MA40943A - Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines - Google Patents
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomainesInfo
- Publication number
- MA40943A MA40943A MA040943A MA40943A MA40943A MA 40943 A MA40943 A MA 40943A MA 040943 A MA040943 A MA 040943A MA 40943 A MA40943 A MA 40943A MA 40943 A MA40943 A MA 40943A
- Authority
- MA
- Morocco
- Prior art keywords
- bromodoma
- inhibitors
- substituted pyrrolopyridines
- pyrrolopyridines
- substituted
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462077703P | 2014-11-10 | 2014-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA40943A true MA40943A (fr) | 2017-09-19 |
Family
ID=54608969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA040943A MA40943A (fr) | 2014-11-10 | 2015-11-09 | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
Country Status (6)
Country | Link |
---|---|
US (1) | US10183009B2 (fr) |
EP (1) | EP3218375B1 (fr) |
JP (1) | JP6669744B2 (fr) |
CN (3) | CN116003409A (fr) |
MA (1) | MA40943A (fr) |
WO (1) | WO2016077378A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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AR095326A1 (es) | 2013-03-15 | 2015-10-07 | Incyte Corp | Heterociclos tricíclicos como inhibidores de la proteína bet |
WO2014176394A1 (fr) | 2013-04-24 | 2014-10-30 | Salk Institute For Biological Studies | Circuit génomique vdr/smad déclenchant une réaction fibreuse |
WO2015095492A1 (fr) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Hétérocycles tricycliques en tant qu'inhibiteurs des protéines bet |
PE20170144A1 (es) | 2014-04-23 | 2017-03-16 | Incyte Corp | 1h-pirrolo[2,3-c] piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteinas bet |
TWI712603B (zh) | 2014-09-15 | 2020-12-11 | 美商英塞特公司 | 作為bet蛋白抑制劑之三環雜環 |
MA40940A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
JP6639497B2 (ja) | 2014-11-10 | 2020-02-05 | ジェネンテック, インコーポレイテッド | ブロモドメインインヒビターおよびその使用 |
WO2016123391A1 (fr) | 2015-01-29 | 2016-08-04 | Genentech, Inc. | Composés thérapeutiques et leurs utilisations |
EP3265453B1 (fr) * | 2015-03-05 | 2022-06-29 | Boehringer Ingelheim International GmbH | Nouvelles pyridinones et isoquinolinones utilisées comme inhibiteurs de bromodomaine brd9 |
AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
US20170121347A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
CR20190027A (es) * | 2016-06-20 | 2019-05-16 | Incyte Corp | Formas sólidas cristalinas de un inhibidor de bet |
CN110167939B (zh) * | 2017-01-11 | 2021-12-31 | 江苏豪森药业集团有限公司 | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 |
BR112019014593A2 (pt) | 2017-01-17 | 2020-02-18 | Heparegenix Gmbh | Inibidor de mkk4 e os sais, solvatos e isômeros ópticos farmaceuticamente aceitáveis do mesmo, composto e os sais, solvatos e isômeros ópticos farmaceuticamente aceitáveis do mesmo e método de inibição seletiva da proteína quinase mkk4 em relação às proteínas quinases jnk1 e mkk7 |
CN110198941B (zh) * | 2017-01-25 | 2021-09-28 | 江苏豪森药业集团有限公司 | 吡咯并吡啶类n-氧化衍生物及其制备方法和应用 |
EP3609896A4 (fr) * | 2017-04-14 | 2020-11-04 | AbbVie Inc. | Inhibiteurs de bromodomaine |
WO2019023149A1 (fr) * | 2017-07-24 | 2019-01-31 | Salk Institute For Biological Studies | Utilisation d'antagonistes de la protéine 9 contenant un bromodomaine en association avec des agonistes du récepteur de la vitamine d dans le traitement du diabète |
BR112020012527A2 (pt) * | 2017-12-20 | 2020-11-24 | Betta Pharmaceuticals Co., Ltd | composto que funciona como inibidor de proteína com bromodomínio, e composição |
CN109970733B (zh) * | 2017-12-28 | 2020-05-08 | 新发药业有限公司 | 一种维罗非尼及其类似物的简便制备方法 |
US10442799B1 (en) | 2018-04-07 | 2019-10-15 | Fuqiang Ruan | Heterocyclic compounds and uses thereof |
CN110577526B (zh) * | 2018-06-07 | 2023-10-27 | 上海翰森生物医药科技有限公司 | 溴域结构蛋白抑制剂的盐及其制备方法和应用 |
