CN103204822B - 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 - Google Patents
作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 Download PDFInfo
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- CN103204822B CN103204822B CN201210189086.8A CN201210189086A CN103204822B CN 103204822 B CN103204822 B CN 103204822B CN 201210189086 A CN201210189086 A CN 201210189086A CN 103204822 B CN103204822 B CN 103204822B
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/62—Benzothiazoles
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/62—Benzothiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
Abstract
Description
R1 | R3 | R5 | R1 | R3 | R5 | R1 | R3 | R5 |
F | Br | F | F | Br | Me | F | Br | H |
F | I | F | F | I | Me | F | I | H |
F | SMe | F | F | SMe | Me | F | SMe | H |
F | OCF3 | F | F | OCF3 | Me | F | OCF3 | H |
F | CF3 | F | F | CF3 | Me | F | CF3 | H |
Cl | Br | F | Cl | Br | Me | Cl | Br | H |
Cl | I | F | Cl | I | Me | Cl | I | H |
Cl | SMe | F | Cl | SMe | Me | Cl | SMe | H |
Cl | OCF3 | F | Cl | OCF3 | Me | Cl | OCF3 | H |
Cl | CF3 | F | Cl | CF3 | Me | Cl | CF3 | H |
Me | Br | F | Me | Br | Me | Me | Br | H |
Me | I | F | Me | I | Me | Me | I | H |
Me | SMe | F | Me | SMe | Me | Me | SMe | H |
Me | OCF3 | F | Me | OCF3 | Me | Me | OCF3 | H |
Me | CF3 | F | Me | CF3 | Me | Me | CF3 | H |
Claims (9)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210189086.8A CN103204822B (zh) | 2012-01-17 | 2012-06-08 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
EP13738359.2A EP2804855B1 (en) | 2012-01-17 | 2013-01-16 | Benzoheterocyclic compounds and use thereof |
JP2014551508A JP6077006B2 (ja) | 2012-01-17 | 2013-01-16 | ベンゾ複素環式化合物およびその使用 |
CA2897259A CA2897259C (en) | 2012-01-17 | 2013-01-16 | Benzoheterocyclic compounds and use thereof |
PCT/CN2013/000037 WO2013107283A1 (en) | 2012-01-17 | 2013-01-16 | Benzoheterocyclic compounds and use thereof |
NZ627631A NZ627631A (en) | 2012-01-17 | 2013-01-16 | Benzoheterocyclic compounds and use thereof |
US14/372,731 US9290468B2 (en) | 2012-01-17 | 2013-01-16 | Benzoheterocyclic compounds and use thereof |
AU2013201455A AU2013201455B8 (en) | 2012-01-17 | 2013-01-16 | Benzoheterocyclic compounds and use thereof |
HK15103824.9A HK1203486A1 (zh) | 2012-01-17 | 2015-04-20 | 苯並雜環化合物及其用途 |
US15/050,045 US9937158B2 (en) | 2012-01-17 | 2016-02-22 | Benzoheterocyclic compounds and use thereof |
Applications Claiming Priority (3)
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CN201210014021 | 2012-01-17 | ||
CN201210014021.X | 2012-01-17 | ||
CN201210189086.8A CN103204822B (zh) | 2012-01-17 | 2012-06-08 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
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CN103204822A CN103204822A (zh) | 2013-07-17 |
CN103204822B true CN103204822B (zh) | 2014-12-03 |
Family
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Family Applications (3)
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CN201210189087.2A Active CN103204827B (zh) | 2012-01-17 | 2012-06-08 | 作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途 |
CN201210190520.4A Active CN103204825B (zh) | 2012-01-17 | 2012-06-08 | 作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途 |
CN201210189086.8A Active CN103204822B (zh) | 2012-01-17 | 2012-06-08 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
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CN201210190520.4A Active CN103204825B (zh) | 2012-01-17 | 2012-06-08 | 作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途 |
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Country | Link |
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US (2) | US9290468B2 (zh) |
EP (1) | EP2804855B1 (zh) |
JP (1) | JP6077006B2 (zh) |
CN (3) | CN103204827B (zh) |
CA (1) | CA2897259C (zh) |
HK (1) | HK1203486A1 (zh) |
NZ (1) | NZ627631A (zh) |
WO (1) | WO2013107283A1 (zh) |
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CN104710417B (zh) * | 2013-12-11 | 2020-09-08 | 上海科州药物研发有限公司 | 氮杂吲哚类衍生物及其合成方法 |
CN105384738B (zh) * | 2014-08-21 | 2017-08-29 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途 |
CN105859543A (zh) * | 2016-05-06 | 2016-08-17 | 蚌埠中实化学技术有限公司 | 一种2,6-二氟-4-溴苯甲酰氯的制备方法 |
WO2020103930A1 (zh) * | 2018-11-22 | 2020-05-28 | 上海科技大学 | 噻唑并环类化合物、其制备方法、中间体和应用 |
CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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2012
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- 2012-06-08 CN CN201210190520.4A patent/CN103204825B/zh active Active
- 2012-06-08 CN CN201210189086.8A patent/CN103204822B/zh active Active
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2013
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- 2013-01-16 WO PCT/CN2013/000037 patent/WO2013107283A1/en active Application Filing
- 2013-01-16 EP EP13738359.2A patent/EP2804855B1/en active Active
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2015
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Patent Citations (2)
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CN101213196A (zh) * | 2005-07-01 | 2008-07-02 | 赛诺菲-安万特 | 吡啶并[2,3-d]嘧啶衍生物,它们的制备,在治疗中的用途 |
WO2007121154A2 (en) * | 2006-04-11 | 2007-10-25 | Janssen Pharmaceutica, N.V. | Substituted benzothiazole kinase inhibitors |
Also Published As
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WO2013107283A1 (en) | 2013-07-25 |
CA2897259C (en) | 2019-05-07 |
AU2013201455B2 (en) | 2015-07-23 |
EP2804855A4 (en) | 2015-07-29 |
HK1203486A1 (zh) | 2015-10-30 |
EP2804855A1 (en) | 2014-11-26 |
US9290468B2 (en) | 2016-03-22 |
US20160235721A1 (en) | 2016-08-18 |
CN103204822A (zh) | 2013-07-17 |
US9937158B2 (en) | 2018-04-10 |
AU2013201455A8 (en) | 2016-04-14 |
US20140371278A1 (en) | 2014-12-18 |
CN103204825A (zh) | 2013-07-17 |
NZ627631A (en) | 2016-10-28 |
EP2804855B1 (en) | 2017-09-20 |
CN103204827A (zh) | 2013-07-17 |
JP6077006B2 (ja) | 2017-02-08 |
CA2897259A1 (en) | 2013-07-25 |
CN103204827B (zh) | 2014-12-03 |
AU2013201455A1 (en) | 2013-08-01 |
AU2013201455C1 (en) | 2016-01-21 |
CN103204825B (zh) | 2015-03-04 |
JP2015503597A (ja) | 2015-02-02 |
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