PE20141658A1 - Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) - Google Patents

Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3)

Info

Publication number
PE20141658A1
PE20141658A1 PE2014000277A PE2014000277A PE20141658A1 PE 20141658 A1 PE20141658 A1 PE 20141658A1 PE 2014000277 A PE2014000277 A PE 2014000277A PE 2014000277 A PE2014000277 A PE 2014000277A PE 20141658 A1 PE20141658 A1 PE 20141658A1
Authority
PE
Peru
Prior art keywords
lag
lymphocytary
gen
join
activation
Prior art date
Application number
PE2014000277A
Other languages
English (en)
Inventor
Heidi Leblanc
Mark Yamanaka
Mark Selby
Kyra D Zens
Alan J Korman
Kent Thudium
Original Assignee
Medarex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669613&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141658(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medarex Llc filed Critical Medarex Llc
Publication of PE20141658A1 publication Critical patent/PE20141658A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

SE REFIERE A UN ANTICUERPO MONOCLONAL HUMANO AISLADO O UNA PORCION DE UNION A ANTIGENO DEL MISMO, QUE SE UNE AL GEN 3 DE ACTIVACION LINFOCITARIA (LAG-3) HUMANA, QUE PRESENTA LAS SIGUIENTES PROPIEDADES: a) SE UNE A LAG-3 DE MONO; b) NO SE UNE A LAG-3 DE RATON; c) INHIBE LA UNION DE LA LAG-3 A MOLECULAS DEL COMPLEJO PRINCIPAL DE HISTOCOMPATIBILIDAD (MHC) DE CLASE II; Y D) ESTIMULA UNA RESPUESTA INMUNITARIA. DICHO ANTICUERPO COMPRENDE UNA REGION VARIABLE DE LA CADENA PESADA QUE TIENE UNA SECUENCIA DE AMINOACIDOS QUE CONSISTEN EN SEQ ID Nos: 37-42; Y UNA REGION VARIABLE DE LA CADENA LIGERA QUE TIENE UNA SECUENCIA DE AMINOACIDOS QUE CONSISTEN EN SEQ ID Nos: 43-48. SE REFIERE TAMBIENA UNA COMPOSICION, UN INMUNOCONJUGADO, UNA MOLECULA DE ACIDO NUCLEICO, UN VECTOR Y UNA CELULA HUESPED. DICHOS ANTICUERPOS SON UTILES PARA EL TRATAMIENTO DE UNA INFECCION VIRICA
PE2014000277A 2008-08-11 2009-08-11 Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) PE20141658A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18854808P 2008-08-11 2008-08-11

Publications (1)

Publication Number Publication Date
PE20141658A1 true PE20141658A1 (es) 2014-11-08

Family

ID=41669613

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2011000142A PE20110306A1 (es) 2008-08-11 2009-08-11 Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3)
PE2014000277A PE20141658A1 (es) 2008-08-11 2009-08-11 Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3)
PE2018002011A PE20190373A1 (es) 2008-08-11 2009-08-11 Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2011000142A PE20110306A1 (es) 2008-08-11 2009-08-11 Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3)

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2018002011A PE20190373A1 (es) 2008-08-11 2009-08-11 Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3)

Country Status (32)

Country Link
US (13) US20110150892A1 (es)
EP (4) EP3597216B1 (es)
JP (6) JP5647981B2 (es)
KR (6) KR102370201B1 (es)
CN (4) CN103923213A (es)
AR (3) AR072999A1 (es)
AU (2) AU2009282134B2 (es)
BR (1) BRPI0917470B8 (es)
CA (1) CA2734335C (es)
CL (4) CL2011000308A1 (es)
CO (1) CO6351751A2 (es)
CY (2) CY1116582T1 (es)
DK (3) DK2320940T3 (es)
EA (2) EA023032B1 (es)
ES (3) ES2537203T3 (es)
HK (2) HK1151985A1 (es)
HR (3) HRP20221191T1 (es)
HU (2) HUE025250T2 (es)
IL (4) IL210731A (es)
LT (2) LT3597216T (es)
MX (2) MX2011001250A (es)
NZ (3) NZ602780A (es)
PE (3) PE20110306A1 (es)
PL (3) PL2905030T3 (es)
PT (3) PT2905030T (es)
SG (1) SG10201706497QA (es)
SI (2) SI2320940T1 (es)
SM (1) SMT201500125B (es)
TN (1) TN2011000025A1 (es)
TW (1) TWI491408B (es)
WO (1) WO2010019570A2 (es)
ZA (1) ZA201101009B (es)

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