BR112017008628A2 - terapia de combinação compreendendo agonistas de ligação a ox40 e inibidores de tigit - Google Patents
terapia de combinação compreendendo agonistas de ligação a ox40 e inibidores de tigitInfo
- Publication number
- BR112017008628A2 BR112017008628A2 BR112017008628A BR112017008628A BR112017008628A2 BR 112017008628 A2 BR112017008628 A2 BR 112017008628A2 BR 112017008628 A BR112017008628 A BR 112017008628A BR 112017008628 A BR112017008628 A BR 112017008628A BR 112017008628 A2 BR112017008628 A2 BR 112017008628A2
- Authority
- BR
- Brazil
- Prior art keywords
- combination therapy
- tigit inhibitors
- binding agonists
- tigit
- binding
- Prior art date
Links
- 101100369641 Mus musculus Tigit gene Proteins 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000037581 Persistent Infection Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000005851 tumor immunogenicity Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
a presente divulgação descreve terapia de combinação compreendendo um agonista de ligação a ox40 e um agente que diminui ou inibe a expressão de tigit e/ou atividade de tigit e métodos para uso dos mesmos, incluindo métodos de tratar condições em que imunogenicidade intensificada é desejada, tal como aumentar a imunogenicidade do tumor para o tratamento de câncer ou de infecção crônica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462076152P | 2014-11-06 | 2014-11-06 | |
PCT/US2015/058087 WO2016073282A1 (en) | 2014-11-06 | 2015-10-29 | Combination therapy comprising ox40 binding agonists and tigit inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017008628A2 true BR112017008628A2 (pt) | 2018-01-30 |
Family
ID=54704069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017008628A BR112017008628A2 (pt) | 2014-11-06 | 2015-10-29 | terapia de combinação compreendendo agonistas de ligação a ox40 e inibidores de tigit |
Country Status (15)
Country | Link |
---|---|
US (3) | US20160152720A1 (pt) |
EP (1) | EP3215536A1 (pt) |
JP (1) | JP2017534633A (pt) |
KR (1) | KR20170072343A (pt) |
CN (1) | CN107073126A (pt) |
AR (1) | AR102553A1 (pt) |
AU (1) | AU2015343494A1 (pt) |
BR (1) | BR112017008628A2 (pt) |
CA (1) | CA2963974A1 (pt) |
IL (1) | IL251618A0 (pt) |
MX (1) | MX2017005929A (pt) |
RU (1) | RU2017119428A (pt) |
SG (1) | SG11201703376QA (pt) |
TW (1) | TW201628650A (pt) |
WO (1) | WO2016073282A1 (pt) |
Families Citing this family (35)
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JP5401001B2 (ja) | 2002-09-11 | 2014-01-29 | ジェネンテック, インコーポレイテッド | 免疫関連疾患の治療のための新規組成物と方法 |
SG10201402815VA (en) | 2008-04-09 | 2014-09-26 | Genentech Inc | Novel compositions and methods for the treatment of immune related diseases |
RS57840B1 (sr) | 2013-03-18 | 2018-12-31 | Biocerox Prod Bv | Humanizovana anti-cd 134 (ox40) antitela i njihove upotrebe |
KR20160030936A (ko) | 2013-07-16 | 2016-03-21 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 tigit 억제제를 사용한 암을 치료하는 방법 |
WO2015153514A1 (en) * | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
IL250583B (en) | 2014-08-19 | 2022-07-01 | Merck Sharp & Dohme | Anti-tigit antibodies |
CN114381521A (zh) | 2014-11-03 | 2022-04-22 | 豪夫迈·罗氏有限公司 | 用于ox40激动剂治疗的功效预测和评估的方法和生物标志物 |
CA2966523A1 (en) | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Assays for detecting t cell immune subsets and methods of use thereof |
SG11201708804WA (en) | 2015-05-07 | 2017-11-29 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit結合劑和彼之用途 |
CA2987410A1 (en) | 2015-05-29 | 2016-12-08 | Bristol-Myers Squibb Company | Antibodies against ox40 and uses thereof |
US10766957B2 (en) | 2015-08-14 | 2020-09-08 | Merck Sharp & Dohme Corp | Anti-TIGIT antibodies |
CR20220186A (es) | 2015-09-25 | 2022-07-07 | Genentech Inc | ANTICUERPOS ANTI-TIGIT Y MÉTODOS DE USO (divisional 2018-0225) |
CN108368176B (zh) * | 2015-10-01 | 2022-06-07 | 波滕扎治疗公司 | 抗tigit抗原结合蛋白及其使用方法 |
