JO2985B1 - مثبطات كينازmapk/erk - Google Patents

مثبطات كينازmapk/erk

Info

Publication number
JO2985B1
JO2985B1 JOP/2007/0555A JOP20070555A JO2985B1 JO 2985 B1 JO2985 B1 JO 2985B1 JO P20070555 A JOP20070555 A JO P20070555A JO 2985 B1 JO2985 B1 JO 2985B1
Authority
JO
Jordan
Prior art keywords
mapk
kinase inhibitors
compounds
erk kinase
methods
Prior art date
Application number
JOP/2007/0555A
Other languages
English (en)
Inventor
Toufike Kanouni
Xianchong Gong
Stephen W Kaldor
Feng Zhou
Qing Dong
Michael B Wallace
Nicholas Scorah
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Application granted granted Critical
Publication of JO2985B1 publication Critical patent/JO2985B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

يتعلق الاختراع الحالي بمركبات ( compounds) من الصيغه التالية للاستخدام مع MEK التي تشمل: حيث تكون المتغيرات كما تحدد هنا، كما يوفر ايضا تركيبات دوائية ( pharmaceutical compositions) مجموعات ( kits) وادوات ( articles) للتصنيع تشمل هذه المركبات ( compounds) الطرق ( methods) والمركبات الوسطية ( intermediates) المفيدة لتصنيع المركبات ( compounds) وطرق ( methods) لاستخدام المركبات( compounds) المذكورة.
JOP/2007/0555A 2006-12-20 2007-12-17 مثبطات كينازmapk/erk JO2985B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87091306P 2006-12-20 2006-12-20

Publications (1)

Publication Number Publication Date
JO2985B1 true JO2985B1 (ar) 2016-09-05

Family

ID=39462025

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2007/0555A JO2985B1 (ar) 2006-12-20 2007-12-17 مثبطات كينازmapk/erk

Country Status (35)

