SG11201708380WA - Humanized sirpa-il15 knockin mice and methods of use thereof - Google Patents
Humanized sirpa-il15 knockin mice and methods of use thereofInfo
- Publication number
- SG11201708380WA SG11201708380WA SG11201708380WA SG11201708380WA SG11201708380WA SG 11201708380W A SG11201708380W A SG 11201708380WA SG 11201708380W A SG11201708380W A SG 11201708380WA SG 11201708380W A SG11201708380W A SG 11201708380WA SG 11201708380W A SG11201708380W A SG 11201708380WA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- knockin mice
- humanized sirpa
- sirpa
- humanized
- Prior art date
Links
- 241000699670 Mus sp. Species 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562146938P | 2015-04-13 | 2015-04-13 | |
US201562148667P | 2015-04-16 | 2015-04-16 | |
US201662287842P | 2016-01-27 | 2016-01-27 | |
PCT/US2016/027164 WO2016168212A1 (en) | 2015-04-13 | 2016-04-12 | Humanized sirpa-il15 knockin mice and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201708380WA true SG11201708380WA (en) | 2017-11-29 |
Family
ID=55910354
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202103445QA SG10202103445QA (en) | 2015-04-13 | 2016-04-12 | Humanized sirpa-il15 knockin mice and methods of use thereof |
SG11201708380WA SG11201708380WA (en) | 2015-04-13 | 2016-04-12 | Humanized sirpa-il15 knockin mice and methods of use thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202103445QA SG10202103445QA (en) | 2015-04-13 | 2016-04-12 | Humanized sirpa-il15 knockin mice and methods of use thereof |
Country Status (16)
Country | Link |
---|---|
US (4) | US10123518B2 (en) |
EP (2) | EP3282835B1 (en) |
JP (3) | JP6752221B2 (en) |
KR (2) | KR20240060648A (en) |
CN (3) | CN107896479B (en) |
AU (2) | AU2016247892B2 (en) |
CA (1) | CA2981186A1 (en) |
DK (1) | DK3282835T3 (en) |
ES (1) | ES2950399T3 (en) |
FI (1) | FI3282835T3 (en) |
IL (2) | IL254727B2 (en) |
MX (3) | MX2017013285A (en) |
PT (1) | PT3282835T (en) |
RU (2) | RU2730599C2 (en) |
SG (2) | SG10202103445QA (en) |
WO (1) | WO2016168212A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2485583T3 (en) | 2009-10-06 | 2016-10-03 | Regeneron Pharma | GENETICALLY MODIFIED MICE AND inoculation |
EP4233537A3 (en) | 2011-02-15 | 2023-09-13 | Regeneron Pharmaceuticals, Inc. | Humanized m-csf mice and uses thereof |
KR101823513B1 (en) * | 2011-09-21 | 2018-01-30 | 엘지전자 주식회사 | Heat pump, air conditioner having the same, and hot water heating system |
CN108782459B (en) | 2012-09-07 | 2021-11-05 | 再生元制药公司 | Genetically modified non-human animals and methods of use thereof |
EP3556206B1 (en) | 2012-11-05 | 2021-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals and methods of use thereof |
MX2016014995A (en) | 2014-05-19 | 2017-03-31 | Regeneron Pharma | Genetically modified non-human animals expressing human epo. |
RU2730599C2 (en) | 2015-04-13 | 2020-08-24 | Ридженерон Фармасьютикалз, Инк. | Humanised mice with sirpa-il15 nokin and methods for using them |
CN108467873B (en) * | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | Preparation method and application of CD132 gene-deleted immunodeficiency animal model |
CN108588126B (en) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Preparation method and application of humanized modified animal model of CD47 gene |
KR20200135274A (en) * | 2017-08-09 | 2020-12-02 | 더 잭슨 래보라토리 | Immunodeficient mice expressing human interleukin 15 |
CN112638154B (en) | 2018-07-16 | 2022-10-18 | 瑞泽恩制药公司 | Non-human animal model of DITRA disease and uses thereof |
CN111837036B (en) * | 2018-12-17 | 2024-06-18 | 百奥赛图江苏基因生物技术有限公司 | Genetically modified non-human animals with human or chimeric genes |
