BR112015018738A2 - compostos de tetra-hidropirrolotiazina - Google Patents

compostos de tetra-hidropirrolotiazina

Info

Publication number
BR112015018738A2
BR112015018738A2 BR112015018738A BR112015018738A BR112015018738A2 BR 112015018738 A2 BR112015018738 A2 BR 112015018738A2 BR 112015018738 A BR112015018738 A BR 112015018738A BR 112015018738 A BR112015018738 A BR 112015018738A BR 112015018738 A2 BR112015018738 A2 BR 112015018738A2
Authority
BR
Brazil
Prior art keywords
tetrahydropyrrolothiazine
compounds
tetrahydropyrrolothiazine compounds
compound
formula
Prior art date
Application number
BR112015018738A
Other languages
English (en)
Other versions
BR112015018738A8 (pt
Inventor
Morgan Watson Brian
James Mergott Dustin
Larry Winneroski Leonard Jr
James Green Steven
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112015018738A2 publication Critical patent/BR112015018738A2/pt
Publication of BR112015018738A8 publication Critical patent/BR112015018738A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

resumo: patente de invenção: "compostos de tetra-hidropirrolotiazina.". a presente invenção fornece um composto de fórmula i: em que r é h ou f; e a é: ou um sal farmaceuticamente aceitável do mesmo.
BR112015018738A 2013-03-12 2014-03-04 compostos de tetra-hidropirrolotiazina, seus usos, e composição farmacêutica BR112015018738A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776819P 2013-03-12 2013-03-12
PCT/US2014/020070 WO2014143579A1 (en) 2013-03-12 2014-03-04 Tetrahydropyrrolothiazine compounds

Publications (2)

Publication Number Publication Date
BR112015018738A2 true BR112015018738A2 (pt) 2017-07-18
BR112015018738A8 BR112015018738A8 (pt) 2018-01-23

Family

ID=50382615

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015018738A BR112015018738A8 (pt) 2013-03-12 2014-03-04 compostos de tetra-hidropirrolotiazina, seus usos, e composição farmacêutica

Country Status (38)

Country Link
US (3) US8841293B1 (pt)
EP (1) EP2970336B1 (pt)
JP (1) JP6095844B2 (pt)
KR (1) KR101688761B1 (pt)
CN (1) CN105026404B (pt)
AP (1) AP2015008713A0 (pt)
AR (1) AR094918A1 (pt)
BR (1) BR112015018738A8 (pt)
CA (1) CA2898500C (pt)
CL (1) CL2015002529A1 (pt)
CR (1) CR20150418A (pt)
CY (1) CY1119585T1 (pt)
DK (1) DK2970336T3 (pt)
EA (1) EA026006B1 (pt)
ES (1) ES2653421T3 (pt)
HK (1) HK1212694A1 (pt)
HR (1) HRP20171851T1 (pt)
HU (1) HUE037487T2 (pt)
IL (1) IL240903B (pt)
JO (1) JO3317B1 (pt)
LT (1) LT2970336T (pt)
MA (1) MA38390B1 (pt)
ME (1) ME02910B (pt)
MX (1) MX2015012628A (pt)
MY (1) MY180083A (pt)
NO (1) NO3039297T3 (pt)
NZ (1) NZ712207A (pt)
PE (1) PE20151542A1 (pt)
PH (1) PH12015502031B1 (pt)
PL (1) PL2970336T3 (pt)
PT (1) PT2970336T (pt)
RS (1) RS56645B1 (pt)
SG (1) SG11201507499XA (pt)
SI (1) SI2970336T1 (pt)
TN (1) TN2015000340A1 (pt)
TW (1) TWI593692B (pt)
UA (1) UA112941C2 (pt)
WO (1) WO2014143579A1 (pt)

