AR045563A1 - Anticuerpos dirigidos a m-csf - Google Patents

Anticuerpos dirigidos a m-csf

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Publication number
AR045563A1
AR045563A1 ARP040103147A ARP040103147A AR045563A1 AR 045563 A1 AR045563 A1 AR 045563A1 AR P040103147 A ARP040103147 A AR P040103147A AR P040103147 A ARP040103147 A AR P040103147A AR 045563 A1 AR045563 A1 AR 045563A1
Authority
AR
Argentina
Prior art keywords
antibodies
csf
antigen
antibody
human
Prior art date
Application number
ARP040103147A
Other languages
English (en)
Inventor
Bruce D Cohen
Jean Beebe
Penelope E Miller
James D Moyer
Jose R Corvalan
Michael Gallo
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33300142&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR045563(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR045563A1 publication Critical patent/AR045563A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/565—Complementarity determining region [CDR]
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Abstract

La presente se refiere a anticuerpos y porciones que ligan antígeno del mismo que se liga específicamente a un (factor de acumulación de colonias de macrófagos) M-CSF, preferentemente M-CSF humano, y que funciona para inhibir al M-CSF. Anticuerpos anti-M-CSF humanos y porciones que ligan antígeno de los mismos. Anticuerpos que son quiméricos, biespecíficos, derivatizados, anticuerpos de cadena simple o porciones de proteínas de fusión. Inmunoglobulinas aisladas de cadena pesada y liviana derivadas de anticuerpos anti-M-CSF humanos y a moléculas de ácido nucleico que codifican tales inmunoglobulinas. Métodos para fabricar anticuerpos anti-M-CSF humanos, a composiciones que comprenden estos anticuerpos y a métodos para usar los anticuerpos y composiciones para diagnóstico y tratamiento. Métodos de terapia con genes que usan moléculas de ácido nucleico que codifican la cadena pesada y/o liviana de moléculas de inmunoglobulina que comprenden los anticuerpos anti-MCSF humanos. Animales transgénicos y plantas transgénicas que comprenden moléculas de ácido nucleico de la presente. Reivindicación 1: Un anticuerpo monoclonal humano o una porción que liga antígeno del mismo, caracterizado porque se liga específicamente a M-CSF. Reivindicación 16: El uso de acuerdo con la reivindicación 15, caracterizado porque la condición es artritis reumatoide. Reivindicación 17: Uso de un anticuerpo o porción que liga antígeno de acuerdo con cualquiera de las reivindicaciones 1-13, caracterizado porque el uso es la preparación de un medicamento para el tratamiento de un tumor sólido tal como un sarcoma, un carcinoma, o de un tumor no sólido tal como un linfoma, en un sujeto, incluyendo un humano. Reivindicación 19: Una línea celular aislada, caracterizada porque produce el anticuerpo o porción que liga antígeno del mismo de acuerdo con cualquiera de las reivindicaciones 1-13 o la cadena pesada o cadena liviana de dicho anticuerpo o dichas porciones que ligan antígeno.
ARP040103147A 2003-09-10 2004-09-02 Anticuerpos dirigidos a m-csf AR045563A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50216303P 2003-09-10 2003-09-10

Publications (1)

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AR045563A1 true AR045563A1 (es) 2005-11-02

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ARP040103147A AR045563A1 (es) 2003-09-10 2004-09-02 Anticuerpos dirigidos a m-csf

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US (8) US7592430B2 (es)
EP (2) EP3170840B1 (es)
JP (6) JP2007528724A (es)
KR (2) KR100938452B1 (es)
CN (2) CN102807617B (es)
AP (1) AP2006003562A0 (es)
AR (1) AR045563A1 (es)
AU (1) AU2004275700B2 (es)
BR (1) BRPI0414269B8 (es)
CA (2) CA2885172C (es)
CR (1) CR8317A (es)
DK (1) DK1670825T3 (es)
EA (1) EA011669B1 (es)
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HK (2) HK1093212A1 (es)
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MA (1) MA28092A1 (es)
MX (2) MXPA06002825A (es)
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PA (1) PA8611701A1 (es)
PE (1) PE20050376A1 (es)
PL (1) PL1670825T3 (es)
PT (1) PT1670825T (es)
RS (1) RS20060171A (es)
SG (2) SG176457A1 (es)
SI (1) SI1670825T1 (es)
TN (1) TNSN06080A1 (es)
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