RU2013116807A - Фармацевтические композиции, содержащие ера и сердечно-сосудистое средство, и способы их применения - Google Patents
Фармацевтические композиции, содержащие ера и сердечно-сосудистое средство, и способы их применения Download PDFInfo
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Abstract
1. Способ лечения смешанной дислипидемии у индивидуума, получающего лечение статином, включающий введение индивидууму 4 капсулы, каждая из которых содержит приблизительно 1 г этилэйкозапентаеноата в день для снижения триглицеридов и LDL-C натощак, по отношению к индивидуумам со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.2. Способ по п.1, в котором этилэйкозапентаеноат составляет по меньшей мере 80% по массе от всех жирных кислот, присутствующих в капсулах.3. Способ по п.1, в котором этилэйкозапентаеноат составляет по крайней мере приблизительно 90%, по массе, всех жирных кислот, существующих в капсулах.4. Способ по п.1, в котором этилэйкозапентаеноат составляет по крайней мере приблизительно 95%, по массе, всех жирных кислот, существующих в капсулах.5. Способ по любому из пп. 1-4, в котором капсулы включают не больше, чем приблизительно 20% докозагексаеновой кислоты или ее сложных эфиров, если таковые имеются.6. Способ по п. 5, в котором капсулы включают не больше, чем приблизительно 5% докозагексаеновой кислоты или ее сложных эфиров, если таковые имеются.7. Способ по п. 5, в котором капсулы включают не больше, чем приблизительно 3% докозагексаеновой кислоты или ее сложных эфиров, если таковые имеются.8. Способ по п. 1, в котором указанная стадия введения уменьшает триглицериды натощак по крайней мере на 10% относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.9. Способ по п. 1, в котором указанная стадия введения уменьшает триглицериды натощак по крайней мере на 15% относительно индивидуумов со смешанной дислипидемией, которые пол
Claims (19)
1. Способ лечения смешанной дислипидемии у индивидуума, получающего лечение статином, включающий введение индивидууму 4 капсулы, каждая из которых содержит приблизительно 1 г этилэйкозапентаеноата в день для снижения триглицеридов и LDL-C натощак, по отношению к индивидуумам со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
2. Способ по п.1, в котором этилэйкозапентаеноат составляет по меньшей мере 80% по массе от всех жирных кислот, присутствующих в капсулах.
3. Способ по п.1, в котором этилэйкозапентаеноат составляет по крайней мере приблизительно 90%, по массе, всех жирных кислот, существующих в капсулах.
4. Способ по п.1, в котором этилэйкозапентаеноат составляет по крайней мере приблизительно 95%, по массе, всех жирных кислот, существующих в капсулах.
5. Способ по любому из пп. 1-4, в котором капсулы включают не больше, чем приблизительно 20% докозагексаеновой кислоты или ее сложных эфиров, если таковые имеются.
6. Способ по п. 5, в котором капсулы включают не больше, чем приблизительно 5% докозагексаеновой кислоты или ее сложных эфиров, если таковые имеются.
7. Способ по п. 5, в котором капсулы включают не больше, чем приблизительно 3% докозагексаеновой кислоты или ее сложных эфиров, если таковые имеются.
8. Способ по п. 1, в котором указанная стадия введения уменьшает триглицериды натощак по крайней мере на 10% относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
9. Способ по п. 1, в котором указанная стадия введения уменьшает триглицериды натощак по крайней мере на 15% относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
10. Способ по п. 1, в котором указанная стадия введения уменьшает триглицериды натощак по крайней мере на 20% относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
11. Способ по п. 1, в котором указанная стадия введения уменьшает триглицериды натощак по крайней мере на 25% и LDL-C по крайней мере на 5% относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
12. Способ по п. 1, в котором указанная стадия введения уменьшает аполипопротеин B натощак относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
13. Способ по п. 1, в котором указанная стадия введения уменьшает аполипопротеин B натощак по крайней мере на 5% относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
14. Способ по п. 1, в котором указанная стадия введения уменьшает VLDL-C натощак относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
15. Способ по п. 1, в котором указанная стадия введения уменьшает VLDL-C натощак по крайней мере на 15% относительно индивидуумов со смешанной дислипидемией, которые получают статин без указанного этилэйкозапентаеноата.
16. Способ по п. 1, в котором статин выбран из ловастатина, мевастатина, питавастатитина, правастатина, розувастатина, флувастатина, аторвастатина и симвастатина.
17. Способ лечения смешанной дислипидемии у индивидуума получающего лечение статином, включающий введение индивидууму 4 капсулы, каждая из которых содержит приблизительно 900 мг этилэйкозапентаеноата ежедневно.
18. Способ лечения смешанной дислипидемии у индивидуума, получающего лечение статином, включающий введение индивидууму 4 капсулы, каждая из которых содержит приблизительно 925 мг или приблизительно 950 мг этилэйкозапентаеноата ежедневно.
19. Способ лечения смешанной дислипидемии у индивидуума, получающего лечение статином, включающий введение индивидууму 4 капсулы, каждая из которых содержит приблизительно 975 мг этилэйкозапентаеноата ежедневно.
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