US US12/050,827 patent/US7777050B2/en not_active Expired - Lifetime
- 2008-03-18 US US12/050,847 patent/US7576114B2/en not_active Expired - Lifetime
-
2009
- 2009-10-07 AU AU2009222613A patent/AU2009222613B2/en active Active
-
2010
- 2010-01-13 CY CY20101100037T patent/CY1109727T1/el unknown
- 2010-03-10 IL IL204419A patent/IL204419A/en active IP Right Grant
- 2010-03-10 IL IL204420A patent/IL204420A/en active Protection Beyond IP Right Term
- 2010-06-09 HK HK10105717.9A patent/HK1141976A1/xx not_active IP Right Cessation
- 2010-06-28 US US12/824,477 patent/US8003805B2/en not_active Expired - Lifetime
- 2010-06-28 US US12/824,547 patent/US8193230B2/en not_active Expired - Lifetime
- 2010-06-28 US US12/824,559 patent/US8178693B2/en not_active Expired - Lifetime
- 2010-06-28 US US12/824,521 patent/US8193229B2/en not_active Expired - Lifetime
- 2010-06-28 US US12/824,497 patent/US7973170B2/en not_active Expired - Lifetime
- 2010-06-29 US US12/826,158 patent/US8193231B2/en not_active Expired - Lifetime
-
2011
- 2011-04-20 DO DO2011000110A patent/DOP2011000110A/es unknown
- 2011-04-20 DO DO2011000109A patent/DOP2011000109A/es unknown
- 2011-06-16 IS IS8959A patent/IS2990B/is unknown
- 2011-06-16 IS IS8960A patent/IS2998B/is unknown
- 2011-06-16 IS IS8961A patent/IS2999B/is unknown
- 2011-07-13 HK HK11107302.5A patent/HK1153139A1/zh not_active IP Right Cessation
-
2012
- 2012-05-03 US US13/463,487 patent/US8513293B2/en not_active Expired - Lifetime
- 2012-08-24 JP JP2012184708A patent/JP5498546B2/ja not_active Expired - Lifetime
- 2012-08-29 CL CL2012002380A patent/CL2012002380A1/es unknown
- 2012-08-29 CL CL2012002381A patent/CL2012002381A1/es unknown
-
2013
- 2013-01-28 DO DO2013000023A patent/DOP2013000023A/es unknown
- 2013-02-25 AR ARP130100567A patent/AR090143A2/es unknown
- 2013-02-25 AR ARP130100568A patent/AR090144A2/es unknown
-
2017
- 2017-07-27 CY CY20171100805T patent/CY1119136T1/el unknown
-
2019
- 2019-02-12 LU LU00100C patent/LUC00100I2/fr unknown
- 2019-03-01 HU HUS1900011C patent/HUS1900011I1/hu unknown
- 2019-03-07 LT LTPA2019007C patent/LTC1482932I2/lt unknown
- 2019-03-13 BE BE2019C510C patent/BE2019C510I2/fr unknown
- 2019-03-15 NL NL300974C patent/NL300974I2/nl unknown
- 2019-03-18 CY CY2019012C patent/CY2019012I2/el unknown