WO2020135518A1 (en) * | 2018-12-25 | 2020-07-02 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric il15 |
US20220354097A1 (en) * | 2019-12-25 | 2022-11-10 | Gempharmatech Co., Ltd. | Il-15 humanized mouse model and use thereof |
WO2021136537A1 (en) * | 2019-12-31 | 2021-07-08 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα/CD47 |
CN111485001A (en) * | 2020-04-14 | 2020-08-04 | 澎立生物医药技术(上海)有限公司 | Construction method of humanized immune system mouse with NK (Natural killer) cell and ADCC (advanced Charge coupled device) capabilities |
WO2021216505A1 (en) * | 2020-04-21 | 2021-10-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cxcl13 gene |
CN111926039B (en) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Construction method and application of IL-13 gene humanized non-human animal |
WO2024020057A1 (en) | 2022-07-19 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified animal model and its use to model the human immune system |
WO2024039744A1 (en) * | 2022-08-16 | 2024-02-22 | Ourotech, Inc. | Methods of forming patient-derived 3d cell cultures for tracking live immune-tumor interactions |
CN117625480B (en) * | 2023-11-30 | 2024-05-31 | 吉林农业大学 | Enterococcus faecalis and application thereof in aspect of resisting porcine rotadisease |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
US5573930A (en) | 1985-02-05 | 1996-11-12 | Cetus Oncology Corporation | DNA encoding various forms of colony stimulating factor-1 |
HU215241B (en) | 1986-10-24 | 1998-11-30 | Cetus Corp. | Process for producing new forms of colony stimulating factor-1 and expression cassette, vector and recombinant host cells used in the process |
EP0322240B1 (en) | 1987-12-23 | 1995-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric immunocompromised mammals and their use |
JP2981486B2 (en) | 1988-06-14 | 1999-11-22 | メディカル・バイオロジー・インスティチュート | Mammalian immune system research methods |
US5849288A (en) | 1990-01-15 | 1998-12-15 | Yeda Research And Development Co. Ltd. | Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells |
EP0438053B1 (en) | 1990-01-15 | 1999-06-16 | Yeda Research And Development Company Limited | Durable engraftment and development of human hematopoietic lineages in normal mammals |
US5652373A (en) | 1990-01-15 | 1997-07-29 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
CA2063408A1 (en) | 1990-05-03 | 1991-11-04 | Susan Mayo | Human lymphoid tissue in an immunocompromised host |
EP0484512A4 (en) | 1990-05-25 | 1993-05-05 | Systemix, Inc. | Human peripheral blood cells in an immunocompromised host |
US5633426A (en) | 1990-05-25 | 1997-05-27 | Systemix, Inc. | In vivo use of human bone marrow for investigation and production |
US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5222982A (en) | 1991-02-11 | 1993-06-29 | Ommaya Ayub K | Spinal fluid driven artificial organ |
CA2103705C (en) | 1991-02-11 | 1996-01-30 | Ayub K. Ommaya | Spinal fluid driven artificial organ |
EP0517199A1 (en) | 1991-06-04 | 1992-12-09 | Yeda Research And Development Company, Ltd. | Durable engraftment of human tissue and cells in normal mammals |
WO1993005796A1 (en) | 1991-09-19 | 1993-04-01 | The Scripps Research Institute | Method for producing human antibodies in a non-human animal, and animals therefor |
EP0539970B1 (en) | 1991-10-30 | 1999-05-26 | Idemitsu Kosan Company Limited | Methods for producing human lymphocytes and human monoclonal antibodies, and human monoclonal antibodies produced thereby |
US6353150B1 (en) | 1991-11-22 | 2002-03-05 | Hsc Research And Development Limited Partnership | Chimeric mammals with human hematopoietic cells |
