FI962855A - Epidermaalisen kasvutekijäreseptoriperheen tyrosiinikinaaseja inhiboivat trisykliset yhdisteet - Google Patents

Epidermaalisen kasvutekijäreseptoriperheen tyrosiinikinaaseja inhiboivat trisykliset yhdisteet Download PDF

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Publication number
FI962855A
FI962855A FI962855A FI962855A FI962855A FI 962855 A FI962855 A FI 962855A FI 962855 A FI962855 A FI 962855A FI 962855 A FI962855 A FI 962855A FI 962855 A FI962855 A FI 962855A
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Finland
Prior art keywords
growth factor
factor receptor
epidermal growth
tyrosine kinases
receptor family
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Application number
FI962855A
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English (en)
Swedish (sv)
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FI962855A0 (fi
FI114098B (fi
Inventor
Alexander James Bridges
William Alexander Denny
David Fry
Alan Kraker
Robert Frederick Meyer
Gorgon William Rewcastle
Andrew Mark Thompson
Howard Daniel Hollis Showalter
Original Assignee
Warner Lambert Co
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Priority claimed from US08/358,352 external-priority patent/US5679683A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI962855A0 publication Critical patent/FI962855A0/fi
Publication of FI962855A publication Critical patent/FI962855A/fi
Application granted granted Critical
Publication of FI114098B publication Critical patent/FI114098B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
FI962855A 1994-01-25 1996-07-15 Trisykliset pyrimidiinijohdannaiset, jotka pystyvät inhiboimaan epidermisen kasvutekijäreseptoriperheen tyrosiinikinaaseja sekä niitä sisältävät farmaseuttiset koostumukset FI114098B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US18673594A 1994-01-25 1994-01-25
US18674594A 1994-01-25 1994-01-25
US18674594 1994-01-25
US18673594 1994-01-25
US08/358,352 US5679683A (en) 1994-01-25 1994-12-23 Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US35835294 1994-12-23
US9500911 1995-01-23
PCT/US1995/000911 WO1995019970A1 (en) 1994-01-25 1995-01-23 Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Publications (3)

Publication Number Publication Date
FI962855A0 FI962855A0 (fi) 1996-07-15
FI962855A true FI962855A (fi) 1996-09-13
FI114098B FI114098B (fi) 2004-08-13

Family

ID=27392144

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962855A FI114098B (fi) 1994-01-25 1996-07-15 Trisykliset pyrimidiinijohdannaiset, jotka pystyvät inhiboimaan epidermisen kasvutekijäreseptoriperheen tyrosiinikinaaseja sekä niitä sisältävät farmaseuttiset koostumukset

Country Status (19)

Country Link
US (1) US6596726B1 (fi)
EP (1) EP0741711A1 (fi)
JP (1) JP3965439B2 (fi)
CN (1) CN1137100C (fi)
AU (1) AU686339B2 (fi)
BG (1) BG63432B1 (fi)
CZ (1) CZ197196A3 (fi)
FI (1) FI114098B (fi)
GE (1) GEP20002330B (fi)
HR (1) HRP950033A2 (fi)
HU (1) HU222572B1 (fi)
IL (1) IL112248A0 (fi)
MD (1) MD1616G2 (fi)
MX (1) MX9602109A (fi)
NO (1) NO307182B1 (fi)
NZ (1) NZ281404A (fi)
PL (1) PL315632A1 (fi)
SK (1) SK89596A3 (fi)
WO (1) WO1995019970A1 (fi)

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HU222572B1 (hu) 2003-08-28
HU9602016D0 (en) 1996-09-30
BG100615A (bg) 1997-02-28
EP0741711A1 (en) 1996-11-13
IL112248A0 (en) 1995-03-30
CN1139430A (zh) 1997-01-01
MD1616G2 (ro) 2001-11-30
JP3965439B2 (ja) 2007-08-29
MD1616F2 (en) 2001-02-28
NO963093L (no) 1996-07-24
BG63432B1 (bg) 2002-01-31
FI962855A0 (fi) 1996-07-15
MX9602109A (es) 1997-05-31
HUT74590A (en) 1997-01-28
SK89596A3 (en) 1997-08-06
JPH09508126A (ja) 1997-08-19
WO1995019970A1 (en) 1995-07-27
MD960211A (en) 1998-04-30
CZ197196A3 (en) 1997-07-16
US6596726B1 (en) 2003-07-22
NZ281404A (en) 1999-05-28
CN1137100C (zh) 2004-02-04
AU686339B2 (en) 1998-02-05
FI114098B (fi) 2004-08-13
AU1833495A (en) 1995-08-08
PL315632A1 (en) 1996-11-25
GEP20002330B (en) 2000-12-25
NO963093D0 (no) 1996-07-24
HRP950033A2 (en) 1997-10-31

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