BR112013021941A2 - agente terapêutico para tumor - Google Patents

agente terapêutico para tumor

Info

Publication number
BR112013021941A2
BR112013021941A2 BR112013021941A BR112013021941A BR112013021941A2 BR 112013021941 A2 BR112013021941 A2 BR 112013021941A2 BR 112013021941 A BR112013021941 A BR 112013021941A BR 112013021941 A BR112013021941 A BR 112013021941A BR 112013021941 A2 BR112013021941 A2 BR 112013021941A2
Authority
BR
Brazil
Prior art keywords
therapeutic agent
tumor therapeutic
formula
hydrogen atom
represented
Prior art date
Application number
BR112013021941A
Other languages
English (en)
Other versions
BR112013021941B1 (pt
Inventor
Junji Matsui
Yasuhiro Funahashi
Yusuke Narita
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BR112013021941A2 publication Critical patent/BR112013021941A2/pt
Publication of BR112013021941B1 publication Critical patent/BR112013021941B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

agente terapêutico para tumor trata-se de um agente terapêutico para tumor para uso combinado de um composto ou sal farmaceuticamente aceitável do mesmo representado pela fórmula (i) e um composto representado pela fórmula (ii): em que r¹ é alquila c~1~-~6~ ou cicloalquila c~3~-~8~, r² é um átomo de hidrogênio ou alcóxi c~1~-~6~ e r³ é um átomo de hidrogênio ou um átomo de halogênio, que exibe um efeito antitumoral excelente em comparação aos casos em que esses são usados individualmente.
BR112013021941-6A 2011-04-18 2012-04-16 Agente terapêutico para tumor BR112013021941B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011091969 2011-04-18
JPP2011-091969 2011-04-18
PCT/JP2012/060279 WO2012144463A1 (ja) 2011-04-18 2012-04-16 腫瘍治療剤

Publications (2)

Publication Number Publication Date
BR112013021941A2 true BR112013021941A2 (pt) 2016-11-16
BR112013021941B1 BR112013021941B1 (pt) 2022-11-16

Family

ID=47041569

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013021941-6A BR112013021941B1 (pt) 2011-04-18 2012-04-16 Agente terapêutico para tumor

Country Status (12)

Country Link
US (1) US8962650B2 (pt)
EP (1) EP2700403B1 (pt)
JP (1) JP6021805B2 (pt)
KR (1) KR101762999B1 (pt)
CN (1) CN103402519B (pt)
AU (1) AU2012246490B2 (pt)
BR (1) BR112013021941B1 (pt)
CA (1) CA2828946C (pt)
IL (1) IL227558A (pt)
MX (1) MX2013009931A (pt)
RU (1) RU2580609C2 (pt)
WO (1) WO2012144463A1 (pt)

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BR112015029386B1 (pt) * 2013-06-26 2023-11-14 Eisai R&D Management Co., Ltd. Uso de eribulina e lenvatinibe como terapia de combinação e kit
US20170027940A1 (en) * 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
MX2017001980A (es) 2014-08-28 2017-05-04 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y metodo para su produccion.
SG11201706630UA (en) 2015-02-25 2017-09-28 Eisai R&D Man Co Ltd Method for suppressing bitterness of quinoline derivative
AU2015384801B2 (en) * 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
TWI604002B (zh) * 2015-03-09 2017-11-01 科騰聚合物美國有限責任公司 用於固化嵌段共聚物乳膠薄膜之改良硫化系統
MX2017015896A (es) 2015-06-16 2018-08-09 Eisai R&D Man Co Ltd Agente anticancerigeno.
CN108135894B (zh) * 2015-08-20 2021-02-19 卫材R&D管理有限公司 肿瘤治疗剂
JP7300394B2 (ja) 2017-01-17 2023-06-29 ヘパリジェニックス ゲーエムベーハー 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
US11479559B2 (en) * 2018-02-11 2022-10-25 Beijing Scitech-Mq Pharmaceuticals Limited Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof
WO2023190709A1 (ja) * 2022-03-31 2023-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 リポソーム組成物およびリポソームを含む医薬組成物
CN115215799A (zh) * 2022-08-12 2022-10-21 上海爱博医药科技有限公司 脲类多靶点酪氨酸激酶抑制剂及其多种医药应用

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RU2013140169A (ru) 2015-05-27
CA2828946A1 (en) 2012-10-26
CN103402519B (zh) 2015-11-25
JPWO2012144463A1 (ja) 2014-07-28
US8962650B2 (en) 2015-02-24
KR101762999B1 (ko) 2017-07-28
RU2580609C2 (ru) 2016-04-10
BR112013021941B1 (pt) 2022-11-16
EP2700403A4 (en) 2014-09-17
KR20140035334A (ko) 2014-03-21
IL227558A (en) 2017-07-31
AU2012246490B2 (en) 2016-08-04
CA2828946C (en) 2016-06-21
US20140031384A1 (en) 2014-01-30
EP2700403B1 (en) 2015-11-25
CN103402519A (zh) 2013-11-20
IL227558A0 (en) 2013-09-30
AU2012246490A1 (en) 2013-08-01
JP6021805B2 (ja) 2016-11-09
MX2013009931A (es) 2013-10-01
WO2012144463A1 (ja) 2012-10-26

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