Country Link
US (4) US8293901B2 (ar)
EP (1) EP2125810B1 (ar)
JP (1) JP5513127B2 (ar)
KR (1) KR101488467B1 (ar)
CN (1) CN101679411B (ar)
AR (1) AR064640A1 (ar)
AU (1) AU2007337003B2 (ar)
BR (1) BRPI0720525B8 (ar)
CA (1) CA2673647C (ar)
CL (1) CL2007003742A1 (ar)
CO (1) CO6230984A2 (ar)
CR (1) CR10937A (ar)
DK (1) DK2125810T3 (ar)
EA (1) EA016312B1 (ar)
EC (1) ECSP099529A (ar)
ES (1) ES2430966T3 (ar)
GE (1) GEP20125511B (ar)
HR (1) HRP20130684T1 (ar)
IL (1) IL199362A (ar)
JO (1) JO2985B1 (ar)
MA (1) MA31151B1 (ar)
MX (1) MX2009006675A (ar)
MY (1) MY157871A (ar)
NO (1) NO342270B1 (ar)
NZ (1) NZ578310A (ar)
PE (1) PE20090071A1 (ar)
PL (1) PL2125810T3 (ar)
PT (1) PT2125810E (ar)
RS (1) RS52887B (ar)
SI (1) SI2125810T1 (ar)
TN (1) TN2009000249A1 (ar)
TW (1) TWI396538B (ar)
UA (1) UA98479C2 (ar)
WO (1) WO2008079814A2 (ar)
ZA (1) ZA200904682B (ar)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1790649A1 (en) * 2005-11-21 2007-05-30 Sanofi-Aventis Substituted bicyclic pyrimidone derivatives
TW200800997A (en) * 2006-03-22 2008-01-01 Astrazeneca Ab Chemical compounds
WO2008140553A2 (en) * 2006-10-23 2008-11-20 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors
JO2985B1 (ar) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
JP5363350B2 (ja) 2007-03-19 2013-12-11 武田薬品工業株式会社 Ｍａｐｋ／ｅｒｋキナーゼ阻害剤
US8022057B2 (en) * 2007-11-12 2011-09-20 Takeda Pharmaceutical Company Limited MAPK/ERK kinase inhibitors
US20090246198A1 (en) * 2008-03-31 2009-10-01 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors and methods of use thereof
CN102216274A (zh) * 2008-11-18 2011-10-12 武田药品工业株式会社 (R)-3-(2,3-二羟基丙基)-6-氟-5-(2-氟-4-碘苯基氨基)-8-甲基吡啶并[2,3-d]嘧啶-4,7(3H,8H)-二酮及其中间体的制备方法
WO2012003338A1 (en) 2010-07-01 2012-01-05 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
TWI505828B (zh) * 2010-12-20 2015-11-01 葛蘭素史克智慧財產（第二）有限公司 新穎醫藥組成物
AR086656A1 (es) 2011-06-03 2014-01-15 Millennium Pharm Inc Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
AU2013225737B2 (en) 2012-03-01 2018-03-01 Array Biopharma Inc. Serine/threonine kinase inhibitors
WO2013144923A1 (en) * 2012-03-30 2013-10-03 Takeda Pharmaceutical Company Limited Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma
JP6386177B2 (ja) * 2014-06-17 2018-09-05 ツーセン ファーマシューティカル カンパニー リミテッド ｍＴＯＲ／ＰＩ３Ｋ阻害剤としてのピリド［１，２−ａ］ピリミジノン類似体
WO2016009306A1 (en) * 2014-07-15 2016-01-21 Lupin Limited Heterocyclyl compounds as mek inhibitors
KR101671404B1 (ko) * 2014-09-02 2016-11-02 한국원자력의학원 항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
JP2016155776A (ja) * 2015-02-24 2016-09-01 学校法人兵庫医科大学 抗腫瘍効果増強剤および抗腫瘍剤
JP6774578B2 (ja) 2017-06-23 2020-10-28 シーストーン ファーマシューティカルズ Ｍｅｋ阻害剤としてのクマリン環系化合物およびその応用。
GB201713975D0 (en) 2017-08-31 2017-10-18 Macrophage Pharma Ltd Medical use
JP7393808B2 (ja) 2018-11-20 2023-12-07 エヌフレクション セラピューティクス インコーポレイテッド 皮膚障害の処置のためのナフチリジノン－アニリン化合物
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430148A (en) 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
ES2247859T3 (es) 1999-01-13 2006-03-01 Warner-Lambert Company Llc Benzoheterociclos y su uso como inhibidores de mek.
KR20020065939A (ko) 2000-01-25 2002-08-14 워너-램버트 캄파니 피리도[2,3-ｄ]피리미딘-2,7-디아민 카이나제 억제제
EE05450B1 (et) 2000-07-19 2011-08-15 Warner-Lambert Company 4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine
PL362049A1 (en) 2000-10-23 2004-10-18 Smithkline Beecham Corporation Novel compounds
US6825180B2 (en) 2001-05-18 2004-11-30 Cell Therapeutics, Inc. Pyridopyrimidine compounds and their uses
PA8569201A1 (es) 2002-03-13 2004-05-21 Array Biopharma Inc "derivados de bencimidazol n3 alquilado como inhibidores de mek" "n3 alkylated benzimimidazole derivatives as mek inhibitors"
PT3000810T (pt) 2002-03-13 2017-10-25 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
MXPA05012645A (es) 2003-05-23 2006-02-08 Zentaris Gmbh Piridopirazinas novedosas y su uso como moduladores de cinasa.
AU2003277715A1 (en) 2003-07-03 2005-01-21 Sunghag Koo Ferment ginseng oil
MXPA06000921A (es) 2003-07-24 2006-03-30 Warner Lambert Co Derivados de benzamidazoles como inhibidores de mek.
BRPI0413005A (pt) * 2003-07-29 2006-09-26 Irm Llc compostos e composições como inibidores da proteìna cinase
US7772234B2 (en) 2003-11-19 2010-08-10 Array Biopharma Inc. Bicyclic inhibitors of MEK and methods of use thereof
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
PL1761528T3 (pl) * 2004-06-11 2008-05-30 Japan Tobacco Inc Pochodne 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pirydo[2,3-D]pirymidyny i związki pokrewne do leczenia raka
DE102004054215A1 (de) 2004-11-10 2006-05-11 Merck Patent Gmbh Pyridopyrimidinonderivate
DE602005016718D1 (de) 2004-12-01 2009-10-29 Merck Serono Sa Coinsins Ä1,2,4ütriazoloä4,3-aüpyridin-derivative zur behandlung hyperproliferativer erkrankungen
JP2009543867A (ja) 2006-07-17 2009-12-10 メルク エンド カムパニー インコーポレーテッド 抗ｈｉｖ剤としての１−ヒドロキシナフチリジン化合物
WO2008140553A2 (en) * 2006-10-23 2008-11-20 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors
WO2008055842A1 (en) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same
JO2985B1 (ar) * 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
US8022057B2 (en) 2007-11-12 2011-09-20 Takeda Pharmaceutical Company Limited MAPK/ERK kinase inhibitors
US20090246198A1 (en) 2008-03-31 2009-10-01 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors and methods of use thereof
CN102216274A (zh) 2008-11-18 2011-10-12 武田药品工业株式会社 (R)-3-(2,3-二羟基丙基)-6-氟-5-(2-氟-4-碘苯基氨基)-8-甲基吡啶并[2,3-d]嘧啶-4,7(3H,8H)-二酮及其中间体的制备方法

