AR098912A1 - Inhibidores de syk - Google Patents

Inhibidores de syk

Info

Publication number
AR098912A1
AR098912A1 ARP140104854A ARP140104854A AR098912A1 AR 098912 A1 AR098912 A1 AR 098912A1 AR P140104854 A ARP140104854 A AR P140104854A AR P140104854 A ARP140104854 A AR P140104854A AR 098912 A1 AR098912 A1 AR 098912A1
Authority
AR
Argentina
Prior art keywords
formula
methyl
syk inhibitors
syk
inhibitors
Prior art date
Application number
ARP140104854A
Other languages
English (en)
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52350364&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR098912(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR098912A1 publication Critical patent/AR098912A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K9/0012—Galenical forms characterised by the site of application
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Abstract

La presente divulgación se refiere a compuestos que son inhibidores de Syk, y a su uso en el tratamiento de diversas enfermedades, que incluye cáncer y afecciones infamatorias. Reivindicación 1: Un compuesto que tiene la estructura de la fórmula (1), o una de sus sales farmacéuticamente aceptables o uno de sus cocristales, donde: R¹ se selecciona del grupo que consiste en los restos de fórmula (2), (3) y (4), donde * indica el átomo de carbono del anillo fenilo indicado de la fórmula (1) al cual R¹ está unido; R² es H o 2-hidroxietoxilo; R³ es H o metilo; y R⁴ es H o metilo.
ARP140104854A 2013-12-23 2014-12-22 Inhibidores de syk AR098912A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361920407P 2013-12-23 2013-12-23

Publications (1)

Publication Number Publication Date
AR098912A1 true AR098912A1 (es) 2016-06-22

Family

ID=52350364

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140104854A AR098912A1 (es) 2013-12-23 2014-12-22 Inhibidores de syk

Country Status (42)

Country Link
US (5) US9968601B2 (es)
EP (2) EP3342773B9 (es)
JP (3) JP6243062B2 (es)
KR (3) KR20200098735A (es)
CN (2) CN107746405B (es)
AP (1) AP2016009274A0 (es)
AR (1) AR098912A1 (es)
AU (3) AU2014370010B2 (es)
BR (1) BR112016014643B1 (es)
CA (1) CA2875877C (es)
CL (1) CL2016001537A1 (es)
CR (1) CR20160287A (es)
CU (1) CU20160097A7 (es)
CY (1) CY1120104T1 (es)
DK (2) DK3342773T3 (es)
DO (1) DOP2016000140A (es)
EA (2) EA201891553A1 (es)
ES (2) ES2664799T3 (es)
GT (1) GT201600123A (es)
HK (2) HK1251563A1 (es)
HR (2) HRP20180460T1 (es)
HU (2) HUE053815T2 (es)
IL (1) IL245846B (es)
LT (1) LT3087075T (es)
MD (1) MD4666C1 (es)
ME (1) ME03001B (es)
MX (2) MX2020000404A (es)
NO (1) NO3183247T3 (es)
NZ (1) NZ721175A (es)
PE (1) PE20160995A1 (es)
PH (1) PH12016501204A1 (es)
PL (2) PL3087075T3 (es)
PT (2) PT3087075T (es)
RS (1) RS57182B1 (es)
SG (3) SG11201604491VA (es)
SI (2) SI3087075T1 (es)
SV (1) SV2016005229A (es)
TW (2) TWI735853B (es)
UA (1) UA118463C2 (es)
UY (1) UY35898A (es)
WO (1) WO2015100217A1 (es)
ZA (1) ZA201800913B (es)

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MX2016001304A (es) 2013-07-30 2016-04-07 Gilead Connecticut Inc Polimorfo de inhibidores de syk.
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EA201690608A1 (ru) 2013-12-04 2016-12-30 Джилид Сайэнс, Инк. Способы лечения раковых заболеваний
UY35898A (es) * 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
TW201617074A (zh) * 2014-07-14 2016-05-16 吉李德科學股份有限公司 Ｓｙｋ（脾酪胺酸激酶）抑制劑
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MX2017013496A (es) * 2015-04-21 2018-02-09 Gilead Sciences Inc Tratamiento de enfermedad cronica de injerto contra hospedero con inhibidores de tirosina cinasa de bazo (syk).
WO2017106564A1 (en) * 2015-12-17 2017-06-22 Gilead Sciences, Inc. Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders
TW201822764A (zh) * 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
AU2017325844A1 (en) * 2016-09-14 2019-03-07 Gilead Sciences, Inc. SYK inhibitors
JOP20180040A1 (ar) 2017-04-20 2019-01-30 Gilead Sciences Inc مثبطات pd-1/pd-l1
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