RU2013140169A - Противоопухолевое терапевтическое средство - Google Patents
Противоопухолевое терапевтическое средство Download PDFInfo
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- RU2013140169A RU2013140169A RU2013140169/15A RU2013140169A RU2013140169A RU 2013140169 A RU2013140169 A RU 2013140169A RU 2013140169/15 A RU2013140169/15 A RU 2013140169/15A RU 2013140169 A RU2013140169 A RU 2013140169A RU 2013140169 A RU2013140169 A RU 2013140169A
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- methoxy
- quinolinecarboxamide
- chloro
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- compound represented
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- TVHJUGIGZSDFSC-UHFFFAOYSA-N CCNC(NC(C(Cl)=C1)=CCC1Oc1c(cc(C(NOC)=O)c(OC)c2)c2ncc1)=O Chemical compound CCNC(NC(C(Cl)=C1)=CCC1Oc1c(cc(C(NOC)=O)c(OC)c2)c2ncc1)=O TVHJUGIGZSDFSC-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
1. Противоопухолевое терапевтическое средство для комбинированного применения:соединения, представленного формулой (I), или его фармацевтически приемлемой соли:,где Rпредставляет собой Cалкил или Cциклоалкил,Rпредставляет собой атом водорода или Cалкокси, иRпредставляет собой атом водорода или атом галогена; исоединения, представленного формулой (II):.2. Противоопухолевое терапевтическое средство по п.1, где соединение, представленное формулой (I), является одним или несколькими соединениями, выбранными из группы, состоящей из:4-[3-хлор-4-(циклопропиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:,4-[3-хлор-4-(метиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:,4-[3-хлор-4-(этиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:,N6-метокси-4-(3-хлор-4-{[(циклопропиламино)карбонил)амино]фенокси}-7-метокси-6-хинолинкарбоксамида:,иN6-метокси-4-(3-хлор-4-{[(этиламино)карбонил]амино}фенокси)-7-метокси-6-хинолинкарбоксамида:.3. Противоопухолевое терапевтическое средство по п.1, где соединение, представленное формулой (I), является 4-[3-хлор-4-(циклопропиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамидом:.4. Противоопухолевое терапевтическое средство для совместного или раздельного введения:соединения, представленного формулой (I), или его фармацевтически приемлемой соли:,где Rпредставляет собой Cалкил или Cциклоалкил,Rпредставляет собой атом водорода или Cалкокси, иRпредставляет собой атом водорода или атом галогена; исоединения, представленного формулой (II):(II).5. Противоопухолевое терапевтическое средство по п.4, где соединение, представленное формулой (I), является одним или несколькими соединени
Claims (11)
1. Противоопухолевое терапевтическое средство для комбинированного применения:
соединения, представленного формулой (I), или его фармацевтически приемлемой соли:
где R1 представляет собой C1-6алкил или C3-8циклоалкил,
R2 представляет собой атом водорода или C1-6алкокси, и
R3 представляет собой атом водорода или атом галогена; и
соединения, представленного формулой (II):
2. Противоопухолевое терапевтическое средство по п.1, где соединение, представленное формулой (I), является одним или несколькими соединениями, выбранными из группы, состоящей из:
4-[3-хлор-4-(циклопропиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
4-[3-хлор-4-(метиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
4-[3-хлор-4-(этиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
N6-метокси-4-(3-хлор-4-{[(циклопропиламино)карбонил)амино]фенокси}-7-метокси-6-хинолинкарбоксамида:
и
N6-метокси-4-(3-хлор-4-{[(этиламино)карбонил]амино}фенокси)-7-метокси-6-хинолинкарбоксамида:
4. Противоопухолевое терапевтическое средство для совместного или раздельного введения:
соединения, представленного формулой (I), или его фармацевтически приемлемой соли:
где R1 представляет собой C1-6алкил или C3-8циклоалкил,
R2 представляет собой атом водорода или C1-6алкокси, и
R3 представляет собой атом водорода или атом галогена; и
соединения, представленного формулой (II):
5. Противоопухолевое терапевтическое средство по п.4, где соединение, представленное формулой (I), является одним или несколькими соединениями, выбранными из группы, состоящей из:
4-[3-хлор-4-(циклопропиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
4-[3-хлор-4-(метиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
4-[3-хлор-4-(этиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
N6-метокси-4-(3-хлор-4-{[(циклопропиламино)карбонил)амино]фенокси}-7-метокси-6-хинолинкарбоксамида:
и
N6-метокси-4-(3-хлор-4-{[(этиламино)карбонил]амино}фенокси)-7-метокси-6-хинолинкарбоксамида:
7. Противоопухолевое терапевтическое средство, содержащее:
соединение, представленное формулой (I), или его фармацевтически приемлемую соль:
где R1 представляет собой C1-6алкил или C3-8циклоалкил,
R2 представляет собой атом водорода или C1-6алкокси, и
R3 представляет собой атом водорода или атом галогена; и
соединение, представленное формулой (II):
8. Противоопухолевое терапевтическое средство по п.7, где соединение, представленное формулой (I), является одним или несколькими соединениями, выбранными из группы, состоящей из:
4-[3-хлор-4-(циклопропиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
4-[3-хлор-4-(метиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
4-[3-хлор-4-(этиламинокарбонил)аминофенокси]-7-метокси-6-хинолинкарбоксамида:
N6-метокси-4-(3-хлор-4-{[(циклопропиламино)карбонил)амино]фенокси}-7-метокси-6-хинолинкарбоксамида:
и
N6-метокси-4-(3-хлор-4-{[(этиламино)карбонил]амино}фенокси)-7-метокси-6-хинолинкарбоксамида:
10. Противоопухолевая фармацевтическая композиция, содержащая соединение представленное формулой (I) или его фармацевтически приемлемую соль
где R1 представляет собой C1-6алкил или C3-8циклоалкил,
R2 представляет собой атом водорода или C1-6алкокси, и
R3 представляет собой атом водорода или атом галогена;
соединение, представленное формулой (II):
11. Метод лечения опухоли, в котором соединение представленное формулой (I) или его фармацевтически приемлемая соль:
где R1 представляет собой C1-6алкил или C3-8циклоалкил,
R2 представляет собой атом водорода или C1-6алкокси, и
R3 представляет собой атом водорода или атом галогена; и
соединение, представленное формулой (II):
вводятся в комбинации.
