CR20220396A - Anticuerpos y proteínas de fusión que se unen a ccr8 y usos de estos - Google Patents

Anticuerpos y proteínas de fusión que se unen a ccr8 y usos de estos

Info

Publication number
CR20220396A
CR20220396A CR20220396A CR20220396A CR20220396A CR 20220396 A CR20220396 A CR 20220396A CR 20220396 A CR20220396 A CR 20220396A CR 20220396 A CR20220396 A CR 20220396A CR 20220396 A CR20220396 A CR 20220396A
Authority
CR
Costa Rica
Prior art keywords
antibodies
fusion proteins
ccr8
bind
embodiments include
Prior art date
Application number
CR20220396A
Other languages
English (en)
Inventor
Changyun Hu
Lara Lewis Mcgrath
Joshua Adam Buggé
Fabien Dépis
Leonard G Presta
Original Assignee
Jounce Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jounce Therapeutics Inc filed Critical Jounce Therapeutics Inc
Publication of CR20220396A publication Critical patent/CR20220396A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

<br /> En la presente descripción se proporcionan diversas modalidades relacionadas con anticuerpos y proteínas de fusión y usos de estos. Algunas de las modalidades incluyen anticuerpos que se unen a CCR8. Algunas de las modalidades incluyen proteínas de fusión que se unen a CCR8. Tales anticuerpos y proteínas de fusión pueden usarse en métodos para tratar, por ejemplo el cáncer.
CR20220396A 2020-02-14 2021-02-09 Anticuerpos y proteínas de fusión que se unen a ccr8 y usos de estos CR20220396A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062976869P 2020-02-14 2020-02-14
US202063130157P 2020-12-23 2020-12-23
PCT/US2021/017268 WO2021163064A2 (en) 2020-02-14 2021-02-09 Antibodies and fusion proteins that bind to ccr8 and uses thereof

Publications (1)

Publication Number Publication Date
CR20220396A true CR20220396A (es) 2022-11-14

Family

ID=74845126

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220396A CR20220396A (es) 2020-02-14 2021-02-09 Anticuerpos y proteínas de fusión que se unen a ccr8 y usos de estos

Country Status (17)

Country Link
US (2) US11692038B2 (es)
EP (1) EP4103285A2 (es)
JP (1) JP2023512837A (es)
KR (1) KR20220142484A (es)
CN (2) CN115087488A (es)
AU (1) AU2021219668A1 (es)
BR (1) BR112022014623A2 (es)
CA (1) CA3169451A1 (es)
CL (1) CL2022002185A1 (es)
CO (1) CO2022011332A2 (es)
CR (1) CR20220396A (es)
DO (1) DOP2022000166A (es)
IL (1) IL295023A (es)
MX (1) MX2022009947A (es)
PE (1) PE20231067A1 (es)
TW (1) TWI832035B (es)
WO (1) WO2021163064A2 (es)

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MX2022009947A (es) * 2020-02-14 2022-11-07 Jounce Therapeutics Inc Anticuerpos y proteinas de fusion que se unen a ccr8 y usos de estos.
TW202216771A (zh) * 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體
JP2023546121A (ja) 2020-10-16 2023-11-01 ラノバ メディシンズ リミテッド 抗ｃｃｒ８モノクローナル抗体およびその使用
JP2024512567A (ja) * 2021-03-23 2024-03-19 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） Ｔ細胞リンパ腫の診断および治療方法
CN117295820A (zh) 2021-03-31 2023-12-26 盐野义制药株式会社 以ccr8作为抗原识别的嵌合抗原受体
IL307533A (en) * 2021-07-27 2023-12-01 Abbvie Inc Anti-CCR8 antibodies
CN118176210A (zh) * 2021-08-20 2024-06-11 高诚生物医药公司 抗ccr8抗体及其用途
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WO2023208182A1 (zh) * 2022-04-29 2023-11-02 江苏恒瑞医药股份有限公司 抗ccr8抗体及其用途
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WO2024006929A1 (en) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Cd73 compounds
WO2024040216A2 (en) * 2022-08-19 2024-02-22 Fibrogen, Inc. Anti-ccr8 antibodies and uses thereof
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WO2024062076A1 (en) * 2022-09-21 2024-03-28 Domain Therapeutics Anti-ccr8 monoclonal antibodies and their therapeutic use
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WO2024077239A1 (en) * 2022-10-07 2024-04-11 Genentech, Inc. Methods of treating cancer with anti-c-c motif chemokine receptor 8 (ccr8) antibodies
WO2024097741A1 (en) 2022-11-04 2024-05-10 Gilead Sciences, Inc. Anticancer therapies using anti-ccr8 antibody, chemo and immunotherapy combinations
WO2024094003A1 (zh) * 2022-11-04 2024-05-10 普米斯生物技术(珠海)有限公司 抗ccr8的抗体及其用途
WO2024109657A1 (zh) * 2022-11-22 2024-05-30 上海宏成药业有限公司 抗ccr8抗体及其用途
CN116473938B (zh) * 2023-06-09 2023-09-19 上海晟燃生物科技有限公司 一种血液肿瘤靶向外泌体递送载体及其应用

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