AR078254A1 - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents

Inmunoglobulinas con dominio variable dual y usos de las mismas

Info

Publication number
AR078254A1
AR078254A1 ARP100103210A ARP100103210A AR078254A1 AR 078254 A1 AR078254 A1 AR 078254A1 AR P100103210 A ARP100103210 A AR P100103210A AR P100103210 A ARP100103210 A AR P100103210A AR 078254 A1 AR078254 A1 AR 078254A1
Authority
AR
Argentina
Prior art keywords
mtx
seq
variable domain
heavy chain
immunoglobulins
Prior art date
Application number
ARP100103210A
Other languages
English (en)
Inventor
Tariq Ghayur
Junjian Liu
Sharmila Manoj
Susan E Brophy
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43649948&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR078254(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR078254A1 publication Critical patent/AR078254A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract

Proteínas de union multivalentes y multiespecíficas producidas por ingeniería genética, métodos para elaborarlas y. específicamente, sus usos en la prevencion, el diagnostico yio el tratamiento de enfermedades. Reivindicacion 1. Una proteína de union que comprende una cadena polipeptídica, caracterizada porque dicha cadena polipeptídica comprende VD 1 -(X1)nVD2-C-(X2)n, en donde; VD1 es un primer dominio variable de la cadena pesada; VD2 es un segundo dominio variable de la cadena pesada; C es un dominio constante de la cadena pesada; X1 es un conector, con la condicion de que no sea CH1; X2 es una region Fc; y n es 0 o 1; en donde la proteína de union une un par de antígenos que se seleccionan del grupo formado por MTX y mCD-3, MTX y mCD-19, MTX y hCD-3 (seq. 2), MTX y hCD-19 (seq. 2), MTX y CD-20, MTX y EGFR (seq. 3), MTX y HER-2 (seq. 1), y MTX y CD-3 (seq. 1).
ARP100103210A 2009-09-01 2010-09-01 Inmunoglobulinas con dominio variable dual y usos de las mismas AR078254A1 (es)

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