DK1360287T4 - Fremgangsmåder til modifikation af eukaryotiske celler - Google Patents

Fremgangsmåder til modifikation af eukaryotiske celler Download PDF

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Publication number
DK1360287T4
DK1360287T4 DK02709544.7T DK02709544T DK1360287T4 DK 1360287 T4 DK1360287 T4 DK 1360287T4 DK 02709544 T DK02709544 T DK 02709544T DK 1360287 T4 DK1360287 T4 DK 1360287T4
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Prior art keywords
modification
methods
eucaryotic cells
eucaryotic
cells
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DK02709544.7T
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English (en)
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DK1360287T3 (da
Inventor
Andrew J Murphy
George D Yancopoulos
Margaret Karow
Aris Economides
David Valenzuela
Lynn Macdonald
Sean Stevens
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Regeneron Pharma
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK02709544.7T 2001-02-16 2002-02-15 Fremgangsmåder til modifikation af eukaryotiske celler DK1360287T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/784,859 US6596541B2 (en) 2000-10-31 2001-02-16 Methods of modifying eukaryotic cells
PCT/US2002/004500 WO2002066630A1 (en) 2001-02-16 2002-02-15 Methods of modifying eukaryotic cells

Publications (2)

Publication Number Publication Date
DK1360287T3 DK1360287T3 (da) 2012-10-08
DK1360287T4 true DK1360287T4 (da) 2019-06-11

Family

ID=25133744

Family Applications (9)

Application Number Title Priority Date Filing Date
DK14172420.3T DK2787075T3 (da) 2001-02-16 2002-02-15 Gnaver, der er i stand til at producere hybride antistoffer indeholdende variable områder fra mennesker og konstante områder fra gnavere
DK14163642.3T DK2767588T3 (da) 2001-02-16 2002-02-15 Anvendelse af mus, der producerer hybride antistoffer indeholdende humane variable områder og konstante områder fra musen som en kilde til DNA, der koder for et humant, variabelt område af antistoffet
DK16171559.4T DK3085779T3 (da) 2001-02-16 2002-02-15 Fremgangsmåde til modifikation af eukaryotiske celler
DK19203913.9T DK3626819T3 (da) 2001-02-16 2002-02-15 Transgen mus, som producerer hybrid-antistoffer indeholdende humane variable områder og konstante områder fra mus
DK02709544.7T DK1360287T4 (da) 2001-02-16 2002-02-15 Fremgangsmåder til modifikation af eukaryotiske celler
DK10010741.6T DK2264163T3 (da) 2001-02-16 2002-02-15 Fremgangsmåder til modifikation af eukaryotiske celler
DK14172437.7T DK2786657T3 (da) 2001-02-16 2002-02-15 Fremgangsmåde til fremstilling af et antistof, som omfatter en variabel human-region og en konstant gnaver-region
DK16171561.0T DK3085780T3 (da) 2001-02-16 2002-02-15 Fremstilling af hybride antistoffer, der indeholder variable humane områder og konstante gnaverområder
DK19172361.8T DK3572508T3 (en) 2001-02-16 2002-02-15 Hybrid antibodies containing heavy chains with human vdj region and mouse heavy chain constant region and light chains with human vj region and mouse light chain constant region

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DK14172420.3T DK2787075T3 (da) 2001-02-16 2002-02-15 Gnaver, der er i stand til at producere hybride antistoffer indeholdende variable områder fra mennesker og konstante områder fra gnavere
DK14163642.3T DK2767588T3 (da) 2001-02-16 2002-02-15 Anvendelse af mus, der producerer hybride antistoffer indeholdende humane variable områder og konstante områder fra musen som en kilde til DNA, der koder for et humant, variabelt område af antistoffet
DK16171559.4T DK3085779T3 (da) 2001-02-16 2002-02-15 Fremgangsmåde til modifikation af eukaryotiske celler
DK19203913.9T DK3626819T3 (da) 2001-02-16 2002-02-15 Transgen mus, som producerer hybrid-antistoffer indeholdende humane variable områder og konstante områder fra mus

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK10010741.6T DK2264163T3 (da) 2001-02-16 2002-02-15 Fremgangsmåder til modifikation af eukaryotiske celler
DK14172437.7T DK2786657T3 (da) 2001-02-16 2002-02-15 Fremgangsmåde til fremstilling af et antistof, som omfatter en variabel human-region og en konstant gnaver-region
DK16171561.0T DK3085780T3 (da) 2001-02-16 2002-02-15 Fremstilling af hybride antistoffer, der indeholder variable humane områder og konstante gnaverområder
DK19172361.8T DK3572508T3 (en) 2001-02-16 2002-02-15 Hybrid antibodies containing heavy chains with human vdj region and mouse heavy chain constant region and light chains with human vj region and mouse light chain constant region

Country Status (19)

Country Link
US (21) US6596541B2 (da)
EP (9) EP3626819B1 (da)
JP (7) JP4412900B2 (da)
AU (1) AU2002244023B2 (da)
CA (1) CA2438390C (da)
CY (8) CY1113964T1 (da)
CZ (1) CZ305619B6 (da)
DE (6) DE10010741T1 (da)
DK (9) DK2787075T3 (da)
ES (8) ES2556767T3 (da)
HK (4) HK1146298A1 (da)
HU (1) HU231221B1 (da)
MX (2) MXPA03007325A (da)
NZ (1) NZ527629A (da)
PL (1) PL217086B1 (da)
PT (8) PT3085779T (da)
TR (2) TR201802443T4 (da)
WO (1) WO2002066630A1 (da)
ZA (1) ZA200306275B (da)

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HUP0303187A3 (en) 2010-01-28
US9528136B2 (en) 2016-12-27
CZ305619B6 (cs) 2016-01-13
EP3572508B1 (en) 2022-11-23
HK1057058A1 (en) 2004-03-12
CY1113964T1 (el) 2016-07-27
EP2787075B1 (en) 2016-11-30
EP2767588B1 (en) 2020-08-19
PT3626819T (pt) 2021-05-25
US20110283376A1 (en) 2011-11-17
HK1198260A1 (en) 2015-03-20
NZ527629A (en) 2005-03-24
ES2744220T3 (es) 2020-02-24
US20140073010A1 (en) 2014-03-13
AU2002244023B2 (en) 2007-05-10
DK3626819T3 (da) 2021-06-28
CY1123912T1 (el) 2022-03-24
HK1198259A1 (en) 2015-03-20
JP2014176391A (ja) 2014-09-25
DK3572508T3 (en) 2022-12-19
US20140017229A1 (en) 2014-01-16

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