BR112018002570A2 (pt) | 2015-10-02 | 2018-10-16 | Hoffmann La Roche | molécula de ligação ao antígeno biespecífica, anticorpo biespecífico, polinucleotídeos, anticorpo que se liga especificamente ao ox40, composição farmacêutica e método para inibir o crescimento de células tumorais em um indivíduo |
CN108883173B (zh) | 2015-12-02 | 2022-09-06 | 阿吉纳斯公司 | 抗体和其使用方法 |
WO2017152088A1 (en) | 2016-03-04 | 2017-09-08 | JN Biosciences, LLC | Antibodies to tigit |
CN109414490A (zh) * | 2016-07-01 | 2019-03-01 | 小利兰·斯坦福大学理事会 | 抑制性免疫受体抑制方法和组合物 |
EP3494139B1 (en) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
CA3041340A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
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JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
EP3618863B1 (en) | 2017-05-01 | 2023-07-26 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
JP2020522691A (ja) | 2017-05-30 | 2020-07-30 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Lag−3陽性腫瘍の処置 |
CA3065304A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody |
KR20200010500A (ko) * | 2017-05-30 | 2020-01-30 | 브리스톨-마이어스 스큅 컴퍼니 | 항-lag-3 항체, pd-1 경로 억제제, 및 면역요법제의 조합을 포함하는 조성물 |
WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
US20200407445A1 (en) | 2017-07-27 | 2020-12-31 | Iteos Therapeutics Sa | Anti-tigit antibodies |
US20210115447A1 (en) * | 2018-06-12 | 2021-04-22 | Oneness Biotech Co., Ltd. | Nucleic acid aptamers targeting lymphocyte activation gene 3 (lag-3) and uses thereof |
WO2020006511A1 (en) * | 2018-06-29 | 2020-01-02 | Gensun Biopharma, Inc. | Trispecific antagonists |
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KR20220103709A (ko) * | 2019-11-21 | 2022-07-22 | 베이진 엘티디 | 항-tigit 항체와의 병용물 형태로 항-ox40 항체를 사용하는 암 치료의 방법 |
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-
2015
- 2015-10-29 RU RU2017119428A patent/RU2017119428A/ru not_active Application Discontinuation
- 2015-10-29 MX MX2017005929A patent/MX2017005929A/es unknown
- 2015-10-29 EP EP15801009.0A patent/EP3215536A1/en not_active Withdrawn
- 2015-10-29 CA CA2963974A patent/CA2963974A1/en not_active Abandoned
- 2015-10-29 CN CN201580059476.5A patent/CN107073126A/zh active Pending
- 2015-10-29 BR BR112017008628A patent/BR112017008628A2/pt not_active Application Discontinuation
- 2015-10-29 KR KR1020177014991A patent/KR20170072343A/ko unknown
- 2015-10-29 JP JP2017523893A patent/JP2017534633A/ja active Pending
- 2015-10-29 AU AU2015343494A patent/AU2015343494A1/en not_active Abandoned
- 2015-10-29 WO PCT/US2015/058087 patent/WO2016073282A1/en active Application Filing
- 2015-10-29 SG SG11201703376QA patent/SG11201703376QA/en unknown
- 2015-10-29 US US14/927,110 patent/US20160152720A1/en not_active Abandoned
- 2015-11-05 AR ARP150103599A patent/AR102553A1/es unknown
- 2015-11-06 TW TW104136746A patent/TW201628650A/zh unknown
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2017
- 2017-04-06 IL IL251618A patent/IL251618A0/en unknown
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2018
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2019
- 2019-02-08 US US16/271,520 patent/US20190169304A1/en not_active Abandoned
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CA2963974A1 (en) | 2016-05-12 |
IL251618A0 (en) | 2017-06-29 |
CN107073126A (zh) | 2017-08-18 |
US20190169304A1 (en) | 2019-06-06 |
SG11201703376QA (en) | 2017-05-30 |
MX2017005929A (es) | 2017-11-20 |
JP2017534633A (ja) | 2017-11-24 |
TW201628650A (zh) | 2016-08-16 |
US20190194339A1 (en) | 2019-06-27 |
KR20170072343A (ko) | 2017-06-26 |
RU2017119428A (ru) | 2018-12-06 |
US20160152720A1 (en) | 2016-06-02 |
AR102553A1 (es) | 2017-03-08 |
RU2017119428A3 (pt) | 2019-10-25 |
WO2016073282A1 (en) | 2016-05-12 |
AU2015343494A1 (en) | 2017-04-27 |
EP3215536A1 (en) | 2017-09-13 |
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