CN110372693B (zh) * | 2018-07-04 | 2022-05-03 | 清华大学 | 一种靶向降解bet蛋白的化合物及其应用 |
CN110776508B (zh) * | 2018-07-27 | 2021-07-16 | 海创药业股份有限公司 | 一种brd4抑制剂及其制备方法和用途 |
CN110818609A (zh) * | 2018-08-11 | 2020-02-21 | 中国药科大学 | 3-乙酰基吲哚类brpf1抑制剂的制备方法及其用途 |
WO2020132004A1 (fr) * | 2018-12-20 | 2020-06-25 | Saint Louis University | Inhibiteurs de bet pour moduler l'expression de dux4 dans la fshd |
GB201905721D0 (en) | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
EP4096651A4 (fr) | 2020-01-29 | 2024-01-24 | Foghorn Therapeutics Inc | Composés et leurs utilisations |
WO2021233371A1 (fr) * | 2020-05-21 | 2021-11-25 | 贝达药业股份有限公司 | Composé fonctionnant comme inhibiteur de protéine de bromodomaine, et composition |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
US11787800B2 (en) | 2020-07-29 | 2023-10-17 | Foghorn Therapeutics Inc. | BRD9 degraders and uses thereof |
CN116322780A (zh) * | 2020-07-29 | 2023-06-23 | 福宏治疗公司 | 化合物及其用途 |
US11767330B2 (en) | 2021-07-06 | 2023-09-26 | Foghorn Therapeutics Inc. | Citrate salt, pharmaceutical compositions, and methods of making and using the same |
WO2023242597A1 (fr) | 2022-06-16 | 2023-12-21 | Amphista Therapeutics Limited | Molécules bifonctionnelles pour la dégradation ciblée de protéines |
WO2024057021A1 (fr) | 2022-09-13 | 2024-03-21 | Amphista Therapeutics Limited | Composés pour la dégradation ciblée d'une protéine |
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WO2015081203A1 (fr) * | 2013-11-26 | 2015-06-04 | Incyte Corporation | Hétérocycles bicycliques servant d'inhibiteurs des protéines bet |
WO2015081246A1 (fr) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Hétérocycles bicycliques servant d'inhibiteurs de protéines bet |
WO2015081280A1 (fr) | 2013-11-26 | 2015-06-04 | Coferon, Inc. | Ligands de bromodomaine pouvant se dimériser dans une solution aqueuse |
CN110452216B (zh) * | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
PE20170144A1 (es) * | 2014-04-23 | 2017-03-16 | Incyte Corp | 1h-pirrolo[2,3-c] piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteinas bet |
JP6639497B2 (ja) * | 2014-11-10 | 2020-02-05 | ジェネンテック, インコーポレイテッド | ブロモドメインインヒビターおよびその使用 |
MA40940A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
EP3632915A1 (fr) | 2014-11-27 | 2020-04-08 | Genentech, Inc. | Composés 4,5,6,7-tetrahydro-1 h-pyrazolo[4,3-c]pyridin-3-amine utilisés comme inhibiteurs de cbp et/ou de ep300 |
CN107278202A (zh) * | 2015-01-23 | 2017-10-20 | 融合生命科学公司 | 用于治疗炎症和癌症的杂环itk抑制剂 |
WO2016123391A1 (fr) | 2015-01-29 | 2016-08-04 | Genentech, Inc. | Composés thérapeutiques et leurs utilisations |
JP6512051B2 (ja) * | 2015-09-28 | 2019-05-15 | 株式会社Jvcケンウッド | 端末装置、通信システム、通信方法、プログラム |
-
2015
- 2015-11-09 MA MA040943A patent/MA40943A/fr unknown
- 2015-11-10 JP JP2017525075A patent/JP6669744B2/ja active Active
- 2015-11-10 CN CN202310032629.3A patent/CN116003409A/zh active Pending
- 2015-11-10 CN CN202211065963.0A patent/CN115583947A/zh active Pending
- 2015-11-10 WO PCT/US2015/060003 patent/WO2016077378A1/fr active Application Filing
- 2015-11-10 EP EP15797766.1A patent/EP3218375B1/fr active Active
- 2015-11-10 CN CN201580072359.2A patent/CN107207493B/zh active Active
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2017
- 2017-05-10 US US15/592,013 patent/US10183009B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20170340605A1 (en) | 2017-11-30 |
JP2017533248A (ja) | 2017-11-09 |
EP3218375B1 (fr) | 2022-04-27 |
EP3218375A1 (fr) | 2017-09-20 |
CN107207493B (zh) | 2023-01-20 |
CN115583947A (zh) | 2023-01-10 |
CN116003409A (zh) | 2023-04-25 |
CN107207493A (zh) | 2017-09-26 |
US10183009B2 (en) | 2019-01-22 |
WO2016077378A1 (fr) | 2016-05-19 |
JP6669744B2 (ja) | 2020-03-18 |
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