Applications Claiming Priority (3)
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JP2011091969 | 2011-04-18 | ||
JP2011-091969 | 2011-04-18 | ||
PCT/JP2012/060279 WO2012144463A1 (ja) | 2011-04-18 | 2012-04-16 | 腫瘍治療剤 |
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RU2013140169A true RU2013140169A (ru) | 2015-05-27 |
RU2580609C2 RU2580609C2 (ru) | 2016-04-10 |
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RU2013140169/15A RU2580609C2 (ru) | 2011-04-18 | 2012-04-16 | Противоопухолевое терапевтическое средство |
Country Status (12)
Country | Link |
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US (1) | US8962650B2 (ru) |
EP (1) | EP2700403B1 (ru) |
JP (1) | JP6021805B2 (ru) |
KR (1) | KR101762999B1 (ru) |
CN (1) | CN103402519B (ru) |
AU (1) | AU2012246490B2 (ru) |
BR (1) | BR112013021941B1 (ru) |
CA (1) | CA2828946C (ru) |
IL (1) | IL227558A (ru) |
MX (1) | MX2013009931A (ru) |
RU (1) | RU2580609C2 (ru) |
WO (1) | WO2012144463A1 (ru) |
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BR112015029386B1 (pt) * | 2013-06-26 | 2023-11-14 | Eisai R&D Management Co., Ltd. | Uso de eribulina e lenvatinibe como terapia de combinação e kit |
US20170027940A1 (en) * | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
MX2017001980A (es) | 2014-08-28 | 2017-05-04 | Eisai R&D Man Co Ltd | Derivado de quinolina muy puro y metodo para su produccion. |
SG11201706630UA (en) | 2015-02-25 | 2017-09-28 | Eisai R&D Man Co Ltd | Method for suppressing bitterness of quinoline derivative |
AU2015384801B2 (en) * | 2015-03-04 | 2022-01-06 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer |
TWI604002B (zh) * | 2015-03-09 | 2017-11-01 | 科騰聚合物美國有限責任公司 | 用於固化嵌段共聚物乳膠薄膜之改良硫化系統 |
MX2017015896A (es) | 2015-06-16 | 2018-08-09 | Eisai R&D Man Co Ltd | Agente anticancerigeno. |
CN108135894B (zh) * | 2015-08-20 | 2021-02-19 | 卫材R&D管理有限公司 | 肿瘤治疗剂 |
JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
US11479559B2 (en) * | 2018-02-11 | 2022-10-25 | Beijing Scitech-Mq Pharmaceuticals Limited | Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof |
WO2023190709A1 (ja) * | 2022-03-31 | 2023-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | リポソーム組成物およびリポソームを含む医薬組成物 |
CN115215799A (zh) * | 2022-08-12 | 2022-10-21 | 上海爱博医药科技有限公司 | 脲类多靶点酪氨酸激酶抑制剂及其多种医药应用 |
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EP2700403A1 (en) | 2014-02-26 |
CA2828946A1 (en) | 2012-10-26 |
CN103402519B (zh) | 2015-11-25 |
JPWO2012144463A1 (ja) | 2014-07-28 |
US8962650B2 (en) | 2015-02-24 |
KR101762999B1 (ko) | 2017-07-28 |
RU2580609C2 (ru) | 2016-04-10 |
BR112013021941B1 (pt) | 2022-11-16 |
BR112013021941A2 (pt) | 2016-11-16 |
EP2700403A4 (en) | 2014-09-17 |
KR20140035334A (ko) | 2014-03-21 |
IL227558A (en) | 2017-07-31 |
AU2012246490B2 (en) | 2016-08-04 |
CA2828946C (en) | 2016-06-21 |
US20140031384A1 (en) | 2014-01-30 |
EP2700403B1 (en) | 2015-11-25 |
CN103402519A (zh) | 2013-11-20 |
IL227558A0 (en) | 2013-09-30 |
AU2012246490A1 (en) | 2013-08-01 |
JP6021805B2 (ja) | 2016-11-09 |
MX2013009931A (es) | 2013-10-01 |
WO2012144463A1 (ja) | 2012-10-26 |
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