Also Published As

Publication number Publication date
NO342270B1 (no) 2018-04-30
KR20090091353A (ko) 2009-08-27
US8030317B2 (en) 2011-10-04
ECSP099529A (es) 2009-08-28
EP2125810A2 (en) 2009-12-02
TW200835496A (en) 2008-09-01
IL199362A (en) 2013-07-31
BRPI0720525B8 (pt) 2021-05-25
ES2430966T3 (es) 2013-11-22
CR10937A (es) 2009-11-20
US8470837B2 (en) 2013-06-25
CN101679411A (zh) 2010-03-24
ZA200904682B (en) 2010-09-29
JP5513127B2 (ja) 2014-06-04
UA98479C2 (en) 2012-05-25
TN2009000249A1 (en) 2010-10-18
SI2125810T1 (sl) 2013-09-30
AU2007337003A1 (en) 2008-07-03
HRP20130684T1 (en) 2013-10-11
KR101488467B1 (ko) 2015-01-30
US8293901B2 (en) 2012-10-23
EA200970605A1 (ru) 2009-12-30
WO2008079814A3 (en) 2008-09-04
JP2010514680A (ja) 2010-05-06
CN101679411B (zh) 2013-04-17
CO6230984A2 (es) 2010-12-20
TWI396538B (zh) 2013-05-21
GEP20125511B (en) 2012-05-10
US20100130518A1 (en) 2010-05-27
US20080255160A1 (en) 2008-10-16
PT2125810E (pt) 2013-07-29
BRPI0720525A2 (pt) 2014-01-07
MX2009006675A (es) 2009-08-12
PL2125810T3 (pl) 2013-09-30
MY157871A (en) 2016-07-29
EA016312B1 (ru) 2012-04-30
PE20090071A1 (es) 2009-04-04
AU2007337003A2 (en) 2009-07-30
AR064640A1 (es) 2009-04-15
NO20092692L (no) 2009-09-16
NZ578310A (en) 2012-01-12
AU2007337003B2 (en) 2013-05-02
MA31151B1 (ar) 2010-02-01
RS52887B (en) 2014-02-28
CA2673647A1 (en) 2008-07-03
EP2125810B1 (en) 2013-04-24
US20120202999A1 (en) 2012-08-09
WO2008079814A2 (en) 2008-07-03
CL2007003742A1 (es) 2008-06-13
US20110065733A1 (en) 2011-03-17
DK2125810T3 (da) 2013-07-29
BRPI0720525B1 (pt) 2020-03-03
CA2673647C (en) 2016-02-09

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