WO1993018144A1 (en) | 1992-03-05 | 1993-09-16 | The Trustees Of Columbia University Of The City Of New York | Recombination activating gene deficient animal |
US5866757A (en) | 1992-06-02 | 1999-02-02 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
US6018096A (en) | 1993-05-03 | 2000-01-25 | Surrogen, Inc. | Animal model for engraftment, proliferation and differentiation of human hematopoietic stem cells |
CA2103693A1 (en) | 1993-08-06 | 1995-02-07 | Steven Gallinger | Animal model of the human immune system |
JPH10503092A (en) | 1994-07-27 | 1998-03-24 | メルク エンド カンパニー インコーポレーテッド | Transgenic non-human animal having modified bradykinin B2 receptor |
US6455756B1 (en) | 1994-08-12 | 2002-09-24 | Novartis Ag | Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice |
US7273753B2 (en) | 1996-08-02 | 2007-09-25 | Center Of Blood Research | Purification and uses of dendritic cells and monocytes |
US6248721B1 (en) | 1997-04-09 | 2001-06-19 | Lung-Ji Chang | Method of using mouse model for evaluation of HIV vaccines |
WO1998044788A2 (en) | 1997-04-09 | 1998-10-15 | Chang Lung Ji | Animal model for evaluation of vaccines |
US20030028911A1 (en) | 1999-08-31 | 2003-02-06 | Manley Huang | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
CA2382383A1 (en) | 1999-08-31 | 2001-03-08 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
EP1244807A1 (en) | 1999-12-09 | 2002-10-02 | Human Genome Sciences, Inc. | Il-6 like polynucleotide |
WO2002022786A1 (en) | 2000-09-14 | 2002-03-21 | Genetrol Biotherapeutics, Inc. | Method and cell composition for screening compounds for anti-inflammatory activity |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20030124091A1 (en) * | 2001-10-26 | 2003-07-03 | Large Scale Biology Corporation | Endothelial cell derived hematopoietic growth factor |
WO2003041495A1 (en) | 2001-11-15 | 2003-05-22 | Kirin Beer Kabushiki Kaisha | Chimeric nonhuman animal |
WO2004005496A1 (en) | 2002-07-05 | 2004-01-15 | Kirin Beer Kabushiki Kaisha | Novel undifferentiated stem cells contained in cord blood, bone marrow, peripheral blood or the like |
CN101250553A (en) | 2002-07-13 | 2008-08-27 | 上海医学遗传研究所 | Human thrombopoietin expression vector and constructing method therefor |
CA2496233A1 (en) | 2002-09-09 | 2004-03-18 | California Institute Of Technology | Methods and compositions for the generation of humanized mice |
IL152232A0 (en) * | 2002-10-10 | 2003-05-29 | Yeda Res & Dev | Promoter to il-18bp, its preparation and use |
EP1418185A1 (en) | 2002-11-11 | 2004-05-12 | Aventis Pharma Deutschland GmbH | Use of EDG2 receptor in an animal model of heart failure |
US7402728B2 (en) | 2002-12-16 | 2008-07-22 | Genentech, Inc. | Transgenic mice expressing human CD20 and/or CD16 |
CN1751236A (en) | 2002-12-16 | 2006-03-22 | 健泰科生物技术公司 | Transgenic mice expressing human CD20 |
CU23472A1 (en) * | 2004-09-17 | 2009-12-17 | Ct Ingenieria Genetica Biotech | ANTAGONIST PEPTIDE OF INTERLEUCINE-15 |
CA2827654C (en) | 2004-10-19 | 2019-04-02 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
EP2019683B2 (en) | 2006-04-25 | 2022-08-03 | The Regents of The University of California | Administration of growth factors for the treatment of cns disorders |
EP1878342A1 (en) | 2006-07-13 | 2008-01-16 | Institut Pasteur | Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses |
WO2008060360A2 (en) | 2006-09-28 | 2008-05-22 | Surmodics, Inc. | Implantable medical device with apertures for delivery of bioactive agents |
EP2088854A1 (en) | 2006-12-05 | 2009-08-19 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Improved xenogenic immune system in a non-human mammal |
CA2687688C (en) | 2007-05-23 | 2017-03-28 | Sangamo Biosciences, Inc. | Methods and compositions for increased transgene expression in t cells |
