AR111419A1 - Compuestos fusionados de indazol piridona como antivirales - Google Patents

Compuestos fusionados de indazol piridona como antivirales

Info

Publication number
AR111419A1
AR111419A1 ARP180101043A ARP180101043A AR111419A1 AR 111419 A1 AR111419 A1 AR 111419A1 AR P180101043 A ARP180101043 A AR P180101043A AR P180101043 A ARP180101043 A AR P180101043A AR 111419 A1 AR111419 A1 AR 111419A1
Authority
AR
Argentina
Prior art keywords
alkyl
halo
optionally substituted
ring
cycloalkyl
Prior art date
Application number
ARP180101043A
Other languages
English (en)
Inventor
Joseph Michael Young
Keith Brice Pfister
Peichao Lu
Subramanian Karur
Wooseok Han
Jiping Fu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR111419A1 publication Critical patent/AR111419A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Abstract

Reivindicación 1: Un compuesto de fórmula (1), caracterizado porque: R¹ es H o halo; R² se selecciona independientemente en cada aparición entre halo, CN, haloalquilo C₁₋₃, haloalcoxi C₁₋₃, -OR³, -N(R)R³, y alquilo C₁₋₃ opcionalmente sustituido con hasta tres grupos seleccionados entre R³, -N(R)R³, CN, -OH, -CONR₂, -COOR, y -OR³; R³ es un alquilo C₁₋₄ que está opcionalmente sustituido con uno a tres grupos seleccionados de halo, haloalquilo C₁₋₃, -OH, alcoxi C₁₋₃, haloalcoxi C₁₋₃, oxo, CN, -NH₂, -NH(alquilo C₁₋₃), -N(alquilo C₁₋₃)₂, -COOR, -CONR₂, cicloalquilo C₃₋₅, y un éter cíclico de 4 - 6 miembros, en el que el cicloalquilo C₃₋₅ y el éter cíclico de 4 - 6 miembros están cada uno opcionalmente sustituidos con uno o dos grupos seleccionados de halo, -OH, alcoxi C₁₋₃, y alquilo C₁₋₃; o R³ es un anillo cicloalquilo C₃₋₅ o éter cíclico de 4 - 6 miembros, en el que el anillo cicloalquilo C₃₋₅ o éter cíclico de 4 - 6 miembros están cada uno opcionalmente sustituidos con uno a tres grupos seleccionados de halo, alquilo C₁₋₃, -OH, alcoxi C₁₋₃, haloalcoxi C₁₋₃, haloalquilo C₁₋₃, -NH₂, -NH(alquilo C₁₋₃), y -N(alquilo C₁₋₃)₂; n es 0, 1, ó 2; W es -COOR⁴, -C(O)NH-SO₂R⁵, -C(O)NH-SO₂NR₂, 5-tetrazolilo, o 1,2,4-oxadiazol-3-il-5(4H)-ona; R⁴ es H o alquilo C₁₋₆ que está opcionalmente sustituido con uno a tres grupos seleccionados de halo, -OR, oxo, CN, y -NR₂; R⁵ es alquilo C₁₋₆ que está opcionalmente sustituido con uno a tres grupos seleccionados de halo, -OR, oxo, CN, y-NR₂; R⁶ es H o alquilo C₁₋₆; R⁷ es H o alquilo C₁₋₆, o R⁷ tomado junto con R⁹ y los átomos que los unen R⁷ con R⁹ forman un anillo como se describe a continuación; R⁸ es H o alquilo C₁₋₆; R⁹ se selecciona entre: (i) H; (ii) alquilo C₁₋₆ opcionalmente sustituido con hasta tres grupos seleccionados entre cicloalquilo C₃₋₆, -OR, -NR₂, halo, CN, COOR, CONR₂, y oxo; y (iii) un anillo seleccionado de (a) cicloalquilo C₃₋₆, (b) fenilo, (c) heterociclilo de 5 - 6 miembros que contiene uno o dos heteroátomos seleccionados de N, O y S como miembros del anillo, y (d) heteroarilo de 5 - 6 miembros que contiene uno o dos heteroátomos seleccionados de N, o y S como miembros del anillo, en el que cada uno de los anillos (a) a (d) está opcionalmente sustituido con hasta tres grupos seleccionados de alquilo C₁₋₂, (CH₂)₀₋₂-OR, -NR₂, halo, CN, COOR, y CONR₂; o R⁹ tomado junto con R⁷ y los átomos que los unen R⁹ con R⁷ forma un anillo cicloalquilo de 3 - 7 miembros, o un anillo heterocíclico de 3 - 7 miembros que contiene N, O ó S como miembro de anillo; en donde el anillo cicloalquilo o heterocíclico está opcionalmente sustituido con hasta tres grupos seleccionados de entre R, -OR, -NR₂, halo, CN, COOR, CONR₂, y oxo; R se selecciona independientemente en cada caso de H y alquilo C₁₋₃ opcionalmente sustituido con uno a tres grupos seleccionados de halo, -OH, alcoxi C₁₋₃, oxo, CN, -NH₂, -NH(alquilo C₁₋₃), -N(alquilo C₁₋₃)₂, y ciclopropilo; y dos grupos R unidos directamente al mismo átomo pueden tomarse opcionalmente junto con el átomo al que ambos están unidos para formar un anillo de 3 - 6 miembros que puede contener opcionalmente un heteroátomo seleccionado de N, O y S como miembro del anillo, y puede estar sustituido con hasta dos grupos seleccionados de -OH, oxo, alquilo C₁₋₃ y alcoxi C₁₋₃; o una sal farmacéuticamente aceptable del mismo.
ARP180101043A 2017-04-27 2018-04-24 Compuestos fusionados de indazol piridona como antivirales AR111419A1 (es)

Applications Claiming Priority (1)

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US201762490890P 2017-04-27 2017-04-27

Publications (1)

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AR111419A1 true AR111419A1 (es) 2019-07-10

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Country Status (9)

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US (3) US10301312B2 (es)
EP (2) EP3615533B1 (es)
JP (1) JP7290573B2 (es)
CN (1) CN110831942B (es)
AR (1) AR111419A1 (es)
ES (1) ES2899922T3 (es)
TW (1) TWI810182B (es)
UY (1) UY37699A (es)
WO (1) WO2018198079A1 (es)

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US20200270252A1 (en) 2020-08-27
EP3615533B1 (en) 2021-09-08
US20190300530A1 (en) 2019-10-03
EP3615533A1 (en) 2020-03-04
US20180312507A1 (en) 2018-11-01
TW201841919A (zh) 2018-12-01
US10301312B2 (en) 2019-05-28
JP7290573B2 (ja) 2023-06-13
CN110831942A (zh) 2020-02-21
TWI810182B (zh) 2023-08-01
WO2018198079A1 (en) 2018-11-01
ES2899922T3 (es) 2022-03-15
UY37699A (es) 2018-11-30
JP2020517667A (ja) 2020-06-18
US10975078B2 (en) 2021-04-13
CN110831942B (zh) 2023-04-04

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