BR112012017269A2 - compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos - Google Patents
compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmosInfo
- Publication number
- BR112012017269A2 BR112012017269A2 BR112012017269A BR112012017269A BR112012017269A2 BR 112012017269 A2 BR112012017269 A2 BR 112012017269A2 BR 112012017269 A BR112012017269 A BR 112012017269A BR 112012017269 A BR112012017269 A BR 112012017269A BR 112012017269 A2 BR112012017269 A2 BR 112012017269A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- heterocyclic compounds
- tricyclic heterocyclic
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Abstract
compostos hiterocíclicos tricíclicos, composições e métodos de uso dos mesmos" a invenção prove novos compostos da formula i apresentantando a fórmula geral: onde r1, r2, r3, x e y são conforme descritos no presente documento. consequentemente, os compostos podem ser providos em composições farmaceuticamente aceitáveis e empregados para o tratamento de transtornos imunológicos ou hiperproliferativos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29440410P | 2010-01-12 | 2010-01-12 | |
US36678510P | 2010-07-22 | 2010-07-22 | |
PCT/EP2011/050239 WO2011086053A1 (en) | 2010-01-12 | 2011-01-11 | Tricyclic heterocyclic compounds, compositions and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012017269A2 true BR112012017269A2 (pt) | 2016-05-03 |
Family
ID=43844551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012017269A BR112012017269A2 (pt) | 2010-01-12 | 2011-01-11 | compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos |
Country Status (12)
Country | Link |
---|---|
US (1) | US8461328B2 (pt) |
EP (1) | EP2523957A1 (pt) |
JP (1) | JP2013517220A (pt) |
KR (1) | KR20140015162A (pt) |
CN (1) | CN102712640A (pt) |
AR (1) | AR079984A1 (pt) |
BR (1) | BR112012017269A2 (pt) |
CA (1) | CA2781578A1 (pt) |
MX (1) | MX2012008049A (pt) |
RU (1) | RU2012132278A (pt) |
TW (1) | TW201129565A (pt) |
WO (1) | WO2011086053A1 (pt) |
Families Citing this family (73)
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MX2011012262A (es) | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il] octano-o heptano-nitrilo como inhibidores de cinasas janus (jak). |
EA025520B1 (ru) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
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2011
- 2011-01-11 CN CN2011800059527A patent/CN102712640A/zh active Pending
- 2011-01-11 US US13/004,808 patent/US8461328B2/en not_active Expired - Fee Related
- 2011-01-11 KR KR1020127021109A patent/KR20140015162A/ko not_active Application Discontinuation
- 2011-01-11 JP JP2012547522A patent/JP2013517220A/ja active Pending
- 2011-01-11 EP EP11700907A patent/EP2523957A1/en not_active Withdrawn
- 2011-01-11 WO PCT/EP2011/050239 patent/WO2011086053A1/en active Application Filing
- 2011-01-11 AR ARP110100078A patent/AR079984A1/es unknown
- 2011-01-11 TW TW100100995A patent/TW201129565A/zh unknown
- 2011-01-11 BR BR112012017269A patent/BR112012017269A2/pt not_active Application Discontinuation
- 2011-01-11 MX MX2012008049A patent/MX2012008049A/es unknown
- 2011-01-11 RU RU2012132278/04A patent/RU2012132278A/ru not_active Application Discontinuation
- 2011-01-11 CA CA2781578A patent/CA2781578A1/en not_active Abandoned
Also Published As
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RU2012132278A (ru) | 2014-02-20 |
MX2012008049A (es) | 2012-08-01 |
CA2781578A1 (en) | 2011-07-21 |
TW201129565A (en) | 2011-09-01 |
CN102712640A (zh) | 2012-10-03 |
WO2011086053A1 (en) | 2011-07-21 |
US20110201593A1 (en) | 2011-08-18 |
JP2013517220A (ja) | 2013-05-16 |
EP2523957A1 (en) | 2012-11-21 |
KR20140015162A (ko) | 2014-02-06 |
US8461328B2 (en) | 2013-06-11 |
AR079984A1 (es) | 2012-03-07 |
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