TW200848431A (en) * | 2007-06-12 | 2008-12-16 | Trubion Pharmaceuticals Inc | Single-chain multivalent binding proteins with effector function |
JP2010534828A (en) * | 2007-07-23 | 2010-11-11 | ビオエクセル エスピーエー | Screening, therapy and diagnosis |
GB0718029D0 (en) | 2007-09-14 | 2007-10-24 | Iti Scotland Ltd | Two step cluster deletion and humanisation |
WO2009042917A1 (en) | 2007-09-28 | 2009-04-02 | The General Hospital Corporation | Methods and compositions for antibody production |
JP2011510750A (en) | 2008-01-29 | 2011-04-07 | クライマン、ギルバート・エイチ | Drug delivery device, kit and methods thereof |
US20090271884A1 (en) | 2008-03-07 | 2009-10-29 | Regeneron Pharmaceuticals, Inc. | ES Cell-Derived Mice From Diploid Host Embryo Injection |
AU2013204613A1 (en) * | 2008-12-24 | 2013-05-16 | The Kingdom of The Netherlands, Represented by The Minister of Health, Welfare and Sport | Modified Streptococcus pneumonia pneumolysin (PLY) polypeptides |
EP2414523B1 (en) | 2009-04-03 | 2020-07-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Dendritic cell-boosted humanized immune system mice |
WO2011002721A1 (en) | 2009-06-29 | 2011-01-06 | Leskov Ilya B | Non-human mammal model of human hematopoietic cancer |
JP2012531896A (en) | 2009-06-29 | 2012-12-13 | チェン,チンフェン | Method for producing a humanized non-human mammal |
RU2425880C2 (en) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Method of producing transgene mice |
WO2011020120A2 (en) * | 2009-08-14 | 2011-02-17 | Revivicor, Inc. | Multi-transgenic pigs for diabetes treatment |
DK2485583T3 (en) | 2009-10-06 | 2016-10-03 | Regeneron Pharma | GENETICALLY MODIFIED MICE AND inoculation |
SG10202011814TA (en) * | 2009-12-21 | 2021-01-28 | Regeneron Pharma | HUMANIZED FCγ R MICE |
EP2618656B1 (en) | 2010-09-20 | 2018-06-20 | Yale University, Inc. | HUMAN SIRPalpha TRANSGENIC ANIMALS AND THEIR METHODS OF USE |
WO2012051572A1 (en) | 2010-10-15 | 2012-04-19 | Massachusetts Institute Of Technology | A humanized non-human mammal model of malaria and uses thereof |
EP4233537A3 (en) | 2011-02-15 | 2023-09-13 | Regeneron Pharmaceuticals, Inc. | Humanized m-csf mice and uses thereof |
EP2747551B1 (en) * | 2011-08-26 | 2020-02-12 | Yecuris Corporation | Fumarylacetoacetate hydrolase (fah)-deficient and immunodeficient rats and uses thereof |
MY186903A (en) | 2011-10-28 | 2021-08-26 | Regeneron Pharma | Humanized il-6 and il-6 receptor |
AU2012324016C1 (en) * | 2011-10-28 | 2018-02-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
EP2644027A1 (en) * | 2012-03-26 | 2013-10-02 | Institut Pasteur | Transgenic immunodefficient mouse expressing human SIRPalpha. |
US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
CN108782459B (en) | 2012-09-07 | 2021-11-05 | 再生元制药公司 | Genetically modified non-human animals and methods of use thereof |
EP3556206B1 (en) | 2012-11-05 | 2021-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals and methods of use thereof |
LT3175706T (en) | 2013-09-23 | 2019-02-25 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized signal-regulatory protein gene |
CN105744829B (en) * | 2013-10-15 | 2018-08-07 | 瑞泽恩制药公司 | The IL-15 animals of humanization |
MX2016014995A (en) | 2014-05-19 | 2017-03-31 | Regeneron Pharma | Genetically modified non-human animals expressing human epo. |
RU2730599C2 (en) | 2015-04-13 | 2020-08-24 | Ридженерон Фармасьютикалз, Инк. | Humanised mice with sirpa-il15 nokin and methods for using them |
US20190216779A1 (en) * | 2016-06-29 | 2019-07-18 | Menlo Therapeutics Inc. | Use of neurokinin-1 antagonists to treat a variety of pruritic conditions |
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