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IN2015DN00960A (pt) 2012-09-25 2015-06-12 Hoffmann La Roche
HUE031764T2 (en) 2012-10-26 2017-07-28 Lilly Co Eli Tetrahydropyrrolothiazine derivatives as BACE inhibitors
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
PL3074400T3 (pl) 2013-11-26 2018-03-30 F.Hoffmann-La Roche Ag Pochodne oktahydrocyklobuta[1,2-c;3,4-c']dipirolu jako inhibitory autotaksyny
TWI684452B (zh) 2014-03-14 2020-02-11 美國禮來大藥廠 胺基噻嗪化合物
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
UA119347C2 (uk) 2014-03-26 2019-06-10 Ф. Хоффманн-Ля Рош Аг Конденсовані [1,4]діазепінові сполуки як інгібітори продукції аутотаксину (atх) та лізофосфатидилової кислоти (lpa)
TWI570127B (zh) * 2014-09-15 2017-02-11 美國禮來大藥廠 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物
TWI599358B (zh) 2014-09-16 2017-09-21 美國禮來大藥廠 組合療法
AR103406A1 (es) * 2015-01-30 2017-05-10 Lilly Co Eli Sal de tosilato
AR103680A1 (es) 2015-02-23 2017-05-24 Lilly Co Eli Inhibidores selectivos de bace1
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
AR104241A1 (es) 2015-04-29 2017-07-05 Lilly Co Eli Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos
PE20180479A1 (es) 2015-09-04 2018-03-07 Hoffmann La Roche Nuevos derivados de fenoximetilo
CA2991615A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
CA2984585A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
RU2724899C2 (ru) 2015-09-24 2020-06-26 Ф. Хоффманн-Ля Рош Аг Новые бициклические соединения в качестве дуальных ингибиторов atx/ca
CA2983782A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
TW201740954A (zh) * 2016-03-16 2017-12-01 美國禮來大藥廠 組合療法
TWI735600B (zh) 2016-07-01 2021-08-11 美商美國禮來大藥廠 抗－N3pGlu類澱粉β肽抗體及其用途
MX2019007103A (es) 2016-12-15 2019-11-05 Amgen Inc Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso.
WO2018112081A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Oxazine derivatives as beta-secretase inhibitors and methods of use
JP7149271B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としての１，４－チアジンジオキシドおよび１，２，４－チアジアジンジオキシド誘導体ならびに使用方法
MX2019007102A (es) 2016-12-15 2019-12-16 Amgen Inc Derivados de tiazina como inhibidores de beta-secretasa y metodos de uso.
EP3555106B1 (en) 2016-12-15 2022-03-09 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
CN110392679B (zh) 2017-03-16 2023-04-07 豪夫迈·罗氏有限公司 可用作双重atx/ca抑制剂的杂环化合物
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー Ａｔｘインヒビターとしての新規二環式化合物

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CA2738150A1 (en) 2008-09-30 2010-04-08 Eisai R&D Management Co., Ltd. Novel fused aminodihydrothiazine derivative
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JPWO2011071109A1 (ja) 2009-12-11 2013-04-22 塩野義製薬株式会社 アミノ基を有する縮合ヘテロ環化合物
GB201100181D0 (en) 2011-01-06 2011-02-23 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101139D0 (en) * 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101140D0 (en) * 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
WO2012138590A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
US8598161B2 (en) 2011-05-24 2013-12-03 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
JO3143B1 (ar) * 2012-04-03 2017-09-20 Lilly Co Eli مركبات تتراهيدرو بيرولو ثيازين

Also Published As

Publication number Publication date
SI2970336T1 (sl) 2017-11-30
KR101688761B1 (ko) 2016-12-21
JP6095844B2 (ja) 2017-03-15
AR094918A1 (es) 2015-09-09
TW201520217A (zh) 2015-06-01
EP2970336B1 (en) 2017-10-04
NO3039297T3 (pt) 2018-03-10
US8841293B1 (en) 2014-09-23
JO3317B1 (ar) 2019-03-13
US20140350245A1 (en) 2014-11-27
PT2970336T (pt) 2017-12-21
DK2970336T3 (da) 2017-11-13
CY1119585T1 (el) 2018-03-07
HK1212694A1 (zh) 2016-06-17
AU2014228351A1 (en) 2015-09-17
BR112015018738A8 (pt) 2018-01-23
UA112941C2 (uk) 2016-11-10
AP2015008713A0 (en) 2015-09-30
PE20151542A1 (es) 2015-10-28
ES2653421T3 (es) 2018-02-07
SG11201507499XA (en) 2015-10-29
PL2970336T3 (pl) 2018-03-30
NZ712207A (en) 2019-09-27
CA2898500A1 (en) 2014-09-18
IL240903A0 (en) 2015-10-29
MA38390A1 (fr) 2018-08-31
CR20150418A (es) 2015-09-16
US20140275044A1 (en) 2014-09-18
PH12015502031A1 (en) 2016-01-18
CA2898500C (en) 2017-11-14
PH12015502031B1 (en) 2016-01-18
MY180083A (en) 2020-11-20
RS56645B1 (sr) 2018-03-30
US8987254B2 (en) 2015-03-24
EA026006B1 (ru) 2017-02-28
LT2970336T (lt) 2018-01-10
CN105026404A (zh) 2015-11-04
WO2014143579A1 (en) 2014-09-18
EA201591491A1 (ru) 2016-01-29
HUE037487T2 (hu) 2018-08-28
ME02910B (me) 2018-04-20
TN2015000340A1 (en) 2017-01-03
MA38390B1 (fr) 2020-01-31
EP2970336A1 (en) 2016-01-20
TWI593692B (zh) 2017-08-01
HRP20171851T1 (hr) 2018-01-12
CL2015002529A1 (es) 2016-03-28
JP2016512252A (ja) 2016-04-25
US20150157641A1 (en) 2015-06-11
MX2015012628A (es) 2016-07-07
CN105026404B (zh) 2016-11-23
KR20150119070A (ko) 2015-10-23
IL240903B (en) 2018-12-31

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements