CO6470839A2 - Composiciones farmacéuticas que contienen epa y un agente cardiovascular y métodos de emplearlas - Google Patents

Composiciones farmacéuticas que contienen epa y un agente cardiovascular y métodos de emplearlas

Info

Publication number
CO6470839A2
CO6470839A2 CO11163910A CO11163910A CO6470839A2 CO 6470839 A2 CO6470839 A2 CO 6470839A2 CO 11163910 A CO11163910 A CO 11163910A CO 11163910 A CO11163910 A CO 11163910A CO 6470839 A2 CO6470839 A2 CO 6470839A2
Authority
CO
Colombia
Prior art keywords
methods
epa
employment
pharmaceutical compositions
compositions containing
Prior art date
Application number
CO11163910A
Other languages
English (en)
Inventor
Mehar Manku
Jonathan Rower
Original Assignee
Amarin Corp Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amarin Corp Plc filed Critical Amarin Corp Plc
Publication of CO6470839A2 publication Critical patent/CO6470839A2/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)

Abstract

En una incorporación, la presente invención provee una composición farmacéutica que contiene EPA y, opcionalmente, uno o más agentes cardiovasculares adicionales. En otra incorporación, el EPA incluye éster etílico de ácido eicosapentaenoico. En otra incorporación, la composición no contiene sustancialmente una cantidad de ácido docosahexaenoico o su derivado (v.g. etil DHA), si lo hubiere.En otras incorporaciones, la presente invención provee métodos de tratar y/o prevenir una enfermedad cardiovascularmente relacionada, métodos que incluyen administrar a un sujeto que lo necesita una composición farmacéutica o una composición (composiciones) que contiene(n) EPA y, opcionalmente, uno o más agentes cardiovasculares adicionales.
CO11163910A 2009-04-29 2011-11-29 Composiciones farmacéuticas que contienen epa y un agente cardiovascular y métodos de emplearlas CO6470839A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17375909P 2009-04-29 2009-04-29

Publications (1)

Publication Number Publication Date
CO6470839A2 true CO6470839A2 (es) 2012-06-29

Family

ID=43032772

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11163910A CO6470839A2 (es) 2009-04-29 2011-11-29 Composiciones farmacéuticas que contienen epa y un agente cardiovascular y métodos de emplearlas

Country Status (16)

Country Link
US (27) US20120093922A1 (es)
EP (4) EP3791880A1 (es)
KR (1) KR101357438B1 (es)
CN (4) CN102413825A (es)
AU (1) AU2010241567B2 (es)
BR (1) BRPI1014405A2 (es)
CA (1) CA2759176C (es)
CO (1) CO6470839A2 (es)
HK (1) HK1202795A1 (es)
MX (3) MX2011011517A (es)
MY (2) MY173994A (es)
NZ (6) NZ734905A (es)
RU (5) RU2624506C2 (es)
SG (1) SG175390A1 (es)
WO (1) WO2010127099A2 (es)
ZA (1) ZA201107623B (es)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
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KR101444489B1 (ko) 2007-02-01 2014-09-24 리스버로직스 코퍼레이션 심혈관 질환을 예방 및 치료하기 위한 화합물
PL2334295T3 (pl) 2008-09-02 2017-12-29 Amarin Pharmaceuticals Ltd Kompozycja farmaceutyczna zawierająca kwas eikozapentaenowy i kwas nikotynowy oraz sposoby jej zastosowania
JP5795304B2 (ja) 2009-03-18 2015-10-14 レスバーロジックス コーポレイション 新規抗炎症剤
PT2421533T (pt) 2009-04-22 2019-01-21 Resverlogix Corp Novos agentes anti-inflamatórios
BRPI1014405A2 (pt) 2009-04-29 2016-04-05 Amarin Corp Plc composições farmacêuticas compreendendo epa e um agente cardiovascular e métodos de seu uso
EP3797591A1 (en) 2009-04-29 2021-03-31 Amarin Pharmaceuticals Ireland Limited Stable pharmaceutical composition and methods of using same
US8492108B2 (en) * 2009-06-12 2013-07-23 Bruce J. Auerbach Methods of treating anemia and red blood cell dysfunction with lecithin cholesterol acyltransferase
KR20120016677A (ko) 2009-06-15 2012-02-24 아마린 파마, 인크. 병용 스타틴 요법을 받는 대상체에서 ｌｄｌ－ｃ 수준을 상승시키지 않으면서 트리글리세리드를 저하시키기 위한 조성물 및 방법
SG10201405994UA (en) 2009-09-23 2014-10-30 Amarin Pharmaceuticals Ie Ltd Pharmaceutical Composition Comprising Omega-3 Fatty Acid And Hydroxy-derivative Of A Statin And Methods Of Using Same
CN102770126A (zh) * 2010-02-25 2012-11-07 百时美施贵宝公司 阿哌沙班制剂
WO2012063272A1 (en) 2010-11-12 2012-05-18 Gentium S.P.A. Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd).
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MY198422A (en) 2023-08-29
US20180042880A1 (en) 2018-02-15
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US8563608B2 (en) 2013-10-22
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US20210113509A1 (en) 2021-04-22
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CN107233337A (zh) 2017-10-10
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US20220079906A1 (en) 2022-03-17
US9056088B2 (en) 2015-06-16
RU2746945C2 (ru) 2021-04-22
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US20140154310A1 (en) 2014-06-05
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US10888537B2 (en) 2021-01-12
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US20210379002A1 (en) 2021-12-09
RU2017121277A (ru) 2018-12-19
RU2648826C2 (ru) 2018-03-28
BRPI1014405A2 (pt) 2016-04-05
EP2424521A4 (en) 2015-03-04
US8680144B2 (en) 2014-03-25
CN102413825A (zh) 2012-04-11
RU2624506C2 (ru) 2017-07-04
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US20130005757A1 (en) 2013-01-03
US20150272917A1 (en) 2015-10-01
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US20130253031A1 (en) 2013-09-26
US10624870B2 (en) 2020-04-21
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US20120302589A1 (en) 2012-11-29
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RU2013106526A (ru) 2014-08-20
US10792267B2 (en) 2020-10-06
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RU2489145C1 (ru) 2013-08-10
US10265287B2 (en) 2019-04-23
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RU2017145265A3 (es) 2021-09-17
US20190070141A1 (en) 2019-03-07
US20190240182A1 (en) 2019-08-08
RU2011148363A (ru) 2013-06-10
US20210000779A1 (en) 2021-01-07
US20210100764A1 (en) 2021-04-08
AU2010241567A1 (en) 2011-11-10
US10220013B2 (en) 2019-03-05
US20120093922A1 (en) 2012-04-19
US20130253030A1 (en) 2013-09-26
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US20150231102A1 (en) 2015-08-20
US20210212974A1 (en) 2021-07-15
US20210100765A1 (en) 2021-04-08
US20130195972A1 (en) 2013-08-01
US20220241234A1 (en) 2022-08-04
US8618166B2 (en) 2013-12-31
SG175390A1 (en) 2011-12-29
US20140155455A1 (en) 2014-06-05
US11154526B2 (en) 2021-10-26
NZ720946A (en) 2017-09-29
US20220079907A1 (en) 2022-03-17
US20170014366A1 (en) 2017-01-19
EP3791880A1 (en) 2021-03-17
US11400069B2 (en) 2022-08-02
AU2010241567B2 (en) 2013-10-31
HK1202795A1 (en) 2015-10-09
RU2017121277A3 (es) 2020-08-10
RU2017145265A (ru) 2019-06-24
US20120121698A1 (en) 2012-05-17
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US10940131B2 (en) 2021-03-09
US20190183831A1 (en) 2019-06-20

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