EP0527181A4 - Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase - Google Patents

Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase

Info

Publication number
EP0527181A4
EP0527181A4 EP19910908779 EP91908779A EP0527181A4 EP 0527181 A4 EP0527181 A4 EP 0527181A4 EP 19910908779 EP19910908779 EP 19910908779 EP 91908779 A EP91908779 A EP 91908779A EP 0527181 A4 EP0527181 A4 EP 0527181A4
Authority
EP
European Patent Office
Prior art keywords
heterocyclicethenediyl
compounds
tyrosine kinase
receptor tyrosine
egf receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910908779
Other versions
EP0527181A1 (en
Inventor
Alfred P. Spada
Paul E. Persons
Alexander Levitzki
Chaim Gilon
Aviv Gazit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Rorer International Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rorer International Holdings Inc filed Critical Rorer International Holdings Inc
Publication of EP0527181A1 publication Critical patent/EP0527181A1/en
Publication of EP0527181A4 publication Critical patent/EP0527181A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
EP19910908779 1990-04-16 1991-04-16 Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase Withdrawn EP0527181A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50998190A 1990-04-16 1990-04-16
US509981 1990-04-16

Publications (2)

Publication Number Publication Date
EP0527181A1 EP0527181A1 (en) 1993-02-17
EP0527181A4 true EP0527181A4 (en) 1993-04-07

Family

ID=24028875

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910908779 Withdrawn EP0527181A4 (en) 1990-04-16 1991-04-16 Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase

Country Status (6)

Country Link
EP (1) EP0527181A4 (en)
JP (1) JPH05507072A (en)
AU (1) AU662480B2 (en)
CA (1) CA2080582A1 (en)
IL (1) IL97873A0 (en)
WO (1) WO1991016305A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU658646B2 (en) * 1991-05-10 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
CA2153905A1 (en) * 1993-11-17 1995-05-26 Shun-Ichi Ikeda Propenone derivatives
GB9406137D0 (en) * 1994-03-28 1994-05-18 Erba Carlo Spa N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation
WO1996035665A1 (en) * 1995-05-10 1996-11-14 Kyowa Hakko Kogyo Co., Ltd. Propenone derivatives
US5710164A (en) * 1995-06-06 1998-01-20 American Home Products Corporation Diheterocyclic styryl nitriles
US6444694B1 (en) * 1995-06-06 2002-09-03 Wyeth Styryl benzimidazole derivatives
WO1997008934A2 (en) * 1995-06-19 1997-03-13 Ontogen Corporation Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
AU708925B2 (en) * 1995-12-01 1999-08-19 Kyowa Hakko Kogyo Co. Ltd. Propenone derivatives
MXPA06006460A (en) 2003-12-11 2006-08-23 Univ Texas Compounds for treatment of cell proliferative diseases.
BRPI0709916B8 (en) 2006-03-31 2021-05-25 Univ Texas anticancer drugs associated with orally bioavailable caffeic acid and the use of these drugs
ES2521676T3 (en) 2008-07-08 2014-11-13 Board Of Regents, The University Of Texas System New proliferation inhibitor and activation agents for signal transducers and transcription activators (STATS)
EP3429569A4 (en) * 2016-03-17 2020-02-26 The Johns Hopkins University Methods for preventing or treating parkinson's disease by the farnesylation of paris

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322738A2 (en) * 1987-12-24 1989-07-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells
WO1991013055A2 (en) * 1990-02-28 1991-09-05 Farmitalia Carlo Erba S.R.L. New aryl- and heteroarylethenylene derivatives and process for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605382A (en) * 1975-06-04 1976-12-07 Sumitomo Chemical Co PROCESS FOR PREPARING INDOLE DERIVATIVES.
JPH05506857A (en) * 1990-04-16 1993-10-07 ローヌ―プーラン　ローラー　インターナショナル　（ホウルディングス）インコーポレイテッド Styryl-Substituted Monocyclic and Bicyclic Heteroaryl Compounds that Inhibit EGF Receptor Tyrosine Kinase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322738A2 (en) * 1987-12-24 1989-07-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells
WO1991013055A2 (en) * 1990-02-28 1991-09-05 Farmitalia Carlo Erba S.R.L. New aryl- and heteroarylethenylene derivatives and process for their preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY. vol. 32, no. 10, WASHINGTON US pages 2344 - 2352 AVIV GAZIT ET AL. 'Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors' *
See also references of WO9116305A1 *

Also Published As

Publication number Publication date
AU7756891A (en) 1991-11-11
CA2080582A1 (en) 1991-10-17
WO1991016305A1 (en) 1991-10-31
JPH05507072A (en) 1993-10-14
AU662480B2 (en) 1995-09-07
IL97873A0 (en) 1992-06-21
EP0527181A1 (en) 1993-02-17

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Owner name: RORER INTERNATIONAL (HOLDINGS), INC.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW

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Effective date: 19960416